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无偿献血人群中HCV/OBI共感染者的分子流行病学特征
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作者 王淏 许茹 +7 位作者 王敏 黄杰庭 廖峭 单振刚 钟惠珊 郑优荣 戎霞 付涌水 《中国输血杂志》 CAS 2019年第2期123-127,共5页
目的了解无偿献血人群丙型肝炎病毒(HCV)感染者中隐匿性乙肝感染(OBI)率,为进一步阐明HCV/OBI的作用机制提供科学依据。方法采用盖立复PROCLEIX TIGRIS、罗氏cobas s 201和罗氏E601等仪器对2011年1月-2015年7月广州无偿献血者中的933(人... 目的了解无偿献血人群丙型肝炎病毒(HCV)感染者中隐匿性乙肝感染(OBI)率,为进一步阐明HCV/OBI的作用机制提供科学依据。方法采用盖立复PROCLEIX TIGRIS、罗氏cobas s 201和罗氏E601等仪器对2011年1月-2015年7月广州无偿献血者中的933(人)份HCV感染者标本做HBV DNA和抗-HBc检测,比较HCV单纯感染者和HCV/OBI共感染者之间性别、年龄、民族和转氨酶的差异;巢式PCR扩增HCV/OBI共感染者HCV C区和S区,并构建进化树和基因分型,荧光定量PCR检测HCV和HBV的病毒载量;另外,随机选取同期本地HCV 6a基因型的44名单纯HCV感染者和16名HCV/HBV共感染者最为对照组,通过巢式PCR扩增各组HCV C区,并对3组对象的HCV核心蛋白氨基酸序列做比对分析。结果本组HCV感染的献血者标本中,有6(人)份HBV DNA和抗-HBc阳性,亦即OBI感染率为6.43‰(6/933);该6份HCV/OBI共感染标本的HCV基因型中6a占83.3%(5/6)、1b占16.7%(1/6),HCV病毒载量(log10IU/mL)为3.8-5.7(5.0±0.69)。HCV单纯感染者和HCV/OBI共感染者的性别、年龄、民族、籍贯和ALT均无明显差异(P>0.05)。HCV单纯感染者、HCV/HBV共感染者和HCV/OBI共感染者HCV核心蛋白序列氨基酸变异数分别为0.8±1.3 vs 0.7±1.5 vs 0.4±0.5(P>0.05),没有在HCV/OBI共感染者中发现一致性的结构或突变规律。结论广州地区无偿献血人群HCV感染者中的OBI阳性率较高。 展开更多
关键词 丙型肝炎病毒 乙型肝炎 隐匿性 共感染 无偿献血者 HCV基因型 PCR
米非司酮治疗隐匿性异位促肾上腺皮质激素综合征的临床观察及文献回顾
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作者 梁亚茹 姚孝礼 施秉银 《中华内分泌代谢杂志》 CAS CSCD 北大核心 2019年第6期506-510,共5页
通过随访2例本院诊断为隐匿性异位促肾上腺皮质激素综合征且服用米非司酮治疗的患者,分析其临床特点、诊疗经过及临床疗效,回顾相关文献,评价米非司酮治疗异位促肾上腺皮质激素综合征患者临床疗效及不良反应。米非司酮治疗可改善患者的... 通过随访2例本院诊断为隐匿性异位促肾上腺皮质激素综合征且服用米非司酮治疗的患者,分析其临床特点、诊疗经过及临床疗效,回顾相关文献,评价米非司酮治疗异位促肾上腺皮质激素综合征患者临床疗效及不良反应。米非司酮治疗可改善患者的临床症状,2例患者均减量至停药,其中病例1合并糖尿病,治疗后可停用降糖药物,其血浆促肾上腺皮质激素(ACTH)、血清皮质醇较前下降;病例2合并高血压,其降压药物种类及剂量减少,血浆ACTH、血清皮质醇较前变化不大,随访过程中发现责任病灶,行手术切除后病情缓解、术后出现皮质醇功能减退症。米非司酮治疗异位促肾上腺皮质激素综合征患者安全有效,但仍需严密随访,若发现责任病灶需进一步明确病灶性质,尽快行手术治疗。 展开更多
关键词 米非司酮 隐匿性 异位促肾上腺皮质激素综合征 手术
High-risk symptoms and quantitative faecal immunochemical test accuracy: Systematic review and meta-analysis 预览
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作者 Noel Pin Vieito Sara Zarraquinos Joaquín Cubiella 《世界胃肠病学杂志:英文版》 SCIE CAS 2019年第19期2383-2401,共19页
BACKGROUND The quantitative faecal immunochemical test for haemoglobin (FIT) has been revealed to be highly accurate for colorectal cancer (CRC) detection not only in a screening setting, but also in the assessment of... BACKGROUND The quantitative faecal immunochemical test for haemoglobin (FIT) has been revealed to be highly accurate for colorectal cancer (CRC) detection not only in a screening setting, but also in the assessment of patients presenting lower bowel symptoms. Therefore, the National Institute for Health and Care Excellence has recommended the adoption of FIT in primary care to guide referral for suspected CRC in low-risk symptomatic patients using a 10 μg Hb/g faeces threshold. Nevertheless, it is unknown whether FIT′s accuracy remains stable throughout the broad spectrum of possible symptoms. AIM To perform a systematic review and meta-analysis to assess FIT accuracy for CRC detection in different clinical settings. METHODS A systematic literature search was performed using MEDLINE and EMBASE databases from inception to May 2018 to conduct a meta-analysis of prospective studies including symptomatic patients that evaluated the diagnostic accuracy of quantitative FIT for CRC detection. Studies were classified on the basis of brand, threshold of faecal haemoglobin concentration for a positive test result, percentage of reported symptoms (solely symptomatic, mixed cohorts) and CRC prevalence (< 2.5%,≥ 2.5%) to limit heterogeneity and perform subgroup analysis to assess the influence of clinical spectrum on FIT′s accuracy to detect CRC. RESULTS Fifteen cohorts including 13073 patients (CRC prevalence 0.4% to 16.8%) were identified. Pooled estimates of sensitivity for studies using OC-Sensor at 10 μg Hb/g faeces threshold (n = 10400) was 89.6%[95% confidence interval (CI): 82.7% to 94.0%). However, pooled estimates of sensitivity for studies formed solely by symptomatic patients (n = 4035) and mixed cohorts (n = 6365) were 94.1%(95%CI: 90.0% to 96.6%) and 85.5%(95%CI: 76.5% to 91.4%) respectively (P < 0.01), while there were no statistically significant differences between pooled sensitivity of studies with CRC prevalence < 2.5%(84.9%, 95%CI: 73.4% to 92.0%) and ≥ 2.5%(91.7%, 95%CI: 83.3% to 96.1%)(P = 0.25 展开更多
关键词 BOWEL DISEASE Colorectal cancer Diagnostic ACCURACY FAECAL HAEMOGLOBIN FAECAL immunochemical TEST FAECAL occult blood TEST Inflammatory BOWEL DISEASE Significant colonic lesion
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Viewpoints of the target population regarding barriers and facilitators of colorectal cancer screening in the Czech Republic 预览
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作者 Radek Kroupa Monika Ondrackova +4 位作者 Petra Kovalcikova Milan Dastych Tomas Pavlik Lumir Kunovsky Jiri Dolina 《世界胃肠病学杂志:英文版》 SCIE CAS 2019年第9期1132-1141,共10页
BACKGROUND Public awareness of colorectal cancer(CRC)and uptake of CRC screening remain challenges.The viewpoints of the target population(asymptomatic individuals older than 50)regarding CRC screening information sou... BACKGROUND Public awareness of colorectal cancer(CRC)and uptake of CRC screening remain challenges.The viewpoints of the target population(asymptomatic individuals older than 50)regarding CRC screening information sources and the reasons for and against participation in CRC screening are not well known in the Czech Republic.This study aimed to acquire independent opinions from the target population independently on the health system.AIM To investigate the viewpoints of the target population regarding the source of information for and barriers and facilitators of CRC screening.METHODS A survey among relatives(aged 50 and older)of university students was conducted.Participants answered a questionnaire about sources of awareness regarding CRC screening,reasons for and against participation,and suggestions for improvements in CRC screening.The effect of certain variables on participation in CRC screening was analyzed.RESULTS Of 498 participants,478(96%)respondents had some information about CRC screening and 375(75.3%)had participated in a CRC screening test.General practitioners(GPs)(n=319,64.1%)and traditional media(n=166,33.3%)were the most common information sources regarding CRC screening.A lack of interest or time and a fear of colonoscopy or positive results were reported as reasons for non-participation.Individuals aged>60 years[adjusted odds ratio(aOR)=2.30,95%confidence interval(CI)(1.42-3.71),P=0.001],females(aOR=1.95,95%CI(1.26-3.01)P=0.003),and relatives of CRC patients(aOR=4.17,95%CI(1.82-9.58)P=0.001)were more likely to participate in screening.Information regarding screening provided by physicians-GPs:(aOR=8.11,95%CI(4.90-13.41),P<0.001)and other specialists(aOR=4.19,95%CI(1.87-9.38),P=0.001)increased participation in screening.Respondents suggested that providing better explanations regarding screening procedures and equipment for stool capturing could improve CRC screening uptake.CONCLUSION GPs and other specialists play crucial roles in the successful uptake of CRC screening.Reduction of the fear o 展开更多
关键词 Colorectal cancer Screening COLONOSCOPY General PRACTITIONER Patient compliance FECAL OCCULT blood test
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隐匿性支气管异物患儿的临床观察 预览
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作者 王翠芝 董洁景 +2 位作者 李兰凤 高秀珍 吕丽格 《河北医药》 CAS 2019年第8期1225-1227,1231共4页
目的分析隐匿性支气管异物患儿临床特点及观察要点,为早期诊断及治疗提供理论参考。方法回顾2014年1月至2017年12月经纤维支气管镜确诊的76例隐匿性支气管异物患儿的临床观察资料。对患儿的年龄、性别、居住环境、院前资料及临床表现等... 目的分析隐匿性支气管异物患儿临床特点及观察要点,为早期诊断及治疗提供理论参考。方法回顾2014年1月至2017年12月经纤维支气管镜确诊的76例隐匿性支气管异物患儿的临床观察资料。对患儿的年龄、性别、居住环境、院前资料及临床表现等进行分析及总结。结果76例患儿中男54例,占71.05%;女22例,占28.95%,男女比例2.45∶1;年龄8月5d~6岁1个月,<1岁12例,占15.79%,1~3岁55例,占72.37%,3~6岁9例,占11.84%;农村49例,占64.47%、城市27例,占35.53%;均存在不同程度的咳嗽,不能提供异物吸入史;其中喘息62例,气促29例,发热19例,肺炎36例。结论无异物吸入史的不明原因咳嗽、喘息、气促、发热的农村1~3岁男孩,是隐匿性支气管异物多发高危人群。 展开更多
关键词 隐匿性 支气管异物 观察 分析
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High prevalence of occult hepatitis C infection in predialysis patients 预览
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作者 Luís Henrique Bezerra Cavalcanti Sette Edmundo Pessoa de Almeida Lopes +3 位作者 Nathália Campello Guedes dos Anjos Lucila Maria Valente Sávio Augusto Vieira de Oliveira Norma Lucena-Silva 《世界肝病学杂志:英文版(电子版)》 2019年第1期109-118,共10页
BACKGROUND Occult hepatitis C virus (HCV) infection (OCI) may be associated with extrahepatic diseases and it is known that the patients with chronic kidney disease (CKD) who are on hemodialysis (HD) present a higher ... BACKGROUND Occult hepatitis C virus (HCV) infection (OCI) may be associated with extrahepatic diseases and it is known that the patients with chronic kidney disease (CKD) who are on hemodialysis (HD) present a higher prevalence of this type of infection than the general population, with a worse clinical outcome. However, there are no data in the literature to assess the presence of OCI in patients prior to the initiation of renal replacement therapy (RRT). Therefore, this study aimed to evaluate the occurrence and epidemiological aspects of OCI in patients with Predialysis CKD. We hypothesize that this infection could occur before RRT initiation. AIM To research the status in predialysis patients when HD patients have high prevalence of OCI. METHODS A cross-sectional study was conducted between 2015 and 2017. Adults with creatinine clearance < 60 mL/min·1.73 m^2 (predialysis patients) were recruited to the study. Pregnant and postpartum women, patients with glomerulopathies, and patients showing positivity for serological markers of hepatitis B virus (HBV), HCV or human immunodeficiency virus infection were excluded. Patients were diagnosed with OCI according to test results of anti-HCV antibody negativity and HCV RNA positivity in either ultracentrifuged serum or, if serum-negative, in peripheral blood mononuclear cells. RESULTS Among the 91 total patients included in the study, the prevalence of OCI was 16.5%. Among these 15 total OCI patients, 1 was diagnosed by 14 ultracentrifuged serum results and 14 were diagnosed by peripheral blood mononuclear cell results. Compared to the non-OCI group, the OCI patients presented higher frequency of older age (P = 0.002), patients with CKD of mixed etiology (P = 0.019), and patients with markers of previous HBV infection (i.e., combined positivity for anti-hepatitis B core protein antibody and anti-hepatitis B surface protein antibody)(P = 0.001). CONCLUSION Among predialysis patients, OCI involved the elderly, patients with CKD of mixed etiology, and patients with prev 展开更多
关键词 OCCULT HEPATITIS infection CHRONIC HEPATITIS C CHRONIC kidney disease HEMODIALYSIS HEPATITIS C virus-RNA PERIPHERAL blood MONONUCLEAR cells
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Regulatory polymorphism of CXCL10 rs1439490 in seronegative occult hepatitis C virus infection 预览
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作者 Xu Wang Song Wang +11 位作者 Zhen-Hua Liu Wen-Qian Qi Qian Zhang Yong-Gui Zhang De-Rong Sun Yan Xu Hong-Guang Wang Zhong-Xie Li Xian-Ling Cong Ping Zhao Chang-Yu Zhou Jiang-Bin Wang 《世界胃肠病学杂志:英文版》 SCIE CAS 2018年第20期2191-2202,共12页
AIM To examine the relationship between the single nucleotide polymorphism CXCL10 rs1439490 and seronegative occult hepatitis C virus(HCV)infection(OCI).METHODS one hundred and three cases of seronegative OCI and 155 ... AIM To examine the relationship between the single nucleotide polymorphism CXCL10 rs1439490 and seronegative occult hepatitis C virus(HCV)infection(OCI).METHODS one hundred and three cases of seronegative OCI and 155 cases of seropositive chronic HCV infection(CHC)were diagnosed at five Liver Centers in Northeastern China,from 2012 to 2016.CXCL10 rs1439490,rs1440802,and IL-28B rs12979860 were analyzed by sequencing.Serum CXCL10 was measured by ELISA.Intrahepatic CXCL10 was determined by quantitative PCR and immunohistochemical semi-quantitative scoring.Liver necroinflammation and fibrosis were scored according to the METAVIR system.RESULTS CXCL10 rs1439490 G/G was more prevalent in OCI patients(n=93/103;90.3%)than in CHC patients(n=116/155;74.8%;P=0.008).OCI patients had lower serum CXCL10 levels than CHC patients(192.91±46.50 pg/mL vs 354.78±102.91 pg/mL,P<0.0001).Of IL-28B rs12979860 C/C patients,OCI patients with rs1439490 G/G had lower serum and liver levels of CXCL10 and lower levels of liver necroinflammation and fibrosis than non-G/G patients.OCI patients had higher alanine aminotransferase normalization rates after Peginterferon treatment than CHC patients(P<0.05)and serum CXCL10 decreased significantly(P<0.0001).Liver necroinflammation and fibrosis were alleviated in 8 OCI patients after treatment.Multivariate analysis indicated that rs1439490 G/G significantly influenced the occurrence of OCI in HCV infection(OR=0.31,95%CI:0.15-0.66,P=0.002).CONCLUSION CXCL10 rs1439490 G/G is positively associated with OCI in HCV infection and antiviral outcome. 展开更多
关键词 OCCULT hepatitis C virus infection CXCL10 Single NUCLEOTIDE POLYMORPHISMS rs1439490
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MRI诊断腕关节舟状骨可疑性骨折临床价值分析 预览
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作者 郭福庆 郭福倩 兰国宾 《医学影像学杂志》 2018年第5期837-840,共4页
目的探讨腕关节舟状骨骨折MRI的诊断价值。方法对怀疑舟状骨骨折的腕关节外伤54例患者行X线检查,筛选出未观察到骨折线的患者进一步行腕关节MRI检查。采集患者的年龄、性别、致伤原因、X线及MRI资料进行分析。结果本研究共纳入可疑性舟... 目的探讨腕关节舟状骨骨折MRI的诊断价值。方法对怀疑舟状骨骨折的腕关节外伤54例患者行X线检查,筛选出未观察到骨折线的患者进一步行腕关节MRI检查。采集患者的年龄、性别、致伤原因、X线及MRI资料进行分析。结果本研究共纳入可疑性舟状骨骨折患者54例,其中男性38例,女性16例,平均年龄36.3岁。受伤机制为高处坠落、跌倒、运动损伤和交通意外等。腕关节MRI显示正常者15例,骨折患者16例和其他损伤患者23例。其中舟状骨骨折11例,其他单发骨折5例。结论腕关节MRI在可疑性舟状骨骨折的诊断和治疗中具有重要作用。 展开更多
关键词 可疑性 舟状骨骨折 磁共振成像
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Systematic review of colorectal cancer screening guidelines for average-risk adults:Summarizing the current global recommendations 预览
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作者 Florence Bénard Alan N Barkun +1 位作者 Myriam Martel Daniel von Renteln 《世界胃肠病学杂志:英文版》 SCIE CAS 2018年第1期124-138,共15页
AIM To summarize and compare worldwide colorectal cancer(CRC)screening recommendations in order to identify similarities and disparities.METHODS A systematic literature search was performed using MEDLINE,EMBASE,Scopus... AIM To summarize and compare worldwide colorectal cancer(CRC)screening recommendations in order to identify similarities and disparities.METHODS A systematic literature search was performed using MEDLINE,EMBASE,Scopus,CENTRAL and ISI Web of knowledge identifying all average-risk CRC screening guideline publications within the last ten years and/or position statements published in the last 2 years.In addition,a hand-search of the webpages of National Gastroenterology Society websites,the National Guideline Clearinghouse,the BMJ Clinical Evidence website,Google and Google Scholar was performed.RESULTS Fifteen guidelines were identified.Six guidelines were published in North America,four in Europe,four in Asia and one from the World Gastroenterology Organization.The majority of guidelines recommend screening average-risk individuals between ages 50 and 75 using colonoscopy(every 10 years),or flexible sigmoidoscopy(FS,every 5 years)or fecal occult blood test(FOBT,mainly the Fecal Immunochemical Test,annually or biennially).Disparities throughout the different guidelines are found relating to the use of colonoscopy,rank order between test,screening intervals and optimal age ranges for screening.CONCLUSION Average risk individuals between 50 and 75 years should undergo CRC screening.Recommendations for optimal surveillance intervals,preferred tests/test cascade as well as the optimal timing when to start and stop screening differ regionally and should be considered for clinical decision making.Furthermore,local resource availability and patient preferences are important to increase CRC screening uptake,as any screening is better than none. 展开更多
关键词 Guidelines Systematic review FECAL OCCULT blood TEST FECAL immunochemical TEST COLONOSCOPY Colorectal cancer Screening Flexible SIGMOIDOSCOPY
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Hepatitis B virus infection:defective surface antigen expression and pathogenesis 预览
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作者 Chun-chen Wu Ying-shan Chen +2 位作者 Liang Cao Xin-wen Chen Meng-ji Lu 《世界胃肠病学杂志:英文版》 SCIE CAS 2018年第31期3488-3499,共12页
Hepatitis B virus(HBV)infection is a global public health concern.HBV causes chronic infection in patients and can lead to liver cirrhosis,hepatocellular carcinoma,and other severe liver diseases.Thus,understanding HB... Hepatitis B virus(HBV)infection is a global public health concern.HBV causes chronic infection in patients and can lead to liver cirrhosis,hepatocellular carcinoma,and other severe liver diseases.Thus,understanding HBV-related pathogenesis is of particular importance for prevention and clinical intervention.HBV surface antigens are indispensable for HBV virion formation and are useful viral markers for diagnosis and clinical assessment.During chronic HBV infection,HBV genomes may acquire and accumulate mutations and deletions,leading to the expression of defective HBV surface antigens.These defective HBV surface antigens have been found to play important roles in the progression of HBV-associated liver diseases.In this review,we focus our discussion on the nature of defective HBV surface antigen mutations and their contribution to the pathogenesis of fulminant hepatitis B.The relationship between defective surface antigens and occult HBV infection are also discussed. 展开更多
关键词 HEPATITIS B SURFACE protein DEFECTIVE SURFACE antigen mutants Endoplasmic reticulum stress FULMINANT HEPATITIS B OCCULT HEPATITIS B virus infection PATHOGENESIS
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Management of computed tomography scan detected hemothorax in blunt chest trauma:What computed tomography scan measurements say? 预览
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作者 Mahdi Malekpour Kenneth Widom +4 位作者 James Dove Joseph Blansfield Mohsen Shabahang Denise Torres Jeffrey L Wild 《世界放射学杂志:英文版(电子版)》 2018年第12期184-189,共6页
AIM To investigate the hemothorax size for which tube thoracostomy is necessary.METHODS Over a 5-year period,we included all patients who were admitted with blunt chest trauma to our level 1 trauma center.Focus was pl... AIM To investigate the hemothorax size for which tube thoracostomy is necessary.METHODS Over a 5-year period,we included all patients who were admitted with blunt chest trauma to our level 1 trauma center.Focus was placed on identifying the hemothorax size requiring tube thoracostomy.RESULTS A total number of 274 hemothoraces were studied.All patients with hemothoraces measuring above 3 cm received a chest tube.The 50%predicted probability of tube thoracostomy was 2 cm.Pneumothorax was associated with odds of receiving tube thoracostomy for hemothoraces below 2 cm(Odds Ratio:4.967,95%CI:2.225-11.097,P<0.0001).CONCLUSION All patients with a hemothorax size greater than 3%underwent tube thoracostomy.Prospective studies are warranted to elucidate the clinical outcome of patients with smaller hemothoraces. 展开更多
关键词 CHEST TRAUMA BLUNT HEMOTHORAX CHEST tube OCCULT Computed tomography scan
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Colorectal cancer screening use among insured adults:Is outof-pocket cost a barrier to routine screening? 预览
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作者 Abhilash Perisetti Hafiz Khan +6 位作者 Nayana E George Rachana Yendala Aamrin Rafiq Summre Blakely Drew Rasmussen Nathan Villalpando Hemant Goyal 《世界胃肠药理与治疗学杂志:英文版(电子版)》 2018年第4期31-38,共8页
AIM To describe the characteristics of adults who needed to see a doctor in the past year but could not due to the extra cost and assess the impact of limited financial resources on the receipt of routine fecal occult... AIM To describe the characteristics of adults who needed to see a doctor in the past year but could not due to the extra cost and assess the impact of limited financial resources on the receipt of routine fecal occult blood test,sigmoidoscopy,or colonoscopy for colon cancer screening among insured patients.METHODS Data obtained from the 2012 Behavioral Risk Factor Surveillance System included 215436 insured adults age 50-75 years.We computed frequencies,adjusted odds ratios(aORs),and 95%CIs using SAS v9.3 software.RESULTS Nine percent of the study population needed to see a doctor in the past year but could not because of cost.The numbers were significantly higher among those aged 50-64(P<0.0001),Non-Hispanic Whites(P<0.0001),and those with a primary care physician(P<0.0001)among other factors.Adjusting for possible confounders,aORs for not seeing the doctor in the past year because of cost were:stool occult blood test within last year aOR=0.88;95%CI:0.76-1.02,sigmoidoscopy within last year aOR=0.72;95%CI:0.48-1.07,colonoscopy within the last year aOR=0.91;95%CI:0.81-1.02.CONCLUSION We found that the limited financial resources within the past 12 mo were significantly associated with colorectal cancer(CRC)non-screening.Patients with risk factors identified in this study should adhere to CRC guidelines and should receive financial help if needed. 展开更多
关键词 FECAL OCCULT blood Healthcare delivery SIGMOIDOSCOPY Colorectal cancer Screening Access to care BEHAVIORAL Risk Factor Surveillance System
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64排螺旋CT标准算法与骨算法薄层重建技术在颅底隐匿性骨折诊断中的应用价值 预览 被引量:2
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作者 范华刚 陈慧婷 《南昌大学学报:医学版》 CAS 2018年第1期72-75,107共5页
目的探讨64排螺旋CT标准算法及骨算法薄层重建技术在颅底隐匿性骨折患者诊断中的应用价值。方法 选取可疑颅底隐匿性骨折患者300例,利用标准算法及骨算法薄层重建分别对颅底是否有骨折进行评判,如有骨折,对骨折部位、范围、周围窦腔及... 目的探讨64排螺旋CT标准算法及骨算法薄层重建技术在颅底隐匿性骨折患者诊断中的应用价值。方法 选取可疑颅底隐匿性骨折患者300例,利用标准算法及骨算法薄层重建分别对颅底是否有骨折进行评判,如有骨折,对骨折部位、范围、周围窦腔及软组织情况做出客观的判断。结果 300例颅脑外伤患者中,厚层扫描未见明确骨折,仅可见部分间接征象。骨算法薄层重建较标准算法薄层重建得到骨折诊断阳性结果高(95.3%比58.4%,P<0.05),标准算法联合骨算法薄层重建骨折诊断阳性率高于标准算法薄层重建(100.0%比58.4%,P<0.05),标准算法联合骨算法薄层重建与骨算法薄层重建骨折诊断阳性率比较差异无统计学意义(100.0%比95.3%,P>0.05)。结论 GE64排螺旋CT骨算法薄层重建在评价颅底隐匿性骨折诊断的准确率明显高于标准算法薄层重建,联合两者对颅底隐匿性骨折诊断具有重要的临床价值。 展开更多
关键词 64排螺旋CT 标准算法 骨算法 颅底骨折 隐匿性
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编辑活动的话语存在 预览
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作者 周艳 《成都工业学院学报》 2018年第4期80-82,共3页
整个社会的文化背景是一个充斥种种话语的巨大“意义场”。编辑活动以“话语”的方式体现自身的思想意志、价值观念和利益诉求等。编辑话语是编辑行为与编辑行为成果的总和,主要体现在出版物的内容与形式之中,具有隐匿性与间接性、多样... 整个社会的文化背景是一个充斥种种话语的巨大“意义场”。编辑活动以“话语”的方式体现自身的思想意志、价值观念和利益诉求等。编辑话语是编辑行为与编辑行为成果的总和,主要体现在出版物的内容与形式之中,具有隐匿性与间接性、多样性与统一性、依附性与限制性的特点。 展开更多
关键词 编辑 话语 意义 隐匿性
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64排128层螺旋CT后处理技术在肋骨隐匿性骨折诊断中的应用价值 预览
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作者 李晓婷 《罕少疾病杂志》 2018年第6期43-44,56,I0001共4页
目的探讨64排128层螺旋CT及其后处理技术在肋骨隐匿性骨折诊断中的应用价值。方法回顾性分析126例可疑肋骨骨折患者,所有病例行X线摄影及CT扫描并行重建后处理,包括容积再现、多平面重组、曲面重组,确定隐匿性骨折数目,比较各种检查方... 目的探讨64排128层螺旋CT及其后处理技术在肋骨隐匿性骨折诊断中的应用价值。方法回顾性分析126例可疑肋骨骨折患者,所有病例行X线摄影及CT扫描并行重建后处理,包括容积再现、多平面重组、曲面重组,确定隐匿性骨折数目,比较各种检查方法对肋骨隐匿性骨折检出率之间的差异。结果126例患者共检出隐匿性骨折68处,容积再现检出35处,多平面重组技术检出67处,曲面重组技术检出50处。结论64排128层螺旋CT多平面重组、曲面重组技术对肋骨隐匿性骨折的显示较容积再现技术更明确;临床工作中64排128层螺旋CT多平面重组、曲面重组及容积再现技术的联合应用有利于提高肋骨隐匿性骨折的检出率。 展开更多
关键词 隐匿性 肋骨骨折 64排128层螺旋CT 后处理技术
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Non-small bowel lesion detection at small bowel capsule endoscopy:A comprehensive literature review 预览
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作者 Apostolos Koffas Faidon-Marios Laskaratos Owen Epstein 《世界临床病例杂志》 2018年第15期901-907,共7页
Small bowel capsule endoscopy is a minimally-invasive endoscopic investigation that is often used in clinical practice to investigate overt or occult gastrointestinal(GI)bleeding among other clinical indications.Inter... Small bowel capsule endoscopy is a minimally-invasive endoscopic investigation that is often used in clinical practice to investigate overt or occult gastrointestinal(GI)bleeding among other clinical indications.International guidance recommends small bowel capsule endoscopy as a first-line investigation to detect abnormalities in the small bowel,when gastroscopy and colonoscopy fail to identify a cause of GI bleeding.It can diagnose with accuracy abnormalities in the small bowel.However,there has been increasing evidence indicating that small bowel capsule endoscopy may also detect lesions outside the small intestine that are within the reach of conventional endoscopy and have been probably missed during prior endoscopic investigations.Such lesions vary from vascular deformities to malignancy and their detection often alters patient management,leading to further endoscopic and/or surgical interventions.The current study attempts to review all available studies in the literature and summarise their relevant findings. 展开更多
关键词 Obscure GASTROINTESTINAL BLEEDING Small BOWEL capsule endoscopy NON-SMALL BOWEL lesions Overt GASTROINTESTINAL BLEEDING OCCULT GASTROINTESTINAL BLEEDING Iron deficiency ANAEMIA
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单侧隐匿性肾衰竭的临床探讨与MSCT分析 预览 被引量:1
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作者 李晓阳 李雅丽 +4 位作者 李建强 赵林 李会菊 马拓 邢国凤 《医学影像学杂志》 2017年第9期1752-1756,共5页
目的通过MSCT分析单侧性、隐匿性肾衰竭的发生和发展情况,提高临床医师对单侧隐匿性肾衰竭的认识程度,做到对单侧隐匿性急性肾衰竭的早期诊断与治疗,减少和避免单侧隐匿性肾衰竭的发生和发展。方法收集单侧急性匿性急性肾衰竭病例50例,... 目的通过MSCT分析单侧性、隐匿性肾衰竭的发生和发展情况,提高临床医师对单侧隐匿性肾衰竭的认识程度,做到对单侧隐匿性急性肾衰竭的早期诊断与治疗,减少和避免单侧隐匿性肾衰竭的发生和发展。方法收集单侧急性匿性急性肾衰竭病例50例,均为肾后性肾梗阻患者,临床追随6个月~6年,所有病例的临床和MSCT扫描检查资料完整。本研究组病例均经临床保守治疗(手术治疗者除外)。本组50例中:单侧输尿管结石患者27例;单侧肾盂输尿管连接部狭窄(UPJO)患者6例;下腔静脉后输尿管3例;子宫内膜癌术后转移累及一侧输尿管4例;卵巢癌术后一侧盆腔转移累及同侧输尿管7例;膀胱癌累及一侧输尿管3例;收集所有患者实验室生化常规检查资料以及临床最后诊断信息以及鉴别诊断信息。结果 MSCT检查:单侧急性肾后性肾梗阻50例(100%),所有病例临床诊断中未涉及急性肾衰竭;研究组50例MSCT追随6个月~6年复查结果:患侧肾萎缩34例(68%);实验室生化常规检查资料肌酐、尿素氮(Cr、BUN)正常(100%)。结论隐匿性急性肾衰竭若无及时治疗,会发展为慢性隐匿性肾衰竭,肾萎缩、肾功能丧失。 展开更多
关键词 肾脏 肾衰竭 隐匿性 体层摄影术 X线计算机
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隐匿性胸部创伤的诊治现状与进展 预览 被引量:3
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作者 谭群友 周景海 《创伤外科杂志》 2017年第2期81-84,共4页
隐匿性胸部创伤指X线片检查正常而CT扫描异常的胸部创伤,发生率为37.3%-71%,以肋骨骨折、气胸、血胸及肺挫伤等较为常见。尽管多数隐匿性胸部创伤不需特殊处理,但有的可能导致严重后果,临床上仍应高度重视。上胸部隐匿性肋骨骨折,提示... 隐匿性胸部创伤指X线片检查正常而CT扫描异常的胸部创伤,发生率为37.3%-71%,以肋骨骨折、气胸、血胸及肺挫伤等较为常见。尽管多数隐匿性胸部创伤不需特殊处理,但有的可能导致严重后果,临床上仍应高度重视。上胸部隐匿性肋骨骨折,提示创伤严重,而下胸部肋骨骨折,可能存在腹腔实质脏器损伤。隐匿性气胸需要机械通气时不必预防性安置胸腔引流,但需密切观察,一旦病情进展,需及时处理。隐匿性血胸厚度≥1.5cm,宜安置胸腔引流管,以免发生并发症。尽管隐匿性肺挫伤发生率高,但其治疗方案需结合其他临床指标。 展开更多
关键词 胸部创伤 隐匿性 诊断 治疗 进展
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腹腔镜诊断和治疗41例隐匿性腹股沟疝的临床观察 预览
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作者 冷蔚 李蜀华 《重庆医学》 北大核心 2017年第33期4680-4681,共2页
目的探讨腹腔镜对隐匿性腹股沟疝诊断和治疗的价值。方法选取2011-2012年该院普外科对腹腔镜手术进行术中腹股沟区探查患者139例为研究对象。全部病例均无腹股沟区慢性疼痛病史,121例术前查体均未发现腹股沟疝,18例腹股沟疝另一侧未发... 目的探讨腹腔镜对隐匿性腹股沟疝诊断和治疗的价值。方法选取2011-2012年该院普外科对腹腔镜手术进行术中腹股沟区探查患者139例为研究对象。全部病例均无腹股沟区慢性疼痛病史,121例术前查体均未发现腹股沟疝,18例腹股沟疝另一侧未发现腹股沟疝。对腹腔镜下突出的疝囊内陷最深处大于或等于10mm,疝环口横径大于或等于8mm者视为阳性,并对观察结果进行记录。对部分符合指征的病例进行同期手术治疗。结果 139例患者中共发现隐匿性腹股沟疝41例,其中双侧腹股沟区12例,右侧腹股沟区18例,左侧腹股沟区11例;股疝2例,斜疝27例,直疝10例,复合疝2例;11例同时完成修补手术。隐匿性腹股沟疝发生率在性别间比较差异有统计学意义(P〈0.05),在年龄、发病部位间比较差异无统计学意义(P〉0.05)。原发疾病为疝的发现为隐匿性腹股沟疝概率较非疝高(P〈0.01)。结论在实施腹腔镜手术时观察腹股沟区域,可以准确地诊断出隐匿性腹股沟疝,为预防其进一步发展为显性疝提供早期干预依据,并可以对部分有指征病例直接实施手术治疗。 展开更多
关键词 腹腔镜 腹股沟 隐匿性
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Genetic variation of occult hepatitis B virus infection 预览 被引量:1
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作者 Zhen-Hua Zhang Chun-Chen Wu +3 位作者 Xin-Wen Chen Xu Li Jun Li Meng-Ji Lu 《世界胃肠病学杂志:英文版》 SCIE CAS 2016年第13期3531-3546,共16页
Occult hepatitis B virus infection(OBI), characterized as the persistence of hepatitis B virus(HBV) surface antigen(HBs Ag) seronegativity and low viral load in blood or liver, is a special form of HBV infection. OBI ... Occult hepatitis B virus infection(OBI), characterized as the persistence of hepatitis B virus(HBV) surface antigen(HBs Ag) seronegativity and low viral load in blood or liver, is a special form of HBV infection. OBI may be related mainly to mutations in the HBV genome, although the underlying mechanism of it remains to be clarified. Mutations especially within the immunodominant 'α' determinant of S protein are 'hot spots' that could contribute to the occurrence of OBI via affecting antigenicity and immunogenicity of HBs Ag or replication and secretion of virion. Clinical reports account for a large proportion of previous studies on OBI, while functional analyses, especially those based on full-length HBV genome, are rare. 展开更多
关键词 HEPATITIS B VIRUS OCCULT VARIATION HEPATITIS B surface ANTIGEN
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