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Neuroinflammation and oxidative stress act in concert to promote neurodegeneration in the diabetic retina and optic nerve:galectin-3 participation 预览
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作者 Henrique Rocha Mendonca Raul Carpi-Santos +1 位作者 Karin da Costa Calaza Ana Maria Blanco Martinez 《中国神经再生研究:英文版》 SCIE CAS CSCD 2020年第4期625-635,共11页
Diabetes is a lifelong disease characterized by glucose metabolic imbalance,in which low insulin levels or impaired insulin signaling lead to hyperglycemic state.Within 20 years of diabetes progression,95%of patients ... Diabetes is a lifelong disease characterized by glucose metabolic imbalance,in which low insulin levels or impaired insulin signaling lead to hyperglycemic state.Within 20 years of diabetes progression,95%of patients will have diabetic retinopathy,the leading cause of visual defects in working-age people worldwide.Although diabetes is considered a microvascular disease,recent studies have shown that neurodegeneration precedes vascular changes within the diabetic visual system,albeit its mechanisms are still under investigation.Neuroinflammation and oxidative stress are intrinsically related phenomena,since macrophage/microglia and astrocytes are the main sources of reactive oxygen species during central nervous system chronic degenerative diseases,and both pathological processes are increased in the visual system during diabetes.The present review will focus on recent findings of the contribution of oxidative stress derived from neuroinflammation in the early neurodegenerative aspects of the diabetic visual system and their relationship with galectin-3. 展开更多
关键词 diabetes diabetic RETINOPATHY GALECTIN-3 NEURODEGENERATION NEUROINFLAMMATION optic nerve oxidative stress retina
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Stroke gets in your eyes:stroke-induced retinal ischemia and the potential of stem cell therapy 预览
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作者 Chase Kingsbury Matt Heyck +2 位作者 Brooke Bonsack Jea-Young Lee Cesar V.Borlongan 《中国神经再生研究:英文版》 SCIE CAS CSCD 2020年第6期1014-1018,共5页
Stroke persists as a global health and economic crisis,yet only two interventions to reduce stroke-induced brain injury exist.In the clinic,many patients who experience an ischemic stroke often further suffer from ret... Stroke persists as a global health and economic crisis,yet only two interventions to reduce stroke-induced brain injury exist.In the clinic,many patients who experience an ischemic stroke often further suffer from retinal ischemia,which can inhibit their ability to make a functional recovery and may diminish their overall quality of life.Despite this,no treatments for retinal ischemia have been developed.In both cases,ischemia-induced mitochondrial dysfunction initiates a cell loss cascade and inhibits endogenous brain repair.Stem cells have the ability to transfer healthy and functional mitochondria not only ischemic neurons,but also to similarly endangered retinal cells,replacing their defective mitochondria and thereby reducing cell death.In this review,we encapsulate and assess the relationship between cerebral and retinal ischemia,recent preclinical advancements made using in vitro and in vivo retinal ischemia models,the role of mitochondrial dysfunction in retinal ischemia pathology,and the therapeutic potential of stem cell-mediated mitochondrial transfer.Furthermore,we discuss the pitfalls in classic rodent functional assessments and the potential advantages of laser Doppler as a metric of stroke progression.The studies evaluated in this review highlight stem cell-derived mitochondrial transfer as a novel therapeutic approach to both retinal ischemia and stroke.Furthermore,we posit the immense correlation between cerebral and retinal ischemia as an underserved area of study,warranting exploration with the aim of these treating injuries together. 展开更多
关键词 laser Doppler MCAO mesenchymal stem cells mitochondrial network mitochondrial transfer ophthalmic artery optic nerve oxygen-glucose deprivation regenerative medicine retinal ganglion cells visual impairment
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MRI Histogram Texture Feature Analysis of the Optic Nerve in the Patients with Optic Neuritis 预览
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作者 Hongjuan Liu Huanfen Zhou +3 位作者 Linxiong Zong Mengqi Liu Shihui Wei Zhiye Chen 《中国医学科学杂志:英文版》 CAS CSCD 2019年第1期18-23,共6页
Objective To evaluate the optic nerve impairment using MRI histogram texture analysis in the patients with optic neuritis. Methods The study included 60 patients with optic neuritis and 20 normal controls. The coronal... Objective To evaluate the optic nerve impairment using MRI histogram texture analysis in the patients with optic neuritis. Methods The study included 60 patients with optic neuritis and 20 normal controls. The coronal T2 weighted imaging (T2WI) with fat saturation and enhanced T1 weighted imaging (T1WI) were performed to evaluate the optic nerve. MRI histogram texture features of the involved optic nerve were measured on the corresponding coronal T2WI images. The normal optic nerve (NON) was measured in the posterior 1/3 parts of the optic nerve. Kruskal-Wallis one-way ANOVA was used to compare the difference of texture features and receiver operating characteristic (ROC) curve were performed to evaluate the diagnostic value of texture features for the optic nerve impairment among the affected optic nerve with enhancement (ONwEN), affected optic nerve without enhancement (ONwoEN), contralateral normal appearing optic nerve (NAON) and NON. Results The histogram texture Energy and Entropy presented significant differences for ONwEN vs. ONwoEN (both P=0.000), ONwEN vs. NON (both P=0.000) and NAON vs. NON (both P<0.05). ROC analysis demonstrated that the area under the curve (AUC) of histogram texture Energy were 0.758, 0.795 and 0.701 for ONwEN vs. ONwoEN, ONwEN vs. NON and NAON vs. NON, AUC of Entropy were 0.758, 0.795 and 0.707 for ONwEN vs. ONwoEN, ONwEN vs. NON and NAON vs. NON. Conclusion The altered MRI histogram texture Energy and Entropy could be considered as a surrogate for MRI enhancement to evaluate the involved optic nerve and normal-appearing optic nerve in optic neuritis. 展开更多
关键词 HISTOGRAM ANALYSIS OPTIC NERVE OPTIC NEURITIS texture ANALYSIS Energy Entropy
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Assessment of optic nerve and optic tract alterations in patients with orbital space-occupying lesions using probabilistic diffusion tractography
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作者 Chun-Nan Wu Shao-Feng Duan +4 位作者 Xue-Tao Mu Yi Wang Peng-Yu Lan Xiao-Lu Wang Kun-Cheng Li 《国际眼科杂志:英文版》 SCIE CAS 2019年第8期1304-1310,共7页
AIM: To investigate the diffusion changes in both the optic nerve and optic tract in orbital space-occupying lesion patients with decreased visual acuity, and its clinical significance using probabilistic diffusion tr... AIM: To investigate the diffusion changes in both the optic nerve and optic tract in orbital space-occupying lesion patients with decreased visual acuity, and its clinical significance using probabilistic diffusion tractography(PDT). METHODS: Twenty patients with orbital space-occupying lesions and 25 age-and gender-matched healthy persons were included. All patients and controls underwent routine orbital magnetic resonance imaging and diffusion tensor imaging(DTI), using a 3.0 T magnetic resonance scanner(Trio Tim Siemens). After the image data were preprocessed, each DTI parameters of the optic nerve and optic tract was obtained by PDT, including fractional anisotropy(FA), mean diffusivity(MD), axial diffusivity(AD) and radial diffusivity(RD). The asymmetry index(AI) of each parameter was calculated. Compared the parameters of the affected side optic nerve and ipsilateral optic tract with the contralateral side by paired sample t-test;compared AI of parameters of optic nerve and optic tract between the patient group and the control group by independent sample t-test. Patients were divided into threesubgroups according to the low vision grade standard of WHO, compared the FA and AI of FA between the three subgroups by single factor variance analysis. RESULTS: The affected side optic nerve presented significantly decreased FA, increased MD, AD, and RD values compared to the unaffected side(P<0.05). The AI of FA, MD, AD, and RD of optic nerve in the patients was significantly higher than that of the controls(P<0.05). The comparison results of the optic tract showed that there was no significant difference between the patient group and control group in terms of the bilateral optic tracts in patients(P>0.05). The AIs of the FA value of the optic nerve in the eyesight <0.1 subgroup was significantly higher than that in the other groups(P<0.05). CONCLUSION: FA, MD, AD, and RD of the affected side optic nerve of the orbital space-occupying lesions have significantly changed, the FA value is the most sensitive. The PDT 展开更多
关键词 ORBITAL space-occupying lesions decreased vision OPTIC never and OPTIC tract PROBABILISTIC diffusion TRACTOGRAPHY magnetic resonance imaging
Effect of Changing Heart Rate on the Ocular Pulse and Optic Nerve Head Deformations
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作者 Yuejiao Jin Xiaofei Wang +4 位作者 Sylvi Febriana Rachmawati Irnadiastputri Rosmin Elsa Mohan Tin Aung Leopold Schmetterer Michal JAGirard 《医用生物力学》 CAS CSCD 北大核心 2019年第A01期183-184,共2页
Objective To study the effect of changing heart rate on the ocular pulse and optic nerve head deformations with a viscoelastic lamina cribrosa.Methods An FE model of a healthy eye was reconstructed.The choroid was bip... Objective To study the effect of changing heart rate on the ocular pulse and optic nerve head deformations with a viscoelastic lamina cribrosa.Methods An FE model of a healthy eye was reconstructed.The choroid was biphasic and consisted of a solid phase(connective tissues)and a fluid phase(blood).The LC was viscoelastic as characterized by a stress-relaxation test.We applied arterial pressures at 18 entry sites(posterior ciliary arteries)and venous pressures at 4 exit sites(vortex veins).The heart rate was varied from 60 bpm to 120 bpm(increment:20 bpm).We reported the ocular pulse amplitude(OPA),pulse volume,optic nerve head(ONH)deformations and the dynamic modulus of the LC at different heart rates.Results With an increasing heart rate,the OPA decreased by 0.04 mmHg for every 10 bpm increase.The pulse volume also exhibited a linear relationship with heart rate,and decreased by 0.13 L.In addition,the storage modulus and the loss modulus of the LC center increased by 0.014 MPa and 0.04 MPa,respectively for every 10 pm increase in heart rate.Conclusions Our model predicted that the OPA,the pulse volume the ONH deformation decreased at a faster heartrate.We also found that the viscoelastic LC became stiffer with an increasing heart rate.Further studies are required to explore the potential links with the vascular dysregulation and axonal loss in glaucoma. 展开更多
关键词 HEART Rate OCULAR PULSE OPTIC NERVE Head Deformations
Activation of autophagy in the retina after optic nerve crush injury in rats
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作者 Li-Hua Kang Su Zhang +1 位作者 Sheng Jiang Nan Hu 《国际眼科杂志:英文版》 SCIE CAS 2019年第9期1395-1401,共7页
AIM: To investigate the activation of autophagy in rat retina after optic nerve crush(ONC) and evaluate its relationship with apoptosis of retinal ganglion cells(RGCs).METHODS: The ONC model was established. Western b... AIM: To investigate the activation of autophagy in rat retina after optic nerve crush(ONC) and evaluate its relationship with apoptosis of retinal ganglion cells(RGCs).METHODS: The ONC model was established. Western blots were performed to investigate expression of p62, LC3 and Beclin-1. Transmission electron microscopy was performed to discover the autophagosomes in the retina after ONC. Immunohistochemistry was used to confirm the distribution of LC3. TUNEL was performed to confirm the relationship between autophagy and RGC apoptosis. RESULTS: p62/Beclin-1 ratio was declined shortly after ONC until to day 7 after ONC and then restored to a normal level at day 21. There was an opposite change in the LC3-II/LC3 I ratio in the retina compared to the p62/Beclin-1 ratio. Increased autophagosomes were found after ONC using transmission electron microscopy, and most of the LC3-stained cells were colocalized with RGCs and Müller cells. More LC3-immunoreactive cells and apoptotic RGCs were found on day 7 following ONC. CONCLUSION: Possible activation of autophagy in RGCs after ONC;autophagy mainly occurred in RGCs and Müller cells, and the apoptosis of RGCs after ONC may be partly associated with autophagic activation. 展开更多
关键词 AUTOPHAGY OPTIC nerve CRUSH apoptosis retinal GANGLION cells rat
Fiber optic displacement sensor used in railway turnout contact monitoring system
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作者 许红彬 李峰 +3 位作者 赵维刚 田秀淑 杜彦良 高阳 《光电子快报:英文版》 EI 2019年第3期165-169,共5页
Railway turnout contact monitoring is very important in high-speed rail operation systems. In order to measure the distance between the sharp rail and the basic rail in a switch system, a wide-range, high-precision fi... Railway turnout contact monitoring is very important in high-speed rail operation systems. In order to measure the distance between the sharp rail and the basic rail in a switch system, a wide-range, high-precision fiber Bragg grating(FBG) displacement sensor was designed. Because the distance between the sharp and basic rails is always greater than 14 cm, the measurement range width and accuracy of the proposed sensor system are ensured through the use of a long spring and a beam of constant strength. A differential compensation method is used to eliminate temperature effects. Test results show that the resolution of the proposed sensor is 0.040 mm and the measuring range is 0—170 mm. A field test was also carried out to evaluate the performance of the sensors. 展开更多
关键词 FBG Fiber OPTIC DISPLACEMENT sensor USED in railway TURNOUT contact monitoring system
Recent developments in novel silica-based optical fibers
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作者 Ting-yun WANG Fu-fei PANG +3 位作者 Su-juan HUANG Jian-xiang WEN Huan-huan LIU Li-bo YUAN 《信息与电子工程前沿:英文版》 SCIE EI CSCD 2019年第4期481-489,共9页
We have summarized our recent work in the area of novel silica-based optical fibers, which can be classified into two types: silica optical fiber doped with special elements including Bi, Al, and Ce, and micro-structu... We have summarized our recent work in the area of novel silica-based optical fibers, which can be classified into two types: silica optical fiber doped with special elements including Bi, Al, and Ce, and micro-structured multi-core fibers. For element-doped optical fiber, the Bi/Al co-doped silica fibers could exhibit a fluorescence spectrum covering the wavelength range between 1000 and 1400 nm with a full width at half maximum(FWHM) of about 150 nm, which enables its use in fiber amplifiers and laser systems. The Ce-doped fiber’s center wavelengths of excitation and emission are about 340 and 430 nm, respectively. The sapphire-derived fiber(SDF) with high alumina dopant concentration in the core can form mullite through heating and cooling with arc-discharge treatment. This SDF can be further developed for an intrinsic Fabry-Perot interferometric that can withstand 1200 ℃, which allows it to be used in high-temperature sensing applications. Owing to the strong evanescent field, microstructured multi-core fiber can be used in a wide range of applications in biological fiber optic sensing, chemical measurement, and interference-related devices. Coaxial-core optical fiber is another novel kind of silica-based optical fiber that has two coaxial waveguide cores and can be used for optical trapping and micro-particle manipulation by generating a highly focused conical optical field. The recent developments of these novel fibers are discussed. 展开更多
关键词 Optical FIBER FIBER OPTIC DEVICE Silica-based SPECIAL FIBER
Optic tecta I superficial inter neurons detect motion in larval zebrafish
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作者 Chen Yin Xiaoquan Li Jiulin Du 《蛋白质与细胞:英文版》 SCIE CAS CSCD 2019年第4期238-248,共11页
Detection of moving objects is an essential skill for animals to hunt prey,recognize conspecifics and avoid predators.The zebrafish,as a vertebrate model,primarily uses its elaborate visual system to distinguish movin... Detection of moving objects is an essential skill for animals to hunt prey,recognize conspecifics and avoid predators.The zebrafish,as a vertebrate model,primarily uses its elaborate visual system to distinguish moving objects against background scenes.The optic tectum(OT)receives and integrates inputs from various types of retinal ganglion cells(RGCs),including direction-selective(DS)RGCs and size-selective RGCs,and is required for both prey capture and predator avoidance.However,it remains largely unknown how motion information is processed within the OT.Here we performed in vivo whole-cell recording and calcium imaging to investigate the role of superficial interneurons(SINs),a specific type of optic tecta I neurons,in motion detection of larval zebrafish.SINs mainly receive excitatory synaptic inputs,exhibit transient ON-or OFF-type of responses evoked by light flashes,and possess a large receptive field(RF).One fifth of SINs are DS and classified into two subsets with separate preferred directions.Furthermore,SINs show size-dependent responses to moving dots.They are efficiently activated by moving objects but not static ones,capable of showing sustained responses to moving objects and having less visual adaptation than periventricular neurons(PVNs),the principal tecta I cells.Behaviorally,ablation of SINs impairs prey capture,which requires local motion detection,but not global looming-evoked escape.Finally,starvation enhances the gain of SINs'motion responses while maintaining their size tuning and DS.These results indicate that SINs serve as a motion detector for sensing and localizing sized moving objects in the visual field. 展开更多
关键词 OPTIC TECTUM MOTION detection direction selectivity visual adaptation ZEBRAFISH
Voluntary running delays primary degeneration in rat retinas after partial optic nerve transection 预览
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作者 Hong-Ying Li Xi Hong +1 位作者 Mi Huang Kwok-Fai So 《中国神经再生研究:英文版》 SCIE CAS CSCD 2019年第4期728-734,共7页
Running is believed to be beneficial for human health.Many studies have focused on the neuroprotective effects of voluntary running on animal models.There were both primary and secondary degeneration in neurodegenerat... Running is believed to be beneficial for human health.Many studies have focused on the neuroprotective effects of voluntary running on animal models.There were both primary and secondary degeneration in neurodegenerative diseases,including glaucoma.However,whether running can delay primary or secondary degeneration or both of them was not clear.Partial optic nerve transection model is a valuable glaucoma model for studying both primary and secondary degeneration because it can separate primary(mainly in the superior retina)from secondary(mainly in the inferior retina)degeneration.Therefore,we compared the survival of retinal ganglion cells between Sprague-Dawley rat runners and non-runners both in the superior and inferior retinas.Excitotoxicity,oxidative stress,and apoptosis are involved in the degeneration of retinal ganglion cells in glaucoma.So we also used western immunoblotting to compare the expression of some proteins involved in apoptosis(phospho-c-Jun N-terminal kinases,p-JNKs),oxidative stress(manganese superoxide dismutase,MnSOD)and excitotoxicity(glutamine synthetase)between runners and non-runners after partial optic nerve transection.Results showed that voluntary running delayed the death of retinal ganglion cells vulnerable to primary degeneration but not those to secondary degeneration.In addition,voluntary running decreased the expression of glutamine synthetase,but not the expression of p-JNKs and MnSOD in the superior retina after partial optic nerve transection.These results illustrated that primary degeneration of retinal ganglion cells might be mainly related with excitotoxicity rather than oxidative stress;and the voluntary running could down-regulate excitotoxicity to delay the primary degeneration of retinal ganglion cells after partial optic nerve transection. 展开更多
关键词 VOLUNTARY running OPTIC nerve injury oxidative stress EXCITOTOXICITY JNKs PRIMARY DEGENERATION secondary DEGENERATION
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Etomidate affects the anti-oxidant pathway to protect retinal ganglion cells after optic nerve transection 预览
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作者 Xuan Zhao Fang Kuang +2 位作者 Yi-Yan You Ming-Mei Wu Si-Wei You 《中国神经再生研究:英文版》 SCIE CAS CSCD 2019年第11期2020-2024,共5页
Our previous studies revealed that etomidate, a non-barbiturate intravenous anesthetic agent, has protective effects on retinal ganglion cells within 7 days after optic nerve transection. Whether this process is relat... Our previous studies revealed that etomidate, a non-barbiturate intravenous anesthetic agent, has protective effects on retinal ganglion cells within 7 days after optic nerve transection. Whether this process is related to anti-oxidative stress is not clear. To reveal its mechanism, we established the optic nerve transection injury model by transecting 1 mm behind the left eyeball of adult male Sprague-Dawley rats. The rats received an intraperitoneal injection of etomidate(4 mg/kg) once per day for 7 days. The results showed that etomidate significantly enhanced the number of retinal ganglion cells retrogradely labeled with Fluorogold at 7 days after optic nerve transection. Etomidate also significantly reduced the levels of nitric oxide and malonaldehyde in the retina and increased the level of glutathione at 12 hours after optic nerve transection. Thus, etomidate can protect retinal ganglion cells after optic nerve transection in adult rats by activating an anti-oxidative stress response. The study was approved by the Animal Ethics Committee at Air Force Medical University, China(approval No. 20180305) on March 5, 2018. 展开更多
关键词 NERVE REGENERATION ETOMIDATE retinal ganglion cells optic NERVE TRANSECTION anti-oxidative stress nitric oxide MALONALDEHYDE glutathione neural REGENERATION
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c-Jun N-terminal kinase 3 deficiency protects axotomized retinal ganglion cells via affecting mitochondria involved apoptosis pathway
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作者 Rong-Rong Wang Cheng-Fang Li +2 位作者 De-Zu Wang Cheng-Wu Zhang Gui-Xiang Liu 《国际眼科杂志:英文版》 SCIE CAS 2019年第1期30-37,共8页
AIM: To illustrate the isoform-specific role and mechanism of c-Jun N-terminal kinases(JNKs) in mouse optic nerve axotomy induced neurotrauma. METHODS: We firstly investigated the expression of JNK1, JNK2, and JNK3 in... AIM: To illustrate the isoform-specific role and mechanism of c-Jun N-terminal kinases(JNKs) in mouse optic nerve axotomy induced neurotrauma. METHODS: We firstly investigated the expression of JNK1, JNK2, and JNK3 in the retinal ganglion cells(RGCs) by double-immunofluorescent staining. Then we created optic nerve axotomy model in wild type as well as JNK1, JNK2, JNK3, isoform specific gene deficiency mice. With that, we checked the protein expression profile of JNKs and its active form, and quantified the survival RGCs number by immunofluorescence staining. We further explored the molecules underlying isoform specific protective effect by real-time polymerase chain reaction(PCR) and Western blotting assay. RESULTS: We found that all the three isoforms of JNKs were expressed in the RGCs. Deficiency of JNK3, but not JNK1 or JNK2, significantly alleviated optic nerve axotomyinduced RGCs apoptosis. We further established that expression of Noxa, a pro-apoptotic member of BH3 family, was significantly suppressed only in JNK3 gene deficiency mice. But tumor necrosis factor receptor 1(TNFR1) and Fas, two key modulators of death receptor mediated apoptosis pathway, did not display obvious change in the expression. CONCLUSION: It is suggested that mitochondria mediated apoptosis, but not death receptor mediated apoptosis got involved in the JNK3 gene deficiency induced RGCs protection. Our study provides a novel insight into the isoform-specific role of JNKs in neurotrauma and indicates some cues for its therapeutics. 展开更多
关键词 retinal GANGLION cells c-Jun N-TERMINAL KINASES optic nerve MITOCHONDRIA NOXA NEUROTRAUMA
Effects of seasonal air temperature variation on airflow and surrounding rock temperature of mines 预览
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作者 Xin Yi Lifeng Ren +4 位作者 Li Ma Gaoming Wei Wencong Yu Jun Deng Chimin Shu 《国际煤炭科学技术学报:英文版》 2019年第3期388-398,共11页
In underground mines, high air temperatures in the summer months lead to an increase in inlet airflow temperatures. This leads to seasonal thermal pollution in the mines. This paper examines the dynamics and effects o... In underground mines, high air temperatures in the summer months lead to an increase in inlet airflow temperatures. This leads to seasonal thermal pollution in the mines. This paper examines the dynamics and effects of seasonal variation in surface air temperatures and surrounding rock temperatures in deep coal mines. It also examines temperature variations in the main ventilation circuit, working face, and surrounding rock. The study results revealed that airflow temperatures were significantly affected by seasonal air temperature variations. The greater the distance was between the inlet and the wellhead of the ventilation shaft, the less the effect was on temperature. Moreover, slight temperature variations (1.0-3.0 ℃) were observed between various points on the return route during the summer months. Airflow temperatures along the airflow inlet to the return route of the working face first decreased, but then increased. The temperature field of the surrounding rock increased gradually with increased distance between the mine roadway and inlet, with recorded rock temperatures as high as 40.53 ℃. The radius of the heat-adjusting layer was between 28 and 33 m. 展开更多
关键词 SEASONAL VARIATION Fiber optic TEMPERATURE measurement Real-time monitoring Deep coal mine Thermal pollution Heat-adjusting layer
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白内障术后视网膜脱离的危险因素分析
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作者 梁丽 刘勤 +2 位作者 文瑾 马建军 严兰凤 《中华眼外伤职业眼病杂志》 2019年第2期101-104,共4页
目的分析白内障手术人工晶状体植入术后出现视网膜脱离(RD)的危险因素。方法回顾性分析2010年6月至2016年5月本院收治的白内障3 548例(3 548眼)的临床资料,随访时间2年。分析术中医源性因素、年龄、眼轴长度及近视等因素与术后视网视脱... 目的分析白内障手术人工晶状体植入术后出现视网膜脱离(RD)的危险因素。方法回顾性分析2010年6月至2016年5月本院收治的白内障3 548例(3 548眼)的临床资料,随访时间2年。分析术中医源性因素、年龄、眼轴长度及近视等因素与术后视网视脱离的关系。结果术后发生RD 36例,占所有白内障手术的1.01%;男性比例较高;眼轴小于24 mm的RD患者发生率较低,而眼轴为27-28 mm的RD患者发生率高达3.59%;白内障手术后RD发生率在50?59岁人群中发生率最高,平均年龄为(58.56 ±9.9)岁,随着年龄的增加RD发生率显著降低。术中并发晶状体后囊破裂、后发性白内障行激光后囊切开术与视网膜脱离密切相关。结论白内障术后视网膜脱离与性别、年龄、眼轴长度、高度近视、术中晶状体后囊破裂及后发性白内障行激光后囊切开术密切相关。 展开更多
关键词 手术 口内障 脱离 视网膜 近视 高度
Discriminating performance of macular ganglion cellinner plexiform layer thicknesses at different stages of glaucoma
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作者 Melih Ustaoglu Nilgun Solmaz Feyza Onder 《国际眼科杂志:英文版》 SCIE CAS 2019年第3期464-471,共8页
AIM: To determine the discriminating performance of the macular ganglion cell-inner plexiform layer(GCIPL) parameters between all the consecutive stages of glaucoma(from healthy to moderate-to-severe glaucoma), and to... AIM: To determine the discriminating performance of the macular ganglion cell-inner plexiform layer(GCIPL) parameters between all the consecutive stages of glaucoma(from healthy to moderate-to-severe glaucoma), and to compare it with the discriminating performances of the peripapillary retinal nerve fiber layer(RNFL) parameters and optic nerve head(ONH) parameters.METHODS: Totally 147 eyes(40 healthy, 40 glaucoma suspects, 40 early glaucoma, and 27 moderate-to-severe glaucoma) of 133 subjects were included. Optical coherence tomography(OCT) was obtained using Cirrus HD-OCT 5000. The diagnostic performances of GC-IPL, RNFL, and ONH parameters were evaluated by determining the area under the curve(AUC) of the receiver operating characteristics. RESULTS: All GC-IPL parameters discriminated glaucoma suspect patients from subjects with healthy eyes and moderate-to-severe glaucoma from early glaucoma patients(P<0.017, for all). Also, minimum, inferotemporal and inferonasal GC-IPL parameters discriminated early glaucoma patients from glaucoma suspects, whereas no RNFL or ONH parameter could discriminate between the two. The best parameters to discriminate glaucoma suspects from subjects with healthy eyes were superonasal GC-IPL, superior RNFL and average c/d ratio(AUC=0.746, 0.810 and 0.746, respectively). Discriminating performances of all the parameters for early glaucoma vs glaucoma suspect comparison were lower than that of the other consecutive group comparisons, with the bestGC-IPL parameters being minimum and inferotemporal(AUC=0.669 and 0.662, respectively). Moreover, minimum GC-IPL, average RNFL, and rim area(AUC=0.900, 0.858, 0.768, respectively) were the best parameters for discriminating moderate-to-severe glaucoma patients from early glaucoma patients.CONCLUSION: GC-IPL parameters can discriminate glaucoma suspect patients from subjects with healthy eyes, and also all the consecutive stages of glaucoma from each other(from glaucoma suspect to moderate-tosevere glaucoma). Further, the discriminating performa 展开更多
关键词 retinal NERVE fiber LAYER optic NERVE head cirrus HD-OCT ganglion cell-inner PLEXIFORM LAYER GLAUCOMA SUSPECT
A Novel High Sensitivity Refractive Index Sensor Based on Multi-Core Micro/Nano Fiber
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作者 Yuefeng QI Jin ZHANG +3 位作者 Qi FENG Xin ZHANG Yanyan LIU Ying HAN 《光子传感器:英文版》 EI CAS CSCD 2019年第3期197-204,共8页
A refractive index sensor based on a multi-core micro/nano fiber is proposed for low refractive index solutions. At first, the mode field distribution of the tapered multi-core fiber is analyzed with the finite elemen... A refractive index sensor based on a multi-core micro/nano fiber is proposed for low refractive index solutions. At first, the mode field distribution of the tapered multi-core fiber is analyzed with the finite element model (FEM). After that, the relationship between the refractive index sensitivity and the diameter of the multi-core micro/nano fiber is calculated. At last, four sensors with different sizes are explored, and when the taper length is 16.20 mm, the refractive index sensitivity of the sensor can reach 5815.50nm/RIU, which agrees with the theoretical analysis. The refractive index measurement error is less than 0.5 %o, which has a high practical application value. The longer the taper length is, the smaller the fiber diameter is. According to the theoretical analysis, when the fiber diameter is less than 4.864 gm, the structure sensor\ refractive index sensitivity is higher than 10000 nm/RIU. At the same time, when the sensor's taper length is 15.99 mm, its temperature sensitivity is -0.1084nm/°C. Compared with single-mode fiber, the sensor proposed here has the advantages of stability, compact structure, and high sensitivity, which has a potential in the field of seawater salinity measurement. 展开更多
关键词 FIBER OPTIC SENSOR refractive INDEX measurement MULTI-CORE FIBER
Distributed Real-time Monitoring Method and Prototype Test of Heating Pipeline Stress 预览
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作者 FENG Xin WANG Zihao +2 位作者 GONG Shilin ZHANG Yajie HAN Yang 《煤气与热力》 2019年第2期H0042-H0046,共5页
In order to quantitatively evaluate the structural safety of the heating pipeline,a real-time monitoring method for the stress state of the heating pipeline based on the distributed optical fiber sensor is proposed.Th... In order to quantitatively evaluate the structural safety of the heating pipeline,a real-time monitoring method for the stress state of the heating pipeline based on the distributed optical fiber sensor is proposed.The implementation scheme of the monitoring system is introduced.According to the mechanical mechanism of bending deformation and thermal expansion deformation of pipeline and the relationship between it and bending stress,axial compressive stress,the theoretical basis for extracting axial nominal strain and axial compressive strain using strain monitoring data to quantify the stress state of heating pipeline is established.The prototype test is carried out using a directly buried heating hot water pipe section to test the effectiveness of the method.The prototype test shows that the monitoring system can obtain the longitudinal strain curve of the working pipe in real time,extract the axial nominal strain,and realize the identification of the anchorage section and transition section of the heating pipeline.The bending stress,axial compressive stress and hoop stress of the working pipe can be quantitatively obtained by using longitudinal strain,axial nominal strain,and the monitoring data of operating temperature and internal pressure.An analysis of the monitoring data found that the maximum value of the equivalent stress may appear in the transition section,which is related to the distribution of the bending stress of the working pipe.According to the monitoring results,the structural safety of the heating pipeline can be evaluated in real time,and the operating parameters of the pipeline are revised according to the current state,which makes up for the defect that the existing monitoring methods can not truly reflect the stress state of the heating pipeline. 展开更多
关键词 HEATING PIPELINE STRESS monitoring DISTRIBUTED fiber OPTIC sensor PROTOTYPE test
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Basics on the use of acid-sensing ion channels’ inhibitors as therapeutics 预览
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作者 Jamileh Dibas Houssam Al-Saad Adnan Dibas 《中国神经再生研究:英文版》 SCIE CAS CSCD 2019年第3期395-398,共4页
Since the discovery of acid-sensing ion channels in 1997,their importance in the health of neurons and other non-neuronal cells has gained significant importance.Acid-sensing ion channels play important roles in media... Since the discovery of acid-sensing ion channels in 1997,their importance in the health of neurons and other non-neuronal cells has gained significant importance.Acid-sensing ion channels play important roles in mediating pain sensation during diseases such as stroke,inflammation,arthritis,cancer,and recently migraine.More interestingly,acid-sensing ion channels may explain the sex differences in pain between males and females.Also,the ability of acid-sensing ion channel blockers to exert neuroprotective effects in a number of neurodegenerative diseases has added a new dimension to their therapeutic value.The current failure rate of -45% of new drugs (dueto toxicity issues)and saving of up to 7 years in the life span of drug approval makes drug repurposing a high priority.If acid-sensing ion channels'blockers undergo what is known as "drug repurposing",there is a great potential to bring them as medications with known safety profiles to new patient populations.However,the route of administration remains a big challenge due to their poor penetration of the blood brain and retinal barriers.In this review,the promise of using acid-sensing ion channel blockers as neuroprotective drugs is discussed. 展开更多
关键词 OPTIC nerve GLAUCOMA NEURODEGENERATION NEUROPROTECTION acid sensing ion channel CALPAIN
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Ocular ultrasound evaluation of optic nerve sheath diameter in military environments
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作者 Maddalena De Bernardo Livio Vitiello +1 位作者 Palmiro Cornetta Nicola Rosa 《军事医学研究:英文版》 CAS CSCD 2019年第3期272-274,共3页
In this letter to the Editor, we would like to comment on the article by Betcher et al., concerning the possibility of teaching military trainees to obtain accurate optic nerve sheath diameter measurements, using a br... In this letter to the Editor, we would like to comment on the article by Betcher et al., concerning the possibility of teaching military trainees to obtain accurate optic nerve sheath diameter measurements, using a brief didactic and a hands-on training session. In particular, this letter notes the importance of the measurement of optic nerve sheath diameter in detecting the eventual elevated intracranial pressure following traumatic brain injury, highlights several limitations in the use of B-scan for such a purpose and suggests a more accurate evaluation with the standardized A-scan. 展开更多
关键词 BLOOMING effect INTRACRANIAL pressure OPTIC NERVE SHEATH diameter
Automatic segmentation of optic disc and cup for CDR calculation
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作者 赵鑫 郭璠 +1 位作者 邹北骥 赵荣昌 《光电子快报:英文版》 EI 2019年第5期381-385,共5页
Glaucoma as an irreversible blinding opioid neuropathy disease, its blindness rate is the second only after cataract in the world. The optic cup-to-disc ratio(CDR) is generally considered to be an important clinical i... Glaucoma as an irreversible blinding opioid neuropathy disease, its blindness rate is the second only after cataract in the world. The optic cup-to-disc ratio(CDR) is generally considered to be an important clinical indicator for judging the severity of glaucoma by ophthalmologists from retinal fundus image. In this letter, we propose an automatic CDR measurement method that consists of a novel optic disc localization method and a simultaneous optic disc and cup segmentation network based on the improved U shape deep convolutional neural network. Experimental results demonstrate that the proposed method can achieve superior performance when compared with other existing methods. Thus, our method can be used as a powerful tool for glaucoma-assisted diagnosis. 展开更多
关键词 cup-to-disc ratio(CDR) AUTOMATIC SEGMENTATION OPTIC DISC
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