期刊文献+
共找到2,561篇文章
< 1 2 129 >
每页显示 20 50 100
Crohn’s disease of esophagus,stomach and duodenum 预览
1
作者 Andréa Maia Pimentel Raquel Rocha Genoile Oliveira Santana 《世界胃肠药理与治疗学杂志:英文版(电子版)》 2019年第2期35-49,共15页
Crohn’s disease with involvement of the esophagus,stomach and duodenum has a prevalence of 0.5%to 4%in symptomatic adult patients,but some studies have shown that these results may be underestimated,since upper gastr... Crohn’s disease with involvement of the esophagus,stomach and duodenum has a prevalence of 0.5%to 4%in symptomatic adult patients,but some studies have shown that these results may be underestimated,since upper gastrointestinal endoscopy is not performed routinely in the initial evaluation of the disease in adult patients,as it is in the pediatric population.In general,involvement of the upper gastrointestinal tract in Crohn’s disease occurs concomitantly with involvement of the lower gastrointestinal tract.The diagnosis depends on clinical,endoscopic,histological and radiological evaluation.The presence of aphthoid ulcers,longitudinal ulcers,bamboo-joint-like appearance,stenoses and fistulas are endoscopic findings suggestive of the disease,and it is important to exclude the presence of Helicobacter pylori infection.The primary histological findings,which facilitate the diagnosis,are the presence of a chronic inflammatory process with a predominance of lymphoplasmacytic cells and active focal gastritis.The presence of epithelioid granuloma,although less frequent,is highly suggestive of the disease in the absence of chronic granulomatous disease.Treatment should include the use of proton pump inhibitors associated with corticosteroids,immunomodulators and biological therapy according to the severity of the disease. 展开更多
关键词 Crohn’s disease UPPER gastrointestinal tract UPPER digestive endoscopy ESOPHAGUS STOMACH DUODENUM Chronic GASTRITIS Focal GASTRITIS EPITHELIOID granuloma
在线阅读 免费下载
上段输尿管尿路上皮细胞癌患者预后的影响因素分析 预览
2
作者 徐惠丽 韩永红 +2 位作者 王纯 卢驰 曾娟 《癌症进展》 2019年第7期856-858,共3页
目的探讨上段输尿管尿路上皮细胞癌患者预后的影响因素。方法依据预后评估结果,133例上段输尿管尿路上皮细胞癌患者中,预后不佳组56例,预后良好组77例。上段输尿管尿路上皮细胞癌患者预后的影响因素采用Logistic逐步回归分析。结果单因... 目的探讨上段输尿管尿路上皮细胞癌患者预后的影响因素。方法依据预后评估结果,133例上段输尿管尿路上皮细胞癌患者中,预后不佳组56例,预后良好组77例。上段输尿管尿路上皮细胞癌患者预后的影响因素采用Logistic逐步回归分析。结果单因素分析结果显示,不同肿块数目、肿瘤直径、病理分级、临床分期、合并慢性肾脏病情况和膀胱灌注化疗情况上段输尿管尿路上皮细胞癌患者的预后情况比较,差异均有统计学意义(P﹤0.05)。Logistic回归分析结果显示,合并慢性肾脏病、肿瘤直径≥3cm、病理分级为G3级、临床分期为Ⅱ~Ⅲ期、未接受膀胱灌注化疗均是影响上段输尿管尿路上皮细胞癌患者预后的独立危险因素。结论合并慢性肾脏病、肿瘤直径≥3cm、病理分级为G3级、临床分期为Ⅱ~Ⅲ期、未接受膀胱灌注化疗均是影响上段输尿管尿路上皮细胞癌患者预后的独立危险因素。 展开更多
关键词 上段输尿管 尿路上皮癌 预后 影响因素
在线阅读 下载PDF
术前红细胞平均血红蛋白量水平与上尿路尿路上皮癌预后的相关性分析
3
作者 谭平 杨璐 +10 位作者 徐航 艾建忠 刘振华 柳良仁 林天海 鲍一歌 金熙 曹德宏 唐钵 李响 魏强 《临床泌尿外科杂志》 2019年第2期98-103,共6页
目的:分析术前红细胞(RBC)相关指标对上尿路尿路上皮癌(UTUC)患者术后的预后影响。方法:回顾性分析2003年1月~2016年12月我院701例UTUC患者的临床资料和随访结果。结果:中位随访时间39(17~67)个月。男401例(57.2%),女300例(42.8%)。515... 目的:分析术前红细胞(RBC)相关指标对上尿路尿路上皮癌(UTUC)患者术后的预后影响。方法:回顾性分析2003年1月~2016年12月我院701例UTUC患者的临床资料和随访结果。结果:中位随访时间39(17~67)个月。男401例(57.2%),女300例(42.8%)。515例(73.5%)诊断为高级别肿瘤,pT3和pT4期分别有247例(35.2%)和100例(14.3%)。患者5年总体生存(OS)、肿瘤特异性生存(CSS)及无复发生存(RFS)分别为54.6%、60.6%及49.0%。术前患者的红细胞压积(HCT)<0.39、血红蛋白(HGB)<114g/L、平均血红蛋白量(MCH)<28.6pg、红细胞平均体积(MCV)<91.3fl、RBC<4.09×1012/L或红细胞分布宽度(RDW)>13.9%,其预后明显较差(均P<0.05)。肿瘤T分期和肿瘤分级、淋巴结转移、同时伴多种组织类型(CVH)是CSS、RFS及OS的独立预测因子;肿瘤基底类型与CSS相关(HR=1.67,95%CI:1.06~2.63,P=0.028)。MCH是CSS(HR=1.54,95%CI:1.04~2.27,P=0.032)和RFS(HR=1.46,95%CI:1.04~2.03,P=0.028)的独立预测因子。然而其他RBC相关因子仅在单因素分析时有预测价值,在多因素分析时差异均无统计学意义。结论:本研究全面分析了RBC相关因子在中国西南UTUC患者中的预后作用,研究结果表明MCH是UTUC患者术后CSS和RFS的独立预后因素。 展开更多
关键词 上尿路 尿路上皮癌 预后 危险因素
The preoperative serum cystatin-C as an independent prognostic factor for survival in upper tract urothelial carcinoma
4
作者 Ping Tan Ming Shi +8 位作者 Jie Chen Hang Xu Nan Xie Huan Xu Yong Jiang Jian-Zhong Ai Liang-Ren Liu Lu Yang Qiang Wei 《亚洲男性学杂志:英文版》 SCIE CAS CSCD 2019年第2期163-169,共7页
Cystatin-C(Cys-C)has been reported as a valuable prognostic biomarker in various malignancies.However,its effect on upper tract urothelial carci noma(UTUC)patie nts has not bee n investigated before.Thus,to explore th... Cystatin-C(Cys-C)has been reported as a valuable prognostic biomarker in various malignancies.However,its effect on upper tract urothelial carci noma(UTUC)patie nts has not bee n investigated before.Thus,to explore the impact of Cys-C on survival outcomes in patients undergoing radical nephroureterectomy(RNU),a total of 538 patients with UTUC who underwent RNU between 2005 and 2014 in our center(West China Hospital,Chengdu,China)were included in this study.Kaplan-Meier method and Cox regressi on an a lyses were performed to assess the relationship betwee n Cys-C and survival outcomes using SPSS versi on 22.0.The cutoff value of Cys-C was set as 1.4 mg I1 using the receiver operating characteristic(ROC)curves and Youden index.The mean age of patients included was 66.1±11.1 years,and the media n follow-up durati on was 38(interquartile ran ge:19-56)mon ths.Overall,162(30.1%)patients had elevated Cys-C,and they were much older and had worse renal function than those with Cys-C<1.4 mg I^-1(both P<0.001).Meanwhile,Kaplan-Meier analysis revealed that the group with elevated Cys-C had worse cancer-specific survival(CSS,P=0.001),disease recurrence-free survival(RFS,P=0.003),and overall survival(OS,P<0.001).Multivariable Cox analysis suggested that the elevated Cys-C was identified as an independent prognostic predictor of CSS(hazard ratio[HR]:1.997,95%confidential interval[CI]:1.331-2.996),RFS(HR:1.429,95%CI:1.009-2.023),and OS(HR:1.989,95%CI:1.366-2.896).In conclusion,our result revealed that the elevated preoperative serum Cys-C was significantly associated with worse outcomes in UTUC patients undergoing RNU. 展开更多
关键词 CYSTATIN-C prognosis RADICAL NEPHROURETERECTOMY upper TRACT UROTHELIAL carcinoma
Effect of secretory IgA combined with conventional anti-infectious drugs on inflammatory response and immune response in children with upper respiratory tract infection
5
作者 Chun-Mei Li 《海南医科大学学报(英文版)》 2018年第1期65-68,共4页
Objective: To investigate the effect of secretory IgA combined with conventional anti-infectious drugs on inflammatory response and immune response in children with upper respiratory tract infection. Methods: A total ... Objective: To investigate the effect of secretory IgA combined with conventional anti-infectious drugs on inflammatory response and immune response in children with upper respiratory tract infection. Methods: A total of 130 children with upper respiratory tract infection who were treated in the hospital between February 2016 and February 2017 were divided into control group and secretory IgA group by random number table method, each group with 65 cases. Control group received routine anti-infectious drug treatment, and secretory IgA group received the secretory IgA combined with conventional anti-infectious drug treatment, which lasted for 1 week. The differences in serum levels of routine inflammatory factors, fat inflammatory factors and immunoglobulin were compared between the two groups before and after treatment. Results: There was no statistically significant difference in serum levels of normal inflammatory factors, fat inflammatory factors and immunoglobulin between the two groups before treatment. After 1 week of treatment, serum conventional inflammatory factors CRP, IL-1 and IL-8 levels of secretory IgA group were lower than those of control group;serum fat inflammatory factors SAA and Chemerin levels were lower than those of control group whereas Leptin level was higher than that of control group;serum immunoglobulin IgA, IgG and IgM contents were higher than those of control group. Conclusion: The secretory IgA combined with conventional anti-infectious drugs can effectively inhibit the systemic inflammatory response and enhance the humoral immune response in children with upper respiratory tract infection. 展开更多
关键词 Upper respiratory TRACT infection in CHILDREN SECRETORY IgA Inflammatory response IMMUNOGLOBULIN
Infectious diseases during the European Union training mission Mali(EUTM MLI)–a four-year experience
6
作者 Hagen Frickmann Ralf Matthias Hagen +1 位作者 Florian Geiselbrechtinger Nagpal Hoysal 《军事医学研究:英文版》 CAS 2018年第4期293-303,共11页
Background: The European Union Training Mission Mali(EUTM MLI) is a multinational military training deployment to the Western African tropical nation of Mali. Based on routinely collected disease and non-battle injury... Background: The European Union Training Mission Mali(EUTM MLI) is a multinational military training deployment to the Western African tropical nation of Mali. Based on routinely collected disease and non-battle injury surveillance data, this study quantifies the true impact of infectious diseases for this tropical mission and potential seasonal variations in infectious disease threats.Methods: Categorized health events during the EUTM MLI mission and associated lost working days were reported using the EpiNATO-2 report. Infection-related health events were descriptively analyzed for a 4-year period from the 12 th week in 2013 to the 13 th week in 2017. Aggregated EpiNATO-2 data collected from all missions other than EUTM MLI were used as a comparator.Results: Among the infectious diseases reported by EUTM MLI, non-severe upper respiratory infections and gastrointestinal diseases dominated quantitatively, accounting for 1.65 and 1.42 consultations per 100 person-weeks, respectively. The number of recorded infectious disease-associated lost working days during the whole study interval was 723. Seasonal changes in disease frequency were detectable. More gastrointestinal infections were seen in the rainy season, and more respiratory infections occurred in the dry season;these were associated with peaks of more than 2.5 consultations per 100 person-weeks for both categories.Conclusion: Despite initial concerns focused on tropical infectious diseases during this mission in tropical Mali, upper respiratory tract and gastrointestinal infections predominate. The relatively low number of reported lost working days may indicate that these infections are at the milder end of the spectrum of infectious diseases despite a likely reporting bias. 展开更多
关键词 TROPICAL DEPLOYMENT INFECTIOUS diseases TROPICAL medicine Gastrointestinal INFECTIONS Upper respiratory tract INFECTIONS MALI
Photodynamic therapy for middle-advanced stage upper gastrointestinal carcinomas:A systematic review and metaanalysis 预览
7
作者 Bo Chen Li Xiong +7 位作者 Wei-Dong Chen Xiao-Hua Zhao Jun He Yan-Wen Zheng Fan-Hua Kong Xi Liu Zi-Jian Zhang Xiong-Ying Miao 《世界临床病例杂志》 2018年第13期650-658,共9页
AIM To determine the therapeutic effect of photodynamic therapy(PDT)for middle-advanced stage upper gastrointestinal carcinomas.METHODS We searched PubMed,EMBASE,the Cochrane Library,China National Knowledge Infrastru... AIM To determine the therapeutic effect of photodynamic therapy(PDT)for middle-advanced stage upper gastrointestinal carcinomas.METHODS We searched PubMed,EMBASE,the Cochrane Library,China National Knowledge Infrastructure,China Science and Technology Journal Database,and Wanfang Database from inception to April 2018 for randomized controlled studies.These studies compared PDT with other palliative therapies(radiotherapy,chemotherapy,or Nd:YAG laser)and compared PDT,radiotherapy,or chemotherapy alone with PDT combined with chemotherapy/radiotherapy.In our meta-analysis,both fixed and random effects models were used to estimate the risk ratio(RR)for dichotomous outcomes(the response rate and one-year survival rate).RESULTS Ten random controlled clinical studies with 953 patients were included in the analysis.The effective rate for PDT was better than that of radiotherapy or Nd:YAG laser for the treatment of middle-advanced upper gastrointestinal carcinomas[RR=1.36;95%confidence interval(CI):1.13-1.65;P=0.001].In addition,PDT combined with chemotherapy had significantly better efficacy and a higher one-year survival rate than PDT or chemotherapy alone(significant remission rate,RR=1.62;95%CI:1.34-1.97;P<0.00001;one-year survival rate,RR=1.81;95%CI:1.13-2.89;P=0.01).CONCLUSION PDT is a useful method for the treatment of middleadvanced stage upper gastrointestinal carcinomas.PDT combined with chemotherapy or radiotherapy can enhance its efficacy and prolong survival time. 展开更多
关键词 Photodynamic therapy RADIOTHERAPY Chemotherapy Upper GASTROINTESTINAL TRACT Nd:YAG laser GASTROINTESTINAL NEOPLASM GASTROINTESTINAL diseases Meta-analysis
在线阅读 免费下载
上尿路尿路上皮癌术后膀胱复发危险因素分析
8
作者 任乾 曾蜀雄 +4 位作者 汤仕杰 戴利和 徐金山 孙颖浩 许传亮 《第二军医大学学报》 CSCD 北大核心 2018年第5期469-473,共5页
目的探讨上尿路尿路上皮癌(UTUC)手术治疗后膀胱复发的危险因素。方法收集2008年1月至2017年12月在我院行手术治疗且随访资料完整的445例UTUC患者病例资料。分析患者的基线数据、手术方法、术后病理结果、随访数据等资料,采用单因素... 目的探讨上尿路尿路上皮癌(UTUC)手术治疗后膀胱复发的危险因素。方法收集2008年1月至2017年12月在我院行手术治疗且随访资料完整的445例UTUC患者病例资料。分析患者的基线数据、手术方法、术后病理结果、随访数据等资料,采用单因素和多因素Cox回归模型分析与UTUC术后膀胱复发相关的危险因素。结果本研究纳入UTUC患者的术后中位随访时间为33.5个月,UTUC术后膀胱复发率为18.0%(80/445),其中66.2%(53/80)的患者膀胱初次复发发生于术后1年内。单因素Cox回归分析发现患者年龄≥65岁(OR=1.99,95%CI:1.22-3.22,P〈0.01)、有膀胱癌病史(OR=2.69,95%CI:1.71-4.24,P〈0.01)、行保留肾单位肿瘤局部切除术(OR=2.15,95%CI:1.30-3.57,P〈0.01)、输尿管下段肿瘤(OR=1.40,95%CI:1.11-1.78,P〈0.01)与UTUC术后膀胱复发密切相关。将上述危险因素纳入多因素Cox回归模型,发现其均为UTUC术后膀胱复发的独立危险因素。结论年龄≥65岁、有膀胱癌病史、行保留肾单位肿瘤局部切除术、输尿管下段肿瘤是UTUC术后膀胱复发的独立危险因素,存在上述危险因素的UTUC患者术后需加强随访监测,定期复查膀胱镜。 展开更多
关键词 上尿路 尿路上皮癌 复发 膀胱肿瘤 危险因素
上尿路尿路上皮癌术后预防性膀胱灌注化疗的临床意义 被引量:8
9
作者 吴肖冰 葛力源 +3 位作者 戴黎阳 云天纬 张古田 郭宏骞 《中华泌尿外科杂志》 CSCD 北大核心 2017年第4期286-289,共4页
目的探讨上尿路尿路上皮癌(upper tract urothelial carcinoma,UTUC)患者行肾输尿管全长切除术后预防性膀胱灌注化疗的临床意义。方法回顾性分析2010年1月至2016年1月收治的47例行肾输尿管全长切除术治疗的UTUC患者的临床资料。男25... 目的探讨上尿路尿路上皮癌(upper tract urothelial carcinoma,UTUC)患者行肾输尿管全长切除术后预防性膀胱灌注化疗的临床意义。方法回顾性分析2010年1月至2016年1月收治的47例行肾输尿管全长切除术治疗的UTUC患者的临床资料。男25例,女22例。年龄45~84岁,平均68岁。按是否行预防性膀胱灌注化疗将患者分为灌注组和未灌注组。灌注组32例,男14例,女18例;年龄45~84岁,平均70.3岁;肿瘤位于左侧20例,右侧12例。未灌注组15例,男11例,女4例;年龄47~79岁,平均65.0岁;肿瘤位于左侧10例,右侧5例。比较两组患者的年龄、性别、肿瘤侧别,差异均无统计学意义。对两组患者进行随访,比较两组的肿瘤分期、分级、复发率、无瘤生存时间。结果47例手术均顺利完成,5例行开放手术,42例行腹腔镜手术,其中经后腹腹腔镜33例,经腹腹腔镜9例(包括4例机器人手术)。47例术后病理均示尿路上皮癌。灌注组32例中,高级别23例,低级别9例;Ta~T1期15例,T1期8例,L期9例;肿瘤位于肾盂19例,输尿管12例,肾盂、输尿管1例;肿瘤直径(2.75±1.49)cm;多发8例,单发24例。未灌注组15例中,高级别12例,低级别3例;Ta~T1期6例,L期4例,L期5例;肿瘤位于肾盂11例,输尿管3例,肾盂、输尿管1例;肿瘤直径(3.11±1.48)cm;多发6例,单发9例。上述指标两组比较差异均无统计学意义(均P〉0.05)。灌注组6例(18.75%)复发,未灌注组7例(46.67%)复发,灌注组的膀胱癌复发率低于未灌注组(18.75%与46.67%,χ^2=3.978,P=0.046)。灌注组平均无瘤生存时间36.5个月,长于未灌注绀平均无瘤生存时间(29.6个月),但二者差异无统计学意义(t=1.079,P=0.286)。患者年龄、肿瘤分级与术后膀胱癌复发存在显著相关性,患者性别、肿瘤侧圳、肿 展开更多
关键词 尿路上皮癌 上尿路 膀胱癌 膀胱灌注化疗 复发
Antimicrobial Efficacy of Curcumin Formulations byPhotodynamic Therapy 预览
10
作者 Kate C. Blanco Natalia M. Inada +1 位作者 Fernanda M. Carbinatto Vanderlei S. Bagnato 《药剂与药理学:英文版》 2017年第8期506-511,共6页
URTI (upper respiratory tract infections) are caused by acute, chronic or recurrent infections including pharyngitis andtonsillitis. The etiologic agents involved are bacteria, virus, and fungi. The standard treatme... URTI (upper respiratory tract infections) are caused by acute, chronic or recurrent infections including pharyngitis andtonsillitis. The etiologic agents involved are bacteria, virus, and fungi. The standard treatment for bacterial infections is the use ofantibiotics. The antibiotic resistance, side effects of drugs and URTI complications indicate the importance of new therapies. PDT(photodynamic therapy) is a treatment option with a fast onset of action, low side effects, and easy administration of PS(photosensitizer) based on this study. The main aim of this study was to develop a new modality for the treatment of infectiouspharyngotonsillitis by photodynamic therapy. In addition, this study aims to evaluate components of the therapy as the PS, curcumin,in two formulations and irradiation conditions in the effectiveness of treatment. The procedure consists of two steps: oraladministration of CFs (curcumin formulations) containing a PS and illumination (450 nm and 0-60 J/cm2). Bacterial isolates wereobtained from patients in a routine clinical pratice. The new methodology has been developed from the principle ofPI (photodynamicinactivation). The strain identification number of colony forming units determined the efficacy of PI using each component, lightingand PS. The use of curcumin formulations in PI presented microbial reduction of 5 log. 展开更多
关键词 Upper respiratory tract infections pharyngitis tonsillitis curcumin photodynamic therapy clinical isolates syrup gum.
在线阅读 下载PDF
Contemporary management of upper tract urothelial cell carcinoma 预览
11
作者 Kellen Choi Ryan McCafferty Samuel Deem 《世界临床泌尿杂志》 2017年第1期1-9,共9页
Upper tract urothelial cell carcinoma(UTUCC),formerly known as transitional cell carcinoma of the upper urinary tract,is a rare oncologic disease in Western countries.Thus its disease process and its management are no... Upper tract urothelial cell carcinoma(UTUCC),formerly known as transitional cell carcinoma of the upper urinary tract,is a rare oncologic disease in Western countries.Thus its disease process and its management are not as well defined as other urologic cancers.We are reviewing the current evidence based literature available to develop a plan for the treatment of UTUCC.A PubMed search was completed using the key words“upper tract urothelial cell carcinoma”,“epidemiology”,“risk factor”,“treatment”and“prognosis”.Six hundred fifty two articles were found.We narrowed our search to articles published between January 2004 and June 2016 for a more contemporary review of the topic.Four hundred seventy articles were then available for review.Further detailed search was performed for relevance on the topic and hundred one articles were selected for the review.Many risk factors have been found to be associated with the development of UTUCC,including tobacco use.Patients are often asymptomatic and may only present with microscopic or gross hematuria.Tumor grade and stage are pivotal in determining the treatment options for UTUCC.Advancements in endoscopic techniques have aided in the diagnosis,grading and treatment of this disease.Treatment options include topical therapy,with combinations of methotrexate,vinblastine,doxorubicin and cisplatin or gemcitibine or cisplatin,endoscopic resection,segmental ureterectomy and ureteral implantation,and nephroureterectomy,including bladder cuff.Treatment recommendations depend on tumor grade and stage,renal function,tumor location and the patient’s prognosis.There are currently no tissue or blood-based biomarkers available to accurately monitor the disease.Further studies of gene expression and biomarkers may hopefully improve the management of this disease.Although rare in many countries,UTUCC is becoming more prevalent due to exposure to carcinogenic herbal remedies and other identifiable risk factors.Numerous treatment modalities,both surgical and chemotherapeut 展开更多
关键词 UROTHELIAL cell carcinoma Diagnosis UPPER TRACT EPIDEMIOLOGY Risk factors Treatment PROGNOSIS
在线阅读 免费下载
Upper tract urothelial carcinoma: Paradigm shift towards nephron sparing management 预览
12
作者 Julia V Fiuk Brad F Schwartz 《世界肾病学杂志:英文版》 2016年第2期158-165,共8页
关键词 下尿路 癌症 治疗方法 临床分析
在线阅读 免费下载
Acute lobar nephritis in children:Not so easy to recognize and manage 预览
13
作者 Cristina Bibalo Andrea Apicella +6 位作者 Veronica Guastalla Pierluigi Marzuillo Floriana Zennaro Carmela Tringali Andrea Taddio Claudio Germani Egidio Barbi 《世界临床儿科杂志》 2016年第1期136-142,共7页
Acute lobar nephritis(ALN)is a localized non-liquefactive inflammatory renal bacterial infection,which typically involves one or more lobes.ALN is considered to be a midpoint in the spectrum of upper urinary tract inf... Acute lobar nephritis(ALN)is a localized non-liquefactive inflammatory renal bacterial infection,which typically involves one or more lobes.ALN is considered to be a midpoint in the spectrum of upper urinary tract infection,a spectrum ranging from uncomplicated pyelonephritis to intrarenal abscess.This condition may be difficult to recognize due to the lack of specific symptoms and laboratory findings.Therefore the disease is probably underdiagnosed.Computed tomography scanning represents the diagnostic gold standard for ALN,but magnetic resonance imagine could be considered in order to limit irradiation.The diagnosis is relevant since initial intravenous antibiotic therapy and overall length of treatment should not be shorter than 3 wk.We review the literature and analyze the ALN clinical presentation starting from four cases with the aim to give to the clinicians the elements to suspect and recognize the ALN in children. 展开更多
关键词 ACUTE LOBAR NEPHRITIS CHILDREN Computed tomography Magnetic resonance IMAGINE Upper urinary tract infection
在线阅读 免费下载
Upper aerodigestive tract disorders and gastro-oesophageal reflux disease 预览
14
作者 Andrea Ciorba Chiara Bianchini +1 位作者 Michele Zuolo Carlo Vittorio Feo 《世界临床病例杂志》 2015年第2期102-111,共10页
A wide variety of symptoms and diseases of the upper aerodigestive tract are associated to gastro-oesophageal reflux disease(GORD).These disorders comprise a large variety of conditions such as asthma,chronic otitis m... A wide variety of symptoms and diseases of the upper aerodigestive tract are associated to gastro-oesophageal reflux disease(GORD).These disorders comprise a large variety of conditions such as asthma,chronic otitis media and sinusitis,chronic cough,and laryngeal disorders including paroxysmal laryngospasm.Laryngopharyngeal reflux disease is an extraoesophageal variant of GORD that can affect the larynx and pharynx.Despite numerous research efforts,the diagnosis of laryngopharyngeal reflux often remains elusive,unproven and controversial,and its treatment is then still empiric.Aim of this paper is to review the current literature on upper aerodigestive tract disorders in relation to pathologic gastro-oesophageal reflux,focusing in particular on the pathophysiology base and results of the surgical treatment of GORD. 展开更多
关键词 Clinical management Gastro-oesophageal REFLUX Extraoesophageal disease UPPER aerodigestive TRACT DISORDERS ETIOPATHOGENESIS Therapy
在线阅读 免费下载
荧光原位杂交技术在上尿路的尿路上皮癌诊断中的临床意义 被引量:1
15
作者 陈松 徐阿祥 +2 位作者 孙圣坤 杨淑霞 张旭 《微创泌尿外科杂志》 2014年第3期共5页
目的:分析荧光原位杂交技术(FIS H )诊断上尿路的尿路上皮癌的敏感性和特异性,进一步评估 FIS H 检测上尿路尿路上皮癌的临床意义.方法:回顾性分析144例临床疑似的上尿路尿路上皮癌病例 FIS H 检测结果,将各组 FIS H 检测结果与病理... 目的:分析荧光原位杂交技术(FIS H )诊断上尿路的尿路上皮癌的敏感性和特异性,进一步评估 FIS H 检测上尿路尿路上皮癌的临床意义.方法:回顾性分析144例临床疑似的上尿路尿路上皮癌病例 FIS H 检测结果,将各组 FIS H 检测结果与病理学结果进行对照比较,总结 FIS H 检测上尿路尿路上皮癌的敏感性和特异性.结果:病理诊断尿路上皮癌101例(肾盂癌49例、输尿管癌47例、肾盂合并输尿管癌5例)、尿路上皮良性病变33例,另有10例病理诊断为肾细胞癌.101例尿路上皮癌中,FIS H阳性55例、阴性46例;FIS H 敏感性为54??5%.33例良性病例中,阴性31例、FIS H 阳性2例,特异性为93??9%.FIS H 检测高级别上尿路尿路上皮癌敏感性为58??9%;低级别肿瘤敏感性28??6%;10例肾细胞癌中透明细胞癌8例,乳头状肾细胞癌2例,其中 FIS H 阳性4例、阴性6例.结论:FIS H对于检测上尿路的尿路上皮癌具有较高的敏感性和高度特异性,是临床诊断上尿路的尿路上皮癌的一种重要的无创检查手段. 展开更多
关键词 荧光原位杂交 尿路上皮癌 上尿路
Potential of metastin and metastin receptor as biomarkers for urological cancers 预览
16
作者 Sunao Shoji Haruhiro Sato +6 位作者 Tetsuro Tomonaga Hakushi Kim Shuichi Soeda Mayura Nakano Toyoaki Uchida Toshiro Terachi Koichi Takeya 《世界临床泌尿杂志》 2013年第2期10-14,共5页
AIM:To investigate the current state of the research of metastin and metastin receptor in the urological cancer field.METHODS:For analyzing the value of metastin and metastin receptor as molecular biomarkers for the p... AIM:To investigate the current state of the research of metastin and metastin receptor in the urological cancer field.METHODS:For analyzing the value of metastin and metastin receptor as molecular biomarkers for the patients with urological cancer,MEDLINE database searches were performed using these terms:metastin,KISS1,kisspeptin,renal(cell)carcinoma(RCC),kidney cancer or urothelial cancer or bladder cancer or prostate cancer or testicular cancer(tumor).Since the articles were evaluated by the validity of the articles based on plausibility,credibility,and evidence levels,the articles were graded according to their level of evidence,using the grading system defined by the Oxford Centre for Evidence-based Medicine.RESULTS:A total of six clinical studies published by individual institutions between 2003 and 2013 were included in this review.The article numbers for each of the evidence levels 2a and 2b were three(50%)and three(50%),respectively.Immunohistochemistry and reverse transcriptase-polymerase chain reaction using tumor tissues were performed to analyze in five articles(83%)and in one article(17%).The value of metastin and/or metastin receptor as molecular biomarkers in clear cell RCC,upper tract urothelial carcinoma,and bladder cancer was evaluated by multivariate analysis.Low expression of metastin receptor in clear cell RCC and low expression of metastin in upper tract urothelial carcinoma were significant risk factors for metastasis,and low metastin expression was an independent prognostic factor in bladder cancer.CONCLUSION:Metastin and metastin receptor have potential as suitable molecular biomarkers for urological cancers.However,future studies of metastin and metastin receptor should undergo external validation to ensure consistency across different patient series,since individual institutional studies lack generalization. 展开更多
关键词 KISS-1 METASTIN METASTIN RECEPTOR Metastasis Renal cell CARCINOMA Upper tract UROTHELIAL CARCINOMA BLADDER cancer
在线阅读 免费下载
内蒙古东部陆西凹陷中北部上侏罗统层序地层格架及体系域特征分析 预览 被引量:12
17
作者 朱筱敏 王贵文 +2 位作者 马立驰 张巨星 孙月平 《古地理学报》 CAS CSCD 2002年第3期 33-39,共7页
对内蒙古东部开鲁盆地陆西凹陷地质和地球物理资料的综合研究表明,上侏罗统沉积以温湿气候条件下的粉、细砂岩及泥岩为特征,其沉积序列可以被划分成周期为3-5 Ma的5个沉积层序,各沉积层序之间均为不整合面或与之相关的整合面.沉积层序... 对内蒙古东部开鲁盆地陆西凹陷地质和地球物理资料的综合研究表明,上侏罗统沉积以温湿气候条件下的粉、细砂岩及泥岩为特征,其沉积序列可以被划分成周期为3-5 Ma的5个沉积层序,各沉积层序之间均为不整合面或与之相关的整合面.沉积层序格架和构型主要受控于构造活动、气候和物源供给.各沉积层序的展布也受盆地结构和断裂差异活动的影响,表现出南厚北薄的地层展布特征.由于在马北斜坡存在地形或断裂坡折带,故可将一个沉积层序细分成低位、湖侵和高位体系域.在明确首次和最大湖泛面基本特征的基础上,重点叙述了层序B的低位、湖侵和高位体系域的近岸水下扇、扇三角洲等沉积体系特征和层序构型主控因素.对有利烃源岩、储层和盖层等成藏基本条件进行分析后,指出靠西绍根断层下降盘的层序C的近岸水下扇和位于坡折带之下的浊积扇是寻找岩性圈闭的有利地区. 展开更多
关键词 内蒙古 开鲁盆地 上侏罗统 层序地层格架 体系域 构造活动
在线阅读 下载PDF
小儿腹膜炎的细菌学调查和抗生素应用
18
作者 金百祥 周以明 《中华小儿外科杂志》 1986年第3期144-146,共3页
小儿腹膜炎是非常重笃的疾患,尤其是新生儿消化道穿孔引起的弥漫性腹膜炎.查明引起腹膜炎的细菌,选择最合适的抗生素是极为重要.
关键词 小儿 腹膜炎 细菌学调查 抗生素应用 CHILDREN upper gastrointestinal tract combination especially positive negative mixed infection GRAM 消化道穿孔 effective CHILDREN 新生儿 弥漫性 survey paper data
上尿路结石合并上尿路上皮癌的临床特征和漏诊原因分析 预览
19
作者 赵志易 谷安娜 +3 位作者 蔡星建 朱武安 张湜 张慕淳 《世界最新医学信息文摘(电子版)》 2019年第3期11-12,共2页
目的探讨上尿路结石合并尿路上皮癌的临床特征和漏诊原因,以减少此类疾病的漏诊误诊。方法回顾性分析上尿路结石合并尿路上皮癌4例,伴腺性分化1例,术前行超声造影、静脉尿路造影(IVU)、CT及荧光原位杂交(FISH)等手段辅助诊断。结果 2例... 目的探讨上尿路结石合并尿路上皮癌的临床特征和漏诊原因,以减少此类疾病的漏诊误诊。方法回顾性分析上尿路结石合并尿路上皮癌4例,伴腺性分化1例,术前行超声造影、静脉尿路造影(IVU)、CT及荧光原位杂交(FISH)等手段辅助诊断。结果 2例获术前诊断后行肾-输尿管切除术,1例PCNL术中见可疑病变,快速病理证实后行肾-输尿管切除术,1例行肾切除术后病理证实肾盂输尿管尿路上皮癌,未进一步治疗;此4例获3~18个月随访,1例因肿瘤远处转移死亡,余3例存活。结论上尿路结石继发肾重度积水、肾功能减退及组织坏死等危险因素时,需警惕其合并恶性肿瘤的可能,超声造影可提高诊断本病的准确率,早期诊断是延长生存期的关键,必要时应积极手术探查并送快速病理,避免延误最佳治疗时机。 展开更多
关键词 上尿路结石 上尿路尿路上皮癌 超声造影 肾结石
在线阅读 下载PDF
尿源性脓毒症的研究进展 预览
20
作者 梁霞 邹望远 《中南大学学报:医学版》 CAS CSCD 北大核心 2019年第4期455-460,共6页
尿源性脓毒症是指由于泌尿系统或者男性生殖器官的感染引起的脓毒症。近年来随着腔镜泌尿外科的发展,尿源性脓毒症的发病率和相关死亡人数逐年上升。作为泌尿外科风险最大、预后最差的并发症之一,尿源性脓毒症病情进展迅速,如对其未能... 尿源性脓毒症是指由于泌尿系统或者男性生殖器官的感染引起的脓毒症。近年来随着腔镜泌尿外科的发展,尿源性脓毒症的发病率和相关死亡人数逐年上升。作为泌尿外科风险最大、预后最差的并发症之一,尿源性脓毒症病情进展迅速,如对其未能早期诊断并及时正确处理,易迅速进展为脓毒症休克,危及患者生命。因此,早期识别及正确诊治尿源性脓毒症对降低相关病死率和改善预后具有重要意义。尿源性脓毒症的治疗关键在于早期液体复苏、早期使用抗生素及控制和消除易感因素,其围手术期处理需要外科,ICU,感染科及麻醉科医生之间的多学科协作及共同管理。本文就尿源性脓毒症的诊断标准及流行病学、病因及发病机制、危险因素和围手术期处理等相关研究进展作一综述。 展开更多
关键词 尿源性脓毒症 上尿路结石 尿路感染
在线阅读 下载PDF
上一页 1 2 129 下一页 到第
使用帮助 返回顶部 意见反馈