目的探讨大力水手结构域(Popdc)各亚型在人心耳中的表达与心房颤动(简称房颤)的相关性。方法本研究以行心脏外科手术病人的右心耳为研究对象,分为窦性心律(简称窦律)组和房颤组,运用免疫组化(IHC)染色、Masson染色、免疫印迹试验(Wester...目的探讨大力水手结构域(Popdc)各亚型在人心耳中的表达与心房颤动(简称房颤)的相关性。方法本研究以行心脏外科手术病人的右心耳为研究对象,分为窦性心律(简称窦律)组和房颤组,运用免疫组化(IHC)染色、Masson染色、免疫印迹试验(Western blot)和定量聚合酶链反应(qPCR)技术,验证Popdc1、2、3各亚型在人心耳中的表达,同时结合病人的年龄、性别、纽约心功能(NYHA)分级、基础疾病等临床资料,分析Popdc各亚型表达变化与房颤的相关关系。结果与窦律组比较,房颤组女性比例更大、风湿性心脏病占比更大、左房直径更大、左室射血分数更低(P均<0.05)。房颤组的Popdc1(IHC 0.06±0.01 vs 0.04±0.01、蛋白1.44±0.51 vs 1.08±0.33、mRNA1.34±0.65 vs 1.07±0.42)、Popdc3(IHC 0.06±0.01 vs 0.05±0.01、蛋白1.75±0.70 vs 1.06±0.11、mRNA 1.23±0.40 vs 1.03±0.26)表达量明显高于窦律组(P均<0.05),而Popdc2(IHC 0.06±0.002 vs 0.07±0.02、蛋白1.49±0.55 vs 1.21±0.53、mRNA 1.05±0.49 vs 1.08±0.37)在两组间无明显表达差别(P均>0.05)。结论Popdc1、Popdc3在房颤患者心房中表达显著升高,这可能是房颤发生及维持的一个新的靶点。展开更多
High genetic variability of human immunodeficiency virus(HIV)has been a major intractable challenge to the practical design of vaccines.But a recent pioneer study published in PNAS Xenobots,is likely to revolutionize ...High genetic variability of human immunodeficiency virus(HIV)has been a major intractable challenge to the practical design of vaccines.But a recent pioneer study published in PNAS Xenobots,is likely to revolutionize HIV prevention as it presented the world's first living robot made of cells.In the advent of this discovery,we herein discuss the possibility of using living biological cell robots to target HIV-infected T lymphocytes,and the prospects of this approach being a new HIV vaccine.We capture the current research status and trend of advances in biological cell robots'design as a new HIV vaccine.The key differences between this novel vaccine and other HIV vaccines are highlighted.展开更多
肝X受体(liver X receptor, LXR)具有典型的核受体结构,包含LXRα(NR1H3)和LXRβ(NR1H2)两种同源亚型。作为一种多功能的转录因子,LXRα可诱导参与胆固醇逆转运、肝糖原代谢以及脂肪酸合成的基因表达,且能抑制一系列炎症反应。LXR特别是...肝X受体(liver X receptor, LXR)具有典型的核受体结构,包含LXRα(NR1H3)和LXRβ(NR1H2)两种同源亚型。作为一种多功能的转录因子,LXRα可诱导参与胆固醇逆转运、肝糖原代谢以及脂肪酸合成的基因表达,且能抑制一系列炎症反应。LXR特别是LXRα不仅在肝纤维化进程中异常低表达,而且在病毒性肝炎、酒精性和非酒精性脂肪肝等形成的肝纤维化疾病中均发挥了一定的作用,提示LXRα与肝纤维化有密切关系。因此,本文就LXR在肝纤维化中发挥的调节作用展开综述。展开更多
This study investigates the optimal projectile/target combination for the production of new neutron-deficient isotopes of superheavy nuclei(SHN). To this end, the dependence of the evaporation residue cross-section(ER...This study investigates the optimal projectile/target combination for the production of new neutron-deficient isotopes of superheavy nuclei(SHN). To this end, the dependence of the evaporation residue cross-section(ERCS) used to synthesize SHN on the mass asymmetry and the isospin of colliding nuclei are analyzed within the dinuclear system(DNS) concept. The predicted ERCSs for the production of new neutron-deficient isotopes of SHN were found to be quite large with the 36 S projectile, and the cross-section of SHN decreases slowly with the charge of compound nuclei owing to the increase in their survival probability,. Wsur is not canceled by the decreasing probability, PCN, that the system will evolve from a touching configuration to the compound nucleus in competition with the quasifission process.展开更多
文摘目的探讨大力水手结构域(Popdc)各亚型在人心耳中的表达与心房颤动(简称房颤)的相关性。方法本研究以行心脏外科手术病人的右心耳为研究对象,分为窦性心律(简称窦律)组和房颤组,运用免疫组化(IHC)染色、Masson染色、免疫印迹试验(Western blot)和定量聚合酶链反应(qPCR)技术,验证Popdc1、2、3各亚型在人心耳中的表达,同时结合病人的年龄、性别、纽约心功能(NYHA)分级、基础疾病等临床资料,分析Popdc各亚型表达变化与房颤的相关关系。结果与窦律组比较,房颤组女性比例更大、风湿性心脏病占比更大、左房直径更大、左室射血分数更低(P均<0.05)。房颤组的Popdc1(IHC 0.06±0.01 vs 0.04±0.01、蛋白1.44±0.51 vs 1.08±0.33、mRNA1.34±0.65 vs 1.07±0.42)、Popdc3(IHC 0.06±0.01 vs 0.05±0.01、蛋白1.75±0.70 vs 1.06±0.11、mRNA 1.23±0.40 vs 1.03±0.26)表达量明显高于窦律组(P均<0.05),而Popdc2(IHC 0.06±0.002 vs 0.07±0.02、蛋白1.49±0.55 vs 1.21±0.53、mRNA 1.05±0.49 vs 1.08±0.37)在两组间无明显表达差别(P均>0.05)。结论Popdc1、Popdc3在房颤患者心房中表达显著升高,这可能是房颤发生及维持的一个新的靶点。
基金AIDS Association of Inner Mongolia University for Nationalities,No.IMUN20190908.
文摘High genetic variability of human immunodeficiency virus(HIV)has been a major intractable challenge to the practical design of vaccines.But a recent pioneer study published in PNAS Xenobots,is likely to revolutionize HIV prevention as it presented the world's first living robot made of cells.In the advent of this discovery,we herein discuss the possibility of using living biological cell robots to target HIV-infected T lymphocytes,and the prospects of this approach being a new HIV vaccine.We capture the current research status and trend of advances in biological cell robots'design as a new HIV vaccine.The key differences between this novel vaccine and other HIV vaccines are highlighted.
文摘肝X受体(liver X receptor, LXR)具有典型的核受体结构,包含LXRα(NR1H3)和LXRβ(NR1H2)两种同源亚型。作为一种多功能的转录因子,LXRα可诱导参与胆固醇逆转运、肝糖原代谢以及脂肪酸合成的基因表达,且能抑制一系列炎症反应。LXR特别是LXRα不仅在肝纤维化进程中异常低表达,而且在病毒性肝炎、酒精性和非酒精性脂肪肝等形成的肝纤维化疾病中均发挥了一定的作用,提示LXRα与肝纤维化有密切关系。因此,本文就LXR在肝纤维化中发挥的调节作用展开综述。
基金the National Natural Science Foundation of China (11705055)Hunan Provincial Natural Science Foundation of China (2018JJ3324)Excellent Youth Fund of Hunan Provincial Education Department (17B154).
文摘This study investigates the optimal projectile/target combination for the production of new neutron-deficient isotopes of superheavy nuclei(SHN). To this end, the dependence of the evaporation residue cross-section(ERCS) used to synthesize SHN on the mass asymmetry and the isospin of colliding nuclei are analyzed within the dinuclear system(DNS) concept. The predicted ERCSs for the production of new neutron-deficient isotopes of SHN were found to be quite large with the 36 S projectile, and the cross-section of SHN decreases slowly with the charge of compound nuclei owing to the increase in their survival probability,. Wsur is not canceled by the decreasing probability, PCN, that the system will evolve from a touching configuration to the compound nucleus in competition with the quasifission process.