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Safety and efficacy of a docetaxel-5FU-oxaliplatin regimen with or without trastuzumab in neoadjuvant treatment of localized gastric or gastroesophageal junction cancer:A retrospective study 预览
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作者 Valeria Basso David Orry +4 位作者 Jean Fraisse Julie Vincent Audrey Hennequin Leila Bengrine Francois Ghiringhelli 《世界胃肠肿瘤学杂志:英文版(电子版)》 CAS 2019年第8期634-641,共8页
BACKGROUND Triplet chemotherapy,with docetaxel-5FU-oxaliplatin FLOT regimen recently became the standard perioperative treatment for localized gastric cancer(GC).An adapted regimen called TeFOX was recently tested in ... BACKGROUND Triplet chemotherapy,with docetaxel-5FU-oxaliplatin FLOT regimen recently became the standard perioperative treatment for localized gastric cancer(GC).An adapted regimen called TeFOX was recently tested in metastatic setting and gave promising results.AIM To determine safety and efficacy of TeFOX perioperative regimen.METHODS This monocentric retrospective study aims to test efficacy and safety of the perioperative TeFOX regimen given alone or in combination with trastuzumab in patients with localized GC.TeFOX consist in docetaxel(50 mg/m^2)with oxaliplatin 85 mg/m^2 and and leucovorin(400mg/m^2^)5 FU bolus(400mg/m^2)on day 1,followed by continuous infusion of 5FU for 46h(2400mg/m^2)every 2 wk.RESULTS Thirty-three consecutive patients were included in this retrospective study.Eighteen patients have a gastroesophageal junction cancer and 11 have a GC.Median follow-up of surviving patients was 32 mo.R0 resection was obtained in 30(91)patients.Twelve patients(36)had a pathological complete response and 8(24)patients a nearly complete pathological response.Median OS and PFS were not reached at data base lock.We have observed 6 metastatic relapses and 1 localized relapse.No relapse was observed in patients with pathological complete responses.The most common grade 3-4 adverse events were peripheral neuropathy(21)and asthenia(20).CONCLUSION TeFOX regimen could be safely administrated in perioperative treatment of localized GC.TeFOX and the FLOT regimen have comparable efficacy and safety profiles. 展开更多
关键词 GASTRIC CANCER NEOADJUVANT chemotherapy TeFOX Retrospective study
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Determining endemic values of cutaneous leishmaniasis in Iranian Fars province by retrospectively detected clusters and receiver operating characteristic curve analysis
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作者 Marjan Zare Abbas Rezaianzadeh +3 位作者 Hamidreza Tabatabaee Hossain Faramarzi Mohsen Aliakbarpour Mostafa Ebrahimi 《亚太热带生物医学杂志:英文版》 CAS 2019年第9期359-364,共6页
Objective: To determine the endemic values of cutaneous leishmaniasis in different cities of Fars province, Iran. Methods: Totally, 29 201 cases registered from 2010 to 2015 in Iranian Fars province were selected, and... Objective: To determine the endemic values of cutaneous leishmaniasis in different cities of Fars province, Iran. Methods: Totally, 29 201 cases registered from 2010 to 2015 in Iranian Fars province were selected, and the endemic values of cutaneous leishmaniasis were determined by retrospective clusters derived from spatiotemporal permutation modeling on a time-series design. The accuracy of the values was assessed using receiver operating characteristic(ROC) curve. SPSS version 22, Arc GIS, and ITSM 2002 software tools were used for analysis. Results: Nine statistically significant retrospective clusters(P<0.05) resulted in finding seven significant and accurate endemic values(P<0.1). These valid endemic scores were generalized to the other 18 cities based on 6 different climates in the province. Conclusions: Retrospectively detected clusters with the help of ROC curve analysis could help determine cutaneous leishmaniasis endemic values which are essential for future prediction and prevention policies in the area. 展开更多
关键词 CUTANEOUS LEISHMANIASIS Retrospective CLUSTERS Receiver operating characteristic curve ENDEMIC VALUES Fars PROVINCE
新中国成立以来我国心外科发展:成就、挑战和应对 预览
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作者 胡盛寿 《中国循环杂志》 CSCD 北大核心 2019年第10期937-943,共7页
我国心血管外科发展几乎与国际同步,自新中国成立至今可以分为三个阶段:学科探索期(1949~1979年);学科形成期(1979~2000年);学科成熟期(2000年至今).本文回顾了本学科总体发展概况和各亚专科在新中国成立以来取得的成就.经过半个多世纪... 我国心血管外科发展几乎与国际同步,自新中国成立至今可以分为三个阶段:学科探索期(1949~1979年);学科形成期(1979~2000年);学科成熟期(2000年至今).本文回顾了本学科总体发展概况和各亚专科在新中国成立以来取得的成就.经过半个多世纪的努力,我国心血管外科终于在新千年赶上了国际学科发展步伐,成就非凡.但是我们也应该看到,我国不同中心、不同区域医疗质量差异巨大,缩小医疗质量差异仍然任重而道远. 展开更多
关键词 中国 心血管外科 综述 回顾
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Characteristics of Cutaneous and Subcutaneous Infectious Granuloma at a Signal Center in China: A Five-Year Retrospective Study
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作者 Zhen-Zhen Yan You-Ming Mei +6 位作者 Hai-Qing Jiang Yong-Nian Shen Pan-Gen Cui Wei-Da Liu Mei-Hua Fu Hong-Sheng Wang Jian-Fang Sun 《国际皮肤性病学杂志(英文)》 2019年第2期94-98,共5页
Objective:Cutaneous and subcutaneous infectious granulorna (CSIG) is a broad group of inflammatory conditions that share important similarities in granulomatous reaction pattem and nonspecific clinical presentation.He... Objective:Cutaneous and subcutaneous infectious granulorna (CSIG) is a broad group of inflammatory conditions that share important similarities in granulomatous reaction pattem and nonspecific clinical presentation.Here,we conducted the retrospective study to identify the clinical,pathological,and epidemiological correlations of CSIG cases at a signal center in China.Methods:Data of patients diagnosed with CSIG between January 1,2011 and December 31,2015 were retrospectively collected,including socio-demographic information,pathogen diagnosis,clinical features,pathological results,treatment,and prognosis.Results:This study included 256 patients (137 males and 119 females) with a mean age of 52 years.Infections were more common in those aged over 40 years old (76.17%).The most common pathogens were Mycobacterium leprae (26.56%),Sporothrix schenckii (23.83%),and Mycobacterium tuberculosis (15.63%).Mycobacterium marinum (8.98%) accounted for51.11% of nontuberculous mycobactedal contagion.Lesions were most common in the distal extremities (32.03%).The predominant clinical forms were plaques (61/142,42.96%) and nodules (41/142,28.87%).Conclusions:Various pathogens were responsible for the CSIG cases in this study,with M.leprae being the most common.CSIG should be considered as a likely diagnosis for patients with lesions on exposed parts of the body that present as plaques or nodules and has a history of trauma. 展开更多
关键词 INFECTIOUS skin diseases GRANULOMA MYCOBACTERIUM FUNGUS retrospective study
对“恶法亦法”的分析与辩驳——基于富勒《法律的道德性》 预览
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作者 刘清泉 《山西青年职业学院学报》 2019年第1期53-57,共5页
“怨毒告密者难题”引发了自然法学与分析实证法学之间关于恶法是否为法的争论。富勒在其著作《法律的道德性》中提出了两组概念,即义务道德与愿望道德、内在道德与外在道德。厘清这两组概念之间的关系,进而分析“道德”是否内在于法律... “怨毒告密者难题”引发了自然法学与分析实证法学之间关于恶法是否为法的争论。富勒在其著作《法律的道德性》中提出了两组概念,即义务道德与愿望道德、内在道德与外在道德。厘清这两组概念之间的关系,进而分析“道德”是否内在于法律,为辩驳分析实证主义关于法律是“邪恶”的,以致人们不去遵守,以及创制一个溯及既往型的法律去宣示原有法律非法性的两个观点奠定了理论基础。同时,富勒所提出的法律内在道德,对现代中国法治建设过程中立法技术、立法程序、法律适用等方面的改进都有着重要的借鉴意义。 展开更多
关键词 “恶法亦法” 内在道德 溯及既往 立法
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区块链数据库:一种可查询且防篡改的数据库 预览
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作者 焦通 申德荣 +3 位作者 聂铁铮 寇月 李晓华 于戈 《软件学报》 EI CSCD 北大核心 2019年第9期2671-2685,共15页
随着比特币、以太币等一系列加密货币的兴起,其底层的区块链技术受到越来越广泛的关注.区块链有防篡改、去中心化的特性.以太坊利用区块链技术来构建新一代去中心化的应用平台.BigchainDB 将区块链技术与传统的分布式数据库相结合,利用... 随着比特币、以太币等一系列加密货币的兴起,其底层的区块链技术受到越来越广泛的关注.区块链有防篡改、去中心化的特性.以太坊利用区块链技术来构建新一代去中心化的应用平台.BigchainDB 将区块链技术与传统的分布式数据库相结合,利用基于联盟投票的共识机制改进传统 Pow 机制中的节点全复制问题,提高了系统的扩展性与吞吐率.但是现有的区块链系统存储的信息大都是固定格式的交易信息,虽然在每个交易里有数据字段,但是现有的区块链系统并不能经由链上对交易内的数据字段的具体细节进行直接查询.如果想要查询数据字段的具体细节,只能先根据交易的哈希值进行查询,得到该交易的完整信息,然后再检索该交易内的数据信息.数据可操作性低,不具备传统数据库的查询功能.首先提出一种区块链数据库系统框架,将区块链技术应用于分布式数据管理;其次提出一种基于哈希指针的不可篡改索引,根据该索引快速检索区块内数据,以此实现区块链的查询;最后,通过实验测试数据库的读写性能,实验结果表明,所提出的不可篡改索引在保证不可篡改的同时具有较好的读写性能. 展开更多
关键词 区块链 数据库 可查询 哈希指针 不可篡改索引 可回溯
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阿托伐他汀致相关性肌病的回顾性分析
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作者 郗玉玲 王涛 邓智建 《中国现代应用药学》 CAS CSCD 北大核心 2019年第14期1802-1806,共5页
目的探讨阿托伐他汀致相关性肌病的特点、影响因素、临床转归情况,促进临床合理用药。方法检索中国知网全文数据库和万方数据库,统计分析他汀相关性肌病的药物不良反应(adverse drug reaction,ADR),并统计患者的年龄、性别、服用日剂量... 目的探讨阿托伐他汀致相关性肌病的特点、影响因素、临床转归情况,促进临床合理用药。方法检索中国知网全文数据库和万方数据库,统计分析他汀相关性肌病的药物不良反应(adverse drug reaction,ADR),并统计患者的年龄、性别、服用日剂量、发生ADR时服药时间、合并用药、基础疾病以及ADR临床表现、肌酸激酶(creatine kinase,CK)的变化、转归情况。结果检索到38篇阿托伐他汀导致肌病发生的相关病例报告,共计41例。男性的发生率(60.98%)明显高于女性;>70岁老人(68.29%)是肌病发生的高危人群;初次服药或既往服用阿托伐他汀正常患者在服用阿托伐他汀过程中新增合并用药的前2个月内是肌病发生的危险期;肌病始发症状多见乏力、肌痛,偶见血尿/褐色尿/棕红色尿,恶心/食欲不振、抽搐、皮肤黄染,少见发热、心慌、局部肿胀。结论阿托伐他汀致相关性肌病发生严重时可导致致死性事件;加强用药教育,避免自行添加药物,注意肌病发生的症状,用药后1~2个月密切监护肝肾功能及CK的变化,一旦出现肌病症状或CK升高,及时就医,避免致死性事件的发生。 展开更多
关键词 阿托伐他汀 肌病 合理用药 回顾性
Development and validation of a model to determine risk of refractory benign esophageal strictures 预览
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作者 Qing Lu Tian-Tian Lei +5 位作者 Yi-Lan Wang Hai-Lin Yan Bo Lin Lin-Lin Zhu Hong-Sheng Ma Jin-Lin Yang 《世界临床病例杂志》 2019年第13期1623-1633,共11页
BACKGROUND Current research has identified several risk factors for refractory benign esophageal strictures (RBES), but research is scarce on the prediction of RBES in benign esophageal strictures patients. Meanwhile,... BACKGROUND Current research has identified several risk factors for refractory benign esophageal strictures (RBES), but research is scarce on the prediction of RBES in benign esophageal strictures patients. Meanwhile, the long-term outcomes of RBES remain unclear. The aim of this study was to develop and validate a model to determine the progression of RBES in patients with benign esophageal strictures. And we also explored the long-term outcomes and safety in patients with RBES. AIM To develop and validate a model to determine the progression of RBES in patients with benign esophageal strictures, based on the demographic data and endoscopic findings. METHODS A total of 507 benign esophageal stricture patients treated by dilation alone or in combination with stenting were retrospectively enrolled between January 2009 and February 2018. The primary outcome was to establish a risk-scoring model predicting RBES in benign esophageal strictures. The secondary outcome was to explore the clinical effectiveness and adverse events in patients with RBES. RESULTS In the study, age, etiology, and number and length of strictures were the independent risk factors for the refractory performance of benign esophageal strictures. According to risk factors of benign esophageal strictures, a risk-scoring model for predicting RBES in benign esophageal strictures was established: The risk score ranged from 0 to 8 points, and the risk scores were divided into low risk (0-2 points), intermediate risk (3-5 points), and high risk (6-8 points). The proportions of RBES in the corresponding risk categories were 1.0%, 12.2%, and 76.0%, respectively. Among 507 patients, 57 had RBES (39 males;median age, 60 years). The success rate of dilation treatment (51.2%, 21/41) was higher than that of stent placement (37.5%, 6/16). CONCLUSION In this study, 11.3%(57/507) patients had RBES at our hospital. The risk-scoring model predicting RBES in benign esophageal strictures could predict the longterm outcome of patients with strictures ahead. 展开更多
关键词 REFRACTORY BENIGN ESOPHAGEAL STRICTURES ESOPHAGEAL DILATION ESOPHAGEAL STENTS Long-term outcomes Retrospective analysis
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Retrospective review of total neoadjuvant therapy 预览
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作者 Laila Babar Veli Bakalov +7 位作者 Stephen Abel Obaid Ashraf Gene Grant Finley Moses S Raj Kristina Lundeen Dulabh K Monga Alexander V Kirichenko Rodney E Wegner 《世界胃肠肿瘤学杂志:英文版(电子版)》 CAS 2019年第10期857-865,共9页
BACKGROUND Neoadjuvant chemoradiotherapy(nCRT)followed by resection and postoperative multi-agent chemotherapy(maChT)is the standard of care for locally advanced rectal cancer.Using this approach,maChT administration ... BACKGROUND Neoadjuvant chemoradiotherapy(nCRT)followed by resection and postoperative multi-agent chemotherapy(maChT)is the standard of care for locally advanced rectal cancer.Using this approach,maChT administration can be delayed for several months,leading to concern for distant metastases.To counteract this,a novel treatment approach known as total neoadjuvant therapy(TNT)has gained popularity,in which patients receive both maChT and nCRT prior to resection.We utilized the National Cancer Database to examine temporal trends in TNT usage,and any potential effect on survival.AIM To study the temporal trends in the usage of TNT and evaluate its efficacy compared to neoadjuvant chemoradiation.METHODS We queried the National Cancer Database for patients with locally advanced rectal cancer,Stage II-III,from 2004-2015 treated with nCRT or TNT.TNT was defined as maChT initiated≥90 d prior to nCRT initiation.Overall survival was calculated from the date of diagnosis to the date of last contact or death using Kaplan-Meier curves to present the cumulative probability of survival,with logrank statistics to assess significance.Multivariable cox regression was used to identify predictors of survival and propensity score analysis accounted for bias.RESULTS We identified 9066 eligible patients,with 8812 and 254 patients receiving neoadjuvant chemoradiation followed by maChT and TNT,respectively.Nodal involvement,stage III disease,and treatment in recent years were predictive of TNT use.There was greater use of TNT with more advanced stage,specifically>1 node involved(odds ratio[OR]=2.88,95%confidence interval[CI]:2.11-3.93,P<0.01)and stage III disease(OR=2.88,95%CI:2.11-3.93,P<0.01).From 2010 to 2012 the use of TNT increased(OR=2.41,95%CI:1.27-4.56,P<0.01)with a greater increase from 2013 to 2015(OR=6.62,95%CI:3.57-12.25,P<0.01).Both the TNT and neoadjuvant chemoradiation arms had a similar 5-year survival at 76%and 78%respectively.Multivariable analysis with propensity score demonstrated that increased age,high comorbidity 展开更多
关键词 Total NEOADJUVANT therapy NEOADJUVANT CHEMORADIATION Multi-agent chemotherapy Locally advanced rectal CANCER National CANCER database Colorectal CANCER RETROSPECTIVE review Gastrointestinal ONCOLOGY Temporal trends Surgical EXCISION
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Effects of Q-Switched Laser Treatments on Acquired Bilateral Nevus of Ota-Like Macules:A Retrospective Comparative Study
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作者 Rong Zeng Yu-Zhen Liu +7 位作者 Tong Lin Li-Fang Guo Yi-Ping Ge Meng-Li Zhang Yin Yang Qiu-Ju Wu Yu-Le Wu Min Li 《国际皮肤性病学杂志(英文)》 2019年第2期70-76,共7页
Objective:Q-switched lasers,including 1064-nm Nd:YAG nansecond laser (QSNYL),755-nm alexandrite nanosecond laser (QSAL),and 694-nm nanosecond ruby laser (QSRL),are clinically available for the treatment of acquired bi... Objective:Q-switched lasers,including 1064-nm Nd:YAG nansecond laser (QSNYL),755-nm alexandrite nanosecond laser (QSAL),and 694-nm nanosecond ruby laser (QSRL),are clinically available for the treatment of acquired bilateral nevus of Ota-like macules (ABNOM).However,no reliable evidence from large-scale comparative studies identifies which type of laser works best.This study aims to determine the differences in the effectiveness,complications,and risk factors of QSNYL,QSAL,and QSRL in the treatment of ABNOM,further to provide evidence for clinician to make optimal choice according to the condition of patients.Methods:We collected the data from 685 ABNOM patients,including clinical features,medical treatments,and follow-up,since 1999 to 2014.The Kruskal-Wallis test was used to compare therapeutic differences between the three groups.The risk factors were analyzed using univariate analysis (x2 test) and multivariate logistic regression analysis.Results:The overall treatment efficiency of the QSNYL group (52.5%) and QSAL group (51.9%) was higher than that of the QSRL group (39.5%) (x2 =17.468,P < 0.001).The onset time of the QSRL and QSAL groups was shorter than that of the QSNYL group.The factors influencing efficacy in the QSNYL group were age at first treatment,number of treatments,coexistence with melesma,and the presence of hyperpigmentation;in the QSAL group was the number of treatments;and in the QSRL group was the number of treatments and hyperpigmentation.The prevalence of hyperpigrnentation in the QSNYL group (30.5%) and the QSAL group (27.5%) was lower than that of the QSRL group (47.3%) (X2=6.576,P<0.001).Concluslon:The QSNYL,QSAL,and QSRL are all effective and safe treatments for ABNOM.Considering the overall efficacy,duration of treatment,side effects,and risk factors,the QSAL is an optimal choice for ABNOM treatment. 展开更多
关键词 ACQUIRED BILATERAL nevus of Ota-like macules Q-switched LASER Nd∶YAG LASER ALEXANDRITE LASER ruby LASER RETROSPECTIVE comparative study
小剂量硫唑嘌呤治疗自身免疫性大疱性皮肤病的回顾性分析 预览
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作者 柯丹 万远芳 《中国中西医结合皮肤性病学杂志》 CAS 2019年第4期289-292,共4页
目的回顾性分析小剂量硫唑嘌呤(AZA)治疗自身免疫性大疱性皮肤病的疗效及安全性。方法分析2017年1月—2018年6月在我科住院的120例自身免疫性大疱性皮肤病患者治疗中糖皮质激素及AZA的使用情况、硫嘌呤甲基转移酶(TPMT)突变基因检测情况... 目的回顾性分析小剂量硫唑嘌呤(AZA)治疗自身免疫性大疱性皮肤病的疗效及安全性。方法分析2017年1月—2018年6月在我科住院的120例自身免疫性大疱性皮肤病患者治疗中糖皮质激素及AZA的使用情况、硫嘌呤甲基转移酶(TPMT)突变基因检测情况,AZA的疗效及不良反应的发生情况。结果120例患者中33例使用了AZA100mg/d,患者根据自身免疫性大疱性皮肤病(ABSIS)评分分为轻度21例,中度77例,重度22例。其中大疱性类天疱疮59例,5例患者使用AZA,均为单纯使用激素后效果不佳的患者,使用AZA后起效时间为12~21d,平均起效时间(15.60±2.32)d;天疱疮患者61例,28例患者使用AZA,与未使用AZA组比较中度和重度患者激素控制量显著下降。30例TPMT基因突变检测阴性的患者有2例使用AZA后仍出现严重不良反应。结论AZA组需要更小的激素控制量,对于单用激素效果不佳的患者联合AZA可以更好控制病情,但是要注意AZA的不良反应,对TPMT基因突变检测阴性的患者也应严密检测其不良反应。 展开更多
关键词 自身免疫性大疱性皮肤病 硫唑嘌呤 回顾性研究
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复古与通变:清中叶礼乐诠释的两种路向——以汪烜、江永为中心 预览
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作者 袁建军 《音乐文化研究》 2019年第1期94-104,M0004共12页
随着清代学术的转型,考据学成为清中叶一种新的学术形态。清代的一批儒者针对宋明理学的空疏流弊进行反思,形成了一股新的学礼、习礼的社会思潮。清中叶徽州婺源二儒汪烜和江永皆为徽派的代表人物,然两人的学术取向有所不同,对于礼乐的... 随着清代学术的转型,考据学成为清中叶一种新的学术形态。清代的一批儒者针对宋明理学的空疏流弊进行反思,形成了一股新的学礼、习礼的社会思潮。清中叶徽州婺源二儒汪烜和江永皆为徽派的代表人物,然两人的学术取向有所不同,对于礼乐的解读,汪烜表现为复古,而江永则表现为通变。由此,通过此二人的个案分析,可以窥探其礼乐研究的异同,同时亦可见出清中叶的礼乐学术发展态势以及徽州礼学的研究特点。 展开更多
关键词 江永 汪烜 礼乐 复古 通变
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Value of Shoulder MRI in Cancer Patients Presenting with Shoulder Related Symptoms 预览
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作者 Bilal Mujtaba Sameh Nassar +5 位作者 Ahmed Taher Felicia Wang Kundan Rao John E. Madewell Rizwan Aslam Kevin McEnery 《健康科学:英文版》 2019年第5期320-325,共6页
Nonspecific shoulder pain is common presentation among elderly patients and patients with a history of cancer. The major concern of shoulder pain in cancer patients is the development of metastases. MRI of the shoulde... Nonspecific shoulder pain is common presentation among elderly patients and patients with a history of cancer. The major concern of shoulder pain in cancer patients is the development of metastases. MRI of the shoulder is the most commonly used imaging modality for assessment of suspected soft tissue pathologies associated with the shoulder pain. In this study, we try to examine the role of shoulder MRI in elderly patients with a history of cancer presenting with nonspecific shoulder complaints for assessment of metastases. 展开更多
关键词 SHOULDER MRI MALIGNANCY RETROSPECTIVE analysis
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Effect of the medication injection site on treatment efficacy in pediatric cerebral palsy: conventional sites vs acupoints
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作者 Sun Yan Chen Hai Wu Chengyan 《中医杂志:英文版》 SCIE CAS CSCD 2019年第5期716-721,共6页
OBJECTIVE: To analyze treatment effectiveness in terms of the medication injection site. METHODS: The medical records of 423 patients with cerebral palsy who were admitted to Maternal and Child Health Hospital between... OBJECTIVE: To analyze treatment effectiveness in terms of the medication injection site. METHODS: The medical records of 423 patients with cerebral palsy who were admitted to Maternal and Child Health Hospital between January 2009 and December 2016 were collected. All cases were divided into T1, T2, T3, and T4 groups based on the use of conventional medication sites and acupoints for administering injectable medicines. RESULTS: In the T1 group, patients received injections at conventional medication sites between 2009 and 2010. In the T2 group, patients received injections at conventional medication sites combined with acupoint injection therapy I from 2011 to 2012. In the T3 group, injection at conventional medication sites plus acupoint injection II was applied between 2013 and 2014. Acupoint injection only was used in the T4 group from 2015 to 2016. Therapeutic effects were statistically compared among the different injection procedures. The overall Gross Motor Function Measure (GMFM) and Fine Motor Function Measure (FMFM) scores were significantly improved after hospital discharge. The GMFM score was considerably higher in the T4 group than in the other groups (all P = 0.001 < 0.05). The GMFM scores were significantly higher in the T2 groups than in the T1 group (P = 0.001< 0.05), but no significant difference was observed between the other paired comparions (P > 0.05). Meanwhile, the FMFM scores were significantly higher in the T2 and T4 groups than in the T1 and T3 groups (all P = 0.001 < 0.05). Site injection therapy can significantly improve gross and fine motor function in children with cerebral palsy. CONCLUSION: It is feasible to administer injectable medicines at acupoints instead of convention sites to enhance the therapeutic effect of treatment in patients with cerebral palsy. 展开更多
关键词 Cerebral PALSY INJECTIONS Acupuncture points RETROSPECTIVE studies
儿童纵隔神经节源性肿瘤的MRI诊断及鉴别
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作者 徐树明 白娟 何玲 《中国基层医药》 CAS 2019年第20期2488-2493,共6页
目的探讨MRI对儿童纵隔神经节源性肿瘤的诊断及鉴别诊断价值,提高其术前诊断准确水平.方法回顾性分析41例经病理证实的儿童纵隔神经节源性肿瘤[节细胞神经瘤GN 19例、节细胞神经母细胞瘤(GNB)6例,神经母细胞瘤(NB)16例]的MRI特点及临床... 目的探讨MRI对儿童纵隔神经节源性肿瘤的诊断及鉴别诊断价值,提高其术前诊断准确水平.方法回顾性分析41例经病理证实的儿童纵隔神经节源性肿瘤[节细胞神经瘤GN 19例、节细胞神经母细胞瘤(GNB)6例,神经母细胞瘤(NB)16例]的MRI特点及临床病理学特征,包括发病年龄、病变大小、肿瘤形态及边界、MRI平扫及增强信号特点等,并与术后病理进行对照,对所获得数据进行统计学分析,计数资料比较采用Fisher精确检查,计量资料采用单因素方差分析,组间比较用SNK-q检验,P<0.05为差异有统计学意义.结果 19例GN平均发病年龄为3.9岁,肿瘤最大径(7.3 ±2.7) cm,肿瘤形态规则12例,边界清18例,肿瘤与椎管相通11例,肿瘤呈多结节融合状0例,肿瘤呈纵长12例,平扫T1 WI呈低信号11例,T2 WI呈均匀高信号12例,肿瘤伴出血坏死囊变2例,增强后呈轻度强化9例,肿瘤包膜完整13例,发生转移0例;6例GNB和16例NB出现上述征象者分别为:4.1岁,1.9岁;(6.8 ±2.6)cm,(6.4 ±2.5)cm;2例,6例;5例, 12例;3例,15例;2例,10例;3例,12例;0例,4例;3例,9例;2例,11例;1例,2例;5例,9例;0例,7例;在发病年龄(F=4.145,P=0.024)、肿瘤与椎管关系( P=0.023)、肿瘤伴出血坏死囊变( P=0.001)、肿瘤呈多结节融合状(P=0.000)、平扫T1 WI信号(P=0.015)、伴发转移(P=0.000)等方面进行比较,均差异有统计学意义(P<0.05).而在肿瘤最大径(F=0.363,P=0.698)、肿瘤形态(P=0.277)、边界(P=0.221)、纵长生长(P=0.401)、平扫T2 WI信号(P=0.835)、强化程度(P=0.338)、肿瘤有无包膜(P=0.423)等方面均差异无统计学意义,(均P>0.05).结论良性GN发病年龄较NB明显偏大,T1WI平扫多呈低信号,增强后以轻度强化为主,GNB和NB的肿瘤形态不规则,NB以多结节融合状为主,易发生出血坏死囊变,T2 WI以混杂高信号为主,多呈中度或明显不均匀强化,NB容易侵犯到椎管内及发生远处转移. 展开更多
关键词 肿瘤 神经上皮 神经节源性肿瘤 儿童 纵隔 磁共振成像 鉴别诊断 回顾性 病理学 交感神经节
Establishment and verification of a surgical prognostic model for cervical spinal cord injury without radiological abnormality 预览
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作者 Jie Wang Shuai Guo +2 位作者 Xuan Cai Jia-Wei Xu Hao-Peng Li 《中国神经再生研究:英文版》 SCIE CAS CSCD 2019年第4期713-720,共8页
Some studies have suggested that early surgical treatment can effectively improve the prognosis of cervical spinal cord injury without radiological abnormality,but no research has focused on the development of a progn... Some studies have suggested that early surgical treatment can effectively improve the prognosis of cervical spinal cord injury without radiological abnormality,but no research has focused on the development of a prognostic model of cervical spinal cord injury without radiological abnormality.This retrospective analysis included 43 patients with cervical spinal cord injury without radiological abnormality.Seven potential factors were assessed:age,sex,external force strength causing damage,duration of disease,degree of cervical spinal stenosis,Japanese Orthopaedic Association score,and physiological cervical curvature.A model was established using multiple binary logistic regression analysis.The model was evaluated by concordant profiling and the area under the receiver operating characteristic curve.Bootstrapping was used for internal validation.The prognostic model was as follows:logit(P)=-25.4545+21.2576VALUE+1.2160SCORE-3.4224TIME,where VALUE refers to the Pavlov ratio indicating the extent of cervical spinal stenosis,SCORE refers to the Japanese Orthopaedic Association score(0–17)after the operation,and TIME refers to the disease duration(from injury to operation).The area under the receiver operating characteristic curve for all patients was 0.8941(95%confidence interval,0.7930–0.9952).Three factors assessed in the predictive model were associated with patient outcomes:a great extent of cervical stenosis,a poor preoperative neurological status,and a long disease duration.These three factors could worsen patient outcomes.Moreover,the disease prognosis was considered good when logit(P)≥-2.5105.Overall,the model displayed a certain clinical value.This study was approved by the Biomedical Ethics Committee of the Second Affiliated Hospital of Xi’an Jiaotong University,China(approval number:2018063)on May 8,2018. 展开更多
关键词 nerve REGENERATION SURGICAL prognostic model CERVICAL SPINAL cord injury retrospective study MULTIPLE binary logistic regression analysis BOOTSTRAPPING internal validation MULTIPLE imputations CERVICAL SPINAL stenosis duration of disease Pavlov ratio neural REGENERATION
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伴髓样特征乳腺癌47例超声回顾性分析
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作者 周彦华 《中国实用乡村医生杂志》 2019年第10期36-38,共3页
目的 总结伴髓样特征乳腺癌病灶的超声声像特征,以期为超声诊断积累经验。方法 回顾性选择2014-2018年于北票市妇幼保健院进行乳腺癌切除术的患者47例,全部患者均经术后病理证实为伴髓样特征乳腺癌,对其超声声像内容,如病灶大小(纵径、... 目的 总结伴髓样特征乳腺癌病灶的超声声像特征,以期为超声诊断积累经验。方法 回顾性选择2014-2018年于北票市妇幼保健院进行乳腺癌切除术的患者47例,全部患者均经术后病理证实为伴髓样特征乳腺癌,对其超声声像内容,如病灶大小(纵径、横径)、形态(是否规则)、边缘(是否光滑)、边界(是否清楚)、周边声晕、回声(内部和后方回声)、钙化等;并以彩色多普勒血流显像检测血流强度(内部、周边)进行汇总分析。结果 47例伴髓样特征乳腺癌患者均为单发,其中超声与病理诊断一致者41例、不一致者6例,诊断符合率为87.2%。41例超声准确诊断的伴髓样特征乳腺癌声像特征:伴髓样特征乳腺癌纵横比多<1(97.6%);边界多清楚(73.2%);形态多不规则(78.0%);边缘多不光滑(75.6%);周边多无声晕(92.7%);内部回声多不均匀(87.8%);后方多回声增强(65.9%);内部多无钙化(82.9);内部和周边多有血流(68.3%和63.4%)。结论 超声检查对伴髓样特征乳腺癌具有较高的诊断准确率,对肿块成像效果较好,但是存在一定的误诊情况;分析其误诊原因有利于进一步提高对本病声像图特征的认识,避免误诊发生。 展开更多
关键词 乳腺癌 髓样 特征 超声 研究 回顾性
医院耐碳青霉烯类肺炎克雷伯菌38例分析 预览
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作者 时荣同 黄峰 许元元 《安徽医药》 CAS 2019年第9期1891-1893,共3页
目的分析医院耐碳青霉烯类肺炎克雷伯菌(CRKP)的分布特征和耐药情况,为临床抗菌药物合理使用预防和感染控制管理提供依据。方法收集2017年1月至2017年12月皖北煤电集团总医院临床标本分离的38株CRKP,通过回顾性调查、同源性分析,运用Exc... 目的分析医院耐碳青霉烯类肺炎克雷伯菌(CRKP)的分布特征和耐药情况,为临床抗菌药物合理使用预防和感染控制管理提供依据。方法收集2017年1月至2017年12月皖北煤电集团总医院临床标本分离的38株CRKP,通过回顾性调查、同源性分析,运用Excel2007软件进行统计分析。结果仅有5株在3月内未入住过重症医学科,占13.16%,其余33株均与重症医学科有关,占86.84%。住院时间长、手术、病情危重、气管插管、抗菌药物使用时间长、抗菌药物使用种类均为危险因素。结论重症医学科应针对其可能的危险因素,加强操作过程管理、规范抗菌药物临床使用、强化医院感染监测等方法,来预防与减少CRKP感染发生。 展开更多
关键词 肺炎克雷伯菌 碳青霉烯类 回顾性 抗生素 重症医学科
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保持气腹压力的持续排气水封瓶装置在腹腔镜手术中的应用 预览
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作者 杨晓健 王德娟 +3 位作者 胡成 李科 黄文涛 邱剑光 《中华腔镜泌尿外科杂志(电子版)》 2019年第1期5-9,共5页
目的研究保持气腹压力的持续排气水封瓶装置在腹腔镜手术中的应用价值。方法对中山大学附属第三医院自2016年5月13日至2017年8月10日54例术中应用保持气腹压力的持续排气水封瓶装置的经腹腔入路腹腔镜手术(下称水封瓶组)与54例使用常规... 目的研究保持气腹压力的持续排气水封瓶装置在腹腔镜手术中的应用价值。方法对中山大学附属第三医院自2016年5月13日至2017年8月10日54例术中应用保持气腹压力的持续排气水封瓶装置的经腹腔入路腹腔镜手术(下称水封瓶组)与54例使用常规排气方法的经腹腔入路腹腔镜手术(下称常规组)按照不同手术方式(前列腺癌根治性切除术、肾部分切除术、肾癌根治性切除术)分别进行回顾性分析,比较两者术中擦镜次数、手术时间、术中出血量、术后引流管引流天数及术后住院天数。结果前列腺癌根治性切除术、肾部分切除术、肾癌根治性切除术水封瓶组术中擦镜次数均明显少于常规组(三组均P<0.001),三种术式水封瓶组和常规组手术时间差异均有统计学意义(P=0.015、0.046、0.024),三种术式间水封瓶组和常规组的术中出血量、术后引流管引流天数、术后住院天数差异均无统计学意义。结论保持气腹压力的持续排气水封瓶装置既能及时排出术中产生的烟雾和废气,又能持续保持恒定的工作气压,大大提高腹腔镜手术的操作效率,降低手术时间。该设计简单方便、经济实惠,值得在各种腹腔镜手术中加以推广。 展开更多
关键词 气腹 持续排气 水封瓶 腹腔镜 回顾性
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No significant difference in clinically relevant findings between Pillcam?SB3 and Pillcam?SB2 capsules in a United States veteran population 预览
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作者 Tyler D Aasen David Wilhoite +3 位作者 Aynur Rahman Kalpit Devani Mark Young James Swenson 《世界胃肠内镜杂志:英文版(电子版)》 2019年第2期124-132,共9页
BACKGROUND Capsule endoscopy(CE)allows for a non-invasive small bowel evaluation for a wide range of gastrointestinal(GI)symptoms and diseases.Capsule technology has been rapidly advancing over recent years,often impr... BACKGROUND Capsule endoscopy(CE)allows for a non-invasive small bowel evaluation for a wide range of gastrointestinal(GI)symptoms and diseases.Capsule technology has been rapidly advancing over recent years,often improving image frequency and quality.The Pillcam?SB3(SB3)capsule is one such technology that offers an adaptive frame rate advantage over the previous versions of the capsule the Pillcam?SB2(SB2).Some have proposed that this improvement in capsule technology may lead to increased diagnostic yields;however,real world clinical data is currently lacking.AIM To evaluate the clinically relevant findings of SB3 and SB2 capsules in a population of United States veterans.METHODS A retrospective analysis of 260 consecutive CE studies was performed including 130 SB3 and 130 SB2 capsule studies.Recorded variables included:age,gender,type of capsule,body mass index,exam completion,inpatient status,opioid use,diabetes,quality of preparation,gastric transit time,small bowel transit time,indication,finding,and if the exam resulted in a change in clinical management.The primary outcome measured was the detection of clinically relevant findings between SB3 and SB2 capsules.RESULTS Mean age of the study population was 67.1±10.4 years and 94.2%of patients were male.Of these 28.1%were on opioid users.The most common indications for capsule procedure were occult GI bleeding(74.6%)and overt GI bleeding(14.6%).Rates of incomplete exam were similar between SB3 and SB2 groups(16.9%vs 9.2%,P=0.066).The overall rate of clinically relevant finding was 48.9%in our study.No significant difference was observed in SB3 vs SB2 capsules for clinically relevant findings(46.2%vs 51.5%,P=0.385)or change in clinical management(40.8%vs 50.0%,P=0.135).CONCLUSION Our study found no significant difference in clinically relevant findings between SB3 and SB2 capsules. 展开更多
关键词 CAPSULE Endoscopy VETERANS RETROSPECTIVE studies CAPSULES Gastrointestinal diseases SB3 SB2
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