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Interval-Valued Dual Hesitant Fuzzy Hamacher Aggregation Operators for Multiple Attribute Decision Making 预览
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作者 Chao JIANG Shenqing JIANG Jianlan CHEN 《系统科学与信息学报:英文版》 CSCD 2019年第3期227-256,共30页
As an generalization of hesitant fuzzy set, interval-valued hesitant fuzzy set and dual hesitant fuzzy set, interval-valued dual hesitant fuzzy set has been proposed and applied in multiple attribute decision making. ... As an generalization of hesitant fuzzy set, interval-valued hesitant fuzzy set and dual hesitant fuzzy set, interval-valued dual hesitant fuzzy set has been proposed and applied in multiple attribute decision making. Hamacher t-norm and t-conorm is an generalization of algebraic and Einstein t-norms and t-conorms. In order to combine interval-valued dual hesitant fuzzy aggregation operators with Hamacher t-norm and t-conorm. We first introduced some new Hamacher operation rules for interval-valued dual hesitant fuzzy elements. Then, several interval-valued dual hesitant fuzzy Hamacher aggregation operators are presented, some desirable properties and their special cases are studied. Further, a new multiple attribute decision making method with these operators is given,and an numerical example is provided to demonstrate that the developed approach is both valid and practical. 展开更多
关键词 multiple ATTRIBUTE decision making interval-valued DUAL hesitant FUZZY set Hamacher T-NORM and t-conorm interval-valued DUAL hesitant FUZZY Hamacher AGGREGATION OPERATORS
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一种内外迭代方法求解三凸函数和优化问题
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作者 唐玉超 吴国荣 朱传喜 《中国科学:数学》 CSCD 北大核心 2019年第5期831-858,共28页
近年来,关于多个凸函数和的优化问题受到广泛关注.本文研究三个凸函数和f(x)+g(x)+h(Bx)的一类凸优化问题,其中f (x)可微且具有Lipschitz连续梯度, g(x)和h(x)是正则下半连续简单凸函数, B是一个有界线性算子.此类优化问题在信号恢复和... 近年来,关于多个凸函数和的优化问题受到广泛关注.本文研究三个凸函数和f(x)+g(x)+h(Bx)的一类凸优化问题,其中f (x)可微且具有Lipschitz连续梯度, g(x)和h(x)是正则下半连续简单凸函数, B是一个有界线性算子.此类优化问题在信号恢复和图像处理等实际问题中有着广泛的应用.为充分利用问题中的可微函数,本文基于向前向后分裂算法和三算子分裂算法框架,建立若干具有内外迭代形式的算法.在推导迭代算法的过程中,本文提出基于对偶和原始对偶方法求解函数g+h?B和h?B的邻近算子.在对参数一定假设条件下,本文证明所提出的迭代算法收敛性.通过与Condat和Vu算法、原始对偶不动点(primal-dual?xed point, PDFP)算法和原始对偶三算子(primal-dual three-operator, PD3O)算法比较,建立三种迭代算法与本文提出的迭代算法之间的联系.最后,通过对融合Lasso问题、约束全变分正则化问题和低秩全变分图像超分辨率重建问题实施一系列数值实验,验证所提出的迭代算法的有效性. 展开更多
关键词 向前向后分裂算法 三算子分裂算法 对偶 原始对偶 全变分
A NONTRIVIAL SOLUTION OF A QUASILINEAR ELLIPTIC EQUATION VIA DUAL APPROACH 预览
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作者 杨先勇 张薇 赵富坤 《数学物理学报:B辑英文版》 SCIE CSCD 2019年第2期580-596,共17页
In this article, we are concerned with the existence of solutions of a quasilinear elliptic equation in R~N which includes the so-called modified nonlinear Schrodinger equation as a special case. Combining the dual ap... In this article, we are concerned with the existence of solutions of a quasilinear elliptic equation in R~N which includes the so-called modified nonlinear Schrodinger equation as a special case. Combining the dual approach and the nonsmooth critical point theory, we obtain the existence of a nontrivial solution. 展开更多
关键词 nontrivial solution QUASILINEAR ELLIPTIC equation NONSMOOTH critical point theory DUAL APPROACH
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On a Class of Constacyclic Codes of Length 4p^8 over Fpm[u]/〈 u^a 〉
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作者 Hai Q. Dinh Bac T. Nguyen Songsak Sriboonchitta 《代数集刊:英文版》 SCIE CSCD 2019年第2期181-194,共14页
For any odd prime p such that p^m ≡ 3 (mod 4), consider all units Λ of the finite commutative chain ring Ra=Fpm[u]/〈u^a〉=Fp^m+uFp^m+…+u^a1Fp^m that have the form Λ=Λ0 + uΛ1 ++ u^a1 Λa1, where Λ0,Λ1,…,Λa1 ... For any odd prime p such that p^m ≡ 3 (mod 4), consider all units Λ of the finite commutative chain ring Ra=Fpm[u]/〈u^a〉=Fp^m+uFp^m+…+u^a1Fp^m that have the form Λ=Λ0 + uΛ1 ++ u^a1 Λa1, where Λ0,Λ1,…,Λa1 p^m,Λ0 ≠ 0,Λ1 ≠ 0. The class of Λ-constacyclic codes of length 4p^s over a is investigated. If the unit Λ is a square, each Λ-constacyclic code of length 4p^s is expressed as a direct sum of a λ-constacyclic code and a λ-constacyclic code of length 2p^s. In the main case that the unit Λ is not a square, we prove that the polynomial x^4 λ0 can be decomposed as a product of two quadratic irreducible and monic coprime factors, where λ^p^s0=Λ0. From this, the ambient ring Ra[x]/<x^4p^sΛ>is proven to be a principal ideal ring, whose maximal ideals are <x^2 + 2ηx + 2η^2> and <x^2 2ηx + 2η^2>, where λ0 =4η^4. We also give the unique self-dual Type 1 Λ-constacyclic codes of length 4p^s over a. Furthermore, conditions for a Type 1 Λ-constacyclic code to be self-orthogonal and dual-containing are provided. 展开更多
关键词 constacyclic CODES DUAL CODES CHAIN RINGS
Thickness evolution of graphite-based cathodes in the dual ion batteries via in operando optical observation 预览
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作者 Na Li Yaoda Xin +4 位作者 Haosen Chen Shuqiang Jiao Hanqing Jiang Wei-Li Song Daining Fang 《能源化学:英文版》 SCIE EI CAS CSCD 2019年第2期122-128,共7页
Graphite has been currently considered as a promising cathode material in dual ion batteries(DIBs)due to its unique features of sp2 hybridized carbon and stacked two-dimensional layered structures.However,unexpected v... Graphite has been currently considered as a promising cathode material in dual ion batteries(DIBs)due to its unique features of sp2 hybridized carbon and stacked two-dimensional layered structures.However,unexpected volume/thickness changes in the graphite cathodes,induced by the intercalation/deintercalation of anions with large molecular size have been known to be a critical problem in designing DIB cells.To understand the volume/thickness changes in the DIB electrodes,in operando optical observing apparatus has been employed to observe the cross-section view of a graphite-based cathode upon cycles in the present work.The observation suggests that the cathode initially presented a huge irreversible thickness change(60%),and such thickness variation was prone to reduce and remain <20% in the following cycles.The results from both in operando observation and electrochemical characterizations collectively indicate that the greater thickness variation at initial cycle should be attributed to both anion intercalation into graphite-based cathodes and irreversible decomposition of chemical components in the DIB system.The method here highlights a universal route for fundamentally understanding the electrodes of huge volume variation. 展开更多
关键词 DUAL ion BATTERIES In OPERANDO optical observation GRAPHITE CATHODE Thickness EVOLUTION
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Sedimentary Facies, Sequence Stratigraphic Patterns in Pre-Cenozoic Inland Compressional Basin: Example from Early Yanshanian Succession of Eastern Yihezhuang Salient, Jiyang Depression, Bohai Bay Basin, China
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作者 Guangzeng Song Hua Wang +2 位作者 Meng Xu Jinda Xu Guoqing Sang 《地球科学学刊:英文版》 SCIE CAS CSCD 2019年第1期194-205,共12页
To improve the success rate of locating hydrocarbon reservoirs in pre-Cenozoic inland compressional basins, taking the Early Yanshanian succession of eastern Yihezhuang salient as an example, this paper studied the se... To improve the success rate of locating hydrocarbon reservoirs in pre-Cenozoic inland compressional basins, taking the Early Yanshanian succession of eastern Yihezhuang salient as an example, this paper studied the sedimentary facies and sequence stratigraphic patterns. First, through seismic profiles, well logs, cores and outcrops, the sequence framework was established and internal sedimentary facies were identified. Further, according to analysis of single-wells and connecting-wells, the vertical evolution and horizontal distribution of sedimentation inside the sequence frameworks were discussed. The following results were acquired:(1) meandering river characterized by dual structures superposing each other was developed, and the dual structures can be further divided into three kinds;(2) the entire Early Yanshanian succession was interpreted as one first-order sequence, composed of three third-order sequences, including SQ-Fz1, SQ-Fz2 and SQ-St from bottom to top. Each third-order sequence can be further divided into three system tracts;(3) in different system tracts, different types of dual structures developed separately, and sedimentary bodies showed different horizontal distribution scales and vertical superposition patterns. Finally, the model of sequence stratigraphic patterns was established. This study enhanced the use of sequence stratigraphy to inland tectonically active basins, and would be helpful to predict reservoirs in pre-Cenozoic residual basins. 展开更多
关键词 Early YANSHANIAN SUCCESSION SEQUENCE STRATIGRAPHIC patterns INLAND compressional BASIN meandering river dual structure
A Study of the Effective Output Strategy of Hebei Red Culture in College English Teaching 预览
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作者 Guan Chen 《管理科学与研究:中英文版》 2019年第1期74-77,共4页
As a part of Chinese culture, red culture plays an important role in politics, education, economy and culture of today's society. Because of the similarities and differences between Chinese culture and foreign cul... As a part of Chinese culture, red culture plays an important role in politics, education, economy and culture of today's society. Because of the similarities and differences between Chinese culture and foreign culture, people's understanding and expression of things are different, and vocabulary in different languages also contains rich cultural connotations with different characteristics. In this paper,"red culture" was taken as an example, and the similarities and differences of its cultural meanings in English and Chinese were analyzed. This paper hopes that the instructor can make better use of cross-cultural factors in vocabulary teaching to help students familiarize themselves with and master all kinds of vocabulary with cultural characteristics. 展开更多
关键词 RED culture ENGLISH teaching Dual CONTEXT of Chinese and ENGLISH
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Feasibility of gastric endoscopic submucosal dissection with continuous low-dose aspirin for patients receiving dual antiplatelet therapy 预览
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作者 Hideaki Harada Satoshi Suehiro +7 位作者 Daisuke Murakami Ryotaro Nakahara Takuya Nagasaka Tetsuro Ujihara Ryota Sagami Yasushi Katsuyama Kenji Hayasaka Yuji Amano 《世界胃肠病学杂志:英文版》 SCIE CAS 2019年第4期457-467,共11页
BACKGROUND Endoscopic submucosal dissection(ESD)for gastric neoplasms during continuous low-dose aspirin(LDA)administration is generally acceptable according to recent guidelines.This retrospective study aimed to inve... BACKGROUND Endoscopic submucosal dissection(ESD)for gastric neoplasms during continuous low-dose aspirin(LDA)administration is generally acceptable according to recent guidelines.This retrospective study aimed to investigate the effect of continuous LDA on the postoperative bleeding after gastric ESD in patients receiving dual antiplatelet therapy(DAPT).AIM To investigate the feasibility of gastric ESD with continuous LDA in patients with DAPT.METHODS A total of 597 patients with gastric neoplasms treated with ESD between January 2010 and June 2017 were enrolled.The patients were categorized according to type of antiplatelet therapy(APT).RESULTS The postoperative bleeding rate was 6.9%(41/597)in all patients.Patients were divided into the following two groups:no APT(n=443)and APT(n=154).APT included single-LDA(n=95)and DAPT(LDA plus clopidogrel,n=59)subgroups.In the single-LDA and DAPT subgroups,56 and 39 patients were received continuous LDA,respectively.The bleeding rate with continuous single-LDA(10.7%)was similar to that with discontinuous single-LDA(10.3%)(P>0.99).Although the bleeding rate with continuous LDA in patients receiving DAPT(23.1%)was higher than that with discontinuous LDA in patients receiving DAPT(5.0%),no significant difference was observed(P=0.141).CONCLUSION The bleeding rate with continuous LDA in patients receiving DAPT was not statistically different from that with discontinuous LDA in patients receiving DAPT.Therefore,continuous LDA administration may be acceptable for ESD in patients receiving DAPT,although patients should be carefully monitored for possible bleeding. 展开更多
关键词 Dual ANTIPLATELET therapy Endoscopic SUBMUCOSAL DISSECTION LOW-DOSE ASPIRIN Postoperative BLEEDING Thienopyridine
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THE ORLICZ BRUNN-MINKOWSKI INEQUALITY FOR DUAL HARMONIC QUERMASSINTEGRALS 预览
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作者 吴翔 李寿贵 《数学物理学报:B辑英文版》 SCIE CSCD 2019年第4期945-954,共10页
Within the framework of Orlicz Brunn-Minkowski theory recently introduced by Lutwak, Yang, and Zhang [20, 21], Gardner, Hug, and Weil [5, 6] et al, the dual harmonic quermassintegrals of star bodies are studied, and a... Within the framework of Orlicz Brunn-Minkowski theory recently introduced by Lutwak, Yang, and Zhang [20, 21], Gardner, Hug, and Weil [5, 6] et al, the dual harmonic quermassintegrals of star bodies are studied, and a new Orlicz Brunn-Minkowski type inequality is proved for these geometric quantities. 展开更多
关键词 Star BODY DUAL HARMONIC quermassintegrals ORLICZ Brunn-Minkowski INEQUALITY
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论人类命运共同体理念的双重理论基础 预览
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作者 赵威 《安徽理工大学学报:社会科学版》 2019年第3期12-16,共5页
人类命运共同体理念是十八大以来习近平总书记治国理政的新理念.是马克思历史唯物主义与现代文明发展的有机结合.也是马克思主义中国化的新的理论成果.人类命运共同体理念是对现今人类正在面临或者可能面临的共同的生存和发展问题.提出... 人类命运共同体理念是十八大以来习近平总书记治国理政的新理念.是马克思历史唯物主义与现代文明发展的有机结合.也是马克思主义中国化的新的理论成果.人类命运共同体理念是对现今人类正在面临或者可能面临的共同的生存和发展问题.提出的既具有历史唯物主义又具有中国传统文化精髓的中国方案.人类命运共同体理念有对“天下”、“天下为公”、“和而不同”等传统思想的继承和发展.更有重视物质实践和普遍联系的历史唯物主义世界观和方法论.具有“历史唯物主义”和“中国传统文化精髓”双重理论基础. 展开更多
关键词 人类命运共同体理念 历史唯物主义 中国传统文化精髓 双重理论基础
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Anisotropic corrosion behavior of sintered(Ce0.15Nd0.85)30FebalB permanent magnets
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作者 Xiaoning Shi Minggang Zhu +3 位作者 Dong Zhou Zheng Jing Meiling Zhang Wei Li 《中国稀土学报:英文版》 SCIE EI CAS CSCD 2019年第3期287-291,共5页
In this work, the corrosion behavior of the surface parallel to the oriented c-axis(c‖) and perpendicular to c-axis(c⊥)in the(Ce0.15Nd0.85)30FebalB dual main phase magnet was studied. With the addition of Ce,the vol... In this work, the corrosion behavior of the surface parallel to the oriented c-axis(c‖) and perpendicular to c-axis(c⊥)in the(Ce0.15Nd0.85)30FebalB dual main phase magnet was studied. With the addition of Ce,the volume fraction of RE-rich phase shown in the backscattered electron(BSE) images is basically approximate on the two surfaces. The free corrosion potential(Ecorr) of the c‖ surface is more negative,which shows the worse corrosion resistance from the perspective of thermodynamics. While the reaction kinetics parameters with the smaller free corrosion current(icorr) and the larger transfer resistance(Rct) react the opposite conclusion in 3.5 wt% NaCl solution. Moreover, the c‖ surface performs smaller ions concentration of corrosion product and less damaged corrosion morphology compared to c⊥ surface after the free corrosion. The inconformity is not affected by the RE-rich phase, but by the anisotropy of the grains that the c‖ surface has larger density of the atoms and the lower ratio of(Nd, Ce)/Fe. 展开更多
关键词 Sintered ND-FE-B Ce Dual MAIN phase ANISOTROPIC ELECTROCHEMISTRY Corrosion
Bleeding risk assessment in elderly patients with acute coronary syndrome 预览
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作者 Lucia Rioboo-Leston Sergio Raposeiras-Roubin +1 位作者 Emad Abu-Assi Andres Iniguez-Romo 《老年心脏病学杂志:英文版》 SCIE CAS CSCD 2019年第2期145-150,共6页
Nowadays,elderly people represent a growing population segment with a well known increased risk of both ischemic and bleeding events.Current acute coronary syndrome guidelines,strongly recommend dual antiplatelet ther... Nowadays,elderly people represent a growing population segment with a well known increased risk of both ischemic and bleeding events.Current acute coronary syndrome guidelines,strongly recommend dual antiplatelet therapy(DAPT)with few specific references for aged patients due to lack of evidence.Patients aged>75 years are misrepresented in the classic derivation trials cohorts.Strategies to reduce the bleeding risk in this group of patients are urgently needed for the daily clinical practice.Identify the specific age related bleeding risk factors and the importance of an integral geriatric assessment remains challenging.Some of the available in-hospital and out-hospital bleeding risk scores have shown a lower to moderate predictive ability in older patients and no specific tools are developed in elderly population.The importance of an appropriate vascular access choice,type and duration of antiplatelet drugs is crucial to reduce the bleeding risk.Increase radial approaches and short DAPT duration leads to reduce hemorrhages.One interesting subgroup of patients is those who need chronic anticoagulation therapy after percutaneous coronary intervention,due to their very high risk of bleeding.New alternatives as dual therapy with oral anticoagulation and only one antiplatlet drug should be considered.In current review,we evaluate the available evidence about bleeding risk in elderly. 展开更多
关键词 ACUTE CORONARY SYNDROME BLEEDING risk Dual ANTIPLATELET treatment ELDERLY patients
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Quasi-Z-Source Based Bidirectional DC-DC Converter and Its Control Strategy
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作者 Yuba Raj Kafle Saad Ul Hasan Graham E.Town 《中国电气工程学报(英文)》 2019年第1期1-9,共9页
This paper presents a quasi-Z-source based isolated bidirectional DC-DC converter(qZIBDC)for renewable energy applications.The converter utilizes a dual active bridge circuit with a quasi-Z-source network on both side... This paper presents a quasi-Z-source based isolated bidirectional DC-DC converter(qZIBDC)for renewable energy applications.The converter utilizes a dual active bridge circuit with a quasi-Z-source network on both sides,so the converter works as buck/boost converter from either side.It has a wider input/output voltage operating range,soft-switching capabilities without additional devices,and higher boost capability than a traditional dual active bridge circuit.Apart from that,shoot-through states are incorporated in its operating cycle to boost the input voltage resulting in high reliability of the proposed converter.Due to the symmetrical structure of the circuit,there is no defined high voltage or low voltage side as in traditional isolated bidirectional DC-DC converter.The operating principle and control strategy of the proposed converter are presented.Simulation and experimental results are provided to verify the effectiveness of the proposed converter topology and its control strategy. 展开更多
关键词 BIDIRECTIONAL DC-DC CONVERTER dual active bridge IMPEDANCE source quasi-Z-source DC-DC CONVERTER
Development of Helicobacter pylori treatment: How do we manage antimicrobial resistance? 预览
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作者 Sho Suzuki Mitsuru Esaki +2 位作者 Chika Kusano Hisatomo Ikehara Takuji Gotoda 《世界胃肠病学杂志:英文版》 SCIE CAS 2019年第16期1907-1912,共6页
Helicobacter pylori (H. pylori) antimicrobial resistance is an urgent, global issue. In 2017, the World Health Organization designated clarithromycin-resistant H. pylori as a high priority bacterium for antibiotic res... Helicobacter pylori (H. pylori) antimicrobial resistance is an urgent, global issue. In 2017, the World Health Organization designated clarithromycin-resistant H. pylori as a high priority bacterium for antibiotic research and development. In addition to clarithromycin, resistance to metronidazole and fluoroquinolones has also increased worldwide. Recent international guidelines for management of H. pylori infection recommend bismuth or non-bismuth quadruple therapy for 14 d as a first-line treatment for H. pylori in areas of high clarithromycin and/or metronidazole resistance. Although these treatment regimens provide acceptable H. pylori eradication rates, the regimens used should not contribute to future resistance of H. pylori to antimicrobials. Moreover, these regimens can promote resistance, due to prolonged therapy with multiple antibiotics. A new strategy that can eradicate H. pylori as well as reduce the antibiotics used is required to prevent future antimicrobial resistance in H. pylori. Dual-therapy with vonoprazan and amoxicillin could be a breakthrough for H. pylori eradication in an era of growing antimicrobial resistance. This regimen may provide a satisfactory eradication rate of H. pylori and also minimize antimicrobial resistance due to single antibiotic use and the strong inhibitory effect of vonoprazan on gastric acid secretion. 展开更多
关键词 HELICOBACTER PYLORI Antibiotic RESISTANCE ANTIMICROBIAL RESISTANCE Dual therapy Vonoprazan
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Trends of Internationalization in China’s Higher Education: Opportunities and Challenges 预览
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作者 Phylis Lan Lin 《美中教育评论:B》 2019年第1期1-12,共12页
Quality of higher education is a key to national economic growth and social development. Internationalization of higher education has been one of the major national trends and governmental agendas in many emerging cou... Quality of higher education is a key to national economic growth and social development. Internationalization of higher education has been one of the major national trends and governmental agendas in many emerging countries in the past few years. International education is transformative. With globalization and the development of the Internet of Things, internationalization of higher education has become an important national goal in China. The purpose of this paper is threefold:(a) to describe a brief history of internationalization of higher education in China;(b) to conceptualize the dualism of internationalization of higher education, the role of the government, and China’s 13th Five Year Plan in China;and (c) to delineate the challenges and opportunities of international collaborations, especially in the dual-degree model under international partnership programs between China and the United States. 展开更多
关键词 INTERNATIONALIZATION higher EDUCATION China dual degree ONE belt ONE road University of Indianapolis INTERNATIONAL PARTNERSHIP INTERNATIONAL EDUCATION
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New AES Dual Ciphers Based on Rotation of Columns
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作者 YANG Min XIAO Benchang MENG Qingshu 《武汉大学学报:自然科学英文版》 CAS CSCD 2019年第2期93-97,共5页
Based on the different representations of the finite field GF(256), there are different Advanced Encryption Standard (AES) implementations, which is called dual ciphers. They have the same encryption process as AES, b... Based on the different representations of the finite field GF(256), there are different Advanced Encryption Standard (AES) implementations, which is called dual ciphers. They have the same encryption process as AES, but with parameters modified. The research of dual ciphers initially aims to find more efficient AES implementations, and later it is found that they can be used to resist side-channel attacks and for white box ciphers. In this paper, based on the rotation of columns, we propose new AES dual ciphers, which use AES directly, but with the input matrices (plaintexts and keys) and output matrix rotated. The key expansion algorithm only needs some change on the computation sequence. Because of these features, there is almost no extra cost in implementing dual ciphers and it is easy for new dual ciphers to work with other side-channel protection methods to protect AES in more dimensions. 展开更多
关键词 AES DUAL CIPHER side channel security differential power analysis TEMPLATE ATTACK
An Inner Product Encryption Scheme Based on Dual Systems
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作者 WEI Duo GAO Haiying 《武汉大学学报:自然科学英文版》 CAS CSCD 2019年第2期125-133,共9页
The inner product encryption scheme can achieve fine-grained access control on ciphertext. For the problem that the existing inner product encryption scheme has poor security and low decryption efficiency, this paper ... The inner product encryption scheme can achieve fine-grained access control on ciphertext. For the problem that the existing inner product encryption scheme has poor security and low decryption efficiency, this paper proposes an inner product encryption scheme with adaptive security based on the dual system encryption method. The scheme is based on bilinear mapping on prime order groups. In the secret key generation algorithm of the scheme, we propose a sharing technique of random vectors and generate a secret key for each component of the attribute vector. And an encryption algorithm with a constant size ciphertext is designed. Under the k-Lin assumption, the method of the experimental sequence is used to prove that the scheme is adaptively secure. The decryption algorithm of the scheme requires only six bilinear pairs. Compared with the existing schemes, the decryption efficiency has been greatly improved. 展开更多
关键词 prime-order dual system GROUPS INNER product ENCRYPTION k-Lin ASSUMPTION adaptively secure
Proliferation inhibition and apoptosis promotion by dual silencing of VEGF and Survivin in human osteosarcoma
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作者 Junquan Gu Zhoujing Ji +1 位作者 Dong Li Qirong Dong 《生物化学与生物物理学报:英文版》 SCIE CAS CSCD 2019年第1期59-67,共9页
Simultaneous silencing of multiple upregulated genes is an attractive and viable treatment strat-egy for many incurable diseases including cancer.Herein we used a dual gene-targeted siRNA conjugate composed of VEGF an... Simultaneous silencing of multiple upregulated genes is an attractive and viable treatment strat-egy for many incurable diseases including cancer.Herein we used a dual gene-targeted siRNA conjugate composed of VEGF and Survivin siRNA sequences in the same backbone to inhibit proliferation and angiogenesis in two human osteosarcoma cell lines.We synthesized siRNA sequences targeting the VEGF and Survivin genes individually (VEGF siRNA and Survivin siRNA) or simultaneously (one-chain-double-target siRNA:dual siRNA).VEGF and Survivin mRNA and protein expression levels in human osteosarcoma MG-63 and Saos-2 cells were detected by qRT- PCR and western blot analysis.VEGF and Survivin protein location and expression were evaluated by immunohistochemistry and immunofluorescence staining.MG-63 and Saos-2 cell migration,proliferation,apoptosis,and angiogenesis were detected by scratch test,MTT assay,flow cytometry,and capillary tube assay respectively.The dual siRNA induced similar downregulation of VEGF and Survivin mRNA and protein levels,compared with VEGF siRNA or Survivin siRNA alone.The dual siRNA caused greater suppression of MG-63 and Saos-2 cell migration,proliferation and angiogenesis,and promoted more cell apoptosis than VEGF siRNA or Survivin siRNA alone,suggesting that the effects of the dual siRNA on inhibiting cell proliferation,migration,and angiogenesis and promoting apoptosis were superior to those of the single-target siRNAs.Simultaneous silencing of VEGF and Survivin using the dual siRNA may be an advantageous alternative for the development of therapeutic strategies against human osteosarcoma. 展开更多
关键词 HUMAN OSTEOSARCOMA MG-63 CELLS Saos-2 CELLS VEGF SURVIVIN DUAL siRNA
Effects of secondary electron emission on plasma characteristics in dual-frequency atmospheric pressure helium discharge by fluid modeling
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作者 王一男 李帅星 +1 位作者 刘悦 王莉 《中国物理B:英文版》 SCIE EI CAS CSCD 2019年第2期346-351,共6页
A one-dimensional(1D) fluid simulation of dual frequency discharge in helium gas at atmospheric pressure is carried out to investigate the role of the secondary electron emission on the surfaces of the electrodes. In ... A one-dimensional(1D) fluid simulation of dual frequency discharge in helium gas at atmospheric pressure is carried out to investigate the role of the secondary electron emission on the surfaces of the electrodes. In the simulation, electrons,ions of He+ and He2+, metastable atoms of He*and metastable molecules of He*2 are included. It is found that the secondary electron emission coefficient significantly influences plasma density and electric field as well as electron heating mechanisms and ionization rate. The particle densities increase with increasing SEE coefficient from 0 to 0.3 as well as the sheath’s electric field and electron source. Moreover, the SEE coefficient also influences the electron heating mechanism and electron power dissipation in the plasma and both of them increase with increasing SEE coefficient within the range from 0 to 0.3 as a result of increasing of electron density. 展开更多
关键词 dual frequency SECONDARY electron emission ATMOSPHERIC pressure DISCHARGE
In college,students receive a dual degree is more important than taking only one major 预览
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作者 禹茹茵 《校园英语》 2019年第15期12-13,共2页
In college,students receive a dual degree is a considered a proud experience during their life in university.However,many people stand at the opposite,they think it is a waste of time and do not have enough energy to ... In college,students receive a dual degree is a considered a proud experience during their life in university.However,many people stand at the opposite,they think it is a waste of time and do not have enough energy to learn both well.I discuss the problem from two aspects and find the advantages overwhelm the disadvantages. 展开更多
关键词 DUAL MAJOR Knowledge Finding JOBS CHOICES
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