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The effects of borneol on the pharmacokinetics and brain distribution of tanshinone IIA,salvianolic acid B and ginsenoside Rg1 in Fufang Danshen preparation in rats 认领
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作者 ZHANG Jie LIU Sheng-Lan +4 位作者 WANG Hui SHI Li-Ying LI Jin-Ping JIA Lu-Juan XIE Bao-Ping 《中国天然药物:英文版》 SCIE CAS CSCD 2021年第2期153-160,共8页
Fufang Danshen preparation(FDP)is consisted of Salviae Miltiorrhizar Radix et Rhizoma(Danshen),Notoginseng Radix et Rhizoma(Sanqi)and Borneolum Syntheticum(borneol).FDP is usually used to treat myocardial ischemia hyp... Fufang Danshen preparation(FDP)is consisted of Salviae Miltiorrhizar Radix et Rhizoma(Danshen),Notoginseng Radix et Rhizoma(Sanqi)and Borneolum Syntheticum(borneol).FDP is usually used to treat myocardial ischemia hypoxia,cerebral ischemia and alzheimer’s disease,etc.In the treatment of cerebrovascular diseases,borneol is usually used to promote the absorption and distribution of the bioactive components to proper organs,especially to the brain.The purpose of this study is investigating the effects of borneol on the pharmacokinetics and brain distribution of tanshinone IIA(TS IIA),salvianolic acid B(SAB)and ginsenoside Rg1 in FDP.Male healthy Sprague-Dawley(SD)rats were given Danshen extracts,Sanqi extracts(Panax notoginseng saponins)or simultaneously administered Danshen extracts,Sanqi extracts and borneol.Plasma and brain samples were collected at different points in time.The concentration of TS IIA,SAB and Rg1 was determined by UPLC-MS/MS method.The main pharmacokinetics parameters of plasma and brain tissue were calculated by using Phoenix WinNolin 6.1 software.In comparison with Danshen and Sanqi alone,there were significant differences in pharmacokinetic parameters of TS IIA,SAB and Rg1,and the brain distribution of SAB and TS IIA when Danshen,Sanqi and borneol were administrated together.Borneol statistically significant shortened tmax of TS IIA,SAB and Rg1 in plasma and brain,increased the bioavaiability of Rg1,inhibited metabolism of Rg1 and enhanced the transport of TS IIA and SAB to brain.These results indicated that borneol could affect the multiple targets components and produce synergistic effects.Through accelerating the intestinal absorption and brain distribution,borneol caused the effective ingredients of Danshen and Sanqi to play a quicker therapeutic role and improved the therapeutic effect. 展开更多
关键词 BORNEOL Fufang Danshen preparation Tanshinone IIA Salvianolic acid B Ginsenoside Rg1 PHARMACOKINETICS
Developmental Dysplasia of the Hip: Management of Graf IIa Dysplastic Hip 认领
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作者 Ali Ahmed Raba Qais Gasibat 《儿科学期刊(英文)》 2020年第2期247-254,共8页
Developmental Dysplasia of the Hip (DDH) describes a wide range of anatomic abnormalities of the growing hips which might result in permanent abnormal gait. Therefore, early detection and management is crucial to impr... Developmental Dysplasia of the Hip (DDH) describes a wide range of anatomic abnormalities of the growing hips which might result in permanent abnormal gait. Therefore, early detection and management is crucial to improve the outcome and minimise the risk of osteoarthritis in later life. Hip ultrasound is used to evaluate DDH based on Graf classification. Graf score is a widely used ultrasound grading score to evaluate DDH in infants. There is conflicting evidence regarding the management of the developmentally immature Graf type IIa hip. Some physicians adopt watchful waiting for natural maturation of hips while other early treatment. This article will provide an evidence-based review on the management modalities of the Graf type IIa hip. 展开更多
关键词 Developmental Dysplasia of the Hip DDH Graf IIa
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丹参酮IIA对小鼠主动脉粥样硬化斑块形成的影响及机制研究 认领
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作者 孙维梁 郭静 +1 位作者 张雨婷 高艳香 《中国体视学与图像分析》 2020年第1期10-17,共8页
目的观察丹参酮ⅡA对高脂饲养Apo E-/-小鼠主动脉粥样硬化斑块形成的影响及其机制。方法将36只8周龄雄性Apo E-/-小鼠和C57BL/6小鼠分为3组:对照组(C57BL/6小鼠予羧甲基纤维素钠灌胃)、模型组(Apo E-/-小鼠予羧甲基纤维素钠灌胃)、模型... 目的观察丹参酮ⅡA对高脂饲养Apo E-/-小鼠主动脉粥样硬化斑块形成的影响及其机制。方法将36只8周龄雄性Apo E-/-小鼠和C57BL/6小鼠分为3组:对照组(C57BL/6小鼠予羧甲基纤维素钠灌胃)、模型组(Apo E-/-小鼠予羧甲基纤维素钠灌胃)、模型+丹参酮ⅡA组(Apo E-/-小鼠予30 mg/kg丹参酮ⅡA灌胃),每组12只。各组均给予高脂饲料喂养26周,取材前6周开始给予丹参酮ⅡA/羧甲基纤维素钠灌胃1次/天,连续42天。取材收集主动脉血管流出道组织,一半进行石蜡包埋切片,HE染色评估主动脉狭窄程度,Movat染色评估斑块进展,免疫组织化学染色检测a-SMA、OPN、PCNA和p-YAP表达并进行定量分析;另一半组织经实时定量PCR检测血管平滑肌细胞标志分子a-SMA和OPN的表达改变。结果与对照组相比,模型组出现明显的动脉粥样硬化斑块,血管中膜SMA蛋白表达减少,血管内膜OPN蛋白表达增加,血管全层SMA mRNA表达减少、OPN mRNA表达增加,血管内膜PCNA及p-YAP蛋白表达增加;与模型组相比,模型+丹参酮ⅡA组主动脉狭窄百分比降低,血管内膜SMA蛋白表达增加、OPN蛋白表达减少,血管全层OPN mRNA表达减少,血管中膜PCNA蛋白、内膜PCNA及p-YAP蛋白表达减少。结论丹参酮ⅡA通过抑制血管平滑肌细胞表型转化,减轻高脂饲养Apo E-/-小鼠主动脉粥样硬化斑块的形成,在此过程中丹参酮ⅡA可能通过抑制PCNA及p-YAP表达而发挥心血管保护作用。 展开更多
关键词 动脉粥样硬化 丹参酮 IIA 小鼠 血管平滑肌 表型转化
Growth characteristics of type IIa large single crystal diamond with Ti/Cu as nitrogen getter in FeNi–C system 认领 被引量:1
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作者 郭明明 李尚升 +5 位作者 胡美华 宿太超 王君卓 高广进 尤悦 聂媛 《中国物理B:英文版》 SCIE EI CAS CSCD 2020年第1期457-462,共6页
High-quality type IIa large diamond crystals are synthesized with Ti/Cu as nitrogen getter doped in an FeNi–C system at temperature ranging from 1230℃to 1380℃and at pressure 5.3–5.9 GPa by temperature gradient met... High-quality type IIa large diamond crystals are synthesized with Ti/Cu as nitrogen getter doped in an FeNi–C system at temperature ranging from 1230℃to 1380℃and at pressure 5.3–5.9 GPa by temperature gradient method.Different ratios of Ti/Cu are added to the Fe Ni–C system to investigate the best ratio for high-quality type IIa diamond.Then,the different content of nitrogen getter Ti/Cu(Ti:Cu=4:3)is added to this synthesis system to explore the effect on diamond growth.The macro and micro morphologies of synthesized diamonds with Ti/Cu added,whose nitrogen concentration is determined by Fourier transform infrared(FTIR),are analyzed by optical microscopy(OM)and scanning electron microscopy(SEM),respectively.It is found that the inclusions in the obtained crystals are minimal when the Ti/Cu ratio is 4:3.Furthermore,the temperature interval for diamond growth becomes narrower when using Ti as the nitrogen getter.Moreover,the lower edge of the synthesis temperature of type IIa diamond is 25℃higher than that of type Ib diamond.With the increase of the content of Ti/Cu(Ti:Cu=4:3),the color of the synthesized crystals changes from yellow and light yellow to colorless.When the Ti/Cu content is 1.7 wt%,the nitrogen concentration of the crystal is less than 1 ppm.The SEM results show that the synthesized crystals are mainly composed by(111)and(100)surfaces,including(311)surface,when the nitrogen getter is added into the synthesis system.At the same time,there are triangular pits and dendritic growth stripes on the crystal surface.This work will contribute to the further research and development of high-quality type IIa diamond. 展开更多
关键词 HIGH TEMPERATURE and HIGH pressure TEMPERATURE gradient method type IIA diamond
Development of Mining Sector of Mongolia:Investor-State Arbitration and International Investment Agreement Clause Dilemma 认领
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作者 Munkhselenge Purevdorj 《美中公共管理:英文版》 2020年第5期221-228,共8页
The research constitutes the host state’s right and investor’s right towards investment disputes,and legal protection for the host state in case of investment dispute.Although investment arbitration deals with cases... The research constitutes the host state’s right and investor’s right towards investment disputes,and legal protection for the host state in case of investment dispute.Although investment arbitration deals with cases mostly on infringement of investor’s rights,the host state’s right is mainly silent on bilateral agreements and other investment agreements.International Investment Agreements(IIAs)are concluded between states.Only states give consent to arbitration in IIA.International arbitration is a voluntary and consent-based method of settling disputes.It can be referred from the present investment agreement that offers and consent provisions are legislated not sufficiently in the investment agreement for the protection of the host state and investor.There exists no prevention and monitoring instrument,or clause in the investment agreement that prevents investor’s“taking advantage”of consent to filing to arbitration.Taking advantage can be defined as exploit or make unfair use of one’s own benefit.This also refers to example of disputes for the host states,which lack of international dispute experiences.The host states,which lack of international dispute experiences,are count to be developing countries,where natural resource and mining are a dominating sector.Mongolian mining disputes are counted to be around 10 in numbers since 2006.Comparing to average yearly number of investor-state dispute settlement(ISDS)cases,the number of cases arouse against Mongolian government is considered to be superior in quantities,and abstract in sequence of period of timing.Convention and Rules on Transparency are still silent on investment agreement infringements on offer and consent provisions.Thus,investment agreements and Bilateral Investment Treaties(BITs)should include clauses on offer and consent provisions of the host state and investor relations on investment dispute in order to protect both rights of the host state and investor,and prevent further infringements in the dispute process. 展开更多
关键词 investor-state arbitration IIA foreign direct investment MINING Mongolia
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Sodium tanshinone ⅡA sulfonate prevents radiation-induced damage in primary rat cardiac fibroblasts 认领
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作者 ZHOU Dan YANG Wen-Ke +5 位作者 ZHANG Yi-Fan XIE Jin-Hui MA Li YANG Hui-Dong LI Yi XIE Ping 《中国天然药物:英文版》 SCIE CAS CSCD 2020年第6期436-445,共10页
This study investigated the effects of X-ray irradiation on primary rat cardiac fibroblasts(CFs) and its potential mechanism, as well as whether sodium tanshinone ⅡA sulfonate(STS) has protective effect on CFs and it... This study investigated the effects of X-ray irradiation on primary rat cardiac fibroblasts(CFs) and its potential mechanism, as well as whether sodium tanshinone ⅡA sulfonate(STS) has protective effect on CFs and its possible mechanism. Our data demonstrated that X-rays inhibited cell growth and increased oxidative stress in CFs, and STS mitigated X-ray-induced injury. Enzyme-linked immuno-sorbent assay showed that X-rays increased the levels of secreted angiotensin Ⅱ(Ang Ⅱ) and brain natriuretic peptide(BNP). STS inhibited the X-ray-induced increases in Ang Ⅱ and BNP release. Apoptosis and cell cycle of CFs were analyzed using flow cytometry. X-rays induced apoptosis in CFs, whereas STS inhibited apoptosis in CFs after X-ray irradiation. X-rays induced S-phase cell cycle arrest in CFs, which could be reversed by STS. X-rays increased the expression of phosphorylated-P38/P38,cleaved caspase-3 and caspase-3 as well as decreased the expression of phosphorylated extracellular signal-regulated kinase 1/2(ERK1/2)/ERK 1/2 and B cell lymphoma 2(Bcl-2)/Bcl-2 associated X protein(BAX) in CFs, as shown by Western blotting. STS mitigated the X-ray radiation-induced expression changes of these proteins. In conclusion, our results demonstrated that STS may potentially be developed as a medical countermeasure to mitigate radiation-induced cardiac damage. 展开更多
关键词 Sodium tanshinone IIA sulfonate Cardiac fibroblasts RADIATION Oxidative Stress Apoptosis
人民银行内审增加价值的思考 认领
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作者 陈国华 《新理财:公司理财》 2019年第2期76-79,共4页
以IIA的内部审计理论为分析框架,以人民银行内部审计实务为分析对象以内部审计增加价值为分析目标,对人民银行内部审计在GRC领域发挥价值增殖作用进行探讨。
关键词 人民银行 价值增殖 内部审计理论 内审 内部审计实务 IIA
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Lower clearance of sodium tanshinone IIA sulfonate in coronary heart disease patients and the effect of total bilirubin: a population pharmacokinetics analysis 认领 被引量:1
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作者 QIN Wei-Wei WANG Li +5 位作者 JIAO Zheng WANG Bin WANG Cheng-Yu QIAN Li-Xuan QI Wei-Lin ZHONG Ming-Kang 《中国天然药物:英文版》 SCIE CAS CSCD 2019年第3期218-226,共9页
This study developed a population pharmacokinetic model for sodium tanshinone IIA sulfonate (STS) in healthy volunteers and coronary heart disease (CHD) patients in order to identify significant covariates for the pha... This study developed a population pharmacokinetic model for sodium tanshinone IIA sulfonate (STS) in healthy volunteers and coronary heart disease (CHD) patients in order to identify significant covariates for the pharmacokinetics of STS. Blood samples were obtained by intense sampling approach from 10 healthy volunteers and sparse sampling from 25 CHD patients, and a population pharmacokinetic analysis was performed by nonlinear mixed-effect modeling. The final model was evaluated by bootstrap and visual predictive check. A total of 230 plasma concentrations were included, 137 from healthy volunteers and 93 from CHD patients. It was a two-compartment model with first-order elimination. The typical value of the apparent clearance (CL) of STS in CHD patients with total bilirubin (TBIL) level of 10 μmol(L?1 was 48.7 L(h?1 with inter individual variability of 27.4%, whereas that in healthy volunteers with the same TBIL level was 63.1 L(h?1. Residual variability was described by a proportional error model and estimated at 5.2%. The CL of STS in CHD patients was lower than that in healthy volunteers and decreased when TBIL levels increased. The bootstrap and visual predictive check confirmed the stability and validity of the final model. These results suggested that STS dosage adjustment might be considered based on TBIL levels in CHD patients. 展开更多
关键词 SODIUM TANSHINONE IIA SULFONATE Nonlinear mixed-effects modeling Population pharmacokinetics Coronary heart disease Total bilinibin
人工智能审计:IIA的框架与应用导向 认领 被引量:2
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作者 曾繁荣 《中国内部审计》 2018年第12期7-11,共5页
人工智能被视为下一个数字前沿领域,内部审计部门有必要了解人工智能的基础知识、可能扮演的角色、由此带来的风险和机会以及在内部审计领域的运用。国际内部审计师协会(IIA)的人工智能审计框架及其各部分的有机联系,为人工智能应... 人工智能被视为下一个数字前沿领域,内部审计部门有必要了解人工智能的基础知识、可能扮演的角色、由此带来的风险和机会以及在内部审计领域的运用。国际内部审计师协会(IIA)的人工智能审计框架及其各部分的有机联系,为人工智能应用于审计领域提供了参考。 展开更多
关键词 IIA 人工智能 审计框架
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国际内部审计师协会的发展与借鉴:来自财务报表的解读 认领
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作者 王兵 魏丽敏 《中国内部审计》 2018年第6期30-34,共5页
本文结合国际内部审计师协会2007年至2016年的财务报表数据,分析国际内部审计师协会的收入来源和经费使用情况,探讨其如何通过自身经营获取发展所需的资金,为中国内部审计协会的发展提供有益的借鉴和参考。
关键词 内部审计 IIA 内审协会 财务报表 经营
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将核技术产业打造成全球联盟--专访国际辐照协会秘书长Paul Wynne 认领
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作者 葛维维 《中国核工业》 2018年第10期12-14,共3页
国际辐照协会(iia)是一个旨在促进世界辐照行业发展的非盈利性组织,同时也是国际原子能机构认可的非政府组织,已经有近半个世纪的发展历程。本次大会期间,本刊记者专访到iia秘书长,就国际核辐照产业的发展进程进行了交流。
关键词 技术产业 全球联盟 国际原子能机构 非盈利性组织 非政府组织 辐照 秘书长 IIA
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“三道防线”模型在高校后勤风险管理中的应用 认领 被引量:2
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作者 金俊荣 《财会月刊(上)》 北大核心 2018年第10期114-118,共5页
IIA的“三道防线”模型为组织提供了一套简易、有效的方式,厘清组织重要的角色和职责,以增进风险管理与控制的沟通,这是目前国际通行并得到IIA及多国监管机构认可并推荐的一种组织内部控制框架。以A高校为例,通过梳理近年来学校后勤审... IIA的“三道防线”模型为组织提供了一套简易、有效的方式,厘清组织重要的角色和职责,以增进风险管理与控制的沟通,这是目前国际通行并得到IIA及多国监管机构认可并推荐的一种组织内部控制框架。以A高校为例,通过梳理近年来学校后勤审计及各项专项检查中暴露出的问题,采用ISO31000风险评估方法,分析原因和结果,并从内部审计角度出发,应用IIA的“三道防线”模型提出风险应对措施及保障措施。 展开更多
关键词 三道防线 后勤管理 审计风险 IIA 内部审计
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国际内部审计专业实务标准变化趋势及对人民银行内审工作的启示 认领
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作者 李官森 《金融发展研究》 北大核心 2018年第10期83-85,共3页
国际内部审计师协会(IIA)《国际内部审计专业实务框架》(IPPF)是在全球范围内权威的内部审计标准体系。其核心部分《国际内部审计专业实务标准》(以下简称《标准》),集中反映了IIA倡导的内审理念和内审实务发展变化。截至2016年10月,II... 国际内部审计师协会(IIA)《国际内部审计专业实务框架》(IPPF)是在全球范围内权威的内部审计标准体系。其核心部分《国际内部审计专业实务标准》(以下简称《标准》),集中反映了IIA倡导的内审理念和内审实务发展变化。截至2016年10月,IIA已先后发布了3个版本的《标准》。本文对比梳理了这3个版本的不同,分析国际内审理论和实务发展的总体趋势和方向,为深化和发展人民银行内审工作提供有益的借鉴和参考。 展开更多
关键词 国际内部审计师协会 实务发展 内审工作 审计专业 标准体系 人民银行 《标准》 IIA
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IIA衡量内部审计部门成熟度的相关解析 认领
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作者 曾繁荣 《中国审计》 北大核心 2017年第15期70-71,共2页
开展内部审计部门成熟度评估是一项重要工作,有助干发现预期和现实之间的内部审计质量差距,从而为培育更成熟的内部审计部门、提升内部审计功能和价值提供指导。国际内部审计师协会(IIA)于2015年提出了衡量内部审计部门成熟度的指... 开展内部审计部门成熟度评估是一项重要工作,有助干发现预期和现实之间的内部审计质量差距,从而为培育更成熟的内部审计部门、提升内部审计功能和价值提供指导。国际内部审计师协会(IIA)于2015年提出了衡量内部审计部门成熟度的指标体系, 展开更多
关键词 内部审计部门 成熟度 IIA 国际内部审计师协会 解析 内部审计功能 质量差距 指标体系
论“一带一路”倡议下中外投资协定中的投资者—国家仲裁机制 认领 被引量:6
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作者 韩秀丽 翟雨萌 《国际法研究》 2017年第5期20-34,共15页
国际投资协定中的投资者—国家仲裁机制在我国"一带一路"倡议的实施中应居于重要地位。一方面,"一带一路"沿线国的中国投资面临着真实的投资风险;另一方面,近年来以"一带一路"沿线国为被申请方的投资仲裁呈上升趋势,这一现实表明... 国际投资协定中的投资者—国家仲裁机制在我国"一带一路"倡议的实施中应居于重要地位。一方面,"一带一路"沿线国的中国投资面临着真实的投资风险;另一方面,近年来以"一带一路"沿线国为被申请方的投资仲裁呈上升趋势,这一现实表明,中国海外投资在"一带一路"沿线国也可能面临类似的投资措施和投资争议。然而,中国与"一带一路"沿线国的投资者—国家仲裁机制却存在着缺位与不足的问题。为了保护中国投资者在"一带一路"沿线国的合法和正当权益,需要考虑设立和加强中国与"一带一路"沿线国之间的投资者—国家仲裁机制。 展开更多
关键词 “一带一路” 投资者—国家仲裁机制 双边投资条约 自由贸易协定 国际投资协定
IIA环境审计发展探究 认领
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作者 游春晖 王菁 《财会通讯:上》 北大核心 2016年第1期92-94,共3页
IIA在企业内部审计发展方面起主导和动态引领作用,本文对IIA环境审计产生背景、内部环境审计的作用、环境审计准则和公告制定、内部环境审计理论研究、内部环境审计实务调查、注册环境审计师资格证书颁发及培训的发展情况做了系统归纳。
关键词 IIA 内部环境审计 审计准则 实务调查
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Discovery of tanshinone derivatives with anti-MRSA activity via targeted bio-transformation 认领
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作者 Wenni He Miaomiao Liu +13 位作者 Pei Huang Wael M.Abdel-Mageed Jianying Han Jeramie D.Watrous Don D.Nguyen Wenzhao Wang Fuhang Song Huanqin Dai Jingyu Zhang Ronald J.Quinn Tanja Grkovi Houwei Luo Lixin Zhang Xueting Liu 《合成和系统生物技术》 SCIE 2016年第3期187-194,共8页
Two potent anti-MRSA tanshinone glycosides(1 and 2)were discovered by targeted microbial biotransformation,along with rapid identification via MS/MS networking.Serial reactions including dehydrogenation,demethylations... Two potent anti-MRSA tanshinone glycosides(1 and 2)were discovered by targeted microbial biotransformation,along with rapid identification via MS/MS networking.Serial reactions including dehydrogenation,demethylations,reduction,glycosylation and methylation have been observed after incubation of tanshinone IIA and fungus Mucor rouxianus AS 3.3447.In addition,tanshinosides B(2)showed potent activities against serial clinical isolates of oxacillin-resistant Staphylococcus aureus with MIC values of 0.78 mg/mL.This is the first study that shows a significant increase in the level and activities of tanshinone glycosides relative to the substrate tanshinone IIA. 展开更多
关键词 BIOTRANSFORMATION GLYCOSYLATION Tanshinone IIA Mucor rouxianus
Tanshinone IIA Could Inhibit Pancreatic Cancer BxPC-3 Cells through Increasing PERK, ATF6, Caspase-12 and CHOP Expression to Induce Apoptosis 认领 被引量:1
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作者 Chin-Cheng Su 《生物医学工程(英文)》 2015年第3期149-159,共11页
Tanshinone IIA (Tan-IIA) is extracted from Dan-Shen. Tan-IIA could inhibit human pancreatic cancer BxPC-3 cells through decreasing TCTP, Mcl-1 and Bcl-xl expression in vitro. Our previous study showed that Tan-IIA can... Tanshinone IIA (Tan-IIA) is extracted from Dan-Shen. Tan-IIA could inhibit human pancreatic cancer BxPC-3 cells through decreasing TCTP, Mcl-1 and Bcl-xl expression in vitro. Our previous study showed that Tan-IIA can inhibit hepatocellular carcinoma hep-J5 cells and human breast cancer BT-20 cells through inducing endoplasmic reticulum (ER) stress. In the present study, we investigated the ER stress related protein expressions in human pancreatic cancer BxPC3 cells were treated with Tan-IIA. The ER stress related protein expressions in human pancreatic cancer BxPC-3 cells were evaluated by western blotting. The results showed that Tan-IIA can increase the protein expressions of PERK, ATF6, Caspase-12 and CHOP, but decrease Bip, PDI, Calnexin, Calreticulin and Bcl-2 expression. These findings indicated that Tan-IIA can inhibit human pancreatic cancer BxPC-3 cells by inducing ER stress to induce apoptosis. 展开更多
关键词 TANSHINONE IIA Pancreatic Cancer BXPC-3 Cells ER Stress Apoptosis
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一类变系数微分代数方程的数值解 认领 被引量:1
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作者 任磊 王文武 《江西师范大学学报:自然科学版》 CAS 北大核心 2014年第1期54-57,共4页
讨论了变系数微分代数方程的数值解.首先给出变系数微分代数方程的系数矩阵Drazin逆的求法,然后研究其差分格式上的数值解,最后利用Drazin逆的方法和隐式RK方法对一类变系数微分代数方程进行了研究,并给出了相应的数值试验,结果表... 讨论了变系数微分代数方程的数值解.首先给出变系数微分代数方程的系数矩阵Drazin逆的求法,然后研究其差分格式上的数值解,最后利用Drazin逆的方法和隐式RK方法对一类变系数微分代数方程进行了研究,并给出了相应的数值试验,结果表明Drazin逆的求解效果较好,但求解过程比较复杂. 展开更多
关键词 变系数微分代数方程 DRAZIN逆 有限算法 Radau IIA
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丹参酮ⅡA对局灶性脑缺血大鼠急性期脑保护作用的相关研究 认领 被引量:3
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作者 刘玲玲 刘红 +4 位作者 尹君玲 陈惠英 刘晓蕾 焦清海 武一平 《中国卒中杂志》 2014年第1期20-25,共6页
目的探讨丹参酮ⅡA(TashinoneⅡA.TSA)对局灶性脑缺血急性期大鼠顶叶皮质磷酸化环腺蔷酸反应元件结合蛋白(phosphorylated cyclic adenosine monophosphate response element binding protein,p-CREB)和CEEB1活性调节转导子(tran... 目的探讨丹参酮ⅡA(TashinoneⅡA.TSA)对局灶性脑缺血急性期大鼠顶叶皮质磷酸化环腺蔷酸反应元件结合蛋白(phosphorylated cyclic adenosine monophosphate response element binding protein,p-CREB)和CEEB1活性调节转导子(transducers of regulated CEEB1,TORC1)的蛋白表达和脑梗死体积的影响。方法采用成年健康雄性SD大鼠,随机分为假手术组、对照组、小剂量TSA组和大剂量TSA组,每组各12只。用线栓法制作右侧大脑中动脉闭塞模型,采用Longa评分判断动物模型成功与否。小剂量TSA组和大剂量TSA组在造模后立刻腹腔注射TSA溶液,剂量分别为:10mg/kg及20mg/kg,假手术组及对照组分别腹腔注射等量的生理盐水。造模成功后24h将大鼠处死,采用2%2,3,5三苯基四唑氯红染色计算梗死体积,应用Westernblotting法检测各组手术侧顶叶皮质梗死灶神经细胞核TOPICl和细胞核p-CREB以及细胞TORC1的蛋白表达。结果与对照组相比,大剂量TSA组大鼠脑组织梗死体积明显降低(P=0.004).细胞核TOPIC{表达显著增加(P〈0.001);与对照组相比,小剂量TSA组大鼠脑组织梗死体积减小,无显著差异(P=0.148),细胞核TORC1蛋白表达升高,也无显著差异(P=0.086),细胞核p-CREB和细胞TORC1的蛋白表达水平无论在大剂量组(P均〈0.001),还是小剂量组(P分别为0.002和0.001)均显著升高。结论TSA可以上调脑梗死大鼠病灶侧顶叶皮质神经细胞TORC1-CREB信号通路的表达。 展开更多
关键词 环腺苷酸反应元件结合蛋白活性调节转导子 环腺苷酸反应元件结合蛋白 丹参酮 IIA 大脑中动脉闭塞
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