A novel Er:YAG laser system operating at 1645 nm with high pulse-repetition-frequency(PRF)of kHz level is demonstrated.A ring cavity with double gain medium end-pumped by two fiber lasers is utilized to obtain high pu...A novel Er:YAG laser system operating at 1645 nm with high pulse-repetition-frequency(PRF)of kHz level is demonstrated.A ring cavity with double gain medium end-pumped by two fiber lasers is utilized to obtain high pulse energy.A novel‘triple-reflection’configuration on a piezoelectric actuator(PZT)is adopted to achieve high-repetition-rate at 3-kHz operation with the ramp-fire locking method.Single frequency pulses with maximum average power of 18.3 W at 3 kHz are obtained,and the pulse duration time is 318 ns.The full line width at half maximum(FWHM)of the pulses measured by the heterodyne technique is 1.71 MHz at 3 kHz.To the best of our knowledge,this is the highest PRF single-frequency laser pulses achieved based Er:YAG gain medium.展开更多
目的探讨TRPC3基因多态性与原发性高血压患者左心室肥厚(LVH)的关系。方法305例原发性高血压患者根据左心室质量指数(LVMI)分为单纯高血压224例(对照组)和高血压合并LVH 81例(LVH组)。分析2组年龄、吸烟史等一般资料差异。留取外周血标...目的探讨TRPC3基因多态性与原发性高血压患者左心室肥厚(LVH)的关系。方法305例原发性高血压患者根据左心室质量指数(LVMI)分为单纯高血压224例(对照组)和高血压合并LVH 81例(LVH组)。分析2组年龄、吸烟史等一般资料差异。留取外周血标本,采用Sequenom MassARRAY®SNP检测技术对TRPC3基因单核苷酸多态性(SNP)位点Rs2292232、Rs4995894、Rs4292355进行基因分型。Logistic回归分析影响患者LVH的因素。结果(1)2组年龄、吸烟史、饮酒史、家族史、尿素、肌酐、空腹血糖、三酰甘油、总胆固醇、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇、24 h平均舒张压(24 h DBP)差异无统计学意义(P>0.05),LVH组较对照组男性比例降低,而24 h平均收缩压(24 h SBP)、体质量指数(BMI)升高(P<0.05)。(2)2组Rs4995894及Rs4292355位点等位基因频率、基因型频率分布差异无统计学意义(P>0.05),TRPC3基因SNP位点Rs2292232基因型频率和等位基因频率分布差异有统计学意义(P<0.05),其中LVH组Rs2292232位点TT基因型频率较对照组更高(P<0.05)。(3)Logistic回归分析显示,女性(OR=0.332,95%CI:0.181~0.610)、较高24 h SBP(OR=1.035,95%CI:1.014~1.056)、TRPC3基因SNP Rs2292232 TT基因型(OR=2.105,95%CI:1.109~3.995)为原发性高血压患者发生LVH的独立危险因素(均P<0.05)。结论TRPC3基因Rs2292232位点SNP与高血压患者发生LVH有关,其中TT基因型患者更易发生LVH。展开更多
t A fluid model is employed to investigate the effect of radio frequency bias on the behavior of an argon inductively coupled plasma(ICP).In particular,the effects of ICP source power,single-frequency bias power,and d...t A fluid model is employed to investigate the effect of radio frequency bias on the behavior of an argon inductively coupled plasma(ICP).In particular,the effects of ICP source power,single-frequency bias power,and dual-frequency bias power on the characteristics of ICP are simulated at a fixed pressure of 30 mTorr(1 Torr=1.33322×102 Pa).When the bias frequency is fixed at 27.12 MHz,the two-dimensional(2D)plasma density profile is significantly affected by the bias power at low ICP source power(e.g.,50 W),whereas it is weakly affected by the bias power at higher ICP source power(e.g.,100 W).When dual-frequency(27.12 MHz/2.26 MHz)bias is applied and the sum of bias powers is fixed at 500 W,a pronounced increase in the maximum argon ion density is observed with the increase of the bias power ratio in the absence of ICP source power.As the ratio of 27.12-MHz/2.26-MHz bias power decreases from 500 W/0 W to 0 W/500 W with the ICP source power fixed at 50 W,the plasma density profiles smoothly shifts from edge-high to center-high,and the effect of bias power on the plasma distribution becomes weaker with the bias power ratio decreasing.Besides,the axial ion flux at the substrate surface is characterized by a maximum at the edge of the substrate.When the ICP source power is higher,the 2D plasma density profiles,as well as the spatiotemporal and radial distributions of ion flux at the substrate surface are characterized by a peak in the reactor center,and the distributions of plasma parameters are negligibly affected by the dual-frequency bias power ratio.展开更多
We demonstrated a high-energy single-frequency erbium-doped yttrium aluminum garnet(Er:YAG)laser.With1470 nm laser diodes(LDs)as pumping sources,single-frequency laser pulses with energy of 28.6 m J,21.6 m J,and 15.0 ...We demonstrated a high-energy single-frequency erbium-doped yttrium aluminum garnet(Er:YAG)laser.With1470 nm laser diodes(LDs)as pumping sources,single-frequency laser pulses with energy of 28.6 m J,21.6 m J,and 15.0 m J are obtained at pulse repetition frequency of 200 Hz,300 Hz,and 500 Hz,respectively.As far as we know,this is the highest single-frequency pulse energy with the Er:YAG gain medium.With the ring cavity design,pulse duration is maintained at hundreds of nanoseconds.This high-energy single-frequency laser with hundreds of nanoseconds pulse duration is a prospective laser source for light detection and ranging applications.展开更多
We demonstrated a continuous wave(cw) single-frequency intracavity frequency-doubled Nd:YVO_4/LBO laser with 532 nm output of 7.5 W and 1.06 μm output of 3.1 W, and low intensity noise in audio frequency region.To su...We demonstrated a continuous wave(cw) single-frequency intracavity frequency-doubled Nd:YVO_4/LBO laser with 532 nm output of 7.5 W and 1.06 μm output of 3.1 W, and low intensity noise in audio frequency region.To suppress the intensity noise of the high power 532 nm laser, a laser frequency locking system and a feedback loop based on a Mach-Zehnder interferometer were designed and used.The influences of the frequency stabilization and the crucial parameters of the MZI, such as the power splitting ratio of the beam splitters and the locking state of the MZI, on the intensity noise of the 532 nm laser were investigated in detail.After the experimental optimizations, the laser intensity noise in the frequency region from 0.4 kHz to 10 kHz was significantly suppressed.展开更多
基金the National Key Research and Development Program of China(Grant No.2017YFB0405203)the National Natural Science Foundation of China(Grant No.61627821).
文摘A novel Er:YAG laser system operating at 1645 nm with high pulse-repetition-frequency(PRF)of kHz level is demonstrated.A ring cavity with double gain medium end-pumped by two fiber lasers is utilized to obtain high pulse energy.A novel‘triple-reflection’configuration on a piezoelectric actuator(PZT)is adopted to achieve high-repetition-rate at 3-kHz operation with the ramp-fire locking method.Single frequency pulses with maximum average power of 18.3 W at 3 kHz are obtained,and the pulse duration time is 318 ns.The full line width at half maximum(FWHM)of the pulses measured by the heterodyne technique is 1.71 MHz at 3 kHz.To the best of our knowledge,this is the highest PRF single-frequency laser pulses achieved based Er:YAG gain medium.
文摘目的探讨TRPC3基因多态性与原发性高血压患者左心室肥厚(LVH)的关系。方法305例原发性高血压患者根据左心室质量指数(LVMI)分为单纯高血压224例(对照组)和高血压合并LVH 81例(LVH组)。分析2组年龄、吸烟史等一般资料差异。留取外周血标本,采用Sequenom MassARRAY®SNP检测技术对TRPC3基因单核苷酸多态性(SNP)位点Rs2292232、Rs4995894、Rs4292355进行基因分型。Logistic回归分析影响患者LVH的因素。结果(1)2组年龄、吸烟史、饮酒史、家族史、尿素、肌酐、空腹血糖、三酰甘油、总胆固醇、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇、24 h平均舒张压(24 h DBP)差异无统计学意义(P>0.05),LVH组较对照组男性比例降低,而24 h平均收缩压(24 h SBP)、体质量指数(BMI)升高(P<0.05)。(2)2组Rs4995894及Rs4292355位点等位基因频率、基因型频率分布差异无统计学意义(P>0.05),TRPC3基因SNP位点Rs2292232基因型频率和等位基因频率分布差异有统计学意义(P<0.05),其中LVH组Rs2292232位点TT基因型频率较对照组更高(P<0.05)。(3)Logistic回归分析显示,女性(OR=0.332,95%CI:0.181~0.610)、较高24 h SBP(OR=1.035,95%CI:1.014~1.056)、TRPC3基因SNP Rs2292232 TT基因型(OR=2.105,95%CI:1.109~3.995)为原发性高血压患者发生LVH的独立危险因素(均P<0.05)。结论TRPC3基因Rs2292232位点SNP与高血压患者发生LVH有关,其中TT基因型患者更易发生LVH。
基金Project supported by the National Natural Science Foundation of China(Grant Nos.11875101 and 11905307).
文摘t A fluid model is employed to investigate the effect of radio frequency bias on the behavior of an argon inductively coupled plasma(ICP).In particular,the effects of ICP source power,single-frequency bias power,and dual-frequency bias power on the characteristics of ICP are simulated at a fixed pressure of 30 mTorr(1 Torr=1.33322×102 Pa).When the bias frequency is fixed at 27.12 MHz,the two-dimensional(2D)plasma density profile is significantly affected by the bias power at low ICP source power(e.g.,50 W),whereas it is weakly affected by the bias power at higher ICP source power(e.g.,100 W).When dual-frequency(27.12 MHz/2.26 MHz)bias is applied and the sum of bias powers is fixed at 500 W,a pronounced increase in the maximum argon ion density is observed with the increase of the bias power ratio in the absence of ICP source power.As the ratio of 27.12-MHz/2.26-MHz bias power decreases from 500 W/0 W to 0 W/500 W with the ICP source power fixed at 50 W,the plasma density profiles smoothly shifts from edge-high to center-high,and the effect of bias power on the plasma distribution becomes weaker with the bias power ratio decreasing.Besides,the axial ion flux at the substrate surface is characterized by a maximum at the edge of the substrate.When the ICP source power is higher,the 2D plasma density profiles,as well as the spatiotemporal and radial distributions of ion flux at the substrate surface are characterized by a peak in the reactor center,and the distributions of plasma parameters are negligibly affected by the dual-frequency bias power ratio.
基金supported by the National Key Research and Development Program of China(No.2017YFB0405203)the National Natural Science Foundation of China(NSFC)(No.61627821)。
文摘We demonstrated a high-energy single-frequency erbium-doped yttrium aluminum garnet(Er:YAG)laser.With1470 nm laser diodes(LDs)as pumping sources,single-frequency laser pulses with energy of 28.6 m J,21.6 m J,and 15.0 m J are obtained at pulse repetition frequency of 200 Hz,300 Hz,and 500 Hz,respectively.As far as we know,this is the highest single-frequency pulse energy with the Er:YAG gain medium.With the ring cavity design,pulse duration is maintained at hundreds of nanoseconds.This high-energy single-frequency laser with hundreds of nanoseconds pulse duration is a prospective laser source for light detection and ranging applications.
基金Project supported by the National Key R&D Program of China(Grant No.2016YFA0301401).
文摘We demonstrated a continuous wave(cw) single-frequency intracavity frequency-doubled Nd:YVO_4/LBO laser with 532 nm output of 7.5 W and 1.06 μm output of 3.1 W, and low intensity noise in audio frequency region.To suppress the intensity noise of the high power 532 nm laser, a laser frequency locking system and a feedback loop based on a Mach-Zehnder interferometer were designed and used.The influences of the frequency stabilization and the crucial parameters of the MZI, such as the power splitting ratio of the beam splitters and the locking state of the MZI, on the intensity noise of the 532 nm laser were investigated in detail.After the experimental optimizations, the laser intensity noise in the frequency region from 0.4 kHz to 10 kHz was significantly suppressed.