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胰十二指肠切除术后胰瘘研究进展 预览
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作者 宋伍侠 林杰 《系统医学》 2019年第2期190-192,共3页
尽管通过外科技术的改进以及围手术期管理能力的提升,胰十二指肠切除术后的死亡率已降低到1%,然而术后胰瘘的发生率仍不能使人满意。术后胰瘘的发生与胰腺组织硬度、胰管直径、肿瘤部位、术中出血量密切相关,同时也受消化道重建方式、... 尽管通过外科技术的改进以及围手术期管理能力的提升,胰十二指肠切除术后的死亡率已降低到1%,然而术后胰瘘的发生率仍不能使人满意。术后胰瘘的发生与胰腺组织硬度、胰管直径、肿瘤部位、术中出血量密切相关,同时也受消化道重建方式、胰管支架管的使用等影响。术后胰瘘的发生率与术后感染、出血、住院时间延长等密切相关。该文对目前胰十二指肠术后胰瘘研究进展做一综述。 展开更多
关键词 胰十二指肠切除术 术后胰瘘 进展
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Heterogeneous Network-Based Chronic Disease Progression Mining
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作者 Chenfei Sun Qingzhong Li +2 位作者 Lizhen Cui Hui Li Yuliang Shi 《大数据挖掘与分析(英文)》 2019年第1期25-34,共10页
Healthcare insurance fraud has caused billions of dollars in losses in public healthcare funds around the world. In particular, healthcare insurance fraud in chronic diseases is especially rampant. Understanding disea... Healthcare insurance fraud has caused billions of dollars in losses in public healthcare funds around the world. In particular, healthcare insurance fraud in chronic diseases is especially rampant. Understanding disease progression can help investigators detect healthcare insurance frauds early on. Existing disease progression methods often ignore complex relations, such as the time-gap and pattern of disease occurrence. They also do not take into account the different medication stages of the same chronic disease, which is of great help when conducting healthcare insurance fraud detection and reducing healthcare costs. In this paper, we propose a heterogeneous network-based chronic disease progression mining method to improve the current understanding on the progression of chronic diseases, including orphan diseases. The method also considers the different medication stages of the same chronic disease. Extensive experiments show that our method can outperform the existing methods by 20% in terms of F-measure. 展开更多
关键词 disease PROGRESSION HETEROGENEOUS network healthcare INSURANCE FRAUD
TRIM家族蛋白在肿瘤中的研究进展 预览
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作者 张帅 邢影 蔡莉 《现代肿瘤医学》 CAS 2019年第11期2025-2028,共4页
近年来,三结构域(tripartite motif,TRIM)家族蛋白逐渐成为国内外肿瘤研究领域的热门研究方向。该家族蛋白可调控肿瘤细胞的增殖、转移、凋亡和自噬等多种生物学行为,介导泛素化、染色体异位和转录、p53信号通路和NF-κB信号通路等分子... 近年来,三结构域(tripartite motif,TRIM)家族蛋白逐渐成为国内外肿瘤研究领域的热门研究方向。该家族蛋白可调控肿瘤细胞的增殖、转移、凋亡和自噬等多种生物学行为,介导泛素化、染色体异位和转录、p53信号通路和NF-κB信号通路等分子调控机制。本文对TRIM家族蛋白在肿瘤发生发展过程中发挥的功能和参与的分子调控机制进行总结,并对TRIM家族蛋白的研究前景进行展望。 展开更多
关键词 TRIM家族蛋白 肿瘤 进展
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A Study on the Features of Thematic Progression in Chinese English Majors’Argumentative Writing 预览
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作者 王佩佩 《海外英语》 2019年第7期256-258,共3页
Based on the six Thematic Progression patterns proposed by Huang Guowen, a comparative study of argumentative writing by Chinese English majors is carried out, aiming at finding out the features of thematic progressio... Based on the six Thematic Progression patterns proposed by Huang Guowen, a comparative study of argumentative writing by Chinese English majors is carried out, aiming at finding out the features of thematic progression in college writing from a developmental perspective. The research results show that the parallel progression, the continuous progression and the concentrated progression are the tendency TP patterns by Chinese English Majors in the argumentative writing. In addition, Grade two is a key stage where the ability has a substantial change. Therefore, teachers and students should take full advantage of the best learning opportunity. 展开更多
关键词 FEATURES THEMATIC PROGRESSION ARGUMENTATIVE WRITING
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超声在新生儿颅脑疾病中的应用现状及进展 预览
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作者 陈珂珂 《影像研究与医学应用》 2019年第8期1-4,共4页
新生儿颅脑疾病是影响新生儿神经系统发育和预后的重要病因,早期诊断及治疗对降低新生儿病死率、减少后遗症有重要临床指导价值。目前新生儿颅脑疾病筛查及诊断的主要影像学检查方法有计算机断层扫描(computed tomography,CT)、磁共振(m... 新生儿颅脑疾病是影响新生儿神经系统发育和预后的重要病因,早期诊断及治疗对降低新生儿病死率、减少后遗症有重要临床指导价值。目前新生儿颅脑疾病筛查及诊断的主要影像学检查方法有计算机断层扫描(computed tomography,CT)、磁共振(magnetic resonance imaging,MRI)、颅脑超声(cerebral ultrasound,CUS)。CT因具放射性,已被建议向其他形式的神经成像过渡,而MRI虽被认为是颅脑检查的最好方法,但是因耗时长、费用高、运送高危患儿及镇静可能产生风险而使其应用受限。CUS自20世纪70年代末应用于临床以来,以其价廉、无辐射、不需要镇静、可床旁快速扫查等优点,已成为评价新生儿颅脑结构的重要方法。现就其在新生儿颅脑疾病中的应用现状及及进展作一综述。 展开更多
关键词 颅脑超声 新生儿 进展
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术前白蛋白/球蛋白比值在非肌层浸润性膀胱癌患者预后评估中的价值 预览
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作者 张景波 韩博 安瑞华 《现代泌尿外科杂志》 CAS 2019年第4期275-279,共5页
目的探究术前白蛋白/球蛋白比值(AGR)与非肌层浸润性膀胱癌(NMIBC)患者预后的关系。方法回顾性分析2012年1月至2015年1月在哈尔滨医科大学附属第一医院行经尿道膀胱肿瘤电切术(TURBT)的219例NMIBC患者的临床资料。AGR由血清白蛋白/(血... 目的探究术前白蛋白/球蛋白比值(AGR)与非肌层浸润性膀胱癌(NMIBC)患者预后的关系。方法回顾性分析2012年1月至2015年1月在哈尔滨医科大学附属第一医院行经尿道膀胱肿瘤电切术(TURBT)的219例NMIBC患者的临床资料。AGR由血清白蛋白/(血清总蛋白-血清白蛋白)计算获得。通过受试者工作特征曲线(ROC曲线),确定AGR截断值,将患者分为低AGR组(AGR<1.56)和高AGR组(AGR≥1.56)。分析两组患者与临床病理特征、无复发生存期(RFS)及无进展生存期(PFS)之间的关系,评估AGR对NMIBC患者预后的预测价值。结果 219例患者中,低AGR组100例(45.7%),高AGR组119例(54.3%)。Kaplan-Meier分析显示低AGR组的RFS和PFS明显低于高AGR组(P<0.001,P=0.005)。Cox多因素分析显示,术前AGR值可以作为NMIBC患者术后复发(P<0.001)及进展(P=0.001)的独立预测因素。结论术前AGR是NMIBC患者术后复发及进展的独立预测指标,可以为患者预后提供参考。低AGR的NMIBC患者复发和进展率较高AGR的更高。 展开更多
关键词 非肌层浸润性膀胱癌 炎症 白蛋白/球蛋白比值 复发 进展
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妊娠对已知分化型甲状腺癌患者结局的影响 预览
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作者 陈春梦 张歆玥(综述) 黄蕤(审校) 《西南医科大学学报》 2019年第3期289-292,共4页
分化型甲状腺癌(differentiated thyroid cancer,DTC)好发于女性患者,且育龄期女性发病率可达男性的4倍。但除少许报道妊娠导致DTC原发和转移病灶迅速进展或术后病灶持续外,妊娠对于DTC患者病情影响小。未治疗DTC妊娠患者通过监测可推... 分化型甲状腺癌(differentiated thyroid cancer,DTC)好发于女性患者,且育龄期女性发病率可达男性的4倍。但除少许报道妊娠导致DTC原发和转移病灶迅速进展或术后病灶持续外,妊娠对于DTC患者病情影响小。未治疗DTC妊娠患者通过监测可推迟手术时间;已治疗 DTC妊娠患者肿瘤复发和进展主要集中在本身复发风险高,特别是存在结构反应不全(structural incomplete response)的孕妇,而病情进展是本身病情发展还是妊娠所致,尚需进一步观察研究。 展开更多
关键词 妊娠 分化型甲状腺癌 复发 进展 预后
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强直性脊柱炎的中医治疗进展
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作者 于盈盈 茅建春 《吉林中医药》 2019年第1期136-139,共4页
强直性脊柱炎中医病因病机有内因和外因之分,内因为肾督两虚、阳失布化,外因多为风寒湿热之邪侵袭。中医治疗方法多样,内治疗法以辨证论治为基础,遵循"急则治其标,缓则治其本"的原则,急性期以祛风寒湿之邪,缓解期则补肾强督,... 强直性脊柱炎中医病因病机有内因和外因之分,内因为肾督两虚、阳失布化,外因多为风寒湿热之邪侵袭。中医治疗方法多样,内治疗法以辨证论治为基础,遵循"急则治其标,缓则治其本"的原则,急性期以祛风寒湿之邪,缓解期则补肾强督,活血通络。寒湿痹阻者温经散寒;湿热痹阻者清热利湿;肾虚督寒者温肾壮督;肾虚血瘀者补肾活血;或辨证联合西药治疗,能延缓疾病进展,改善预后;外治疗法有针灸、中药熏洗、穴位贴敷及其他疗法,如运动疗法等,具有操作安全、不良反应小等优势。中医治疗强直性脊柱炎可改善患者的症状和生活质量,减少西药不良反应,有助于患者恢复自信及促进功能康复。 展开更多
关键词 强直性脊柱炎 中医治疗 进展
Intraocular pressure fluctuation and the risk of glaucomatous damage deterioration: a Meta-analysis
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作者 Zhen-Zhen Guo Karen Chang Xin Wei 《国际眼科杂志:英文版》 SCIE CAS 2019年第1期123-128,共6页
AIM: To systematically review whether the increased fluctuation of intraocular pressure(IOP) is a risk factor for open angle glaucoma(OAG) progression. METHODS: Scientific studies relevant to IOP fluctuation and glauc... AIM: To systematically review whether the increased fluctuation of intraocular pressure(IOP) is a risk factor for open angle glaucoma(OAG) progression. METHODS: Scientific studies relevant to IOP fluctuation and glaucoma progression were retrieved from MEDLINE,EMBASE and CENTRAL databases, and were listed as references in this paper. The hazard ratio(HR) was calculated by using fixed or random-effects models according to the heterogeneity of included studies. RESULTS: Individual data for 2211 eyes of 2637 OAG patients in fourteen prospective studies were included in this Meta-analysis. All studies were longitudinal clinical studies with follow-up period ranging from 3 to 8.5 y. The combined HR was 1.23(95%CI 1.04-1.46, P=0.02) for the association between IOP fluctuation and glaucoma onset or progression with the evidence of heterogeneity(P<0.1).Subgroup analyses with different types of IOP fluctuation were also evaluated. Results indicated that the summary HR was 0.98(95%CI 0.78-1.24) in short-term IOP fluctuation group, which showed no statistical significance with heterogeneity, whereas, the combined HR was 1.43(95%CI1.13-1.82, P=0.003) in long-term IOP fluctuation group without homogeneity. Sensitivity analysis further showed that the pooled HR was 1.10(95%CI 1.03-1.18, P=0.004) for long-term IOP fluctuation and visual function progression with homogeneity among studies(P=0.3). CONCLUSION: Long-term IOP fluctuation can be a risk factor for glaucoma progression based on the presentedevidence. Thus, controlling the swing of IOP is crucial for glaucoma or glaucoma suspecting patients. 展开更多
关键词 INTRAOCULAR pressure FLUCTUATION GLAUCOMA visual field PROGRESSION
胃癌组织中miRNA182表达与患者病情进展及预后之间的关联分析 预览
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作者 储怀祝 曹洪涛 +2 位作者 吕海栋 徐建国 刘国庆 《空军医学杂志》 2019年第2期132-134,共3页
目的分析讨论miRNA182表达特征与胃癌病情进展及预后的关联情况。方法选取2015年1月—2016年1月在青海省人民医院接受治疗的首发未转移胃癌患者75例,选择所有患者胃癌原发灶及癌旁正常黏膜组织作为研究对象,全部患者随访2年,收集并分析m... 目的分析讨论miRNA182表达特征与胃癌病情进展及预后的关联情况。方法选取2015年1月—2016年1月在青海省人民医院接受治疗的首发未转移胃癌患者75例,选择所有患者胃癌原发灶及癌旁正常黏膜组织作为研究对象,全部患者随访2年,收集并分析miRNA182表达与不同疾病进展状态以及随访预后之间的关联情况。结果胃癌组织中的miRNA182的相对表达量远高于癌旁组织;分别使用性别、年龄以及肿瘤的直径和分期进行分层分析,胃癌组织中的表达量在各个亚层中也均高于癌旁组织中的表达量;且胃癌组织中的miRNA182表达水平在肿瘤直径≥5cm以及肿瘤TNM分期在Ⅲ和Ⅳ期患者中更高;不同预后状态之间的miRNA182表达量提示复发、转移以及死亡的患者miRNA182表达水平分别高于未复发、未转移以及存活的患者水平,差异均具有统计学意义(P<0.05)。结论胃癌组织中miRNA182表达水平增高,肿瘤原发灶越大、分期越高,miRNA182表达水平也越高,即病情相对严重的患者miRNA182表达更高;而且miRNA182高表达提示病情进展以及预后不良。 展开更多
关键词 miRNA182 胃癌 病情进展 预后
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Fibroblast growth factor receptor 4 single nucleotide polymorphism Gly388Arg in head and neck carcinomas 预览
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作者 Eva Wimmer Stephan Ihrler +3 位作者 Olivier Gires Sylvia Streit Wolfgang Issing Christoph Bergmann 《世界临床肿瘤学杂志(英文版)》 2019年第3期136-148,共13页
BACKGROUND Head and neck squamous cell carcinoma(HNSCC) is considered to be a progressive disease resulting from alterations in multiple genes regulating cell proliferation and differentiation like receptor tyrosine k... BACKGROUND Head and neck squamous cell carcinoma(HNSCC) is considered to be a progressive disease resulting from alterations in multiple genes regulating cell proliferation and differentiation like receptor tyrosine kinases(RTKs) and members of the fibroblast growth factor receptors(FGFR)-family. Singlenucleotide polymorphism(SNP) Arg388 of the FGFR4 is associated with a reduced overall survival in patients with cancers of various types. We speculate that FGFR4 expression and SNP is associated with worse survival in patients with HSNCC.AIM To investigate the potential clinical significance of FGFR4 Arg388 in the context of tumors arising in HNSCC, a comprehensive analysis of FGFR4 receptor expression and genotype in tumor tissues and correlated results with patients’ clinical data in a large cohort of patients with HNSCC was conducted.METHODS Surgical specimens from 284 patients with HNSCC were retrieved from the Institute of Pathology at the Ludwig-Maximilian-University in Germany.Specimens were analyzed using immunohistochemistry and polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP). The expression of FGFR4 was analyzed in 284 surgical specimens of HNSCC using immunohistochemstry. FGFR4 polymorphism was detected by PCR-RFLP.Patients’ clinical data with a minimum follow-up of 5 years were statistically evaluated with a special emphasis on survival analysis employing Kaplan-Meier estimator and Cox regression analysis.RESULTS Concerning the invasive tumor areas the intensity of the FGFR4 expression was evaluated in a four-grade system: no expression, low expression, intermediate and high expression. FGFR4 expression was scored as 'high'(+++) in 74(26%),'intermediate'(++) in 103(36.3%), and 'low'(+) in 107(36.7%) cases. Analyzing the FGFR4 mutation it was found in 96 tumors(33.8%), 84 of them(29.6%) having a heterozygous and 12(4.2%) homozygous mutated Arg388 allele. The overall frequency concerning the mutant alleles demonstrated 65% vs 34% mutated alleles in general. FGFR4 Arg388 wa 展开更多
关键词 FIBROBLAST growth factor receptor 4 Single-nucleotide polymorphism Head and NECK SQUAMOUS cell carcinoma Reduced survival Cancer progression POLYMERASE chain reaction IMMUNOHISTOCHEMISTRY Outcome
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痰中端粒酶催化基团mRNA表达与肺癌发生及进展的相关性 预览
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作者 许斌 姜彦多 孟媛 《实用癌症杂志》 2019年第5期750-752,共3页
目的探讨痰中端粒酶催化基团mRNA表达与肺癌发生及进展的相关性。方法将首诊确诊肺癌患者75例纳入研究,并对患者进行为期1年的随访;研究同时选取同期可比的普通肺炎患者100例纳入研究作为对照组。收集受试对象痰液,分析痰中端粒酶及其... 目的探讨痰中端粒酶催化基团mRNA表达与肺癌发生及进展的相关性。方法将首诊确诊肺癌患者75例纳入研究,并对患者进行为期1年的随访;研究同时选取同期可比的普通肺炎患者100例纳入研究作为对照组。收集受试对象痰液,分析痰中端粒酶及其催化基团mRNA表达与肺癌发生及进展的相关性。采用SPSS17.0统计软件包分析处理数据。结果肺癌患者的痰中端粒酶及其催化基团mRNA表达均高于健康对照组,差别均有统计学意义(P<0.05),与病情控制良好或好转患者比较,病情恶化或进展的患者以及出现死亡的患者痰中端粒酶及其催化基团mRNA表达阳性率均更高,差别均有统计学意义(P<0.05)。结论肺癌病理背景下可见痰中端粒酶及其催化基团mRNA表达增高。痰中的端粒酶及其催化基团mRNA阳性检出具有提示肺癌的肿瘤标志价值,痰中的端粒酶及其催化基团mRNA高阳性率还同时提示病情恶化及不良的预后。 展开更多
关键词 痰液 端粒酶催化基团mRNA 肺癌 发生 进展 相关性
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膀胱癌组织中Tiam1表达与膀胱癌进展及复发的关系 预览
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作者 苏宏伟 李婷 +4 位作者 刘军超 凌海滨 李晨 刘鑫 李向东 《河北医药》 CAS 2019年第9期1285-1289,共5页
目的通过免疫组化SP法及RT-PCR方法检测膀胱癌组织T淋巴瘤侵袭转移诱导因子1(T-lymphoma invasion and metastasis inducing factor 1,Tiam1)表达,探讨Tiam1与膀胱癌发展及复发的关系。方法应用免疫组化SP法及RT-PCR方法检测50例正常膀... 目的通过免疫组化SP法及RT-PCR方法检测膀胱癌组织T淋巴瘤侵袭转移诱导因子1(T-lymphoma invasion and metastasis inducing factor 1,Tiam1)表达,探讨Tiam1与膀胱癌发展及复发的关系。方法应用免疫组化SP法及RT-PCR方法检测50例正常膀胱及233例膀胱癌患者肿瘤组织中Tiam1表达变化,分析膀胱癌组织中Tiam1表达与膀胱癌分期、分级、复发的关系及其预测价值。结果正常膀胱组织及膀胱癌中均有Tiam1蛋白及RNA的不同表达,膀胱癌组织中呈过表达(P<0.05),高分期、高分级、淋巴结阳性及复发患者Tiam1表达量分别高于低分期、淋巴结阴性及无复发患者(P<0.05);多因素相关分析表明,Tiam1是膀胱癌患者进展及复发的独立危险因素。结论 Tiam1对膀胱癌预后有重要意义。 展开更多
关键词 膀胱尿路上皮癌 T淋巴瘤侵袭转移诱导因子1 免疫组化 进展 复发
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术中放疗在胰腺癌中的应用进展 预览
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作者 李珊 赵春波(综述) 乔文波(审校) 《实用肿瘤学杂志》 CAS 2019年第3期280-283,共4页
虽然胰腺癌手术方式和放、化疗方案有了长足发展,但胰腺癌仍然是致死率最高的恶性肿瘤,5年总生存率仅约为4%。研究表明,胰腺癌局部复发进展是致死率高的重要原因,局部切除后失败率仍高达50%~80%。所以,如何提高胰腺癌局部控制率一直是... 虽然胰腺癌手术方式和放、化疗方案有了长足发展,但胰腺癌仍然是致死率最高的恶性肿瘤,5年总生存率仅约为4%。研究表明,胰腺癌局部复发进展是致死率高的重要原因,局部切除后失败率仍高达50%~80%。所以,如何提高胰腺癌局部控制率一直是关注的热点。由于胰腺临近的器官、组织(如骨髓、脊髓、肾脏、肝脏、肠等)较多从而限制外照射(EBRT)剂量。提高局部控制率和减少治疗毒副反应是未来治疗的趋势。术中放疗有剂量学和直视下治疗的优势,已越来越多的应用于胰腺癌的治疗,成为综合治疗中的重要部分。本文整理、总结了近年来有关胰腺癌术中放疗临床研究结果,以期为广大临床医生提供参考。 展开更多
关键词 胰腺癌 术中放射治疗(IORT) 放射治疗 进展
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透明质酸填充鼻唇沟的临床应用进展 预览
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作者 赵喜迎 王磊 +1 位作者 谭谦 郭芳芳 《中国美容医学》 CAS 2019年第3期161-163,共3页
鼻唇沟是位于颧颊部与上唇之间充当分界线的凹陷性面部线条,随年龄增长而逐渐加深,是面部老化的标志之一,也是面部年轻化治疗重点之一。近年来,医学美容技术和生物材料科学迅猛发展,透明质酸注射填充鼻唇沟促使面部年轻化的方法逐渐受... 鼻唇沟是位于颧颊部与上唇之间充当分界线的凹陷性面部线条,随年龄增长而逐渐加深,是面部老化的标志之一,也是面部年轻化治疗重点之一。近年来,医学美容技术和生物材料科学迅猛发展,透明质酸注射填充鼻唇沟促使面部年轻化的方法逐渐受到越来越多的医者及就医者的青睐。它优点明显:操作简单、方便、即刻疗效明显且可反复使用,但也存在一些相关并发症。本文就透明质酸填充鼻唇沟的相关临床应用进展及并发症作如下综述。 展开更多
关键词 鼻唇沟 透明质酸 面部年轻化 面部老化 进展 并发症
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In vivo imaging of structural,metabolic and functional brain changes in glaucoma 预览
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作者 Anisha Kasi Muneeb A.Faiq Kevin C.Chan 《中国神经再生研究:英文版》 SCIE CAS CSCD 2019年第3期446-449,共4页
Glaucoma,the world's leading cause of irreversible blindness,is a condition for which elevated intraocular pressure is currently the only modifiable risk factor.However,the disorder can continue to progress even a... Glaucoma,the world's leading cause of irreversible blindness,is a condition for which elevated intraocular pressure is currently the only modifiable risk factor.However,the disorder can continue to progress even at reduced intraocular pressure.This indicates additional key factors that contribute to the etiopathogenesis.There has been a growing amount of literature suggesting glaucoma as a neurodegenerative disease of the visual system.However,it remains debatable whether the observed pathophysiological conditions are causes or consequences.This review summarizes recent in vivo imaging studies that helped advance the understanding of early glaucoma involvements and disease progression in the brains of humans and experimental animal models.In particular,we focused on the non-invasive detection of early structural and functional brain changes before substantial clinical visual field loss in glaucoma patients;the eye-brain interactions across disease severity;the metabolic changes occurring in the brain's visual system in glaucoma;and,the widespread brain involvements beyond the visual pathway as well as the potential behavioral relevance.If the mechanisms of glaucomatous brain changes are reliably identified,novel neurotherapeutics that target parameters beyond intraocular pressure lowering can be the promise of the near future, which would lead to reduced prevalence of this irreversible but preventable disease. 展开更多
关键词 GLAUCOMA intraocular pressure eye-brain-behavior relationship IRREVERSIBLE BLINDNESS magnetic resonance imaging METABOLIC BRAIN CHANGES sensitivity disease progression
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miRNA-29调控乳腺癌发生发展的研究进展 预览
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作者 张沿君 石代红 刘健 《当代医学》 2019年第8期183-184,共2页
miRNA-29(miR-29)家族是微小RNA(microRNAs,miRNAs)家族成员,包括miR-29a、miR-29b和miR-29c,已有报道在多种癌症中异常表达。更多证据表明异常的miR-29表达与肿瘤的发生发展有关,因此,miR-29s是癌症研究中分析良好的一组miRNAs。最新... miRNA-29(miR-29)家族是微小RNA(microRNAs,miRNAs)家族成员,包括miR-29a、miR-29b和miR-29c,已有报道在多种癌症中异常表达。更多证据表明异常的miR-29表达与肿瘤的发生发展有关,因此,miR-29s是癌症研究中分析良好的一组miRNAs。最新研究表明,miRNA-29作为医学生物领域中重要的肿瘤分子标志物,在乳腺癌的发生、发展进程中发挥着重要作用。本文对miRNA-29调控乳腺癌发生、发展的作用予以概述。 展开更多
关键词 miRNA-29 乳腺癌 肿瘤发生 肿瘤侵袭
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冲击渐进振动系统的双参数分岔分析 预览
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作者 吕小红 罗冠炜 《振动与冲击》 EI CSCD 北大核心 2019年第7期50-56,76共8页
建立了冲击渐进振动系统的力学模型。分析了激振器和缓冲垫发生碰撞的类型,以及滑块渐进运动的条件。给出了系统可能呈现的四种运动状态的判断条件和运动微分方程。通过二维参数分岔分析得到在(ω,l)-参数平面内各点处,系统呈现的周期... 建立了冲击渐进振动系统的力学模型。分析了激振器和缓冲垫发生碰撞的类型,以及滑块渐进运动的条件。给出了系统可能呈现的四种运动状态的判断条件和运动微分方程。通过二维参数分岔分析得到在(ω,l)-参数平面内各点处,系统呈现的周期振动的类型。详细分析了1/1和2/1基本碰撞运动的分岔特点,以及系统参数、冲击速度和滑块渐进率之间的关联关系。1/1基本碰撞运动经周期倍化分岔产生2/2周期振动,经虚擦边分岔或多重滑移分岔产生2/1基本碰撞运动。2/1基本碰撞运动经实擦边分岔,虚擦边分岔或多重滑移分岔产生3/1基本碰撞运动。由于p/1(p=1, 2)基本碰撞运动的虚擦边分岔,使得p/1基本碰撞运动在向稳定的(p+1)/1基本碰撞运动转迁的过程中出现一个中间过渡区域。此外,在一定参数条件下,系统呈现1/1基本碰撞运动的概周期运动和周期泡现象。 展开更多
关键词 非光滑系统 冲击振动 渐进 基本碰撞运动 分岔
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Role and mechanism of circ-PRKCI in hepatocellular carcinoma 预览
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作者 Su-Xia Qi Hui Sun +3 位作者 Hui Liu Jing Yu Zhi-Yong Jiang Ping Yan 《世界胃肠病学杂志:英文版》 SCIE CAS 2019年第16期1964-1974,共11页
BACKGROUND The circular RNA circ-PRKCI is an endogenous non-coding RNA that forms a covalently closed ring after reverse splicing, which plays a key role in the occurrence and development of multiple digestive system ... BACKGROUND The circular RNA circ-PRKCI is an endogenous non-coding RNA that forms a covalently closed ring after reverse splicing, which plays a key role in the occurrence and development of multiple digestive system tumors. AIM To investigate the role and mechanism of circ-PRKCI in the occurrence and development of hepatocellular carcinoma (HCC). METHODS This study used real-time polymerase chain reaction to detect the expression of circ-PRKCI in tumor tissues, tumor adjacent tissues, and blood in patients with HCC and other digestive system tumor cells. A series of functional tests were performed to explore whether circ-PRKCI affects the growth of HCC cells and what is its mechanism in HCC. Meanwhile, fluorescence in situ hybridization was used to detect the subcellular localization of circ-PRKCI. Survival analysis was performed to predict the correlation between circ-PRKCI and the prognosis of HCC. Chi-square test and t-test were performed for statistical analyses. RESULTS The level of circ-PRKCI was significantly higher in HCC tissues than in tumor adjacent tissues, and in HCC cell lines than in cells lines of esophageal, liver, stomach, and colon cancers. A series of functional tests showed that circ-PRKCI substantially inhibited cell apoptosis and promoted cell invasion. It was found that circ-PRKCI can act as the sponge of miRNA-545 to reduce the expression of AKT3 protein. Moreover, the result of survival analysis showed that circ-PRKCI target gene E2F7 can reduce liver cancer patients’ survival rate. And clinical data suggested that the distribution of circ-PRKCI rose with the depth of invasion, lymph node metastasis, distant metastasis, and TNM stage, indicating that circ- PRKCI may affect the survival and prognosis of patients with HCC by regulating E2E7. CONCLUSION This study explores the role and mechanism of circ-PRKCI in HCC, which provides a new research direction and theoretical basis for the treatment of HCC. 展开更多
关键词 Circ-PRKCI HEPATOCELLULAR carcinoma Cell INVASION Protein KINASE B signaling pathway PROGRESSION
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The diluted atropine for inhibition of myopia progression in Korean children
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作者 Ji-Sun Moon Sun Young Shin 《国际眼科杂志:英文版》 SCIE CAS 2018年第10期1657-1662,共6页
关键词 ATROPINE KOREAN CHILDREN MYOPIA PROGRESSION
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