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Evidence and explanation for the involvement of the nucleus accumbens in pain processing 认领
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作者 Haley N.Harris Yuan B.Peng 《中国神经再生研究:英文版》 SCIE CAS CSCD 2020年第4期597-605,共9页
The nucleus accumbens(NAc)is a subcortical brain structure known primarily for its roles in pleasure,reward,and addiction.Despite less focus on the NAc in pain research,it also plays a large role in the mediation of p... The nucleus accumbens(NAc)is a subcortical brain structure known primarily for its roles in pleasure,reward,and addiction.Despite less focus on the NAc in pain research,it also plays a large role in the mediation of pain and is effective as a source of analgesia.Evidence for this involvement lies in the NAc’s cortical connections,functions,pharmacology,and therapeutic targeting.The NAc projects to and receives information from notable pain structures,such as the prefrontal cortex,anterior cingulate cortex,periaqueductal gray,habenula,thalamus,etc.Additionally,the NAc and other pain-modulating structures share functions involving opioid regulation and motivational and emotional processing,which each work beyond simply the rewarding experience of pain offset.Pharmacologically speaking,the NAc responds heavily to painful stimuli,due to its high density ofμopioid receptors and the activation of several different neurotransmitter systems in the NAc,such as opioids,dopamine,calcitonin gene-related peptide,γ-aminobutyric acid,glutamate,and substance P,each of which have been shown to elicit analgesic effects.In both preclinical and clinical models,deep brain stimulation of the NAc has elicited successful analgesia.The multi-functional NAc is important in motivational behavior,and the motivation for avoiding pain is just as important to survival as the motivation for seeking pleasure.It is possible,then,that the NAc must be involved in both pleasure and pain in order to help determine the motivational salience of positive and negative events. 展开更多
关键词 analgesia CIRCUITRY deep brain stimulation NOCICEPTION nucleus ACCUMBENS PAIN PAIN relief PAIN signaling REWARD STRIATUM
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疼痛患者疼痛灾难化影响因素的研究进展 认领
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作者 王银燕 魏绍辉 《护士进修杂志》 2020年第9期792-795,共4页
目的疼痛是世界范围内的一个普遍健康问题,疼痛会导致许多不良结果。越来越多的研究表明疼痛灾难化是疼痛的一个重要心理风险因素,影响一系列疼痛相关的结果。因此,提高对疼痛患者疼痛灾难化的关注度,及时干预预防,对疼痛管理有重要意... 目的疼痛是世界范围内的一个普遍健康问题,疼痛会导致许多不良结果。越来越多的研究表明疼痛灾难化是疼痛的一个重要心理风险因素,影响一系列疼痛相关的结果。因此,提高对疼痛患者疼痛灾难化的关注度,及时干预预防,对疼痛管理有重要意义。本研究旨在通过对疼痛灾难化的影响因素进行全面综述,以期为临床医护人员制定针对性的和有效的预防干预措施提供参考,进一步促进疼痛患者的康复。 展开更多
关键词 疼痛 疼痛灾难化 影响因素 疼痛护理
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Lumbar interspinous pressure pain threshold values for healthy young men and women and the effect of prolonged fully flexed lumbar sitting posture:An observational study 认领
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作者 Martin Petersson Allan Abbott 《世界骨科杂志(英文版)》 2020年第3期158-166,共9页
BACKGROUND Low back pain(LBP)is a common condition with large burden worldwide.Exposure to prolonged sitting with a flexed lumbar posture has been suggested in the literature to be a potential risk factor for self-rep... BACKGROUND Low back pain(LBP)is a common condition with large burden worldwide.Exposure to prolonged sitting with a flexed lumbar posture has been suggested in the literature to be a potential risk factor for self-reported LBP.No study has previously investigated whether exposure to prolonged flexed sitting posture provokes discomfort/pain and decreased interspinous pressure pain thresholds for healthy young men and women without back pain,despite this being a suggested risk factor for LBP.AIM To investigate whether sitting in a prolonged flexed lumbar posture provokes discomfort and lowers interspinous pressure pain thresholds in the lumbar spine for healthy young men and women without previous LBP.METHODS This is a an observational before and after study of 26 participants(13 men,13 women)between 20-35 years old.Algometry was used to examine the pain threshold for pressure applied between spinous processes of the lumbar spine L1-L5.Pressure algometer measures were performed in prone before and after participants were instructed to sit in a fully flexed posture for a maximum of 15 min or until discomfort was experienced in the low back(Borg CR10=7/10).Wilcoxon signed-rank test was used for analyze values from the before and after test conditions.Mann-Whitney U test was used to investigate potential gender difference.RESULTS Fully flexed lumbar spine sitting posture up to 15 min provoked temporary discomfort but the proportion of participants experiencing discomfort 7/10 in the low back was 62%.For all pain pressure threshold locations tested,there was a significant difference for the study population with moderate-large decreased(r=-0.56)pressure pain threshold after exposure to prolonged flexed sitting posture(P<0.01).Comparisons between gender did not show any significant difference.CONCLUSION The result showed that exposure to fully flexed lumbar sitting posture for up to 15 min produced temporary discomfort in the low back in young healthy adults with no previous history of LBP and significantly reduced lumb 展开更多
关键词 Low back PAIN PAIN pressure threshold Algometer POSTURE SPINE PAIN mechanism
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加味芍药甘草汤辅助治疗对癌性疼痛患者疼痛介质及炎性因子的影响 认领
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作者 曹迪 张亚密 《中国医药导报》 CAS 2020年第7期143-146,共4页
目的探讨加味芍药甘草汤辅助治疗对癌性疼痛患者疼痛介质及炎性因子的影响。方法选取陕西中医药大学附属医院2017年10月~2019年3月接收的癌性疼痛患者123例,根据随机数字表法将患者分为对照组(n=61)、研究组(n=62)。对照组患者给予硫酸... 目的探讨加味芍药甘草汤辅助治疗对癌性疼痛患者疼痛介质及炎性因子的影响。方法选取陕西中医药大学附属医院2017年10月~2019年3月接收的癌性疼痛患者123例,根据随机数字表法将患者分为对照组(n=61)、研究组(n=62)。对照组患者给予硫酸吗啡缓释片治疗,研究组在对照组的基础上联合加味芍药甘草汤,疗程4周。比较两组临床疗效、疼痛介质[5-羟色胺(5-HT)、前列腺素E2(PGE2)、P物质(SP)、内皮素-1(ET-1)]及炎性因子[白细胞介素-1β(IL-1β)、白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)]水平,记录两组治疗期间不良反应情况。结果研究组治疗后的临床总有效率高于对照组(P<0.05)。两组治疗后5-HT、PGE2、SP、ET-1水平均低于治疗前,且研究组低于对照组(P<0.05)。两组治疗后IL-1β、IL-6、TNF-α水平均低于治疗前,且研究组低于对照组(P<0.05)。两组治疗期间不良反应发生率比较差异无统计学意义(P>0.05)。结论加味芍药甘草汤治疗癌性疼痛患者可有效改善机体疼痛介质及炎性因子水平,疗效确切,且不增加不良反应发生率,具有一定的临床应用价值。 展开更多
关键词 加味芍药甘草汤 疼痛 疼痛介质 炎性因子
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疼痛共情量表的汉化及其在医学生中的信效度检验 认领
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作者 尚静 叶旭春 +4 位作者 王怡 毕轩懿 王茹 王婧婷 梁丽玲 《中华现代护理杂志》 2020年第9期1140-1145,共6页
目的引进并汉化疼痛共情量表(the Empathy for Pain Scale,EPS),检验中文版EPS在医学生中的信效度。方法经过翻译、回译、语义分析、专家咨询及文化调试,最终确定中文版EPS条目。于2018年6—10月,采用便利抽样法,选取531名在校本科生进... 目的引进并汉化疼痛共情量表(the Empathy for Pain Scale,EPS),检验中文版EPS在医学生中的信效度。方法经过翻译、回译、语义分析、专家咨询及文化调试,最终确定中文版EPS条目。于2018年6—10月,采用便利抽样法,选取531名在校本科生进行问卷调查。采用相关分析法和临界比值法进行项目分析,采用内容效度、结构效度、效标关联效度进行量表的效度检验,计算Cronbach'sα系数、折半信度检验量表的内在一致性。结果中文版EPS保留原12个条目,析出2个因子,2个因子命名为身心不适反应和移情反应,累计方差贡献率为69.059%。量表各条目的内容效度为0.83~1.00,总内容效度为0.94。中文版EPS总分与中文版人际反应指针量表(IRI-C)得分呈正相关(r=0.370,P<0.01);量表的Cronbach'sα系数为0.914,身心不适反应、移情反应2个维度的Cronbach'sα系数分别为0.935和0.775,量表的折半信度为0.896。结论中文版EPS包含4个场景、2个维度,具有良好的信效度,可用于测量我国医学生的疼痛共情水平。 展开更多
关键词 疼痛 疼痛共情量表 量表汉化 信度 效度
核心稳定训练在非特异性腰背痛患者中应用效果的系统评价 认领
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作者 陈宇 罗春梅 +2 位作者 汪涓 李亚雯 曾婷 《中华现代护理杂志》 2020年第9期1176-1182,共7页
目的系统性评价核心稳定训练与一般运动或手法治疗对非特异性腰背痛患者的康复疗效。方法计算机检索Medline、EMBASE、PubMed、Cochrane Central Register of Controlled Trials、PsycINFO、中国生物医学文献数据库、CNKI、中国科技期... 目的系统性评价核心稳定训练与一般运动或手法治疗对非特异性腰背痛患者的康复疗效。方法计算机检索Medline、EMBASE、PubMed、Cochrane Central Register of Controlled Trials、PsycINFO、中国生物医学文献数据库、CNKI、中国科技期刊全文数据库和万方数据库,检索时间从建库到2018年10月20日。收集所有核心稳定训练对非特异性腰背痛患者康复效果的随机对照试验(RCT)和临床对照研究。2名研究者按照纳入和排除标准独立检索文献、筛选文献、评价纳入文献的质量,并提取资料,使用Revman 5.3软件进行Meta分析。结果共纳入14篇文献,均为RCT。Meta分析结果显示,核心稳定运动训练组与一般运动训练组疼痛改善对比结果(Z=4.67,P<0.001)[OR=1.01,95%CI(-1.43,-0.59)],证据显示有统计学意义(P<0.05);稳定运动训练和一般运动训练后患者的脊柱功能障碍评分对比(Z=5.03,P<0.01)[OR=-7.18,95%CI(-9.98,-4.38)],证据显示有统计学意义(P<0.05)。其他指标对比结果均无统计学意义(P>0.05)。结论核心运动组和手法治疗组都能有效地降低非特异腰背痛患者疼痛,并且核心稳定训练能促进非特异性腰背痛患者功能障碍的缓解,鼓励将核心稳定训练作为非特异性腰痛患者肌肉骨骼康复的一部分。 展开更多
关键词 META分析 康复 疼痛 核心稳定训练 腰背痛 系统评价
脑瘫患儿慢性疼痛评估工具的研究进展 认领
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作者 裴菊红 马英萍 +3 位作者 王兴蕾 韩春彦 赵存 豆欣蔓 《中国护理管理》 CSCD 北大核心 2020年第2期308-312,共5页
本文旨在对脑瘫患儿慢性疼痛评估工具进行综述,并提出临床实践使用建议,以期为动态监测脑瘫患儿慢性疼痛进展,制定个性化疼痛评估方案提供借鉴。
关键词 脑瘫 疼痛 慢性疼痛 护理评估 综述
集束化干预对妇科腹腔镜术后非切口疼痛的影响 认领
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作者 赵德宇 储婷婷 +1 位作者 周翠 程桂芝 《安徽医药》 CAS 2020年第3期557-560,共4页
目的探讨集束化护理干预对妇科腹腔镜术后病人非切口疼痛的影响。方法将2016年7月至2017年7月中国科学技术大学附属第一医院行妇科腹腔镜手术病人120例,采用信封法随机分为观察组和对照组,每组60例,观察组采用集束化护理干预,对照组采... 目的探讨集束化护理干预对妇科腹腔镜术后病人非切口疼痛的影响。方法将2016年7月至2017年7月中国科学技术大学附属第一医院行妇科腹腔镜手术病人120例,采用信封法随机分为观察组和对照组,每组60例,观察组采用集束化护理干预,对照组采用传统腹腔镜术后常规护理,两组均采用“长海痛尺”进行疼痛评定,并在出院前使用自制满意度调查表进行测评。结果对照组与观察组非切口疼痛发生率分别为术后6 h:71.67%,41.67%(P<0.05);术后24 h:53.33%,33.33%(P<0.05);术后48 h:23.33%,8.33%(P<0.05)。对照组与观察组疼痛评分分别为术后6 h:(5.32±2.58)分,(4.07±1.87)分(P>0.05);术后24 h:(3.02±0.85)分,(2.70±0.46)分(P<0.05);术后48 h:(1.90±0.88)分,(1.62±0.49)分(P<0.05)。对照组与观察组病人住院满意度分别为83.33%,96.66%(P<0.05)。结论集束化护理干预能有效预防和降低妇科腹腔镜术后非切口疼痛的发生,增加病人舒适度,促进术后快速康复,提高病人住院满意度及围手术期护理质量,且简便易行、经济有效,值得临床推广。 展开更多
关键词 疼痛 手术后/护理 妇科外科手术 腹腔镜检查 集束化护理干预 非切口疼痛
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臂丛神经阻滞麻醉下麦肯基手法松解术对肩周炎患者疼痛及肩关节活动度的影响 认领
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作者 常红侠 景桂霞 《实用临床医药杂志》 CAS 2020年第3期108-110,114,共4页
目的探讨臂丛神经阻滞麻醉下麦肯基手法松解术对肩周炎患者疼痛及肩关节活动度的影响。方法回顾性分析80例肩周炎患者的临床资料,并按治疗方案分为2组各40例。对照组应用痛点阻滞法,研究组应用臂丛神经阻滞麻醉下麦肯基手法松解术。比较... 目的探讨臂丛神经阻滞麻醉下麦肯基手法松解术对肩周炎患者疼痛及肩关节活动度的影响。方法回顾性分析80例肩周炎患者的临床资料,并按治疗方案分为2组各40例。对照组应用痛点阻滞法,研究组应用臂丛神经阻滞麻醉下麦肯基手法松解术。比较2组患者疗效、治疗前后的肩关节活动度、视觉模拟评分法(VAS)评分。结果治疗1个疗程后,研究组近期总有效率显著高于对照组(P<0.05)。治疗3个月后,研究组远期总有效率显著高于对照组(P<0.05)。研究组治疗后肩关节疼痛VAS评分显著低于对照组(P<0.05)。治疗后,研究组肩关节活动度均显著大于对照组(P<0.05)。结论对于肩周炎患者,在痛点阻滞治疗基础上,辅以臂丛神经阻滞麻醉下麦肯基手法松解术,可进一步增强镇痛效果,改善肩关节活动度,提高近期、远期治疗效果。 展开更多
关键词 臂丛神经阻滞麻醉 麦肯基手法松解术 肩周炎 肩关节活动度 疼痛 痛点阻滞法
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Parental Presence Promoted Children Anesthesia Recovery: A Randomized Controlled Study 认领
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作者 Rong Hai Liu Zhang +2 位作者 Xin Liang Gaijing Wang Zumei Gao 《长江医药(英文)》 2020年第1期54-61,共8页
Objective: There are few studies about restlessness and awakening of children during recovering from anesthesia accompanied by parents. Only one related study was retrieved in China. The purpose of this study is to in... Objective: There are few studies about restlessness and awakening of children during recovering from anesthesia accompanied by parents. Only one related study was retrieved in China. The purpose of this study is to investigate the effect of awakening, agitation and pain level in children after tonsillectomy accompanied by their parents. Methods: Children who met the inclusion criteria were randomly divided into experimental group and control group according to coin tossing method. There were 30 cases in the experimental group and 32 in the control group. The control group received routine nursing while the experimental group was given parental presence on the basis of routine nursing. Steward awakening score, Pediatric anesthesia emergence delirium (PAED), Scale and FLACC pain assessment scale were used to evaluate the children when they entered anesthesia recovery room and awaked respectively. Results: There was no significant difference in the scoring of three scales between the two groups when they entered anesthesia recovery room (P > 0.05). There was significant difference in Steward awakening score and PAED scale between the two groups when they came to recovery room (P P > 0.05). Conclusion: Parental presence can improve the recovery effect and reduce the restlessness of children after operation. Our study suggests that anesthetic children should be accompanied by their parents in the future. 展开更多
关键词 PARENTAL PRESENCE CHILDREN AGITATION PAIN
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慢性阻塞性肺疾病患者疼痛研究现状 认领
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作者 葛丽 汤培凤 +1 位作者 刘薇群 葛津津 《上海医药》 CAS 2020年第2期35-37,共3页
本文从慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)患者的疼痛流行特点、疼痛影响因素、疼痛评估量表的应用及疼痛管理现状等方面进行综合阐述,以期为COPD患者的疼痛管理研究及实践提供参考。
关键词 慢性阻塞性肺疾病 疼痛 疼痛量表
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自我管理对类风湿性关节炎患者疼痛缓解的效果评价:Meta分析和系统评价 认领
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作者 鲍嘉敏 宋永嘉 +2 位作者 陈锦漫 梁倩倩 王拥军 《世界中医药》 CAS 2020年第7期1030-1037,共8页
目的:分析自我管理对类风湿性关节炎患者疼痛缓解的效果。方法:通过检索PubMed、Embase、Web of Science、Cochrane Library、Clinical Trails 5个数据库1980年1月1日至2018年7月31日的文献,按照纳入标准筛选文献后,收集以自我管理对RA... 目的:分析自我管理对类风湿性关节炎患者疼痛缓解的效果。方法:通过检索PubMed、Embase、Web of Science、Cochrane Library、Clinical Trails 5个数据库1980年1月1日至2018年7月31日的文献,按照纳入标准筛选文献后,收集以自我管理对RA患者疼痛缓解研究的随机对照试验,提取所需数据用RevMan 5.3软件进行Meta分析。结果:共纳入8篇文献,采用Cochrane协作网的“偏倚风险评估”工具对文献质量进行评价,其中6篇文献为A级(低度偏倚),2篇文献为B级(中度偏倚)。Meta分析结果显示,VAS疼痛评分(SMD=-0.32,P=0.50);疼痛自评(SMD=0.10,P=0.65);生命质量评分QoL(SMD=-0.72,P=0.38);健康评估问卷HAQ(MD=-0.12,P=0.31);DAS-28(MD=-0.28,P=0.42。结论:自我管理对RA患者疼痛缓解差异没有统计学意义。其临床及家庭应用价值和意义还需要进一步的证实。 展开更多
关键词 类风湿性关节炎 自我管理 疼痛 VAS 疼痛自评 生命质量评分 健康评估问卷 META分析
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Skin-Adhesive Tape versus Interrupted Suture in Episiotomy Skin Repair: Randomized Control Trial 认领
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作者 Ahmed Sherif Maged El-Shourbagy 《妇产科期刊(英文)》 2020年第2期254-263,共10页
Introduction: The ideal method for perineal repair should be quick, easy to perform and preferably, with minimal pain. Aim: To compare skin adhesive tape and interrupted?absorbable subcuticular suture for episiotomy r... Introduction: The ideal method for perineal repair should be quick, easy to perform and preferably, with minimal pain. Aim: To compare skin adhesive tape and interrupted?absorbable subcuticular suture for episiotomy repair after birth as regard postoperative pain, skin closure time and wound infection. Design: Prospective double-blinded randomized controlled trial. Methods: Three-hundred qualified patients were equally distributed between two groups. Group 1 underwent skin repair with skin adhesive tape, while group 2 underwent the currently traditional method for perineal repair by interrupted suture. Pain was evaluated at 2, 4, 6 and 12 hours after birth then daily until one week using Wong-Baker faces pain rating scale with verbal expression for pain intensity as primary outcome. Skin closure time and wound infection were also evaluated as secondary outcomes. Results: Statistically significant difference in pain was?found at 4 and 6 hours, and 3,?4,?5 and 7 days after perineal repair in favor of the adhesive tape group (p = 0.04 and 0.02 respectively) (p = 0.002, 0.002, 0.003 and 0.001 respectively). No statistically significant difference was found in skin closure time between both groups, and no cases of wound infection occurred in both groups (p = 0.3). Conclusion: Skin adhesive tape may be superior to skin suturing in decreasing pain resulting from perineal repair after birth;however, further studies are needed to assess long-term effects, calculate costs and accurately measure patients’ satisfaction, which were not addressed in this study. 展开更多
关键词 SKIN Adhesive TAPE Interrupted SUTURES EPISIOTOMY SKIN Repair Pain
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Compounds of traditional Chinese medicine and neuropathic pain 认领
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作者 LI Shun-Hua LI Lin +1 位作者 YANG Ru-Nan LIANG Shang-Dong 《中国天然药物:英文版》 SCIE CAS CSCD 2020年第1期28-35,共8页
Neuropathic pain(NP)has become a serious global health issue and a huge clinical challenge without available effective treatment.P2 receptors family is involved in pain transmission and represents a promising target f... Neuropathic pain(NP)has become a serious global health issue and a huge clinical challenge without available effective treatment.P2 receptors family is involved in pain transmission and represents a promising target for pharmacological intervention.Traditional Chinese medicine(TCM)contains multiple components which are effective in targeting different pathological mechanisms involved in NP.Different from traditional analgesics,which target a single pathway,TCMs take the advantage of multiple components and multiple targets,and can significantly improve the efficacy of treatment and contribute to the prediction of the risks of NP.Compounds of TCM acting at nucleotide P2 receptors in neurons and glial cells could be considered as a potential research direction for moderating neuropathic pain.This review summarized the recently published data and highlighted several TCMs that relieved NP by acting at P2 receptors. 展开更多
关键词 Traditional Chinese medicine Diabetic NEUROPATHIC PAIN HIV-gp120-associated NEUROPATHIC PAIN Chronic CONSTRICTION injury NUCLEOTIDE RECEPTORS
针刺联合自拟消瘤止痛汤改善癌性疼痛的作用 认领
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作者 徐超 《中国继续医学教育》 2020年第8期161-162,共2页
目的探讨针刺联合自拟消瘤止痛汤改善癌性疼痛的作用。方法选定2017年2月—2018年12月本院收诊的102例癌性疼痛患者,分层随机法分为观察组51例(针刺联合自拟消瘤止痛汤)与对照组51例(三阶梯癌痛疗法),比较两组镇痛持续时间、镇痛起效时... 目的探讨针刺联合自拟消瘤止痛汤改善癌性疼痛的作用。方法选定2017年2月—2018年12月本院收诊的102例癌性疼痛患者,分层随机法分为观察组51例(针刺联合自拟消瘤止痛汤)与对照组51例(三阶梯癌痛疗法),比较两组镇痛持续时间、镇痛起效时间与不良反应发生率指标。结果治疗结束,观察组镇痛持续时间长于对照组且差别有统计学意义(P<0.05);观察组镇痛起效时间短于对照组且差别有统计学意义(P<0.05);观察组不良反应发生率(1.96%)低于对照组(15.69%)且差别有统计学意义(P<0.05)。结论针刺联合自拟消瘤止痛汤方法可有效减轻癌性疼痛患者疼痛感。 展开更多
关键词 疼痛 癌性 自拟消瘤止痛汤 针刺 镇痛 三阶梯癌痛疗法
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Notch3信号介导小胶质细胞活化在慢性前列腺炎疼痛中的作用 认领
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作者 张恒 付炯 +3 位作者 何鹏 王永权 杨忠 周占松 《局解手术学杂志》 2020年第4期267-272,共6页
目的观察Notch3介导L5~S2脊段背角小胶质细胞活化在慢性前列腺炎疼痛中的作用。方法大鼠分为实验组(慢性前列腺炎组)和对照组,实验组通过完全弗氏佐剂(CFA)注射前列腺来制作大鼠慢性前列腺炎疼痛模型,对照组注射生理盐水,采用热辐射甩... 目的观察Notch3介导L5~S2脊段背角小胶质细胞活化在慢性前列腺炎疼痛中的作用。方法大鼠分为实验组(慢性前列腺炎组)和对照组,实验组通过完全弗氏佐剂(CFA)注射前列腺来制作大鼠慢性前列腺炎疼痛模型,对照组注射生理盐水,采用热辐射甩尾痛阈测定和前列腺组织病理学检查鉴定疼痛模型,分别在注射CFA后0、4、12、24 d,采用qRT-PCR检测L5~S2脊段后角小胶质细胞活化标志物IBA-1和受体Notch3 mRNA的表达,采用ELISA检测小胶质细胞炎症因子TNF-α和IL-1β的分泌,并在鞘内注射小胶质细胞和Notch3抑制剂后检测小胶质细胞TNF-α和IL-1β蛋白的表达。结果前列腺组织病理和热痛域实验证实慢性前列腺炎疼痛模型建立成功。实验组大鼠Notch3、IBA-1、TNF-α及IL-1β的表达在第4天开始增加,第12天达到最高水平,第24天开始下降,均显著高于对照组,差异有极显著性统计学意义(P<0.01)。抑制小胶质细胞和Notch3受体后,TNF-α和IL-1β的分泌明显减少(P<0.05)。结论慢性前列腺炎疼痛中Notch3介导L5~S2脊段中枢小胶质细胞活化,炎症因子分泌增加,与慢性前列腺炎呈现的持续顽固神经炎性疼痛有关。 展开更多
关键词 前列腺炎 疼痛 脊髓中枢 NOTCH3 小胶质细胞 动物模型 慢性无菌性前列腺炎 慢性盆腔疼痛综合征
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腹部手术加速康复患者疼痛控制结局影响因素的研究 认领
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作者 付丽萍 冯霞 +2 位作者 裘丹英 喻晓芬 陈肖敏 《中华现代护理杂志》 2020年第10期1261-1266,共6页
目的探讨腹部手术加速康复患者疼痛控制结局的影响因素,为改进疼痛控制提供依据。方法2018年5-11月,采用目的抽样法选取浙江省人民医院肝胆胰外科15例接受加速康复的腹部手术患者,以质性研究中现象学方法为指导对其进行半结构式访谈。应... 目的探讨腹部手术加速康复患者疼痛控制结局的影响因素,为改进疼痛控制提供依据。方法2018年5-11月,采用目的抽样法选取浙江省人民医院肝胆胰外科15例接受加速康复的腹部手术患者,以质性研究中现象学方法为指导对其进行半结构式访谈。应用Colaizzi 7步分析法分析资料,归纳出主题。结果通过对访谈资料进行分析,归纳出影响疼痛控制结局的5个主题:活动性疼痛和撤除患者自控镇痛泵后疼痛的管理;止痛治疗不良反应;患者、家属对疼痛及疼痛治疗的认知;疼痛治疗信息支持;非医疗技术服务因素对患者疼痛控制满意度的影响。结论建议探索符合我国国情的急性疼痛服务组织的运作模式,通过多学科协作,加强对腹部手术患者活动性疼痛和撤除患者自控镇痛泵后疼痛的管理,加强对止痛治疗不良反应的预防和治疗,加强对疼痛治疗的信息支持,改变患者及其家属的疼痛及疼痛治疗的认知,注重应用非医疗技术服务因素提高患者对疼痛控制的满意度,改进疼痛控制结局。 展开更多
关键词 疼痛 手术后 疼痛控制 加速康复外科 腹部手术 质性研究 现象学
G蛋白偶联受体MrgprD研究进展及对中医药研究的启示 认领
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作者 王地均 金香 +1 位作者 唐宗湘 王长明 《南京中医药大学学报》 CAS CSCD 北大核心 2020年第3期419-423,共5页
中医药在止痒、镇痛方面具有副作用小、疗效明确的优势,但是其作用的分子生物学机制并不清楚。MrgprD(Mas-related gene D)是G蛋白偶联受体Mrg(Mas-related genes)家族的一个成员,特异表达于外周初级感觉神经元上。综述了MrgprD近20年... 中医药在止痒、镇痛方面具有副作用小、疗效明确的优势,但是其作用的分子生物学机制并不清楚。MrgprD(Mas-related gene D)是G蛋白偶联受体Mrg(Mas-related genes)家族的一个成员,特异表达于外周初级感觉神经元上。综述了MrgprD近20年的研究现状,为认识MrgprD的新功能并为相关疾病治疗提供参考。鉴于MrgprD在痛觉和痒觉产生中的作用,可能成为中医药镇痛、止痒的作用靶点,为中医药的研究提供思考。 展开更多
关键词 MrgprD DRG 痛觉 痒觉 神经病理性疼痛 中医药
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Acupuncture-Induced Pain Relief and Salivary Hormone Changes in Men and Women 认领
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作者 Ilaria Ceccarelli Fu Bao Tian +5 位作者 Stefano Pieretti Paola Minosi Samuele Paparo Barbaro Paolo Fiorenzani Jessica Pinassi Anna Maria Aloisi 《内分泌与新陈代谢疾病期刊(英文)》 2020年第3期29-43,共15页
Objective: The aim of the present study was to examine the efficacy of acupuncture in the treatment of pain together with the determination of different hormonal parameters for possible correlations in men and women o... Objective: The aim of the present study was to examine the efficacy of acupuncture in the treatment of pain together with the determination of different hormonal parameters for possible correlations in men and women of different ages. Methods: 39 women and 38 men suffering from pain and seeking acupuncture received acupuncture treatment twice a week for 5 weeks. Pain and quality of life parameters were collected via written questionnaires (VAS, QUID and SF-36), while testosterone and cortisol were determined in the saliva. Results: Cortisol and testosterone salivary levels were higher in controls than in pain subjects and higher in men than in women. Acupuncture treatment improved all parameters, decreased pain and changed the hormonal values differently depending on sex and age. Conclusions: Sex and age are important factors in changing the effects of acupuncture in the treatment of pain. 展开更多
关键词 PAIN ACUPUNCTURE HORMONES SALIVA
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Changes in sternocleidomastoid and descending portion of trapezius muscles in terms of electromyography and pressure pain threshold: women with chronic neck pain after acupuncture treatment 认领
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作者 OdinêMaria Rêgo Bechara Marcelo Palinkas +5 位作者 Paulo Batista de Vasconcelos Marisa Semprini Selma Siéssere Sandra Valéria Racan Simone Cecilio Hallak Regalo César Bataglion 《中医杂志:英文版》 SCIE CAS CSCD 2020年第1期144-149,共6页
OBJECTIVE:To evaluate the sternocleidomastoid and the descending portion of the trapezius muscles in terms of electromyographic activity and pressure pain threshold in women with chronic cervical pain after acupunctur... OBJECTIVE:To evaluate the sternocleidomastoid and the descending portion of the trapezius muscles in terms of electromyographic activity and pressure pain threshold in women with chronic cervical pain after acupuncture treatment.METHODS:Twenty-five women,aged 18-50 years[(31±3)years],with chronic neck and temporomandibular disorder participated in the study.The electromyographic activity of the sternocleidomastoid muscle and the descending portion of the trapezius muscle were recorded at rest,during shoulder elevation,(left and right)rotation of the neck and crucifix position.Maximum voluntary contraction was used to normalize the electromyographic activity data.The points used for acupuncture were Jiache(ST 6),Xiaguan(ST 7),Quanliao(SI 18),Tinggong(SI 19),Yifeng(TE-17),Fengchi(GB 20),Renzhong(GV 26),Yangbai(GB-14),and points of the lower and upper limbs:Tai chong(LV 3),Zusanli(ST 36),Sanyinjiao(SP 6),Kunlun(BL 60),He Gu(LI4)and Yanglingquan(GB 34).The treatment course was 10 sessions,30 min long per session,and twice a week.The final electromyographic activity and pressure pain threshold data collection were performed 15 d after treatment completion.RESULTS:The normalized electromyographic activity and pressure pain threshold data were tabulated and submitted to statistical analysis using t-test(P<0.05).Significant difference was observed during shoulder elevation for the left trapezius muscle,during neck rotation from the right side to the left,and pressure pain threshold for the trapezius and sternocleidomastoid muscles,bilaterally,after the acupuncture treatment.CONCLUSION:The acupuncture treatment improved the neck muscles in terms of electromyographic activity and increased the tolerance to chronic pain in women. 展开更多
关键词 Acupuncture Chronic PAIN NECK muscles ELECTROMYOGRAPHY PAIN THRESHOLD
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