期刊文献+

弥漫性大B细胞淋巴瘤组织NF-κB/p65、Bcl-2和Bax表达及意义 认领 被引量:7

Expression and significance of nuclear factor κB/p65,Bcl-2 and Bax in diffuse large B-cell lymphoma
在线阅读 免费下载
收藏 分享 导出
摘要 目的探讨弥漫性大B细胞淋巴瘤(diffuse large B cell lymphoma,DLBCL)组织核转录因子κB(nuclear factor-kappa B,NF-κB)/p65、Bcl-2和Bax蛋白表达及其对临床B症状、国际预后指数(international prognostic index,IPI)得分、临床分期等病理特征和预后的影响。方法组织标本来自于2012年3月至2015年2月我院接受手术治疗的78例DLBCL患者和30例反应增生性淋巴结患者,采用免疫组化方法比较DLBCL患者和反应增生性淋巴结患者淋巴组织NF-κB/p65、Bcl-2和Bax蛋白表达情况,分析它们与病理参数、生存期的关系。结果 DLBCL组织中,NF-κB/p65和Bcl-2阳性率分别为39.74%和51.28%,显著高于反应增生性淋巴结组织(P<0.05),Bax阳性率为32.05%,显著低于反应增生性淋巴结组织(P<0.05);DLBCL组织NF-κB/p65阳性表达与B症状、IPI得分、临床分期有关(P<0.05),Bcl-2阳性表达与IPI得分、临床分期有关(P<0.05),Bax阳性表达与临床分期有关(P<0.05);NF-κB/p65与Bcl-2呈正相关(r=0.53,P<0.05),NF-κB/p65与Bax呈负相关(r=-0.51,P<0.05),Bcl-2与Bax呈负相关(r=-0.62,P<0.05);NF-κB/p65、Bcl-2阳性表达者生存期较短,Bax阳性表达者生存期较长。结论DLBCL组织中NF-κB/p65、Bcl-2高表达,Bax低表达,有助于DLBCL预后评估。 Objective To investigate the expression of NF-κB/p65,Bcl-2 and Bax in diffuse large B cell lymphoma(DLBCL)and the effect on pathological characteristics such as clinical B symptoms,international prognostic index(IPI)scores,clinical stage and prognosis. Methods Tissue samples were obtained from 78 patients with DLBCL and 30 patients with reactive proliferative lymph nodes who underwent surgery from March 2012 to February 2015. Immunohistochemical methods were used to compare lymphoid tissue NF-κB/p65,Bcl-2 and Bax protein expression in patients with DLBCL or reactive proliferative lymph nodes,their relationship with pathological parameters and survival time was analyzed. Results The positive rates of NF-κB/p65 and Bcl-2 in DLBCL tissues were 39.74% and 51.28%,respectively,significantly higher than those in the proliferative lymph node tissues(P<0.05). The positive rate of Bax was 32.05%,significantly lower than that in the reaction hyperplasia lymph node tissue(P<0.05). NB-κB/p65 positive expression in DLBCL was associated with B symptoms,IPI score and clinical stage(P<0.05),Bcl-2 positive expression was associated with IPI score and clinical stage(P<0.05),the positive expression of Bax was associated with clinical stage(P<0.05). NF-κB/p65 was positively correlated with Bcl-2(r = 0.53,P<0.05),NF-κB/p65 was negatively correlated with Bax(r =-0.51,P<0.05),Bcl-2 was negatively correlated with Bax(r =-0.62,P<0.05). The patients with NF-κB/p65,Bcl-2 positive expression had shorter survival time,and patients with Bax positive expression had longer survival time. Conclusion The high expression of NF-κB/p65,Bcl-2 and low expression of Bax in DLBCL tissues contribute to the prognosis evaluation of DLBCL.
作者 王静 李馨筱 吴琳娜 刘凡 WANG Jing;LI Xinxiao;WU Linna;LIU Fan(Department of Health Management,West China Hospital of Sichuan University,Chengdu,Sichuan,China,610041)
出处 《分子诊断与治疗杂志》 2019年第1期33-38,共6页 JOURNAL OF MOLECULAR DIAGNOSTICS AND THERAPY
基金 四川省科技厅支撑计划项目(2010SZ0170)。
关键词 DLBCL NF-ΚB/P65 BCL-2 BAX 生存分析 DLBCL NF-κB/p65 Bcl-2 Bax Survival analysis
  • 相关文献

参考文献14

二级参考文献138

共引文献108

同被引文献38

引证文献7

二级引证文献1

维普数据出版直通车
今日学术
投稿分析
职称考试

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部 意见反馈