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磁共振DWI对肺内孤立性病变鉴别诊断价值
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作者 任进军 赵宝宏 +3 位作者 迟红卫 訾学荣 徐倩 郭志军 《临床放射学杂志》 CSCD 北大核心 2019年第4期626-629,共4页
目的评价MRI扩散加权成像(DWI)对肺内孤立性病变的鉴别诊断价值。方法搜集经手术、活检或临床治疗随访后证实的56例肺内孤立性病变患者,其中恶性35例,良性21例,行MRI胸部常规T1WI、T2WI和DWI检查,b值选择300,500,800和1000 s/mm2。分别... 目的评价MRI扩散加权成像(DWI)对肺内孤立性病变的鉴别诊断价值。方法搜集经手术、活检或临床治疗随访后证实的56例肺内孤立性病变患者,其中恶性35例,良性21例,行MRI胸部常规T1WI、T2WI和DWI检查,b值选择300,500,800和1000 s/mm2。分别测量不同b值时的表观扩散系数(ADC)和病变脊髓比值(LSR)。计算不同b值时受试者工作特征(ROC)曲线下ADC和LSR面积。结果良、恶性肺内孤立性病变在b值300~800 s/mm2时,其ADC值有统计学意义(t=2.07,P300=0.04<0.05;t=4.68,P500=0.000;t=3.32,P800=0.03<0.05);ROC曲线下面积分别为0.72、0.88、0.66、0.54。而b值在300~1000 s/mm2时,其LSR值均有统计学意义(P300~1000<0.001),ROC曲线下面积分别为0.98、0.93、0.92、0.93。结论 DWI的ADC和LSR值可以实现良、恶性肺内孤立性病变定量分析;LSR值的鉴别诊断效能优于ADC值,更有实用性。 展开更多
关键词 磁共振成像 扩散加权成像 病变
Is CT scan a predictor of instability in recurrent dislocation shoulder?
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作者 K.P.Shijith Munish Sood +1 位作者 Ajay Deep Sud Amresh Ghai 《中华创伤杂志:英文版》 CAS CSCD 2019年第3期177-181,共5页
Purpose: Glenoid bone defect and the defect on the posterior-superior surface of the humerus “Hill- Sachs lesion” are the commonly seen bony lesions in patients with recurrent dislocation shoulder. Computed tomograp... Purpose: Glenoid bone defect and the defect on the posterior-superior surface of the humerus “Hill- Sachs lesion” are the commonly seen bony lesions in patients with recurrent dislocation shoulder. Computed tomography (CT) scan is considered as the best option in assessing the bony defects in the recurrent dislocation shoulder. The aim of this study was to assess the clinical and radiological corelation in the patients with recurrent dislocation shoulder. Methods: Forty-four patients of recurrent dislocation shoulder who were evaluated between January 2015 and December 2017 at a tertiary care center, clinically and radiologically using CT scan and meeting the inclusion criteria, were included. The correlation between the clinical history of the number of dislocations and the bone loss using CT scan was evaluated. Two sided statistical tests were performed at a significance level of α=0.05. The analysis was conducted using IBM SPSS STATISTICS (version 22.0). Results: All the patients were male with mean age of 25.95 (SD ± 4.2) years were evaluated. Twenty-four patients sustained injury in sporting activities while 20 patients sustained injury in training. There were an average of 4.68 (SD ± 3.1, range 2e15, median 3) episodes of dislocation. Forty-one patients had the glenoid bone loss while 40 had the Hill-Sachs lesions. The mean glenoid width defect was 10.80%(range 0e27%) while the mean Hill-Sachs defect was 14.27 mm (range 0e26.6 mm). The mean area of bone loss of the glenoid surface was 10.81%(range 0e22.4%). The lesions were on track in 34 patients and off track in 10 patients. Conclusions: CT scan of the shoulder joint is an effective method for assessing the amount of bone loss. The number of dislocations are correlated significantly with off-track lesions and the amount of bone loss on the glenoid and Hill-Sachs lesion. The glenoid width bone loss of more than 9.80% or Hill-Sachs defect of more than 14.80 mm are the critical defects after which the frequency of dislocations increases. 展开更多
关键词 SHOULDER joint RECURRENT DISLOCATION HILL-SACHS LESION
寻常型银屑病常见皮疹的皮肤镜表现特点 预览
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作者 李俊杰 王玉玲 +3 位作者 周韵聪 王鲁梅 张峰 唐亚平 《皮肤性病诊疗学杂志》 2019年第1期7-11,共5页
目的:观察寻常型银屑病常见皮疹的皮肤镜表现特征,为皮肤镜鉴别诊断银屑病提供依据。方法:收集2016年1月至2018年2月我院皮肤科经临床诊断且11例经组织病理确诊为寻常型银屑病的86例患者。常见皮疹包括丘疹、红斑、斑块、头皮皮疹、掌... 目的:观察寻常型银屑病常见皮疹的皮肤镜表现特征,为皮肤镜鉴别诊断银屑病提供依据。方法:收集2016年1月至2018年2月我院皮肤科经临床诊断且11例经组织病理确诊为寻常型银屑病的86例患者。常见皮疹包括丘疹、红斑、斑块、头皮皮疹、掌跖皮疹、甲银屑病及治疗后皮疹,使用皮肤镜观察皮疹的背景颜色、鳞屑颜色、鳞屑分布、血管形态、血管分布。结果:典型的皮肤镜表现为亮红色背景,白色鳞屑弥漫性分布,点状血管、小球状血管规则一致性排列;而不同皮疹的皮肤镜表现有差异。结论:银屑病具有典型的皮肤镜影像表现,而不同皮疹有相对特异性表现,可用于临床辅助诊断。 展开更多
关键词 寻常型银屑病 皮疹 皮肤镜 皮肤镜表现
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Professor Jiping ZHAO's experiences in the differentiation and treatment of peripheral facial paralysis with acupuncture
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作者 郑媛媛 王朋 赵吉平 《世界针灸杂志:英文版》 CSCD 2019年第1期76-79,共4页
Professor Jiping ZHAO has unique thoughts on the diagnosis and treatment of peripheral facial paralysis.She pays the great attention to clinical differentiation in treatment with acupuncture,especially meridian differ... Professor Jiping ZHAO has unique thoughts on the diagnosis and treatment of peripheral facial paralysis.She pays the great attention to clinical differentiation in treatment with acupuncture,especially meridian differentiation.She believes that the differentiation of lesion is core and the early judgment is critical for the better therapeutic effects on in tractable facial paralysis.The local acupoints are selected in the guide of the theory of meridian sinew and stimulated on the base of three-needling theory.The distal acupoints are decided in light of the syndrome differentiation,of which,Hegu(合谷LI 4),Zusanli(足三里ST 36)and Taichong(太冲LR 3)are the basic acupoints.Additionally,Professor ZHAO lays the emphasis on the 5th branch of facial nerve(cervical branch)in diagnosis and treatment. 展开更多
关键词 Peripheral facial PARALYSIS Lesion MERIDIAN muscle region Three NEEDLING Experiences of FAMOUS PHYSICIAN
儿童胼胝体病变的诊治进展
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作者 冀笑冰(综述) 赵亚娟(审校) 《国际儿科学杂志》 2019年第6期411-414,共4页
胼胝体是中枢神经系统的重要组成结构,位于大脑纵裂底部,连接了左右两侧大脑半球的横行神经纤维束,是大脑半球中最大的联合纤维。胼胝体可发生多种病变,表现为多种临床症状,但多无特异性。临床上常见的胼胝体病变包括胼胝体出血、胼胝... 胼胝体是中枢神经系统的重要组成结构,位于大脑纵裂底部,连接了左右两侧大脑半球的横行神经纤维束,是大脑半球中最大的联合纤维。胼胝体可发生多种病变,表现为多种临床症状,但多无特异性。临床上常见的胼胝体病变包括胼胝体出血、胼胝体梗死、胼胝体脱髓鞘、胼胝体发育不全、胼胝体肿瘤、胼胝体损伤、伴有胼胝体压部可逆性病灶的临床症状轻微脑炎/脑病等。目前国内对儿童胼胝体病变的研究相对较少,该文对儿童胼胝体病变的研究现状作一综述。 展开更多
关键词 胼胝体 病变 儿童 临床表现
Internal mammary artery harvesting with its distal end occluded
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作者 Yoandy Lopez-de la Cruz Yolepsis Quintero-Fleites 《中华医学杂志:英文版》 SCIE CAS CSCD 2019年第11期1385-1386,共2页
To the Editor:We have read with great interest the comment of Chen et al"What can we learn from cases of internal mammary artery damage in coronary artery bypass graft ", The advice that the authors propose ... To the Editor:We have read with great interest the comment of Chen et al"What can we learn from cases of internal mammary artery damage in coronary artery bypass graft ", The advice that the authors propose in relation to the internal mammary artery (IMA) harvesting is very useful because they are based on a 20-year experience in more than 10,000 patients. 展开更多
关键词 CORONARY ARTERY MAMMARY LESION of internal MAMMARY ARTERY
A benign lesion similar to breast cancer
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作者 Yan Zhao Wen-Chao Wang Ting Lu 《中华医学杂志:英文版》 SCIE CAS CSCD 2019年第2期250-252,共3页
To the Editor:We here reported a case of a breast lesion found by rapid pathological examination of frozen sections on February 2, 2018.The lesion was very similar to breast cancer in terms of gross observation and hi... To the Editor:We here reported a case of a breast lesion found by rapid pathological examination of frozen sections on February 2, 2018.The lesion was very similar to breast cancer in terms of gross observation and histological features.Immunohistochemistry and phos-phatidylinositol-3-kinase (PIK3CA) gene sequencing were performed.The clinicopathological features of the lesion were reported in detail. 展开更多
关键词 BREAST LESION performed CLINICOPATHOLOGICAL
三叉神经痛的临床解剖学研究进展 预览
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作者 康爽 刁玉领 《黑龙江医学》 2019年第3期302-305,共4页
与三叉神经相关的疾病最常见的为三叉神经痛、三叉神经鞘瘤及脑膜瘤等。熟悉和掌握解剖结构是成功手术的前提,临床解剖学的认识和发展,会带动临床手术的发展和革新。
关键词 三叉神经痛 颅底 病变
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High-risk symptoms and quantitative faecal immunochemical test accuracy: Systematic review and meta-analysis 预览
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作者 Noel Pin Vieito Sara Zarraquinos Joaquín Cubiella 《世界胃肠病学杂志:英文版》 SCIE CAS 2019年第19期2383-2401,共19页
BACKGROUND The quantitative faecal immunochemical test for haemoglobin (FIT) has been revealed to be highly accurate for colorectal cancer (CRC) detection not only in a screening setting, but also in the assessment of... BACKGROUND The quantitative faecal immunochemical test for haemoglobin (FIT) has been revealed to be highly accurate for colorectal cancer (CRC) detection not only in a screening setting, but also in the assessment of patients presenting lower bowel symptoms. Therefore, the National Institute for Health and Care Excellence has recommended the adoption of FIT in primary care to guide referral for suspected CRC in low-risk symptomatic patients using a 10 μg Hb/g faeces threshold. Nevertheless, it is unknown whether FIT′s accuracy remains stable throughout the broad spectrum of possible symptoms. AIM To perform a systematic review and meta-analysis to assess FIT accuracy for CRC detection in different clinical settings. METHODS A systematic literature search was performed using MEDLINE and EMBASE databases from inception to May 2018 to conduct a meta-analysis of prospective studies including symptomatic patients that evaluated the diagnostic accuracy of quantitative FIT for CRC detection. Studies were classified on the basis of brand, threshold of faecal haemoglobin concentration for a positive test result, percentage of reported symptoms (solely symptomatic, mixed cohorts) and CRC prevalence (< 2.5%,≥ 2.5%) to limit heterogeneity and perform subgroup analysis to assess the influence of clinical spectrum on FIT′s accuracy to detect CRC. RESULTS Fifteen cohorts including 13073 patients (CRC prevalence 0.4% to 16.8%) were identified. Pooled estimates of sensitivity for studies using OC-Sensor at 10 μg Hb/g faeces threshold (n = 10400) was 89.6%[95% confidence interval (CI): 82.7% to 94.0%). However, pooled estimates of sensitivity for studies formed solely by symptomatic patients (n = 4035) and mixed cohorts (n = 6365) were 94.1%(95%CI: 90.0% to 96.6%) and 85.5%(95%CI: 76.5% to 91.4%) respectively (P < 0.01), while there were no statistically significant differences between pooled sensitivity of studies with CRC prevalence < 2.5%(84.9%, 95%CI: 73.4% to 92.0%) and ≥ 2.5%(91.7%, 95%CI: 83.3% to 96.1%)(P = 0.25 展开更多
关键词 BOWEL DISEASE Colorectal cancer Diagnostic ACCURACY FAECAL HAEMOGLOBIN FAECAL immunochemical TEST FAECAL occult blood TEST Inflammatory BOWEL DISEASE Significant colonic lesion
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268例腮腺部包块病变临床病理特征的研究 预览
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作者 刘禄 杨娜 《临床医药实践》 2019年第1期42-45,共4页
目的:探讨腮腺部包块经手术切除治疗后病变的临床病理特征。方法:收集遂宁市中心医院口腔颌面外科收治的因腮腺部肿块行手术切除治疗的患者268例,切除包块经病理科行病理活组织检查,以病理诊断为研究依据。分析268例腮腺部肿块的病变特... 目的:探讨腮腺部包块经手术切除治疗后病变的临床病理特征。方法:收集遂宁市中心医院口腔颌面外科收治的因腮腺部肿块行手术切除治疗的患者268例,切除包块经病理科行病理活组织检查,以病理诊断为研究依据。分析268例腮腺部肿块的病变特征及临床病理联系。结果:腮腺部包块268例,其中男144例(53.73%),女124例(46.27%);肿瘤性病变173例(64.55%),非肿瘤性病变95例(35.45%);良性肿瘤中多形性腺瘤65例,在良性肿瘤组中占54.17%,Warthin瘤38例,在良性肿瘤组中占31.67%,较多见。恶性肿瘤中腺样囊性癌20例,在恶性肿瘤组中占33.74%,黏液表皮样癌11例,在恶性肿瘤组中占20.75%,较多见。结论:临床工作中腮腺部肿块为较常见的临床症状,腮腺部肿块的类型繁多,病变性质多样,临床及病理工作中需提高认识,作出正确病理诊断。 展开更多
关键词 腮腺 包块 肿瘤 病变 临床病理特征
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肉芽肿性乳腺炎的MRI表现 预览
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作者 刘金良 王增奎 +3 位作者 许晶晶 张兆福 李晓冬 孙志红 《影像研究与医学应用》 2019年第7期8-9,共2页
目的:总结分析肉芽肿性乳腺炎的核磁共振表现。方法:选择我院2016年1月—2017年12月病理检查确诊为肉芽肿性乳腺炎的6例患者,分析其病灶形态、T2WI脂肪抑制信号、DWI信号、动态增强强化方式、TIC等核磁共振影像特征。结果:所有患者病灶... 目的:总结分析肉芽肿性乳腺炎的核磁共振表现。方法:选择我院2016年1月—2017年12月病理检查确诊为肉芽肿性乳腺炎的6例患者,分析其病灶形态、T2WI脂肪抑制信号、DWI信号、动态增强强化方式、TIC等核磁共振影像特征。结果:所有患者病灶均位于同一象限内,边缘不清晰,不规则多结节,2例散播,4例淋巴结增大,T2加权脂肪抑制以及弥散加权均为高信号,均为不均匀强化,其中3例可见环状脓肿,TIC曲线包括流出型1例,平台型3例,缓升型2例。结论:肉芽肿性乳腺炎核磁共振影像学检验结果具有一定征性,可通过术前检验判定提高诊断结果的准确率,有助于后期诊疗工作的有效开展。 展开更多
关键词 肉芽肿性乳腺炎 核磁共振 病灶
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Endoscopic management of massive rectal bleeding from a Dieulafoy's lesion: Case report 预览
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作者 Mario Rene Pineda-De Paz Massiel Madelin Rosario-Morel +2 位作者 Jose Guadalupe Lopez-Fuentes Luis Ariel Waller-Gonzalez Rodrigo Soto-Solis 《世界胃肠内镜杂志:英文版(电子版)》 2019年第7期438-442,共5页
BACKGROUND Rectal Dieulafoy's lesions (DLs) are very rare;however, they can be life threatening when presented with massive hemorrhage. CASE SUMMARY A 44-year-old female with medical history of chronic renal failu... BACKGROUND Rectal Dieulafoy's lesions (DLs) are very rare;however, they can be life threatening when presented with massive hemorrhage. CASE SUMMARY A 44-year-old female with medical history of chronic renal failure who was on renal replacement therapy presented with lower gastrointestinal hemorrhage. Physical examination revealed signs of hypovolemic shock and massive rectal bleeding. Complete blood count revealed abrupt decrease in hematocrit. After hemodynamic stabilization, an urgent colonoscopy was performed. A rectal DL was diagnosed, and it was successfully treated with two hemoclips. There were no signs of recurrent bleeding at thirty days of follow-up. CONCLUSION Rectal DLs represent an unusual cause of lower gastrointestinal bleeding. Massive hemorrhage can increase the morbidity and mortality of these patients. Endoscopic management continues to be the reference standard in the diagnosis and therapy of these lesions. Thermal, mechanical (hemoclip or band ligation), or combination therapy (adrenaline injection combined with thermal or mechanical therapy) should be considered the first choice for treatment. 展开更多
关键词 Dieulafoy's LESION Endoscopic HEMOSTASIS MASSIVE RECTAL BLEEDING Case report
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MK-801 attenuates lesion expansion following acute brain injury in rats: a meta-analysis 预览
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作者 Nan-Xing Yi Long-Yun Zhou +8 位作者 Xiao-Yun Wang Yong-Jia Song Hai-Hui Han Tian-Song Zhang Yong-Jun Wang Qi Shi Hao Xu Qian-Qian Liang Ting Zhang 《中国神经再生研究:英文版》 SCIE CAS CSCD 2019年第11期1919-1931,共13页
OBJECTIVE: To evaluate the efficacy and safety of MK-801 and its effect on lesion volume in rat models of acute brain injury.DATA SOURCES: Key terms were "stroke","brain diseases","brain injur... OBJECTIVE: To evaluate the efficacy and safety of MK-801 and its effect on lesion volume in rat models of acute brain injury.DATA SOURCES: Key terms were "stroke","brain diseases","brain injuries","brain hemorrhage, traumatic","acute brain injury","dizocilpine maleate","dizocilpine","MK-801","MK801","rat","rats","rattus" and "murine". PubMed, Cochrane library, EMBASE, the China National Knowledge Infrastructure, WanFang database, the VIP Journal Integration Platform(VJIP) and SinoMed databases were searched from their inception dates to March 2018.DATA SELECTION: Studies were selected if they reported the effects of MK-801 in experimental acute brain injury. Two investigators independently conducted literature screening, data extraction, and methodological quality assessments.OUTCOME MEASURES: The primary outcomes included lesion volume and brain edema. The secondary outcomes included behavioral assessments with the Bederson neurological grading system and the water maze test 24 hours after brain injury.RESULTS: A total of 52 studies with 2530 samples were included in the systematic review. Seventeen of these studies had a high methodological quality. Overall, the lesion volume(34 studies, n = 966, MD =-58.31, 95% CI:-66.55 to-50.07;P < 0.00001) and degree of cerebral edema(5 studies, n = 75, MD =-1.21, 95% CI:-1.50 to-0.91;P < 0.00001) were significantly decreased in the MK-801 group compared with the control group. MK-801 improved spatial cognition assessed with the water maze test(2 studies, n = 60, MD =-10.88, 95% CI:-20.75 to-1.00;P = 0.03) and neurological function 24 hours after brain injury(11 studies, n = 335, MD =-1.04, 95% CI:-1.47 to-0.60;P < 0.00001). Subgroup analysis suggested an association of reduction in lesion volume with various injury models(34 studies, n = 966, MD =-58.31, 95% CI:-66.55 to-50.07;P = 0.004). Further network analysis showed that 0–1 mg/kg MK-801 may be the optimal dose for treatment in the middle cerebral artery occlusion animal model.CONCLUSION: MK-801 effectively reduces b 展开更多
关键词 nerve REGENERATION acute BRAIN injury NEUROLOGICAL function spatial cognition water MAZE test LESION volume BRAIN edema rat systematic review META-ANALYSIS neural REGENERATION
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Diagnosis and therapeutic strategies for small bowel vascular lesions 预览
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作者 Eiji Sakai Ken Ohata +1 位作者 Atsushi Nakajima Nobuyuki Matsuhashi 《世界胃肠病学杂志:英文版》 SCIE CAS 2019年第22期2720-2733,共14页
Small bowel vascular lesions, including angioectasia (AE), Dieulafoy’s lesion (DL) and arteriovenous malformation (AVM), are the most common causes of obscure gastrointestinal bleeding. Since AE are considered to be ... Small bowel vascular lesions, including angioectasia (AE), Dieulafoy’s lesion (DL) and arteriovenous malformation (AVM), are the most common causes of obscure gastrointestinal bleeding. Since AE are considered to be venous lesions, they usually manifest as a chronic, well-compensated condition. Subsequent to video capsule endoscopy, deep enteroscopy can be applied to control active bleeding or to improve anemia necessitating blood transfusion. Despite the initial treatment efficacy of argon plasma coagulation (APC), many patients experience re-bleeding, probably because of recurrent or missed AEs. Pharmacological treatments can be considered for patients who have not responded well to other types of treatment or in whom endoscopy is contraindicated. Meanwhile, a conservative approach with iron supplementation remains an option for patients with mild anemia. DL and AVM are considered to be arterial lesions;therefore, these lesions frequently cause acute life-threatening hemorrhage. Mechanical hemostasis using endoclips is recommended to treat DLs, considering the high re-bleeding rate after primary APC cauterization. Meanwhile, most small bowel AVMs are large and susceptible to re-bleeding therefore, they usually require surgical resection. To achieve optimal diagnostic and therapeutic approaches for each type of small bowel lesion, the differences in their epidemiology, pathology and clinical presentation must be understood. 展开更多
关键词 ANGIODYSPLASIA Angioectasia Dieulafoy's lesion ARTERIOVENOUS MALFORMATION Obscure gastrointestinal bleeding Video capsule endoscopy Deep ENTEROSCOPY Argon plasm coagulation
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CT及MRI在腔隙性脑梗死中诊断中的应用价值分析 预览
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作者 姜本忱 《当代医学》 2019年第14期106-107,共2页
目的探讨CT及MRI在腔隙性脑梗死中诊断中的应用价值分析。方法选取本院2016年7月至2018年4月收治的腔隙性脑梗死患者62例作为观察对象,分别采用CT和MRI为患者进行检查,对两种检查方法的病灶检出数量、各项检查指标的差异进行比较。结果 ... 目的探讨CT及MRI在腔隙性脑梗死中诊断中的应用价值分析。方法选取本院2016年7月至2018年4月收治的腔隙性脑梗死患者62例作为观察对象,分别采用CT和MRI为患者进行检查,对两种检查方法的病灶检出数量、各项检查指标的差异进行比较。结果 MRI组病灶检出数量与CT组相比,组间出现的差异具有统计学意义(P<0.05);MRI组检出病灶大小明显小于CT组,其检查时间、检查费用明显多于CT组,两组比较差异具有统计学意义(P<0.05)。结论相比于CT检查,MRI可显著提高腔隙性脑梗死的早期诊断价值,有利于快速发现和明确微小病灶,但检查用时比较长,费用较高,临床可根据患者的具体情况合理选择辅助检查方法。 展开更多
关键词 CT MRI 腔隙性脑梗死 病灶 诊断
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华中地区口腔黏膜扁平苔藓病变危险因素的临床调研 预览
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作者 韩智 周庆 孙涛 《河北医药》 CAS 2019年第7期1083-1086,共4页
目的探讨华中地区口腔黏膜扁平苔藓患者癌变的主要危险因素。方法根据是否有发生癌变将156例口腔黏膜扁平苔藓患者分为癌变组(n=62)和非癌变组(n=94)。采用HAMA、HAMD量表评估患者的不良情绪;采用ELISA法检测患者血清TNF-α、IL-6、IL-... 目的探讨华中地区口腔黏膜扁平苔藓患者癌变的主要危险因素。方法根据是否有发生癌变将156例口腔黏膜扁平苔藓患者分为癌变组(n=62)和非癌变组(n=94)。采用HAMA、HAMD量表评估患者的不良情绪;采用ELISA法检测患者血清TNF-α、IL-6、IL-8的表达量;采用RT-PCR法检测患者HSP-60、HSP-70表达水平;采用PCR法检测患者幽门螺旋杆菌表达情况;对差异显著的影响因子进行多因素Logistic回归分析。结果癌变组受试者平均年龄明显高于非癌变组[(50.38±5.61)岁vs(45.16±3.18)岁]、乙肝病毒感染率明显高于非癌变组(8.06%vs 2.45%);非癌变组受试者情绪状态明显优于癌变组,且差异有统计学意义(P<0.05);癌变组受试者血清炎性因子浓度、HSP-60与HSP-70 mRNA相对表达量以及口腔各部位幽门螺旋杆菌阳性检出率均明显高于非癌变组(P<0.05);多因素Logistic回归分析结果显示,年龄、HAMA量表评分、幽门螺旋杆菌阳性表达、HSP-60表达水平与口腔黏膜扁平苔藓患者癌变显著相关(P<0.05)。结论年龄、HAMA量表评分、幽门螺旋杆菌阳性表达、HSP-60表达水平是影响华中地区口腔黏膜扁平苔藓患者癌变的主要危险因素。 展开更多
关键词 华中地区 口腔粘膜扁平苔藓 病变 危险因素
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Peritoneal cavernous hemangiomatosis: A case report 预览
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作者 Li-Yuan Fu Hong-Yu Chen +1 位作者 Xiao-Li Diao Zhen-Jun Wang 《世界临床病例杂志》 2019年第4期489-493,共5页
BACKGROUND Cavernous hemangiomatosis in the liver and spleen has been reported, but it occurs less commonly in the peritoneum. Here we report a case of peritoneal cavernous hemangiomatosis and share some valuable info... BACKGROUND Cavernous hemangiomatosis in the liver and spleen has been reported, but it occurs less commonly in the peritoneum. Here we report a case of peritoneal cavernous hemangiomatosis and share some valuable information about this disease. CASE SUMMARY A 57-year-old Chinese man had a huge abdominal mass with abdominal distention and a significant reduction of food consumption. An enhanced abdominal and pelvic computed tomography and positron emission tomography–computed tomography revealed multiple cystic masses on the peritoneum, greater omentum, small intestinal mesentery and the surface of the spleen, and a high maximum standardized uptake value of the largest cystic lesion. Exploratory laparotomy was performed, and multiple cystic masses were found on the surface of the peritoneum, greater omentum, mesentery of the small intestine, and surface of the liver and spleen. Dark red bloody cystic fluid was present in the cystic tumor. Pathological examination showed that in the stromal components, the irregular vascular wall was thin. The vessel lumen was interlinked, and the lumen was lined with flat endothelium. According to the intraoperative findings and pathologic results, the patient was diagnosed with peritoneal cavernous hemangiomatosis. CONCLUSION The possibility of peritoneal cavernous hemangiomatosis should be considered when multiple cystic masses are found in the abdominal cavity by preoperative examination. 展开更多
关键词 PERITONEUM Hemangiomatosis CAVERNOUS hemangiomatosis CYSTIC LESION Case report
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Impact of main vessel calcification on procedural and clinical outcomes of bifurcation lesion undergoing provisional single-stenting intervention:a multicenter,prospective,observational study 预览
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作者 Jing BAI Yan YUE +14 位作者 Hong-Qi FENG Shu-Xin HAO Liang PENG Ming ZHANG Shaheena Nazneen Li-Feng LIU Zhe TANG Xiao-Lin YU Yu-Tao XIE Fu-Xiang SHAN Ming-Zhi SHEN Jiang-Tao WANG Xue-Hua WAN Yun-Dai CHEN Yu WANG 《老年心脏病学杂志:英文版》 SCIE CAS CSCD 2019年第2期156-163,共8页
Background Few data on the combined effects of bifurcation and calcification on coronary artery disease(CAD)patients undergoing percutaneous coronary intervention(PCI)are available.This study evaluated the impact of m... Background Few data on the combined effects of bifurcation and calcification on coronary artery disease(CAD)patients undergoing percutaneous coronary intervention(PCI)are available.This study evaluated the impact of main vessel(MV)calcification on the procedural and long-term outcomes in patients with CAD who underwent provisional single stent PCI.Methods This is a multicenter,prospective,observational study.Patients with bifurcation lesions were enrolled at 10 PCI centers in China from January 2015 to December 2017.Intravascular ultrasound or optical coherence tomography was performed in all patients to evaluate the MV calcification.Patients were treated with provisional single stent strategy using drug eluting stents and followed-up at 1 month,6 months and 12 months after discharge by telephone contact or outpatient visit.Repeated coronary imaging was performed within one year.We compared the procedural success rates in MV and in side branch(SB),and target lesion failure(TLF),defined as a composite of cardiac death,non-fatal myocardial infarction,definite or possible stent thrombosis and target lesion revascularization between patients with and without MV calcification.Results A total of 185 subjects were enrolled according to the inclusion and exclusion criteria of this study.MV calcification was detected in 119(64.3%,calcification group)and not found in 66(35.7%,non-calcification group)patients.The angiographic success rate of MV was 95.8%in the calcification group and 97.0%in the non-calcification group(P=0.91);the angiographic success rate of SB was 32.8%in the calcification group and 53.0%in the non-calcification group(P<0.05).During the one-year follow-up period,TLF occurred in 14(11.8%)patients in the calcification group and in 13(19.7%)in the non-calcification group{P=0.31).Multivariate regression analysis showed the same result(HR=1.23,95%CI:0.76-1.52,P=0.47).Calcification on group had higher recurrent angina than non-calcification group(13.51%vs.17.65%,P<0.05).Conclusions In patients with coronary bif 展开更多
关键词 Bifurcation lesion CORONARY artery disease CORONARY calciflcation Percutaneous CORONARY INTERVENTION
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Signal transducer and activator of transcription 3 promotes the Warburg effect possibly by inducing pyruvate kinase M2 phosphorylation in liver precancerous lesions 预览
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作者 Yang-Hui Bi Wen-Qi Han +4 位作者 Ruo-Fei Li Yun-Jiao Wang Zun-Shu Du Xue-Jiang Wang Ying Jiang 《世界胃肠病学杂志:英文版》 SCIE CAS 2019年第16期1936-1949,共14页
BACKGROUND Study shows that signal transducer and activator of transcription 3 (STAT3) can increase the Warburg effect by stimulating hexokinase 2 in breast cancer and upregulate lactate dehydrogenase A and pyruvate d... BACKGROUND Study shows that signal transducer and activator of transcription 3 (STAT3) can increase the Warburg effect by stimulating hexokinase 2 in breast cancer and upregulate lactate dehydrogenase A and pyruvate dehydrogenase kinase 1 in myeloma. STAT3 and pyruvate kinase M2 (PKM2) can also be activated and enhance the Warburg effect in hepatocellular carcinoma. Precancerous lesions are critical to human and rodent hepatocarcinogenesis. However, the underlying molecular mechanism for the development of liver precancerous lesions remains unknown. We hypothesized that STAT3 promotes the Warburg effect possibly by upregulating p-PKM2 in liver precancerous lesions in rats.AIM To investigate the mechanism of the Warburg effect in liver precancerous lesions in rats.METHODS A model of liver precancerous lesions was established by a modified Solt-Farber method. The liver pathological changes were observed by HE staining and immunohistochemistry. The transformation of WB-F344 cells induced with Nmethyl- N’-nitro-N-nitrosoguanidine and hydrogen peroxide was evaluated by the soft agar assay and aneuploidy. The levels of glucose and lactate in the tissue and culture medium were detected with a spectrophotometer. The protein levels of glutathione S-transferase-π, proliferating cell nuclear antigen (PCNA), STAT3, and PKM2 were examined by Western blot and immunofluorescence.RESULTS We found that the Warburg effect was increased in liver precancerous lesions in rats. PKM2 and p-STAT3 were upregulated in activated oval cells in liver precancerous lesions in rats. The Warburg effect, p-PKM2, and p-STAT3 expression were also increased in transformed WB-F344 cells. STAT3 activation promoted the clonal formation rate, aneuploidy, alpha-fetoprotein expression, PCNA expression, G1/S phase transition, the Warburg effect, PKM2 phosphorylation, and nuclear translocation in transformed WB-F344 cells. Moreover, the Warburg effect was inhibited by stattic, a specific inhibitor of STAT3, and further reduced in transformed WB-F344 cell 展开更多
关键词 WARBURG effect Hepatic PROGENITOR cell Signal transducer and activator of transcription 3 PYRUVATE kinase M2 LIVER PRECANCEROUS lesion
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Malignant transformation of hepatocellular adenoma in a young female patient after ovulation induction fertility treatment: A case report 预览
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作者 Juan Glinka Rodrigo Sanchez Clariá +7 位作者 Eugenia Fratanoni Juan Spina Eduardo Mullen Victoria Ardiles Oscar Mazza Juan Pekolj Martin de Santibanes Eduardo de Santibanes 《世界胃肠外科杂志:英文版(电子版)》 2019年第4期229-236,共8页
BACKGROUND Hepatocellular adenoma (HCA) is a rare benign liver tumor usually affecting young women with a history of prolonged use of hormonal contraception. Although the majority is asymptomatic, a low proportion may... BACKGROUND Hepatocellular adenoma (HCA) is a rare benign liver tumor usually affecting young women with a history of prolonged use of hormonal contraception. Although the majority is asymptomatic, a low proportion may have significant complications such as bleeding or malignancy. Despite responding to the hormonal stimulus, the desire for pregnancy in patients with small HCA is not contraindicated. However, through this work we demonstrate that intensive hormonal therapies such as those used in the treatment of infertility can trigger serious complications CASE SUMMARY A 33-year-old female with a 10-year history of oral contraceptive use was diagnosed with a hepatic tumor as an incidental finding in an abdominal ultrasound. The patient showed no symptoms and physical examination was unremarkable. Laboratory functional tests were within normal limits and tests for serum tumor markers were negative. An abdominal magnetic resonance imaging (MRI) was performed, showing a 30 mm × 29 mm focal lesion in segment VI of the liver compatible with HCA or Focal Nodular Hyperplasia with atypical behavior. After a total of six years of follow-up, the patient underwent ovulationinduction treatment for infertility. On a following MRI, a suspected malignancy was warned and hence, surgery was decided. The surgical specimen revealed malignant transformation of HCA towards trabecular hepatocarcinoma with dedifferentiated areas. There was non-evidence of tumor recurrence after three years of clinical and imaging follow-up. CONCLUSION HCAs can be malignant regardless its size and low-risk appearance on MRI when an ovultation induction therapy is indicated. 展开更多
关键词 HEPATOCELLULAR ADENOMA MALIGNANT transformation FOCAL liver LESION ADENOMA OVULATION induction Case report
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