期刊文献+

薄膜水化法制备辅酶Q10脂质体 认领 被引量:5

Preparation of coenzyme Q10 liposomes by thin-film rehydration method
在线阅读 免费下载
收藏 分享 导出
摘要 辅酶Q10是一种人体内不可缺少的参与代谢的营养物.由于其是脂溶性的,生物利用率很低。文中以卵磷脂为主要壁材,采用薄膜水化法制得稳定性较好的辅酶Q10脂质体,可以改善其水溶性,提高生物利用率。研究了胆固醇、聚乙二醇(PEG)、水化温度和pH对脂质体包封辅酶Q10效果的影响。贮藏试验表明:较佳的贮藏条件为4℃避光,脂质体双分子层对辅酶Q10有明显的保护作用,而且辅酶Q10也有效抑制了磷脂的氧化,并能稳定脂质体双分子层。 Coenzyme Q10 (CoQ10) is a kind of indispensable nutriment for life. Because of the solubility, its bioavailability was limited. In order to improve the bioavailabifity of CoQao, thin-film rehydration method was selected to prepare stable CoQ10 liposomes, with lecithin as its primary wall materials. In this study, the effect of cholesterol, polyethylene glycol (PEG), pH value and temperature of rehydration on the encapsulation qualities were studied. The optimal storage condition was light-avoiding at 4 ~C. During the storage, liposomal bilayer provided evident protection effect for CoQ10. It is also seen that lecithin oxidation was inhibited and the stability of bilayer structure was improved by CoO10.
作者 朱斌 许时婴 夏书芹 ZHU Bin ,XU Shi-ying, XIA Shu-qin( School of Food Science and Technology, Southern Yangtze University, Wuxi, Jiangsu 214036, China)
出处 《食品与机械》 CSCD 北大核心 2006年第6期 39-41,79,共4页 Food and Machinery
关键词 辅酶Q10 脂质体 聚乙二醇 丙二醛 Coenzyme Liposomes PEG Malondialdehyde ( MDA )
  • 相关文献

参考文献9

  • 1Palamakula A, Khan M A. Evaluation of cytotoxicity of oils used in coenzyme Q 10 Self-Emulsifying Drug Delivery Systems (SEDDS) [ J ].International Journal of Pharmaceutics, 2004 (273) :63 - 73. 被引量:1
  • 2夏书芹,许时婴.辅酶Q10纳米脂质体稳定性的研究[J].食品与发酵工业,2006,32(2):28-32. 被引量:12
  • 3Keller B C. Liposomes in nutrition [ J ].Trends in Food Science & Technology, 2001 (12) :25 -31. 被引量:1
  • 4Matthew J. Hasik, Dennis H. Kim, Laurens E. Howle, David Needham, Donald P. Prush. Evaluation of synthetic phospholipids ultrasound contrast agents[ J ]. Ultrasound, 2002 (40) :973 - 982. 被引量:1
  • 5张路,简江波,袁媛,杨柏灿,刘昌胜.纳米马钱子碱脂质体制备工艺研究[J].中成药,2005,27(6):632-637. 被引量:22
  • 6丁劲松,杨敏,陈琼.聚乙二醇衍生化磷脂与脂质体立体稳定性[J].中国医药工业杂志,2004,35(1):55-58. 被引量:4
  • 7Needham D, Mclntosh TJ, Lasic DD. Repulsive interactions and mechanical stability of polymer-grafted lipid membranes [ J ]. Biochim Biophys Acts, 1992,1108 ( 1 ):40 - 48. 被引量:1
  • 8Woodle MC, Lasic DD. Sterically stabilized liposomes[ J]. Biochim Biophys Acta, 1992, 1113(2) :171 -199. 被引量:1
  • 9Blume G, Cevc G. Molecular mechanism of the lipid vesicle longevity in vivo[J]. Biochim Biophys Acta, 1993, 1146 (2) : 157 - 168. 被引量:1

二级参考文献25

  • 1夏书芹,许时婴.吐温80增溶-紫外分光光度法测定辅酶Q_(10)脂质体的载量及包封率[J].食品与发酵工业,2005,31(10):131-135. 被引量:11
  • 2侯新朴,张俊梅,鲁先道.PEG修饰脂膜对延长脂质体在血内循环时间的研究[J].药学学报,1996,31(6):451-454. 被引量:7
  • 3周之鸿 徐宁宁 等.脂质体中磷脂的含磷量测定[J].药学通报,1987,2:77-77. 被引量:5
  • 4翁帼英 陈明非.脂质体中卵磷脂的氧化产物与溶血的关系[J].生物化学与生物物理进展,1990,17(1):76-76. 被引量:9
  • 5Yokoyama S, Takeda T, Abe M. Preparation of ganglioside Gm3 liposomes and their membrane properties [ J ]. Colloids and Surfaces B: Biointerfaces Volume,2003,27(2) : 181-187. 被引量:1
  • 6Dimitrios G Fatouros, Sophia G Antimisiaris. Effect of Amiphiphilic Drugs on the Stability and Zeta-potential of Their Liposome Formulation : A Study with Prednisolone, Diazepam, and Griseofulvin [ J ]. Colloid Interface Sci,2002,251:271-277. 被引量:1
  • 7Fresta, Massimo, Puqlisi, Giovanni. Corticosteroid dermal delivery with skin-lipid liposomes [ J ]. Controlled Released, 1997,44 : 141-151. 被引量:1
  • 8Shalaev EY, Kang AV. Study of the solid-liquid slate diagram of the water-glycine-sucrose systerm [ J ]. Cryobiology, 1994,31 ( 4 ) : 374-382. 被引量:1
  • 9Sivakumar, P. A, Panduranga Rao, K. The use of cholesteryl pullulan for the preparation of stable vincristine liposome[ J ]. Carbohydrate Polymers ,2003,51 (3) : 327-332. 被引量:1
  • 10Jonzthan S.Co-enzyme Q10 Dietary Supplement[P].United States Patent:6652891,2003-9-25 被引量:1

共引文献35

同被引文献63

引证文献5

二级引证文献30

维普数据出版直通车
今日学术
投稿分析
职称考试

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部 意见反馈