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Livin蛋白在髓母细胞瘤中的表达及临床意义 认领 被引量:4

The expression and clinical significance of Livin protein in medulloblastoma
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摘要 目的观察Livin蛋白在髓母细胞瘤中的表达,并探讨Livin蛋白的表达与髓母细胞瘤临床预后的关系。方法应用免疫组化二步法检测45例髓母细胞瘤及10例正常小脑组织中Livin蛋白的表达,并用相关统计学方法进行分析。结果 45例髓母细胞瘤中Livin蛋白阳性表达率82.2%,Livin蛋白的表达强度与肿瘤大小差异显著,Livin蛋白阳性患者的预后明显差于Livin蛋白阴性患者,COX回归分析提示Livin蛋白的表达、肿瘤切除程度,术后的治疗是髓母细胞瘤患者预后的独立风险因素。结论 (1)Livin蛋白参与了髓母细胞瘤细胞凋亡的调控。(2)Livin蛋白的表达与髓母细胞瘤临床预后呈负相关。 Objective To observe the expression of Livin protein in medulloblastoma,and to investigate the relationship between the expression of Livin protein and the prognosis of medulloblastoma.Methods We used the two step immunohistochemistry to examine the expression situation of Livin protein in 45 samples of medulloblastomas as well as 10 samples of normal cerebellum's tissues and analyzed the data by corresponding statistical methods.Results Among 45 cases of medulloblastoma,Livin protein expression rate was 82.2%,and the expression intensity of Livin protein was significantly different from the effect of tumor's size,the prognosis of the positive expression group of Livin protein was greatly worse than the negative expression group.COX regression analysis showed that the expression of Livin,the degree of tumor resection and postoperative treatment were the independent risk foctors of prognosis in medulloblastoma patiets.Conclusion(1)Livin protein was involved in the regulation of cell apoptosis of medulloblastoma.(2) The correlation of the expression of Livin protein was negative with the prognosis of medulloblastoma.
作者 周利军 况建国 Zhou Lijun Kuang Jianguo.2008 grade of medical department of graduate school,Nanchang,330006,China
出处 《江西医药》 CAS 2011年第2期 117-119,共3页 Jiangxi Medical Journal
关键词 髓母细胞瘤 LIVIN 免疫组织化学 预后 medulloblastoma Livin immunohistochemistry prognosis
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参考文献8

  • 1Hong Chang, Aaron D,Schimmer. Livin/melanoma inhibitor of apoptosis protein as a potential therapeutic target for the treatment of malignancy. Mol Cancer Ther, 2007,6(1):24. 被引量:1
  • 2Wagener N,Cmkovic-Mertens I,Vetter C,et al.Expression of inhibitor of apoptosis protein Livin in renal cell carcinoma and non-tumorous adult kidney.Br J Cancer,2007,97(9) : 1271. 被引量:1
  • 3Choi J,Hwang YK,Sung KW,et al. Expression of Livin,an antiapoptotic protein,is an independent favorable prognosis factor in childhood acute lymphoblastic leukemia. Blood, 2007,109(2),471. 被引量:1
  • 4Yi Zhao,Xin Deng,Qiang Wang. Expression and clinical significance of apoptsis associated gene Livin and Smac/DIABLO in human gastric carcinomas.Chinese Journal of Cancer,2009,28(6):1. 被引量:1
  • 5杨辛治,袁贤瑞,史帅涛.Livin蛋白在脑胶质瘤组织中的表达与预后的关系[J].国际神经病学神经外科学杂志,2007,34(6):497-499. 被引量:3
  • 6Wrensch M,Minn Y,Chew T,et al.Epidemiology of primary brain tumors:current concepts and review of the literature,Neuro-Oncology,2002,4(4):278. 被引量:1
  • 7Kim DK,Alvarado CS,Abramowsky CR,et al.Expression of inhibitorof-apoptosis protein (IAP) Livin by neuroblastoma cells:correlation with prognosis factors and outcome .Pediatr Dev Pathol,2005,8(6): 621. 被引量:1
  • 8Kempkensteffen C,Hinz S,Christoph F,et al.Expression of the apoptosis inhibitor Livin in renal cell carcinomas:correlations with pathology and outcome. Tumor Biol,2007, 28:132. 被引量:1

二级参考文献6

  • 1Kasof GM, Gomes BC. Livin, a novel inhibitor of apoptosis protein family member. J Biol Chem, 2001, 276: 3238-3246. 被引量:1
  • 2Ka H, Joan S, Hunt Js. Temporal and spatial patterns of expression of inhibitors of apoptosis in human placentas. Am J Pathol, 2003, 163(2) : 413-422. 被引量:1
  • 3Vucic D, Deshayes K, Acherlyh H, et al. SMAC negatively regulates the antiap- optotic activity of melanoma inhibitor of apoptosis (ML-IAP). J Biol Chem, 2002, 277( 14): 12275-12279. 被引量:1
  • 4Dias N, Stein CA. Potential roles of antisense oligonucleotides in cancer therapy. Eur J Phamaceutics, 2002 , 54 ( 3 ) : 263-269. 被引量:1
  • 5Hariu H, Hirohashi Y, Torigoe T, et al. Aberrant expression and potency as a cancer immunotherapy target of inhibitor of apoptosis protein family, Livin/ML -lAP in lung cancer. Clin Cancer Res, 2005, 11(3) :1000-1009. 被引量:1
  • 6Kah FG, Hunt JS, Temporal and spatial patterns of expression of inhibitors of apoptosis in human placentas. Am J Pathol, 2003, 163(2) : 413-422. 被引量:1

共引文献2

同被引文献24

  • 1Li F,Yin X,Luo X,et al.Livin promotes progression of breast canc-er through induction of epithelial-mesenchymal transition and activa-tion of AKT signaling[J].Cell Signal,2013,25(6):1413-1422. 被引量:1
  • 2Cazzaniga P,Gradilone A,Giulianil L,et al.Expression and prog-nostic significance of Livin,Survivin and other apoptosis-relatedgenes in the progression of superficial bladder cancer[J].AnnalsOncol,2003,14(1):85-90. 被引量:1
  • 3Xi RC,Biao WS,Gang ZZ.Significant elevation of survivin andlivin expression in human colorectal cancer:inversecorrelation be-tween expression and overall survival[J].Onkologie,2011,34(8/9):428-432. 被引量:1
  • 4Wang L,Zhang Q,Liu B. Chal enge and promise:roles for Livin in progression and therapy of cancer[J].Molecular Cancer Therapeutics,2008,(12):3661-3669. 被引量:1
  • 5Gazzaniga P,Gradilone A,Giuliani L. Expression and prog nostic significance of livin,survivin and other apoptosis-related genes in the progression of superficial bladder cancer[J].Ann On col,2003,(01):85-90. 被引量:1
  • 6Xi RC,Biao WS,Gang ZZ. Significant elevation of survivin and liv in expression in human colorectal cancer:inversecorrelation be tween expression and overal survival[J].Onkologie,2011,(8-9):428-432. 被引量:1
  • 7Dai CH,Li J,Shi SB. Survivin and Smac gene expressions but not livin are predictors of prognosis in non-smal cel lung cancer patients treated with adjuvant chemotherapy fol owing surgery[J].Japanese Journal of Clinical Oncology,2010,(04):327-335. 被引量:1
  • 8Xiang Y,Yao H,Wang S. Prognostic value of Survivin and Livin in nasopharyngeal carcinoma[J].Laryngoscope,2006,(01):126-130. 被引量:1
  • 9Choi J,Hwang YK,Sung KW. Expression of Livin,an anti apoptotic protein,is an independent favorable prognostic factor in childhood acute lymphoblastic leukemia[J].Blood,2007,(02):471-477. 被引量:1
  • 10郭慧琳,张幸平.166例乳腺癌患者临床病理学特征及其与预后的关系[J].重庆医科大学学报,2008,33(4):486-489. 被引量:12

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