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孕期体重管理改善妊娠期糖尿病患者妊娠结局及顺产率的临床效果 预览
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作者 张晓霞 陶克蓉 《临床医学研究与实践》 2019年第1期128-129,共2页
目的分析孕期体重管理改善妊娠期糖尿病患者妊娠结局及顺产率的临床效果。方法抽取我院妇产科收治的88例妊娠期糖尿病患者,采用随机数字表法将其分为对照组和观察组,各44例。对照组应用常规管理,观察组在常规管理的基础上增加孕期体重... 目的分析孕期体重管理改善妊娠期糖尿病患者妊娠结局及顺产率的临床效果。方法抽取我院妇产科收治的88例妊娠期糖尿病患者,采用随机数字表法将其分为对照组和观察组,各44例。对照组应用常规管理,观察组在常规管理的基础上增加孕期体重管理。分析两组的管理效果。结果观察组的空腹血糖、早餐后2h血糖、中餐后2h血糖、晚餐后2h血糖及睡前血糖均低于对照组(P<0.05)。观察组的并发症总发生率低于对照组,顺产率高于对照组(P<0.05)。结论将孕期体重管理应用于妊娠期糖尿病患者中,对改善妊娠结局、提高顺产率具有重要作用,值得临床应用。 展开更多
关键词 孕期体重管理 妊娠期糖尿病 妊娠结局 顺产
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Mode of delivery, birth weight and the incidence of congenital nasolacrimal duct obstruction
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作者 Ayse Dolar Bilge 《国际眼科杂志:英文版》 SCIE CAS 2019年第7期1134-1138,共5页
AIM: To study any possible association of congenital nasolacrimal duct obstruction(CNLDO) with mode of delivery, birth weight and gestational age. METHODS: We retrospectively reviewed charts of all patients(n=2591) un... AIM: To study any possible association of congenital nasolacrimal duct obstruction(CNLDO) with mode of delivery, birth weight and gestational age. METHODS: We retrospectively reviewed charts of all patients(n=2591) under the age of 3 y who were born between April 2015 and May 2017 and were examined at the Ophthalmology Clinic of Emsey Hospital Istanbul, Turkey. We identified patients(n=105) who were diagnosed as CNLDO. The mode of delivery, birth weight and gestational age along with any adverse event during or after delivery or any other health history were determined. Birth statistical data were obtained from the hospital’s medical records database. RESULTS: Gestational age of babies who were born via cesarean section(CS) was lower than gestational age of babies who were born via normal spontaneous vaginal delivery(NSVD;P=0.002). Babies who were born via CS were found to have 3.75 times higher risk of developing NLDO when compared to babies who were born via NSVD(OR=3.754). CONCLUSION: There is a possible association between CS and CNLDO. 展开更多
关键词 CONGENITAL nasolacrimal DUCT OBSTRUCTION cesarian section normal SPONTANEOUS VAGINAL delivery
自发性脑脊液耳漏的研究进展
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作者 王玥 刘芊 王海波 《山东大学耳鼻喉眼学报》 CAS 2019年第2期130-135,142共7页
自发性脑脊液耳漏是一类无明显颞骨创伤史、手术史、感染、肿瘤等原因的一类脑脊液耳漏。病理生理学目前尚不清楚,主要公认的有“先天性缺陷论”和“蛛网膜颗粒论”两种形成学说。成人和儿童漏口部位存在一定差异,常见于乳突天盖、鼓室... 自发性脑脊液耳漏是一类无明显颞骨创伤史、手术史、感染、肿瘤等原因的一类脑脊液耳漏。病理生理学目前尚不清楚,主要公认的有“先天性缺陷论”和“蛛网膜颗粒论”两种形成学说。成人和儿童漏口部位存在一定差异,常见于乳突天盖、鼓室盖、底板周围、窦脑膜角、内听道底、后颅窝等。该病临床表现不特异,不及时治疗严重者引起脑膜炎危及生命。行颞骨HRCT、葡萄糖定量及核素脑池显影等检查确诊后,应积极行手术治疗。 展开更多
关键词 脑脊液耳漏 自发性 病因学 诊断 外科手术
糖尿病患者肾周积液分析(附7例报告) 预览
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作者 葛鹏 李道兵 +1 位作者 舒露 王瑞祥 《齐齐哈尔医学院学报》 2019年第9期1120-1123,共4页
目的探讨糖尿病患者自发性肾周积液的危险因素和治疗方案。方法回顾性分析2013年3月—2017年11月本院收治的7例糖尿病合并自发性肾周积液患者的临床资料,Ⅰ型糖尿病1例,Ⅱ型糖尿病6例,糖尿病病史1个月~15年。7例无创伤突发腰痛,行B超及... 目的探讨糖尿病患者自发性肾周积液的危险因素和治疗方案。方法回顾性分析2013年3月—2017年11月本院收治的7例糖尿病合并自发性肾周积液患者的临床资料,Ⅰ型糖尿病1例,Ⅱ型糖尿病6例,糖尿病病史1个月~15年。7例无创伤突发腰痛,行B超及CTU检查发现患侧肾脏包膜下积液,其中6例行患肾肾周穿刺引流及内引流术,术中肾周引流出血液证实为肾周血肿。均行止血、抗感染及降血糖治疗。结果 B超、CT提示患肾周围积血或积液,中位体积为186.00 (127.25~806.00) ml。入院时空腹血糖(18.12±7.21) mmol/L,中位尿白细胞数1116.00 (47.50~3631.25)个/μL,中位血肌酐86.00 (70.25~317.00)μmol/L。治疗两周后复查空腹血糖(7.17±2.74) mmol/L,中位尿白细胞数94.00 (0~781.50)个/μL,中位血肌酐70.00 (66.00~207.00)μmol/L。治疗后1~3个月复查CT提示中位肾周积液体积0(0~21.36) ml。随访观察1~4年,除1例术后2年死于慢性肾功能衰竭合并肺炎,余患者未见复发。结论糖尿病患者长期高血糖、短期内血糖波动幅度大以及泌尿系感染加重可能是自发性肾周积液的危险因素,尽早稳定血糖浓度、控制感染以及内外引流能较好的减轻肾周积液、恢复患肾形态和功能。 展开更多
关键词 糖尿病 血糖浓度 泌尿系感染 肾周积液 自发性
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临床可应用和潜在的自发性脑出血后血肿扩大预测因素的研究进展
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作者 王洋 王勋 +1 位作者 代大伟 张黎明 《中国临床神经科学》 2019年第3期313-320,共8页
自发性脑出血(ICH)是脑卒中的第二大常见病因,发病率较高,近40%的自发性ICH患者出现血肿扩大,且血肿扩大与不良预后和病死率密切相关。因此,对ICH后血肿扩大的早期预测和早期处置极具重要性。文中总结了近几年公认的ICH后预测血肿扩大... 自发性脑出血(ICH)是脑卒中的第二大常见病因,发病率较高,近40%的自发性ICH患者出现血肿扩大,且血肿扩大与不良预后和病死率密切相关。因此,对ICH后血肿扩大的早期预测和早期处置极具重要性。文中总结了近几年公认的ICH后预测血肿扩大的可能因子(主要包括影像学特征以及9分临床预测量表和BRAIN 24分临床预测量表),同时对潜在的预测因子(如血糖、C反应蛋白、白细胞介素6等)的研究进展进行综述,以期为临床ICH患者血肿扩大的早期干预提供帮助。 展开更多
关键词 自发性 脑出血 血肿扩大 预测因子
Risk factors, clinical features, and short-term prognosis of spontaneous fungal peritonitis in cirrhosis:A matched case-control study 预览
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作者 Chun-Hong Huang Lan-Tian Pang +3 位作者 Li-Chen Xu Tian-Tian Ge Qiao-Mai Xu Zhi Chen 《世界临床病例杂志》 2019年第17期2438-2449,共12页
BACKGROUND Spontaneous peritonitis is one of the most common infectious complications in cirrhotic patients with ascites.Spontaneous fungal peritonitis (SFP) is a type of spontaneous peritonitis that is a less recogni... BACKGROUND Spontaneous peritonitis is one of the most common infectious complications in cirrhotic patients with ascites.Spontaneous fungal peritonitis (SFP) is a type of spontaneous peritonitis that is a less recognized but devastating complication in end-stage cirrhosis.Although high mortality was previously noted,scant data are available to fully define the factors responsible for the occurrence of SFP and its mortality.AIM To illustrate the differences between SFP and spontaneous bacterial peritonitis (SBP) and discuss the risk factors for the occurrence of SFP and its short-term mortality.METHODS We performed a matched case-control study between January 1,2007 and December 30,2018.Patients with SFP were included in a case group.Sex-,age-,and time-matched patients with SBP were included in a control group and were further divided into control-1 group (positive bacterial culture) and control-2 group (negative bacterial culture).The clinical features and laboratory parameters,severity models,and prognosis were compared between the case and control groups.Logistic regression analysis was used to determine the risk factors for occurrence,and the Cox regression model was used to identify the predictive factors for short-term mortality of SFP.RESULTS Patients with SFP exhibited more severe systemic inflammation,higher ascites albumin and polymorphonuclear neutrophils,and a worsened 15-d mortality than patients in the control groups.Antibiotic administration (case vs control-1: OR = 1.063,95%CI: 1.012-1.115,P = 0.014;case vs control-2: OR = 1.054,95%CI: 1.014-1.095,P = 0.008) remarkably increased the occurrence of SFP or fungiascites.Hepatorenal syndrome (HR = 5.328,95%CI: 1.050-18.900) and total bilirubin (μmol/L;HR = 1.005,95%CI: 1.002-1.008) represented independent predictors of SFP-related early mortality.CONCLUSION Long-term antibiotic administration increases the incidence of SFP,and hepatorenal syndrome and total bilirubin are closely related to short-term mortality. 展开更多
关键词 SPONTANEOUS FUNGAL PERITONITIS Risk FACTOR CIRRHOSIS
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卵泡刺激素受体在胎盘血管形成及维持妊娠中的作用 预览
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作者 王舒可 郑梅玲 《国际生殖健康/计划生育杂志》 CAS 2019年第5期418-421,共4页
早期认为卵泡刺激素受体(FSHR)仅存在于卵巢及睾丸内,后被证实其广泛存在于生殖系统如子宫内膜、子宫肌层、输卵管等诸多部位,具有诱导类固醇激素合成、调节子宫肌层收缩、调节正常生殖内分泌功能等作用。另有研究发现,恶性肿瘤组织、... 早期认为卵泡刺激素受体(FSHR)仅存在于卵巢及睾丸内,后被证实其广泛存在于生殖系统如子宫内膜、子宫肌层、输卵管等诸多部位,具有诱导类固醇激素合成、调节子宫肌层收缩、调节正常生殖内分泌功能等作用。另有研究发现,恶性肿瘤组织、胎盘组织中的血管内皮细胞同样有FSHR表达,并在促进血管生成中起重要作用。在正常妊娠期间,胚胎着床后胎盘血运形成是否良好对胚胎的发育十分关键,早期胚胎胎盘血运不良是导致胚胎自然流产的重要因素之一,中晚期胚胎胎盘血运构建不良则会导致早产、胎儿生长受限、妊娠期高血压疾病等并发症发生,提示FSHR对维持正常妊娠起关键性作用。现对FSHR在生殖系统及妊娠期间胎盘血管生成过程中作用的研究进展进行综述。 展开更多
关键词 卵泡刺激素 流产 自然 新生血管化 生理性 胎盘 妊娠
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大鼠自发性及药物相关性胰岛纤维化研究进展 预览
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作者 周飞 王浩安 《实验动物与比较医学》 CAS 2019年第3期249-252,共4页
胰岛纤维化是大鼠常见的自发性疾病,随着年龄的增长,病变发生率逐渐升高,且雄性发生率高于雌性。该病的发病原因及机制目前尚未定论。许多药物也能引起或加重大鼠胰岛纤维化,胰岛血管损伤被认为与该病变的发生相关。本文综述了大鼠自发... 胰岛纤维化是大鼠常见的自发性疾病,随着年龄的增长,病变发生率逐渐升高,且雄性发生率高于雌性。该病的发病原因及机制目前尚未定论。许多药物也能引起或加重大鼠胰岛纤维化,胰岛血管损伤被认为与该病变的发生相关。本文综述了大鼠自发性及药物相关性胰岛纤维化的研究,为实验动物研究及毒性病理学家提供一定的参考。 展开更多
关键词 大鼠 胰岛纤维化 自发性 药物相关
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Search for decay modes of heavy and superheavy nuclei
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作者 A.Soylu 《中国物理C:英文版》 SCIE CAS CSCD 2019年第7期37-47,共11页
Spontaneous fission(SF) with a new formula based on a liquid drop model is proposed and used in the calculation of the SF half-lives of heavy and superheavy nuclei(Z = 90–120). The predicted half-lives are in agreeme... Spontaneous fission(SF) with a new formula based on a liquid drop model is proposed and used in the calculation of the SF half-lives of heavy and superheavy nuclei(Z = 90–120). The predicted half-lives are in agreement with the experimental SF half-lives. The half-lives of decay(AD) for the same nuclei are obtained by using the Wentzel-Kramers-Brillouin(WKB) method together with Bohr-Sommerfeld(BS) quantization condition considering the isospin-dependent effects for the cosh potential. The decay modes and branching ratios of superheavy nuclei(Z =104-118) with experimental decay modes are obtained, and the modes are compared with the experimental ones and with the predictions found in the literature. Although some nuclei have predicted decay modes that are different from their experimental decay modes, decay modes same as the experimental ones are predicted for many nuclei. The SF and AD half-lives, branching ratios, and decay modes are obtained for superheavy nuclei(Z = 119–120) with unknown decay modes and compared with the predictions obtained in a previous study. The present results provide useful information for future experimental studies performed on both the AD and SF of superheavy nuclei. 展开更多
关键词 alpha decay SPONTANEOUS FISSION SUPERHEAVY Wentzel-Kramers-Brillouin(WKB) method
雄激素在女性生殖内分泌疾病发生及治疗中的作用 预览
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作者 徐霄 李雪莲(审校者) 《国际妇产科学杂志》 CAS 2019年第1期5-10,共6页
雄激素在女性生殖系统健康的维持中发挥重要作用,过量或缺乏雄激素都可能导致女性发生生殖内分泌疾病。高雄激素血症是多囊卵巢综合征(PCOS)的重要特征和致病因素之一,可能通过影响表观遗传学、下丘脑神经内分泌、卵泡发育、卵巢功能和... 雄激素在女性生殖系统健康的维持中发挥重要作用,过量或缺乏雄激素都可能导致女性发生生殖内分泌疾病。高雄激素血症是多囊卵巢综合征(PCOS)的重要特征和致病因素之一,可能通过影响表观遗传学、下丘脑神经内分泌、卵泡发育、卵巢功能和代谢发挥致病作用。雄激素在复发性自然流产中的作用机制主要是影响子宫内膜容受性和胚胎植入。早发性卵巢功能不全的妇女常表现为睾酮水平低,雄激素缺乏可能与颗粒细胞凋亡以及卵巢功能降低有关。降低雄激素的相关治疗是PCOS临床治疗的重要部分,而雄激素补充治疗可用于早发性卵巢功能不全妇女,但其疗效和长期用药的安全性尚需进一步研究。 展开更多
关键词 雄激素类 多囊卵巢综合征 流产 自然 治疗
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Dynamic Alterations in Spontaneous Brain Activity in Mothers:A Resting-State Functional Magnetic Resonance Imaging Study
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作者 Kaihua Zhang Mengxing Wang +4 位作者 Jilei Zhang Junyao Xie Xueyun Su Xiaoxia Du Zhong Chen 《神经科学通报:英文版》 SCIE CAS CSCD 2019年第4期766-770,共5页
Becoming a mother is one of the most monumental experiences in a woman's lifetime. Women typically bear the primary caregiving responsibility for their infants, and they undergo numerous changes both mentally and ... Becoming a mother is one of the most monumental experiences in a woman's lifetime. Women typically bear the primary caregiving responsibility for their infants, and they undergo numerous changes both mentally and physically, including behavioral, emotional, and hormonal changes, during the postpartum period. Studies have indicated that hormonal, experiential, and temporal factors significantly regulate emotional and cognitive brain functions during the postpartum period [1]. The determination of the neural basis of a maternal brain is critically important for understanding mother-infant attachments and thus perpetuating the human species. Until recently, limited investigations of the neuroanatomical and functional status of mothers have contributed to understanding the processing of maternal behaviors. 展开更多
关键词 DYNAMIC Alterations SPONTANEOUS BRAIN ACTIVITY IMAGING STUDY
ASAF: altered spontaneous activity fingerprinting in Alzheimer's disease based on multisite fMRI
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作者 Jiachen Li Dan Jin +20 位作者 Ang Li Bing Liu Chengyuan Song Pan Wang Dawei Wang Kaibin Xu Hongwei Yang Hongxiang Yao Bo Zhou Alexandre Bejanin Gael Chetelat Tong Han Jie Lu Qing Wang Chunshui Yu Xinqing Zhang Yuying Zhou Xi Zhang Tianzi Jiang Yong Liu Ying Han 《科学通报:英文版》 SCIE EI CSCD 2019年第14期998-1010,共13页
Several monocentric studies have noted alterations in spontaneous brain activity in Alzheimer's disease (AD), although there is no consensus on the altered amplitude of low-frequency fluctuations in AD patients. T... Several monocentric studies have noted alterations in spontaneous brain activity in Alzheimer's disease (AD), although there is no consensus on the altered amplitude of low-frequency fluctuations in AD patients. The main aim of the present study was to identify a reliable and reproducible abnormal brain activity pattern in AD. The amplitude of local brain activity (AM), which can provide fast mapping of spontaneous brain activity across the whole brain, was evaluated based on multisite rs-fMRI data for 688 subjects (215 normal controls (NCs), 221 amnestic mild cognitive impairment (aMCI) 252 AD). Two-sample t-tests were used to detect group differences between AD patients and NCs from the same site. Differences in the AM maps were statistically analyzed via the Stouffer's meta-analysis. Consistent regions of lower spontaneous brain activity in the default mode network and increased activity in the bilateral hippocampus/parahippocampus, thalamus, caudate nucleus, orbital part of the middle frontal gyrus and left fusiform were observed in the AD patients compared with those in NCs. Significant correlations (P?<?0.05, Bonferroni corrected) between the normalized amplitude index and Mini-Mental State Examination scores were found in the identified brain regions, which indicates that the altered brain activity was associated with cognitive decline in the patients. Multivariate analysis and leave-one-site-out cross-validation led to a 78.49% prediction accuracy for single-patient classification. The altered activity patterns of the identified brain regions were largely correlated with the FDG-PET results from another independent study. These results emphasized the impaired brain activity to provide a robust and reproducible imaging signature of AD. 展开更多
关键词 Brain SPONTANEOUS activity Multisite Biomarkers Leave-one-site-out cross-validation Alzheimer's disease
Intraperitoneal rupture of the hydatid cyst: Four case reports and literature review 预览
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作者 Sami Akbulut Fatih Ozdemir 《世界肝病学杂志:英文版(电子版)》 2019年第3期318-329,共12页
BACKGROUND Most patients with hydatid cysts are asymptomatic, and they are diagnosed incidentally during radiological evaluations performed for other reasons. However, some patients develop symptoms and complications ... BACKGROUND Most patients with hydatid cysts are asymptomatic, and they are diagnosed incidentally during radiological evaluations performed for other reasons. However, some patients develop symptoms and complications due to cyst size, location, and the relationship between the cyst and adjacent structures. The most serious complications that can occur are rupture of the cysts into the biliary tract, vascular structures, hollow viscus, and peritoneal cavity. We aimed to describe the management of four cases of intraperitoneal rupture of hydatid cysts. CASE SUMMARIES Four patients aged between 27 and 44 years (two men and two women) were admitted to our clinic with sudden abdominal pain (n = 4), hypotension (n = 3), and anaphylaxis (n = 2). Three of the perforated cysts were located in the liver, and one was located in the spleen. Two patients developed cyst rupture after minor trauma, and the other two developed spontaneous rupture. Enzymelinked immunosorbent assay IgG results were positive for two patients and negative for the other two. All patients received albendazole treatment after surgical intervention (range: 2-6 mo). Two patients developed hepatic abscesses requiring drainage;one of these patients also developed hydatid cyst recurrence during postoperative follow-up (range: 25-80 mo). CONCLUSION Intraperitoneal rupture is a life-threatening complication of hydatid cysts. It is important to manage patients with surgical intervention as soon as possible with aggressive medical treatment for anaphylactic reactions. 展开更多
关键词 HYDATID CYST COMPLICATION Inraperitoneal RUPTURE Spontaneous RUPTURE TRAUMATIC RUPTURE Anaphylactic reactions Case report
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新辅助放化疗与手术间隔时间对中晚期直肠癌患者疗效和生存的影响
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作者 何丽琳 《实用肿瘤杂志》 CAS 2019年第1期78-81,共4页
目的探讨新辅助放化疗和手术治疗的时间间隔对中晚期直肠癌患者病理完全缓解(pathologic complete remission,p CR)、无瘤生存(disease free survival,DFS)和总生存(overall survival,OS)的影响。方法回顾性分析行术前同步放化疗联合全... 目的探讨新辅助放化疗和手术治疗的时间间隔对中晚期直肠癌患者病理完全缓解(pathologic complete remission,p CR)、无瘤生存(disease free survival,DFS)和总生存(overall survival,OS)的影响。方法回顾性分析行术前同步放化疗联合全直肠系膜切除术治疗且随访≥36个月的100例ⅢA和ⅢB期直肠癌患者资料。新辅助放化疗与手术的间隔时间≤7周的46例患者为研究组,> 7周的54例患者为对照组。比较两组治疗效果及术后3年生存情况。结果两组患者手术时间、术中输血人次、住院时间及术后并发症发生情况等比较,差异均无统计学意义(均P> 0. 05)。研究组p CR以及镜下切缘无癌残留切除率均低于对照组(6. 5%vs 21. 7%,82. 6%vs96. 3%,均P <0. 05)。研究组术后3年局部复发或转移率高于对照组(54. 3%vs 31. 5%),3年DFS低于对照组(28. 3%vs 55. 6%),差异均具有统计学意义(均P <0. 05)。两组3年OS比较,差异无统计学意义(P> 0. 05)。结论临床治疗ⅢA和ⅢB期直肠癌患者时,延长新辅助放化疗与手术之间的时间间隔可以提高手术切除效果、p CR和DFS,有效控制术后恶性肿瘤的局部复发与转移率,且不增加术后并发症发生率,但对OS无影响。 展开更多
关键词 直肠肿瘤/病理学 直肠肿瘤/治疗 药物疗法 放射疗法 化学疗法 辅助 存活率 肿瘤消退 自行性 综合疗法 回顾性研究
Spontaneous fungal peritonitis:Micro-organisms,management and mortality in liver cirrhosis-A systematic review 预览
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作者 Tooba Tariq Furqan B Irfan +3 位作者 Mehdi Farishta Brian Dykstra Eric Martin Sieloff Archita P Desai 《世界肝病学杂志:英文版(电子版)》 2019年第7期596-606,共11页
BACKGROUND Spontaneous peritonitis is an infection of ascitic fluid without a known intraabdominal source of infection. spontaneous fungal peritonitis (SFP) is a potentially fatal complication of decompensated cirrhos... BACKGROUND Spontaneous peritonitis is an infection of ascitic fluid without a known intraabdominal source of infection. spontaneous fungal peritonitis (SFP) is a potentially fatal complication of decompensated cirrhosis, defined as fungal infection of ascitic fluid in the presence of ascitic neutrophil count of greater than 250 cells/mL. AIM To determine the prevalence of fungal pathogens, management and outcomes (mortality) of SFP in critically ill cirrhotic patients. METHODS Studies were identified using PubMed, EMBASE, Cochrane Central Register of Controlled Trials and Scopus databases until February 2019. Inclusion criteria included intervention trials and observation studies describing the association between SFP and cirrhosis. The primary outcome was in-hospital, 1-mo, and 6- mo mortality rates of SFP in cirrhotic patients. Secondary outcomes were fungal microorganisms identified and in hospital management by anti-fungal medications. The National Heart, Lung and Blood Institute quality assessment tools were used to assess internal validity and risk of bias for each included study. RESULTS Six observational studies were included in this systematic review. The overall quality of included studies was good. A meta-analysis of results could not be performed because of differences in reporting of outcomes and heterogeneity of the included studies. There were 82 patients with SFP described across all the included studies. Candida species, predominantly Candida albicans was the fungal pathogen in majority of the cases (48%-81.8%) followed by Candida krusei (15%- 25%) and Candida glabrata (6.66%-20%). Cryptococcus neoformans (53.3%) was the other major fungal pathogen. Antifungal therapy in SFP patients was utilized in 33.3% to 81.8% cases. The prevalence of in hospital mortality ranged from 33.3% to 100%, whereas 1-mo mortality ranged between 50% to 73.3%. CONCLUSION This systematic review suggests that SFP in end stage liver disease patient is associated with high mortality both in the hospital and at 1-mo, and th 展开更多
关键词 SPONTANEOUS FUNGAL PERITONITIS Bacterial PERITONITIS Liver Cirrhosis Critical
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High Power Linearly Polarized Raman Fiber Laser With Stable Temporal Output
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作者 Jiaxin SONG Hanshuo WU +3 位作者 Jun YE Jiangming XU Hanwei ZHANG Pu ZHOU 《光子传感器:英文版》 EI CAS CSCD 2019年第1期43-48,共6页
We demonstrate a high power linearly polarized Raman fiber laser(RFL)pumped by an amplified spontaneous emission(ASE)source.Temporal-stable operation of RFL could be ensured owing to the employment of ASE,which mitiga... We demonstrate a high power linearly polarized Raman fiber laser(RFL)pumped by an amplified spontaneous emission(ASE)source.Temporal-stable operation of RFL could be ensured owing to the employment of ASE,which mitigates the inherent intensity noise compared with the classic scheme adopting laser oscillator as pump source.In this experiment,the RFL has up to 119.5W output power,with central wavelength of 1129.2nm,and full width at half maximum(FWHM)linewidth of about 4.18nm.The polarization extinction ratio(PER)of the Raman laser is about 23dB.Moreover,this laser has excellent long-term and short-term stabilities in terms of the output power and time domain. 展开更多
关键词 RAMAN fiber laser amplified SPONTANEOUS emission LINEARLY polarized
Preventive Effect of Perioperative Management Using Oral Clopidogrel on Postoperative Rebleeding in Patients with Spontaneous Intracerebral Hemorrhage 预览
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作者 Tao Yang Zhong-Xiao Lin +1 位作者 Xi-Lin Zhang Xing-Ming Zhong 《脑血管病电子杂志(英文)》 2019年第1期11-14,共4页
Background: With the aging society in China and the increasing incidence of cardiovascular and cerebrovascular diseases,spontaneous cerebral hemorrhage with the use of oral clopidogrel has become common in patients. O... Background: With the aging society in China and the increasing incidence of cardiovascular and cerebrovascular diseases,spontaneous cerebral hemorrhage with the use of oral clopidogrel has become common in patients. Owing to its inhibition of platelet aggregation,oral clopidogrel results in a high incidence of postoperative intracranial rebleeding,and the prognosis is poor. The purpose of this study is to determine the effect of perioperative management of spontaneous intracerebral hemorrhage (SICH) using oral clopidogrel on postoperative rebleeding. Methods: From January 2010 to June 2018,64 patients with SICH who took clopidogrel orally and finally received surgical treatment were selected from Huzhou First People’s Hospital and the Second Affiliated Hospital of Wenzhou Medical University. The influencing factors of postoperative rebleeding were analyzed via a case-control study. Results: All patients with SICH were divided into two groups according to the standard time of drug withdrawal before surgery: drug withdrawal at < 3 days and ≥ 3 days. The incidence of postoperative rebleeding after drug withdrawal at ≥ 3 days was significantly lower than that after drug withdrawal at < 3 days. Thereafter,all patients were divided into two groups according to the adenosine diphosphate (ADP) inhibition rate detected using a thromboelastography monitor: ADP inhibition rate of < 60% and ≥ 60%. The incidence of postoperative rebleeding in the ADP inhibition rate of < 60% group was significantly lower than that in the ADP inhibition rate of ≥ 60% group. In addition,drug withdrawal at ≥ 3 days and ADP inhibition rate of < 60% had a synergistic effect on the prevention of postoperative rebleeding. Conclusions: Patients with drug withdrawal at ≥ 3 days can undergo active early surgery. The ADP inhibition rate of ≥ 60% can be used as the predictive index of high-risk postoperative rebleeding in patients with SICH taking oral clopidogrel. By reducing the ADP inhibition rate to < 60%,the incidence of postoperativ 展开更多
关键词 Spontaneous INTRACEREBRAL HEMORRHAGE CLOPIDOGREL ADENOSINE DIPHOSPHATE PERIOPERATIVE management
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Temporal trends of cirrhosis associated conditions 预览
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作者 Tomoki Sempokuya Guangxiang Zhang Kazuma Nakagawa 《世界肝病学杂志:英文版(电子版)》 2019年第1期74-85,共12页
AIM To evaluate the national inpatient trends of discharges, mortalities and financial impacts associated with four common conditions of cirrhosis. METHODS The publicly available Healthcare Cost and Utilization Projec... AIM To evaluate the national inpatient trends of discharges, mortalities and financial impacts associated with four common conditions of cirrhosis. METHODS The publicly available Healthcare Cost and Utilization Project National Inpatient Sample database was utilized to examine the temporal trends of total number of discharges, mortalities and inpatient costs related to hospitalization with a primary diagnosis of HC, transjugular intrahepatic portosystemic shunt (TIPS), esophageal varices with bleeding (EV) and spontaneous bacterial peritonitis (SBP) from 2005 to 2014. The ten-year temporal trends were assessed using simple linear regressions and multiple regression analysis. Two-sided P < 0.05 was considered statistically significant. RESULTS From 2005 to 2014, the total number of discharges with cirrhosis-associated complications trended up for HC, SBP and EV (HC by 70% increase, P < 0.0001; SBP by 819% increase, P = 0.0002; EV by 9% increase, P = 0.016), but not for TIPS (P = 0.90). HC related to viral hepatitis showed faster increase by 357%(P < 0.0001) in comparison to HC not related to viral hepatitis by 33 %(P = 0.0006). Overall, in-hospital mortality rates for each condition decreased from 2005 to 2014 (HC by 29% reduction, P = 0.0024; SBP by 26% reduction, P = 0.0038; TIPS by 32% reduction, P = 0.021) except for EV (P = 0.34). After adjustment for inflation, aggregate cost of hospitalization for EV, HC, and SBP significantly increased by 20%, 86%, and 980%, respectively, from 2005 to 2014 (all P < 0.02), while TIPS had trend toward decreasing cost by 3%(P = 0.95). CONCLUSION The number of hospitalizations and costs for some of the cirrhosis-associated conditions increased. However, the inpatient mortality rates for most of these conditions decreased. 展开更多
关键词 CIRRHOSIS Hepatic ENCEPHALOPATHY Spontaneous bacterial PERITONITIS Esophageal VARICES Transjugular INTRAHEPATIC portosystemic SHUNT
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双歧杆菌三联活菌胶囊对肝硬化自发性细菌性腹膜炎患者肠黏膜屏障功能的保护作用 预览
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作者 刘少宁 张丽伟 《当代医学》 2019年第6期37-39,共3页
目的对肝硬化自发性细菌性腹膜炎(spontaneous bacterial peritonitis,SBP)患者应用双歧杆菌三联活菌胶囊医治的肠黏膜屏障功能保护作用进行研究。方法对本院2016 年3 月至2018 年3 月诊治SBP60 例患者临床资料进行分析,按照不同医治方... 目的对肝硬化自发性细菌性腹膜炎(spontaneous bacterial peritonitis,SBP)患者应用双歧杆菌三联活菌胶囊医治的肠黏膜屏障功能保护作用进行研究。方法对本院2016 年3 月至2018 年3 月诊治SBP60 例患者临床资料进行分析,按照不同医治方案分成两组,将行常规方案医治30 例患者设为对照组,将行双歧杆菌三联活菌胶囊医治30 例患者设为实验组,比对分析两组临床疗效、肠黏膜屏障功能指标和肝功能。结果实验组总有效概率93.33%高于对照组的73.33%(P<0.05);实验组降钙素原(3.05±1.02)ng/ml 及总胆红素、丙氨酸氨基转移酶水平(32.40±7.24)μmol/L、(22.40±7.12)U/L 均优于对照组(P<0.05)。结论对SBP 患者应用双歧杆菌三联活菌胶囊医治有利于保护其肠黏膜屏障功能,且可改善患者临床症状和肝功能,可被临床应用。 展开更多
关键词 细菌性腹膜炎 自发性 肝硬化 双歧杆菌三联活菌胶囊 肠黏膜屏障功能 肝功能
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Similarities and differences between mesenchymal stem/progenitor cells derived from various human tissues 预览
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作者 Urszula Kozlowska Agnieszka Krawczenko +4 位作者 Katarzyna Futoma Tomasz Jurek Marta Rorat Dariusz Patrzalek Aleksandra Klimczak 《世界干细胞杂志:英文版(电子版)》 2019年第6期347-374,共28页
BACKGROUND Mesenchymal stromal/stem cells (MSCs) constitute a promising tool in regenerative medicine and can be isolated from different human tissues. However, their biological properties are still not fully characte... BACKGROUND Mesenchymal stromal/stem cells (MSCs) constitute a promising tool in regenerative medicine and can be isolated from different human tissues. However, their biological properties are still not fully characterized. Whereas MSCs from different tissue exhibit many common characteristics, their biological activity and some markers are different and depend on their tissue of origin. Understanding the factors that underlie MSC biology should constitute important points for consideration for researchers interested in clinical MSC application. AIM To characterize the biological activity of MSCs during longterm culture isolated from: bone marrow (BM-MSCs), adipose tissue (AT-MSCs), skeletal muscles (SMMSCs), and skin (SK-MSCs). METHODS MSCs were isolated from the tissues, cultured for 10 passages, and assessed for: phenotype with immunofluorescence and flow cytometry, multipotency with differentiation capacity for osteo-, chondro-, and adipogenesis, stemness markers with qPCR for mRNA for Sox2 and Oct4, and genetic stability for p53 and c-Myc;27 bioactive factors were screened using the multiplex ELISA array, and spontaneous fusion involving a co-culture of SM-MSCs with BM-MSCs or AT-MSCs stained with PKH26 (red) or PKH67 (green) was performed. RESULTS All MSCs showed the basic MSC phenotype;however, their expression decreased during the follow-up period, as confirmed by fluorescence intensity. The examined MSCs express CD146 marker associated with proangiogenic properties;however their expression decreased in AT-MSCs and SM-MSCs, but was maintained in BM-MSCs. In contrast, in SK-MSCs CD146 expression increased in late passages. All MSCs, except BM-MSCs, expressed PW1, a marker associated with differentiation capacity and apoptosis. BM-MSCs and AT-MSCs expressed stemness markers Sox2 and Oct4 in long-term culture. All MSCs showed a stable p53 and c-Myc expression. BM-MSCs and AT-MSCs maintained their differentiation capacity during the follow-up period. In contrast, SK-MSCs and SM-MSCs had a limited ability to d 展开更多
关键词 MESENCHYMAL stem/progenitor cells Bone marrow MSCS ADIPOSE tissue MSCS Muscle-derived MSCS Skin-derived MSCS Cytokines and TROPHIC factors of MSCS Spontaneous fusion of MSCS
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