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Structure and function of a novel cold regulated cold shock domain containing protein from an obligate psychrophilic yeast,Glaciozyma antarctica 认领
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作者 Jennifer CHARLES Makdi MASNODDIN +1 位作者 Farhan NAZAIE Nur Athirah YUSOF 《极地科学进展:英文版》 CSCD 2020年第2期137-145,共9页
Cold shock domain(CSD)-containing proteins are one of the groups of the evolutionarily conserved nucleic acid-binding proteins in all three domains of life consisting of an ancient beta-barrel fold that serves to bind... Cold shock domain(CSD)-containing proteins are one of the groups of the evolutionarily conserved nucleic acid-binding proteins in all three domains of life consisting of an ancient beta-barrel fold that serves to bind nucleic acids.The c DNA of a novel protein-coding gene containing CSD was cloned from Glaciozyma antarctica designated as Ga16676.The full length of Ga16676 gene with the size of 1335 bp encodes for an N-terminal CSD with conserved nucleic acids binding motif RNP1 and RNP2.The Ga16676 gene was cloned in p ET30 Ek/LIC,sequenced,expressed and its resistance towards cold was characterized.Recombinant protein expression of Ga16676 showed overexpressed soluble expression in both supernatant and pellet forms at 20℃.The effects of recombinant CSD protein overexpression on colony formation shows that E.coli cells were able to grow at 37℃and 20℃but not at 4℃while E.coli_Ga16676 cells were able to grow at all temperatures tested.In addition,E.coli_Ga16676 cells showed higher growth rate compared to empty E.coli cells at 10℃.Structural analysis of Ga16676 reveals some interesting findings such as more aromatic interactions for efficient binding in low energy environment,a longer loop that may contribute to structural flexibility and clustering of charged amino acids on the protein surface that is important for protein stability and flexibility. 展开更多
关键词 cold shock protein(CSP) cold adaptation cold stress stress response stress tolerance Glaciozyma antarctica psychrophilic yeast
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The Factors Associated with the Attitudes of Nurses Working in Medical Facilities towards Family Nursing 认领
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作者 Motoko Hori Akemi Yamazaki +8 位作者 Akemi Soeda Kazumi Odatsu Momoko Buyo Miyuki Matumoto Rie Tokutani Hiroko Mine Akemi Tsumura Chisato Kimura Yuichi Nakayama 《护理学期刊(英文)》 2020年第2期171-183,共13页
The aim of this study was to clarify the attitudes of nurses working in medical facilities towards family nursing and the related factors. A quantitative cross-sectional design was used. The study period was from Dece... The aim of this study was to clarify the attitudes of nurses working in medical facilities towards family nursing and the related factors. A quantitative cross-sectional design was used. The study period was from December 2017 to February 2018. 638 nurses with more than 5 years clinical experience were recruited from seven medical facilities. The questionnaire included the Families’ Importance in Nursing Care-Nurses’ Attitudes (FINC-NA), the Family Sense of Coherence (FSOC), and items on nursing practice ability, job satisfaction, and background characteristics. A multiple regression analysis with FINC-NA as the dependent variable and a path analysis of nursing practice ability as the dependent variable were performed. Responses from 416 nurses (effective response rate, 65.2%) were analyzed. Variables that were significantly related to FINC-NA (p < 0.05) were nursing practice ability, FSOC, job satisfaction, family nursing learning experience, presence of a partner and experience in family nursing. Multiple regression analysis with FINC-NA as the dependent variable revealed significant regression coefficients for nursing practice ability, FSOC and job satisfaction. Moreover, path analysis with nursing practice ability as the dependent variable showed job satisfaction, FSOC, managerial experience, family nursing learning experience were significant. In addition, it was revealed that the direct effect of FSOC on FINC-NA to mediate nursing practice ability was higher than the indirect effect, but the direct effect of job satisfaction on FINC-NA was lower than the indirect effect. It was suggested that it is important that nurses recognize their own thoughts, behaviors and ways of coping with stress within their family, and establish a good work environment and strive to enhance their nursing practice ability. 展开更多
关键词 FAMILY NURSING ATTITUDE Stress NURSING Practice ABILITY
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Deterioration of Dry Skin in Arthritis Model Mice via Stress-Induced Changes in Immune Cells in the Thymus and Spleen 认领
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作者 Kenji Goto Keiichi Hiramoto +1 位作者 Ion Takada Kazuya Ooi 《生物科学与医学(英文)》 2020年第1期23-37,共15页
Objective: Skin dryness is a characteristic of rheumatoid arthritis model mice. A previous study reported that the stress hormone glucocorticoid (i.e., corticosterone) is related to the induction of dry skin in arthri... Objective: Skin dryness is a characteristic of rheumatoid arthritis model mice. A previous study reported that the stress hormone glucocorticoid (i.e., corticosterone) is related to the induction of dry skin in arthritic mice. However, the mechanism through which stress induces dry skin in these mice is still unclear. Therefore, in this study, we examined the relationship between stress and induction of dry skin in arthritic mice. Methods: Physical stress load in mice with DBA/1JJmsSlc collagen-induced arthritis was treated with water immersion stress, and transepidermal water loss and the expression of markers associated with allergic reactions and inflammation was evaluated. Results: Deterioration of skin dryness was observed in stressed arthritic mice compared with that in unstressed arthritic mice. Moreover, plasma levels of interleukin-6 and corticosterone were increased in stressed arthritic mice compared with those in unstressed arthritic mice. We also observed decreased regulatory T cell numbers and increased T helper type 2 cell numbers in the thymus of stressed arthritic mice compared with those in unstressed arthritic mice. Conclusion: These results suggested that abnormalities in the immune system were related to deterioration of dry skin in stressed arthritic mice. Thus, reduction of stress may prevent deterioration of dry skin in mice with arthritis. 展开更多
关键词 ARTHRITIS Dry Skin STRESS HELPER T CELLS Regulatory T CELLS
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Assessment of Stress on Serum Estradiol and Cortisol Levels in Female Subordinate Naked Mole Rats Following Isolation from Natal Colony 认领
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作者 Amos Onyansi Makori Albert Wafula Nyongesa +1 位作者 Hesbon Odongo Rael Jepkogei Masai 《生物科学与医学(英文)》 2020年第3期9-17,共9页
This study investigated the effects of isolation of subordinate naked mole rats from natal colonies on their reproductive success. Naked mole rat is one of the known mammals that exhibit eusociality. It has been noted... This study investigated the effects of isolation of subordinate naked mole rats from natal colonies on their reproductive success. Naked mole rat is one of the known mammals that exhibit eusociality. It has been noted that naked mole rats have their reproduction restricted to one queen and less than three males;the rest of the animals within the colony remain sterile. The study aimed at establishing whether the reproductive suppression in subordinate naked mole rats is the outcome of social stress exerted by breeding female in the colony or other unknown environmental factors within the colony set-up. Experimental period was 20 weeks and it involved two stages, acclimatization and isolation. Before acclimation, 2 female subordinate naked mole rats were sacrificed. Blood samples were collected and appropriately preserved for later analysis. On the 2nd, 4th and 6th weeks of acclimatization, 2 female mole rats were sacrificed at each stage and blood samples were harvested for analysis. On week 7, eighteen subordinate females were isolated and randomly assigned into two groups of 9 animals each in two separate cages for 14 weeks. One week 8, 2 subordinate females from each group were randomly selected, sacrificed and blood samples collected for analysis. The same procedure was repeated on week 12 and 20 of study. Hormonal analysis was done using ELISA technique. The Statistical analysis done using student t-test at 95% confidence level and significance level was set at P < 0.05. Results showed increase in cortisol levels only in singly isolated females which were the greatest on week 8 (from 35.5 ng/ml to 123.4 ng/ml). Mean estradiol in singly isolated females was 18 ± 2.52 pg/ml while females paired with males had 19.0 ± 3.0 pg/ml hence no significant difference (paired t = -1.73, P = 0.23). Conclusively, the observed reproductive suppression among subordinate naked mole rats in natal colonies is probably due to presence of queen or other reproductive aspects that may not be directly related to stress. 展开更多
关键词 ISOLATION SUBORDINATE Naked MOLE Rat Reproductive Success Stress ESTRADIOL
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关注电烧伤所致精神障碍 认领
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作者 张庆富 《中华烧伤杂志》 CAS CSCD 北大核心 2020年第6期415-418,共4页
电烧伤是一种特殊原因烧伤,其损伤机制复杂,是烧伤救治的难点之一。电烧伤不仅严重毁损机体的组织和器官,同时显著影响患者的心理健康。许多电烧伤患者饱受躯体和心理的双重打击,使治疗难度增加,康复时间延长。有的患者虽然躯体损伤得... 电烧伤是一种特殊原因烧伤,其损伤机制复杂,是烧伤救治的难点之一。电烧伤不仅严重毁损机体的组织和器官,同时显著影响患者的心理健康。许多电烧伤患者饱受躯体和心理的双重打击,使治疗难度增加,康复时间延长。有的患者虽然躯体损伤得到了良好修复,但因伤后精神障碍而丧失劳动能力,甚至死亡。因此,电烧伤的诊疗除了重视患者躯体损伤修复,还要关注患者的心理治疗与康复。 展开更多
关键词 烧伤 精神障碍 应激 心理学 应激障碍 创伤后
Neuroprotective mechanism of L-cysteine after subarachnoid hemorrhage 认领
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作者 Ye Xiong Dan-Qing Xin +7 位作者 Quan Hu Ling-Xiao Wang Jie Qiu Hong-Tao Yuan Xi-Li Chu De-Xiang Liu Gang Li Zhen Wang 《中国神经再生研究:英文版》 SCIE CAS CSCD 2020年第10期1920-1930,共11页
Hydrogen sulfide,which can be generated in the central nervous system from the sulfhydryl-containing amino acid,L-cysteine,by cystathionine-β-synthase,may exert protective effects in experimental subarachnoid hemorrh... Hydrogen sulfide,which can be generated in the central nervous system from the sulfhydryl-containing amino acid,L-cysteine,by cystathionine-β-synthase,may exert protective effects in experimental subarachnoid hemorrhage;however,the mechanism underlying this effect is unknown.This study explored the mechanism using a subarachnoid hemorrhage rat model induced by an endovascular perforation technique.Rats were treated with an intraperitoneal injection of 100 mM L-cysteine(30μL)30 minutes after subarachnoid hemorrhage.At 48 hours after subarachnoid hemorrhage,hematoxylin-eosin staining was used to detect changes in prefrontal cortex cells.L-cysteine significantly reduced cell edema.Neurological function was assessed using a modified Garcia score.Brain water content was measured by the wet-dry method.L-cysteine significantly reduced neurological deficits and cerebral edema after subarachnoid hemorrhage.Immunofluorescence was used to detect the number of activated microglia.Reverse transcription-polymerase chain reaction(RT-PCR)was used to detect the levels of interleukin 1β and CD86 mRNA in the prefrontal cortex.L-cysteine inhibited microglial activation in the prefrontal cortex and reduced the mRNA levels of interleukin 1βand CD86.RT-PCR and western blot analysis of the complement system showed that L-cysteine reduced expression of the complement factors,C1q,C3αand its receptor C3aR1,and the deposition of C1q in the prefrontal cortex.Dihydroethidium staining was applied to detect changes in reactive oxygen species,and immunohistochemistry was used to detect the number of NRF2-and HO-1-positive cells.L-cysteine reduced the level of reactive oxygen species in the prefrontal cortex and the number of NRF2-and HO-1-positive cells.Western blot assays and immunohistochemistry were used to detect the protein levels of CHOP and GRP78 in the prefrontal cortex and the number of CHOP-and GRP78-positive cells.L-cysteine reduced CHOP and GRP78 levels and the number of CHOP-and GRP78-positive cells.The cystathionine-β-synthas 展开更多
关键词 aminooxyacetic acid central nervous system complement deposition CYSTATHIONINE-Β-SYNTHASE early brain injury endoplasmic reticulum STRESS hydrogen sulfide NEUROINFLAMMATION oxidative STRESS SUBARACHNOID hemorrhage
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Osmoprotectants and Antioxidative Enzymes as Screening Tools for Salinity Tolerance in Radish (Raphanus sativus) 认领
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作者 Rabab Sanoubar Antonio Cellini +1 位作者 Giuseppe Gianfranco Francesco Spinelli 《园艺学报:英文版》 2020年第1期14-24,共11页
The research addresses the identification of a screening methodology for salt stress tolerance in radish cultivars. In the first experiment, two different radish cultivars(long white and round red) were compared in th... The research addresses the identification of a screening methodology for salt stress tolerance in radish cultivars. In the first experiment, two different radish cultivars(long white and round red) were compared in their morphological and physiological responses to different salinity levels. Round red radish showed better morphological and physiological responses to incremental salinity in terms of yield and better adaptation of overall water relations. In the second experiment, the most tolerant genotype from the first experiment was used as a control against other seven round red radish genotypes ranked by their salinity tolerance according to morphological, physiological and biochemical indices. Salt stress did not significantly affect malondialdehyde(MDA) and hydrogen peroxide(H2O2) content, and ascorbate peroxidase(APX) activity in the studied cultivars. Nonetheless, the relatively salt tolerant cultivar SAXA2 showed higher ability to accumulate compatible solutes(e.g.proline and proteins) and maintain osmotic adjustment. In addition, cultivar SAXA2 also showed considerable increase in glutathione reductase(GR) activity. Our results supported that accumulation of proline and higher GR activity are associated with radish salt tolerance, whereas no relationship with salinity was observed in superoxide dismutase(SOD), MDA and H2O2 content. 展开更多
关键词 RADISH salt STRESS OXIDATIVE STRESS secondary METABOLITE ANTIOXIDANT ENZYME
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A 3D elastic-plastic-viscous constitutive model for soils considering the stress path dependency 认领
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作者 LU DeChun MIAO JinBo +2 位作者 DU XiuLi TIAN Yu YAO YangPing 《中国科学:技术科学英文版》 SCIE EI CAS CSCD 2020年第5期791-808,共18页
In order to consider the stress path dependency of soils,this paper decomposes any arbitrary stress path into several infinitesimal stress paths.Then the infinitesimal stress path is further transformed into the super... In order to consider the stress path dependency of soils,this paper decomposes any arbitrary stress path into several infinitesimal stress paths.Then the infinitesimal stress path is further transformed into the superposition of two parts,i.e..a constant stress ratio part and a constant mean stress part,which arc sufficiently close to the real stress path.T he plastic strain increments under the transformed paths arc determined separately,and then the plastic strain under any path is obtained.Based on the in­stantaneous loading line of normally consolidated soil,a reference state line is proposed to determine the overconsolidation ratio and creep time of soil.The overconsolidation ratio is introduced into the viscous How rule to obtain the viscous strain increment.The strcss-strain-timc relationship for triaxial compression condition is extended to 3D stress condition by the transformed stress method.The proposed model adopts only seven material parameters and each of them has a clear physical meaning.Com­parisons with test results demonstrate that the model can not only reasonably predict the plastic strain under typical stress paths of excavation,but adequately capture the time-dependent behaviours of soils,including creep,stress relaxation and strain rate effect. 展开更多
关键词 SOILS clastic-plastic-viscous constitutive model stress path dependency reference stale line CREEP stress relaxation
Assessing anxiety,depression,and stress among inpatients with cancer 认领
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作者 Honghong Xu Ruotong Xue +9 位作者 Yi Cheng Yujie Zhang Jie Rao Mei Liu Shiying Yu Lingxiang Liu Yiqian Liu Yongqian Shu Liuqing Yang Hanping Shi 《肿瘤学与转化医学:英文版》 2020年第3期126-130,共5页
Objective This study aimed to assess anxiety,depression,and stress among inpatients with cancer.Methods Two hundred thirty-five hospitalized patients with cancer were surveyed with the Depression Anxiety Stress Scales... Objective This study aimed to assess anxiety,depression,and stress among inpatients with cancer.Methods Two hundred thirty-five hospitalized patients with cancer were surveyed with the Depression Anxiety Stress Scales(simplified Chinese Version).The software program SPSS 25.0 was used for statistical analysis of the survey data.Results The average scores of depression,anxiety,and stress of inpatients with cancer were 12.17,11.84,and 13.98 respectively,which were higher than the normal range.The scores of anxiety and stress of inpatients with different caregivers were statistically different(P=0.024/0.036).The anxiety and stress scores of inpatients with spouses as caregivers were higher than those of inpatients with children as caregivers.There was a statistically significant difference in the incidence of stress between inpatients with cancer with religious beliefs and inpatients with cancer without religious beliefs(P=0.026),and those with religious beliefs had greater incidence of stress.The score of anxiety was significantly higher for inpatients with children than for inpatients without children(P=0.040).Conclusion The anxiety,depression,and stress levels of inpatients with cancer are relatively high.It is necessary to pay special attention to the psychological status of these patients during clinical diagnosis and treatment to improve their quality of life. 展开更多
关键词 inpatients with cancer ANXIETY DEPRESSION STRESS
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步态周期下半月板损伤对膝关节生物力学性能的影响 认领
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作者 吴铮 任静 +5 位作者 万建杉 孙嵘 武成聪 刘克廷 刘涛 欧华 《中国组织工程研究》 CAS 北大核心 2020年第21期3299-3303,共5页
背景:目前国内外对膝关节半月板的生物力学分析十分广泛,但大多集中于对膝关节屈曲运动状态下的研究,针对完整步态周期下膝关节半月板生物力学的有限元分析还不完善。目的:通过对比外侧半月板撕裂模型与健康半月板模型,了解完整步态周... 背景:目前国内外对膝关节半月板的生物力学分析十分广泛,但大多集中于对膝关节屈曲运动状态下的研究,针对完整步态周期下膝关节半月板生物力学的有限元分析还不完善。目的:通过对比外侧半月板撕裂模型与健康半月板模型,了解完整步态周期下半月板损伤后的生物力学变化机制。方法:以健康成年人膝关节CT扫描数据为基础,建立包括胫-股骨、半月板、关节软骨在内的健康膝关节有限元模型,并在健康模型基础上进一步构建膝关节外侧半月板撕裂模型,探究在完整步态周期下膝关节外侧半月板撕裂的生物力学机制,并与健康膝模型进行对比。结果与结论:①两种模型完整步态周期内的胫骨软骨瞬时应力变化趋势一致,但半月板撕裂模型中胫骨软骨在每一个瞬时受到的应力值均大于健康半月板模型,半月板撕裂模型与健康模型中胫骨软骨所受最大应力值分别为30,20.5 MPa;②两种模型完整步态周期内的半月板瞬时应力变化趋势是一致的,但撕裂模型中完整步态周期内半月板受到的应力均大于健康模型,半月板撕裂模型与健康模型中半月板所受最大应力值分别为69.8,41.3 MPa;③在步态周期的前60%,半月板撕裂模型中的胫骨软骨最大应力分布远大于健康模型,且随着步态周期的增长,接触范围逐渐向软骨外部边缘蔓延;在步态周期的60%以后,作用在胫骨软骨上的应力较小,最大应力的分布范围也比较小;④两种模型中健康内侧半月板应力分布基本一致,而撕裂的外侧半月板最大应力分布范围较健康内侧半月板广,在裂纹周围出现了较严重应力集中现象,且随着步态周期的进行,应力集中区域逐渐向裂纹靠近半月板前角处偏移;⑤结果表明半月板是人体膝关节中重要的承重部件,从生物力学角度可以较为直观地观察到半月板损伤对人体膝关节的危害。 展开更多
关键词 半月板 生物力学 应力 有限元分析 应力分布 胫骨软骨 完整步态周期 数字化骨科
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Hypoxia and oxidative stress:The role of the anaerobic gut,the hepatic arterial buffer response and other defence mechanisms of the liver 认领
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作者 Samapriya Pasan Hewawasam 《世界荟萃分析杂志》 2020年第2期78-88,共11页
The liver is considered a vital organ and is the hub for multiple chemical functions,such as intermediary metabolism and the detoxification of ingested toxins,which are essential for the preservation of life,hence,the... The liver is considered a vital organ and is the hub for multiple chemical functions,such as intermediary metabolism and the detoxification of ingested toxins,which are essential for the preservation of life,hence,the origin or the word“liver”.The liver has enormous,highly diversified catalytic potential.This enormous catalytic potential generates massive oxidative stress,which is important for the functions of the liver but is detrimental to the viability of the liver.The liver receives approximately 80%of its blood supply from the portal vein,which brings less saturated blood from the gastrointestinal tract.Hepatocytes operate in a relatively hypoxic microenvironment due to this portal inflow.The development of this hypoxic microenvironment of the liver is an important evolutionary adaptation for its detoxification function that is not recognized in the literature as a defence mechanism against the oxidative stress generated during the detoxification process.This review describes liver function in relation to its oxidative catalytic potential and the oxidative stress generated by it as well as the evolutionary defence mechanisms present in the liver against this oxidative stress to provide new insights into liver function. 展开更多
关键词 ANAEROBIC GUT lumen OXIDATIVE STRESS LIVER defences against OXIDATIVE STRESS Hepatic arterial buffer response HYPOXIA LIVER function
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Pathological significance of tRNA-derived small RNAs in neurological disorders 认领
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作者 Chuan Qin Pei-Pei Xu +7 位作者 Xin Zhang Chao Zhang Chang-Bin Liu De-Gang Yang Feng Gao Ming-Liang Yang Liang-Jie Du Jian-Jun Li 《中国神经再生研究:英文版》 SCIE CAS CSCD 2020年第2期212-221,共10页
Non-coding RNAs(ncRNAs) are a type of RNA that is not translated into proteins. Transfer RNAs(tRNAs), a type of ncRNA, are the second most abundant type of RNA in cells. Recent studies have shown that tRNAs can be cle... Non-coding RNAs(ncRNAs) are a type of RNA that is not translated into proteins. Transfer RNAs(tRNAs), a type of ncRNA, are the second most abundant type of RNA in cells. Recent studies have shown that tRNAs can be cleaved into a heterogeneous population of ncRNAs with lengths of 18–40 nucleotides, known as tRNA-derived small RNAs(tsRNAs). There are two main types of tsRNA, based on their length and the number of cleavage sites that they contain: tRNA-derived fragments and tRNA-derived stress-induced RNAs. These RNA species were first considered to be byproducts of tRNA random cleavage. However, mounting evidence has demonstrated their critical functional roles as regulatory factors in the pathophysiological processes of various diseases, including neurological diseases. However, the underlying mechanisms by which tsRNAs affect specific cellular processes are largely unknown. Therefore, this study comprehensively summarizes the following points:(1) The biogenetics of tsRNA, including their discovery, classification, formation, and the roles of key enzymes.(2) The main biological functions of tsRNA, including its miRNA-like roles in gene expression regulation, protein translation regulation, regulation of various cellular activities, immune mediation, and response to stress.(3) The potential mechanisms of pathophysiological changes in neurological diseases that are regulated by tsRNA, including neurodegeneration and neurotrauma.(4) The identification of the functional diversity of tsRNA may provide valuable information regarding the physiological and pathophysiological mechanisms of neurological disorders, thus providing a new reference for the clinical treatment of neurological diseases. Research into tsRNAs in neurological diseases also has the following challenges: potential function and mechanism studies, how to accurately quantify expression, and the exact relationship between tsRNA and miRNA. These challenges require future research efforts. 展开更多
关键词 EPIGENETICS molecular biology NEUROLOGICAL disorders review sequencing STRESS tRNA tRNA-derived FRAGMENTS tRNA-derived small RNAs tRNA-derived stress-induced RNA
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不同程度心理应激对小鼠卵巢内氧化应激水平的影响 认领
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作者 程蕊 刘妍 +2 位作者 杨慧 马瑞红 夏天 《国际生殖健康/计划生育杂志》 CAS 2020年第2期93-96,共4页
目的:探讨不同程度刺激对小鼠卵巢氧化应激水平的影响,以期为不孕症患者辅助心理治疗提供理论依据。方法:80只雌鼠随机分为4组,给予不同程度且不可预知性刺激4周,观察小鼠体质量及行为学改变。造模成功后,检测小鼠血清中超氧化物歧化酶(... 目的:探讨不同程度刺激对小鼠卵巢氧化应激水平的影响,以期为不孕症患者辅助心理治疗提供理论依据。方法:80只雌鼠随机分为4组,给予不同程度且不可预知性刺激4周,观察小鼠体质量及行为学改变。造模成功后,检测小鼠血清中超氧化物歧化酶(SOD)含量、活性氧(ROS)水平,小鼠卵巢组织中SOD活性、丙二醛(MDA)含量、SOD2、过氧化氢酶(CAT)、谷胱甘肽过氧化物酶(GSH-Px)3种抗氧化物酶的m RNA水平。结果:不同程度心理应激组与正常组相比,小鼠体质量降低,不动时间和中央区域滞留时间延长,进入中央区域次数及中央区域活动时间减少,差异有统计学意义(P<0.05);血清中ROS水平升高,SOD含量降低,卵巢组织中SOD活性降低,MDA含量升高,SOD2、CAT及GSH-Px活性降低,差异有统计学意义(P<0.05)。结论:心理应激能够降低小鼠的自主活动欲望和探索欲望,ROS的累积引发机体内氧化应激反应,影响女性生殖功能。 展开更多
关键词 应激 心理学 氧化性应激 活性氧 超氧化物歧化酶 小鼠
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精神专科医院医护人员的压力管理 认领
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作者 陈静 《中国卫生产业》 2020年第6期74-76,共3页
医护人员的压力现状不容忽视,由于职业地位、工作性质和工作环境等的特殊性,加之其高风险性、不确定性及环境相对封闭和社会的歧视,医护人员面临更大的压力。压力管理一般指的是通过一些特定的方法来加强个体面对压力的能力,并针对压力... 医护人员的压力现状不容忽视,由于职业地位、工作性质和工作环境等的特殊性,加之其高风险性、不确定性及环境相对封闭和社会的歧视,医护人员面临更大的压力。压力管理一般指的是通过一些特定的方法来加强个体面对压力的能力,并针对压力所致个人身心问题实施针对性处理。有研究指出,通过压力管理能够有效改善精神专科医院医护人员所面临的压力,对提高医护人员心理健康水平具有重要意义。该文探讨了压力的定义,精神科医护人员的压力状况和压力源以及压力的表现和副性作用,最后提出几点缓解压力的建议意见,以期帮助精神科的医务人员掌握管理压力的能力,从而提高个人的生活和工作质量。 展开更多
关键词 压力 压力管理 精神专科 医护人员
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Plant growth-promoting rhizobacteria--alleviators of abiotic stresses in soil: A review 认领
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作者 Madhurankhi GOSWAMI Suresh DEKA 《土壤圈:英文版》 SCIE CAS CSCD 2020年第1期40-61,共22页
With the continuous increase in human population,there is widespread usage of chemical fertilizers that are responsible for introducing abiotic stresses in agricultural crop lands.Abiotic stresses are major constraint... With the continuous increase in human population,there is widespread usage of chemical fertilizers that are responsible for introducing abiotic stresses in agricultural crop lands.Abiotic stresses are major constraints for crop yield and global food security and therefore require an immediate response.The implementation of plant growth-promoting rhizobacteria(PGPR)into the agricultural production system can be a profitable alternative because of its efficiency in plant growth regulation and abiotic stress management.These bacteria have the potential to promote plant growth and to aid in the management of plant diseases and abiotic stresses in the soil through production of bacterial phytohormones and associated metabolites as well as through significant root morphological changes.These changes result in improved plant-water relations and nutritional status in plants and stimulate plants’defensive mechanisms to overcome unfavorable environmental conditions.Here,we describe the significance of plant-microbe interactions,highlighting the role of PGPR,bacterial phytohormones,and bacterial metabolites in relieving abiotic environmental stress in soil.Further research is necessary to gather in-depth knowledge on PGPR-associated mechanisms and plant-microbe interactions in order to pave a way for field-scale application of beneficial rhizobacteria,with the aim of building a healthy and sustainable agricultural system.Therefore,this review aims to emphasize the role of PGPR in growth promotion and management of abiotic soil stress with the goal of developing an eco-friendly and cost-effective strategy for future agricultural sustainability. 展开更多
关键词 PHYTOHORMONES plant-microbe interaction ROOT COLONIZATION ROOT morphological change secondary metabolites STRESS alleviation STRESS tolerance
Evaluation of stress-control layout at the Subtropolis Mine,Petersburg,Ohio 认领
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作者 Anthony Iannacchione Tim Miller +4 位作者 Gabriel Esterhuizen Brent Slaker Michael Murphy Natalie Cope Scott Thayer 《矿业科学技术学报:英文版》 SCIE EI CSCD 2020年第1期77-83,共7页
The Subtropolis room-and-pillar mine extracts the Vanport Limestone(Allegheny Formation,Pennsylvanian System)near Petersburg,Ohio.Strata instability problems associated with excessive concentrations of lateral stress ... The Subtropolis room-and-pillar mine extracts the Vanport Limestone(Allegheny Formation,Pennsylvanian System)near Petersburg,Ohio.Strata instability problems associated with excessive concentrations of lateral stress caused the mine operator to implement a change in layout design.This mining method has been identified as a stress control layout and has been used by other underground stone mines in the past with varying degrees of success.Practical experience has shown that entry headings advance in the direction of the principal lateral stress,producing lower stress concentrations with better mining conditions.It is important to minimize stress concentrations along the mining front,so an arrowshaped advance is recommended.This technique advances more developments(headings)in a"good"direction and reduces developments(crosscuts)in the"bad direction."As is expected,the stress control layout enhances the potential for shear failures in crosscuts.It is,therefore,important to focus crosscut engineering interventions that either:(a)lower stress concentrations(for example,an arched roof)or(b)enhance strength of the strata containing the shears(for example,rock reinforcement).This study focuses on observing strata conditions on a regular basis and monitoring the response of these strata to changing geologic and mining conditions through 3D Dynamic LiDAR scans. 展开更多
关键词 Horizontal STRESS Stress-control LAYOUTS Underground stone mines
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Study of Descriptive Determinants of Moral Harassment at Work in a Factory in Senegal 认领
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作者 Abou Sy Ekué Kafui Kokou +6 位作者 Jean Augustin Diegane Tine Ndeye Amelie Makareme Sy Aissatou Diallo Ibrahima Seck Mor Ndiaye Taiwo Lateef Sheikh Mamadou Habib Thiam 《健康(英文)》 2020年第2期106-117,共12页
Introduction: Globalization and the attendant contemporary system of work organization, industrial competitiveness and workplace hostility could be a source of stress. Behaviors considered to be hostile tend to consti... Introduction: Globalization and the attendant contemporary system of work organization, industrial competitiveness and workplace hostility could be a source of stress. Behaviors considered to be hostile tend to constitute the foundation on which moral harassment at work rests and contributes significantly to work place mental health. Methodology: We conducted a quantitative, cross sectional descriptive study between April 1 and June 30, 2018 at the Grands Moulins de Dakar “GMD”. We used a questionnaire containing the socio-demographic data to which we added the Masson Meret and Steiner questionnaire called, “Ambiance in professional environment”. We used the Epi info software for data entry and analysis. Results: Sample population was 100 subjects with average age of 42.18 years ± 7.6, a male predominance of 91% and average length of service in the company was 15.27 years ± 10.1. Hostile behavior was more frequently reported than stress, with 49% and 28% respectively. Among the hostile behavior we found criticism in the professional field in 35% of the cases and rumors mongering was observed in 25% of the cases. The most reported stress symptom was general fatigue (45%), hostile behavior was more common in males (40 - 49 years of age and those with more than 10 dependents). Of the officers who felt generally unwell, 78.9% were victims of hostile behavior. Conclusion: Hostile behavior forms the basis of moral harassment at work and their devious nature makes them difficult to detect, this contrasts with its harmful consequences on the health of the staff. Potentially harmful workplace stress has become more frequently encountered in the contemporary workplace and has constituted an occupational hazard. The most common symptoms reported are feeling unwell and general fatigue. 展开更多
关键词 Bulling MORAL HARASSMENT PSYCHOSOCIAL VIOLENCE Stress Senegal
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The Influence of a Posture on the Autonomic Nervous System and Stress Hormones in Saliva 认领
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作者 Yusuke Goto Ailing Hu +2 位作者 Takuji Yamaguchi Nobuhiro Suetake Hiroyuki Kobayashi 《健康(英文)》 2020年第2期118-126,共9页
Humans and animals give several impressions to their recipients with their postures. In this study, the influence of postures on a body was examined through the perspective of the endocrine system and the autonomic ne... Humans and animals give several impressions to their recipients with their postures. In this study, the influence of postures on a body was examined through the perspective of the endocrine system and the autonomic nervous system. The subjects were 18 healthy adults (7 males and 11 females). A slouching posture like arching back was defined as a low power pose (LP), and a posture straightening back and throwing out chest is defined as a high power pose (HP). Starting at rest, the subjects took LP posture and changed to HP posture, and their autonomic nervous functions were measured and their saliva was collected before and after taking each posture. In taking LP posture, the decrease of the parasympathetic nervous activity, the increase of the pathetic nervous activity and the increase of chromogranin A in saliva were observed. The increase of the autonomic nervous activity, and the decrease of chromogranin A which had been increased by taking LP posture were observed by taking HP posture. There was no influence on cortisol by taking either of the postures. This study suggested that bad postures such as curving back affected stress reactions through the perspective of the endocrine system and the automatic nervous system. 展开更多
关键词 Stress POSTURE AUTONOMIC Nervous System SALIVA CORTISOL CHROMOGRANIN A
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Protective and defensive roles of non-glandular trichomes against multiple stresses:structure–function coordination 认领
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作者 George Karabourniotis Georgios Liakopoulos +1 位作者 Dimosthenis Nikolopoulos Panagiota Bresta 《林业研究:英文版》 SCIE CAS CSCD 2020年第1期1-12,共12页
As superficial structures,non-glandular trichomes,protect plant organs against multiple biotic and abiotic stresses.The protective and defensive roles of these epidermal appendages are crucial to developing organs and... As superficial structures,non-glandular trichomes,protect plant organs against multiple biotic and abiotic stresses.The protective and defensive roles of these epidermal appendages are crucial to developing organs and can be attributed to the excellent combination of suitable structural traits and chemical reinforcement in the form of phenolic compounds,primarily fl avonoids.Both the formation of trichomes and the accumulation of phenolics are interrelated at the molecular level.During the early stages of development,non-glandular trichomes show strong morphological similarities to glandular ones such as the balloon-like apical cells with numerous phenolics.At later developmental stages,and during secondary wall thickening,phenolics are transferred to the cell walls of the trichomes.Due to the diff use deposition of phenolics in the cell walls,trichomes provide protection against UV-B radiation by behaving as optical fi lters,screening out wavelengths that could damage sensitive tissues.Protection from strong visible radiation is also aff orded by increased surface light refl ectance.Moreover,the mixtures of trichome phenolics represent a superfi-cial chemical barrier that provides protection against biotic stress factors such as herbivores and pathogens.Although the cells of some trichomes die at maturity,they can modulate their quantitative and qualitative characteristics during development,depending on the prevailing conditions of the external biotic or abiotic environment.In fact,the structure and chemical constituents of trichomes may change due to the particular light regime,herbivore damage,wounding,water stress,salinity and the presence of heavy metals.Hence,trichomes represent dynamic protective structures that may greatly aff ect the outcome of many plant–environment interactions. 展开更多
关键词 Non-glandular TRICHOMES Phenolics Flavonoids Protection Defence Biotic STRESS Abiotic STRESS
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Molecular Regulation of Plant Responses to Environmental Temperatures 认领
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作者 Yanglin Ding Yiting Shi Shuhua Yang 《分子植物:英文版》 SCIE CAS CSCD 2020年第4期544-564,共21页
Temperature is a key factor governing the growth and development,distribution,and seasonal behavior of plants.The entireplant life cycle is affected by environmental temperatures.Plants grow rapidly and exhibit specif... Temperature is a key factor governing the growth and development,distribution,and seasonal behavior of plants.The entireplant life cycle is affected by environmental temperatures.Plants grow rapidly and exhibit specific changes in morphology under mild average temperature conditions,a response termed thermomorphogenesis.When exposed to chilling or moist chilling low temperatures,flowering or seed germination is accelerated in some plant species;these processes are known as vernalization and cold stratification,respectively.Interestingly,once many temperate plants are exposed to chilling temperatures for some time,they can acquire the ability to resist freezing stress,a process termed cold acclimation.In the face of global climate change,heat stress has emerged as a frequent challenge,which adversely affects plant growth and development.In this review,we summarize and discuss recent progress in dissecting them olecular mechanism sregulating plant thermomorphogenesis,vernalization,and responses to extreme temperatures.We also discuss the remaining issues that are crucial for understanding the interactions between plants and temperature. 展开更多
关键词 cold stress heat stress PLANTS temperature responses thermomorphogenesis VERNALIZATION
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