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Prevalence, Risk Factors and Outcome of Preterm Premature Rupture of Membranes at the Bamenda Regional Hospital 认领
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作者 Dobgima Walter Pisoh Claude Hector Mbia +5 位作者 William Ako Takang Obelda Guiswe Beltus Djonsala Mbah Cypress Munje Ascensius Achuo Mforteh Dohbit Julius Sama Robert John Ivo Leke 《妇产科期刊(英文)》 2021年第3期233-251,共19页
<strong>Background: </strong><span style="font-family:""><span style="font-family:Verdana;">Preterm premature rupture of membranes (PPROM) is one of the most common com... <strong>Background: </strong><span style="font-family:""><span style="font-family:Verdana;">Preterm premature rupture of membranes (PPROM) is one of the most common complications of pregnancy. It is one of the leading identifiable cause of preterm deliveries, and an important cause of maternal and perinatal morbidity and mortality.</span><b> </b><span style="font-family:Verdana;">The aim of this study was to determine the prevalence of PPROM, to identify its associated factors and to evaluate the </span><span style="font-family:Verdana;">early outcome (within 72 hrs after delivery) following PPROM at the Ba</span><span><span style="font-family:Verdana;">menda Regional Hospital (BRH). </span><b><span style="font-family:Verdana;">Methods: </span></b><span style="font-family:Verdana;">A cross-sectional study was</span></span><span style="font-family:Verdana;"> conducted in March and April 2020. Three hundred and eighty-seven women who delivered at the labour room of the BRH were included in this study. Interviewer-administered questionnaires were used to obtain data. The cases of PPROM were women who had lost amniotic fluid continuously before hospitalisation and whose gestational age was between 28 weeks + 0 days and 36 weeks + 6 days. Descriptive statistics followed by logistic regression analyses </span><span><span style="font-family:Verdana;">were conducted with level of significance set at p-value <0.05. </span><b><span style="font-family:Verdana;">Results:</span></b></span><b> </b><span style="font-family:Verdana;">Among </span><span style="font-family:Verdana;">the 387 participants included in the study, 19 had PPROM giving a preva</span><span style="font-family:Verdana;">lence of 4.91%. Of 57 preterm deliveries, PPROM accounted for 33.33% (n = </span><span style="font-family:Verdana;">19). The statistically significant independent factors associated with lower</span><span style="font-family:Verdana;"> odds of PPROM were the age groups 20</span></span><span style="font-family:""> </span><span style="font-fami 展开更多
关键词 Preterm PROM Maternal Outcome Perinatal Outcome Associated Factors
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Relation Ship of Maternal Haemoglobin Concentration Measured in Labour with Neonatal Outcome among Sudanese Women 认领
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作者 Nada Elamin Abdallah Badi Hassabelrasol Ata Almoula +2 位作者 Nahla Idris Abdalla Idris Yassir Hamadalnil Siddig Omer M. Handady 《妇产科期刊(英文)》 2021年第2期131-139,共9页
<strong>Objective:</strong><span style="font-family:;" "=""><span style="font-family:Verdana;"> Data showed that maternal anaemia during pregnancy negatively ... <strong>Objective:</strong><span style="font-family:;" "=""><span style="font-family:Verdana;"> Data showed that maternal anaemia during pregnancy negatively affects maternal/fetal outcomes. We here attempted to re-confirm this in this specific region of Sudan, with special reference to fetal/neonatal outcome. </span><b><span style="font-family:Verdana;">Methodology:</span></b><span style="font-family:Verdana;"> This cross-sectional observational study was carried out at Omdurman Maternity and Khartoum North Teaching Hospitals-Sudan from March 2018 to March 2019, with 246 pregnant women presented in labour enrolled. Maternal characteristics, haemoglobin (Hb) measured after labour initiation and fetal/neonatal outcomes were analyzed. </span><b><span style="font-family:Verdana;">Results:</span></b><span style="font-family:Verdana;"> When maternal anemia was defined as Hb less than 10.0 g/dL, 80 (32.5%) had anemia and 166 had not. Anemic women (Hb;8.3 ± 0.31), compared with non-anemic women (Hb;11.4 ± 0.61), were significantly more likely to have low birth weight (LBW) infants (40% vs. 15.7%) and still birth (12.5% vs. 4.8%). There was a correlation between hemoglobin concentration and the followings: LBW, respiratory distress syndrome, neonatal nursery admission, still birth, early neonatal death, and low Apgar score. </span><b><span style="font-family:Verdana;">Conclusions:</span></b><span style="font-family:Verdana;"> Maternal aneamia negatively affected fetal/neonatal outcomes. This data may be useful to make health policy in this area.</span></span> 展开更多
关键词 Maternal Hemoglobin PREGNANCY Neonatal Outcome Birth Weight Apgar Score Sudanese Women
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Breast Asymmetry Evaluation Using Objective Measures after Breast Cancer Surgery 认领
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作者 Jaejong Park Fariha M. Haque +2 位作者 Achille Louodom Chedjou Michael J. Miller Alok Sutradhar 《生物医学工程(英文)》 2021年第1期1-10,共10页
Although a positive cosmetic outcome is an important goal of breast cancer reconstruction, the objective analysis of breast aesthetics has yet to reach a gold standard or unified method to quantify breast symmetry. Se... Although a positive cosmetic outcome is an important goal of breast cancer reconstruction, the objective analysis of breast aesthetics has yet to reach a gold standard or unified method to quantify breast symmetry. Several scoring systems, both subjective and objective, have been developed over the years to ensure the desirable outcome in breast symmetry, but these methods have yet to reach the unanimous acceptance in terms of accuracy, value and ease of use to be implemented in the clinical setting. By assessing several existing symmetry scores, most of which are based on 2D imaging, along with our own set of symmetry parameters applied to 3D patient images, the goal of this study is to determine if there is an advantage of 3D imaging in formulating an accurate objective breast aesthetic score over the existing objective scores. A reliable breast aesthetic score would improve the decision-making in surgery as well as improve patient satisfaction. Additionally, knowing the quantity and degree of breast asymmetry objectively will improve outcome and reduce revision rates, minimizing patient suffering and improving the overall quality of patient life and body image. 展开更多
关键词 Asymmetry Breast Surgery Outcome Research Surface Imaging 3D Scan
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Incidence and Risk Factors of Acute Kidney Injury in ICU Patients of Omdurman Teaching Hospital 认领
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作者 Abdel Mumin Sid Ahmed Nusaiba Hassan Mohamed Eltahir 《肾脏病(英文)》 2021年第1期43-57,共15页
<strong>Background:</strong> Acute kidney injury (AKI) is a common complication in critically ill patients and it is commonly associated with high mortality and morbidity with adverse short and long term o... <strong>Background:</strong> Acute kidney injury (AKI) is a common complication in critically ill patients and it is commonly associated with high mortality and morbidity with adverse short and long term outcome. <strong>Objectives:</strong> The main objective of this study was to determine the incidence of acute kidney injury in ICU patients in Omdurman teaching hospital, and to assess the risk factors associated with the development of acute kidney injury in a critically ill patient. We also intended to find out the impact of acute kidney injury on ICU outcomes. <strong>Methods:</strong> In this descriptive prospective, cohort hospital-based study, 211 patients were studied and followed up during admission in ICU from November 2019 until July 2020 in Omdurman teaching hospital. <strong>Results:</strong> 61 patients of the total 211 patients developed renal impairment during their stay in ICU. 64% (39 patients) were males and 36% (22 patients) were female, mean age was 41 ± 5, renal impairment developed after a mean of 5 days of admission and the most common cause was decreased level of consciousness and severe hypotension, sepsis accounting for 40% of the admission. The outcome in ICU showed that the mortality rate was high up to 41% in patients who developed acute kidney injury, Sepsis accounted for over 96% (24 patients) who have passed away. <strong>Conclusions:</strong> Development of AKI in ICU is an important risk factor for poor outcomes in critically setting. Prevention is the best method for avoiding AKI, with the early identification and recognition of high-risk patients. 展开更多
关键词 Acute Kidney Injury ICU Risk Factors OUTCOME FREQUENCY
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Happy Hypoxia in COVID-19 Patients at Kinshasa University Hospital (Democratic Republic of the Congo): Frequency and Vital Outcome 认领
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作者 Ben Bepouka Hippolyte Situakibanza +34 位作者 Ossam Odio Jean Robert Makulo Madone Mandina Murielle Longokolo Nadine Mayasi Kazadi Mutombo Tresor Pata Godelive Nsangana Felly Tshikangu Donatien Mangala Dupont Maheshe Christine Namasale Serge Nkarnkwin Jonathan Muamba Gorby Ndaie Rodrigue Ngwizani Hervé Mole Gabriel Makeya Tharcisse Mabiala Patrick Mukuna Roger Kabango Patricia Kabuni Yves Yanga Aliocha Nkodila Hervé Keke Nice Musangu Papy Tshimanga Yamin Kokusa Bertin Nsitwayizatadi Eric Mukenge Guyguy Kamwiziku Gabriel Mbunsu Jean Claude Makangara Marcel Mbula Jean Marie Kayembe 《生物科学与医学(英文)》 2021年第2期12-20,共9页
<strong>Background: </strong>Happy hypoxia is a new feature found in COVID-19 patients. It consists of the presence of severe hypoxemia but normal breathing rate. Failure to identify this hypoxia may have ... <strong>Background: </strong>Happy hypoxia is a new feature found in COVID-19 patients. It consists of the presence of severe hypoxemia but normal breathing rate. Failure to identify this hypoxia may have negative consequences on the survival of the patient. The objective of the present study was to measure the frequency of patients with happy hypoxia and to evaluate their survival at the Kinshasa University Hospital (KUH). <strong>Methods: </strong>This was a historical cohort of 141 hospitalized patients with COVID-19 at KUH from March 23 to June 15, 2020. Happy hypoxia was defined as oxygen saturation below 90% without dyspnea. Socio-demographic data, co-morbidities, follow up time of hospitalization and outcomes were studied. Survival was assessed using the Kaplan Meier curve. <strong>Results:</strong> Out of 141 hospitalized patients with COVID-19, 79 (56%) patients were at the severe or critical stage and 9 (6.4%) had a happy hypoxia on admission. Patients who had happy hypoxia on admission were generally older than 60 years of age (55.6%) (p = 0.023). Comparison of survival curves, based on the presence or absence of happy hypoxia, shows a statistically significant difference (p = 0.001). The presence of happy hypoxia reduces survival. <strong>Conclusion:</strong> The frequency of happy hypoxia among COVID-19 patients was low. Survival was reduced in patients with happy hypoxia. Prehospital pulse oximetry could serve as an early warning signal for the detection of happy hypoxemia in COVID-19 patients. 展开更多
关键词 COVID-19 Happy Hypoxia FREQUENCY OUTCOME DR Congo
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Fetal Outcome and Mode of Delivery in a Patient with Meconium-Stained Amniotic Fluid 认领
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作者 Amjaad Althaqafi Renad Hashem Ateeq +3 位作者 Douaa Mohammed Al-Bukhar Daniyah Hassan Danish Raghad Alamoudi Hassan S. O. Abduljabbar 《妇产科期刊(英文)》 2021年第1期12-19,共8页
<strong>Background:</strong><span><span><span style="font-family:""><span style="font-family:Verdana;"> Meconium stained amniotic fluid (MSAF), especially o... <strong>Background:</strong><span><span><span style="font-family:""><span style="font-family:Verdana;"> Meconium stained amniotic fluid (MSAF), especially observed before term, is considered a sign of fetal jeopardy. Although many studies characterized this condition and associated it with delivery mode, data is lacking in this area, Saudi Arabia. Thus, we attempted to study it. </span><b><span style="font-family:Verdana;">Methods:</span></b><span style="font-family:Verdana;"> All data were retrieved from pregnant patients with MSAF who delivered at King Abdul, Saudi Arabia, from January 2015 to December 2018. </span><b><span style="font-family:Verdana;">Results:</span></b><span style="font-family:Verdana;"> 758 showed MSAF, of which 83% had vaginal delivery, whereas remaining 17% had an emergency caesarean section. Of them, 32 (4.2%) infants developed meconium aspiration syndrome, and 7 (21.8%) were admitted to the NICU. </span><b><span style="font-family:Verdana;">Conclusion:</span></b><span style="font-family:Verdana;"> It was reconfirmed that MSAF is associated with a newborn risk, especially meconium aspiration syndrome. Patients had a higher rate for emergent caesarean section and baby admission to NICU. These data may be useful to make health/reproductive-health poly-making in this area.</span></span></span></span> 展开更多
关键词 MECONIUM Fetal Outcome Mode of Delivery
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文章速递阿替普酶静脉溶栓前应用依达拉奉对老年急性脑梗死预后的影响 认领
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作者 丁桂兵 吴岩峰 +2 位作者 陈亮 吴晋 张鹏 《实用老年医学》 CAS 2021年第3期301-305,共5页
目的探讨老年急性脑梗死病人在应用阿替普酶(recombinant tissue plasminogen activator,rt-PA)静脉溶栓前预先使用依达拉奉的有效性和安全性。方法采用回顾性分析的方法,纳入2014~2018年南京医科大学第二附属医院脑卒中登记系统中接受r... 目的探讨老年急性脑梗死病人在应用阿替普酶(recombinant tissue plasminogen activator,rt-PA)静脉溶栓前预先使用依达拉奉的有效性和安全性。方法采用回顾性分析的方法,纳入2014~2018年南京医科大学第二附属医院脑卒中登记系统中接受rt-PA静脉溶栓及依达拉奉联合治疗的老年急性脑梗死病人,共135例。依据应用rt-PA静脉溶栓和依达拉奉的前后顺序,将病人分为依达拉奉前治疗组(67例)和依达拉奉后治疗组(对照组,68例)。分析2组病人在rt-PA静脉溶栓24 h、7 d后NIHSS评分,90 d改良Rankin量表(modified Rankin Scale,mRS)评分,溶栓后颅内出血和症状性颅内出血的发生率以及7 d、90 d死亡率等。应用Logistic回归分析方法探讨治疗后90 d预后的影响因素。结果2组24 h及7 d NIHSS评分差异有统计学意义[(8.67±8.55)分比(11.88±8.30)分;(5.08±5.35)分比(8.60±7.91)分]。2组90 d良好预后率差异有统计学意义(53.73%比27.94%)。溶栓后,依达拉奉前治疗组脑出血发生率(9.1%比18.3%,P<0.01)、症状性脑出血发生率(2.0%比8.7%,P<0.01)明显低于依达拉奉后治疗组,差异有统计学意义。2组7 d死亡率差异无统计学意义(4.0%比4.9%),依达拉奉前治疗组90 d死亡率明显低于依达拉奉后治疗组,差异有统计学意义(4.0%比12.5%,P=0.04)。Logistic回归分析显示,依达拉奉前治疗为预后良好的独立影响因素(OR=0.28,95%CI0.14~0.58)。结论在老年急性脑梗死病人中,rt-PA静脉溶栓前使用依达拉奉对90 d后神经功能改善效果优于溶栓后使用,同时可明显降低症状性脑出血发生率。 展开更多
关键词 急性脑梗死 老年人 依达拉奉 阿替普酶 预后
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文章速递成年发病的急性播散性脑脊髓炎并吉兰-巴雷综合征6例分析 认领
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作者 陈林林 韩晓琛 +3 位作者 安利 白文浩 王晓艳 姚生 《中国神经免疫学和神经病学杂志》 CAS 北大核心 2021年第2期110-114,119,共6页
目的探讨成年发病的急性播散性脑脊髓炎(acute disseminated encephalomyelitis,ADEM)并吉兰-巴雷综合征(Guillain-Barrésyndrome,GBS)的临床表现、脑脊液、神经电生理、影像学特点及预后。方法收集6例患者的临床资料,对其临床症... 目的探讨成年发病的急性播散性脑脊髓炎(acute disseminated encephalomyelitis,ADEM)并吉兰-巴雷综合征(Guillain-Barrésyndrome,GBS)的临床表现、脑脊液、神经电生理、影像学特点及预后。方法收集6例患者的临床资料,对其临床症候、脑脊液结果、神经电生理、头和脊髓影像改变特点及预后进行回顾性分析。结果(1)6例患者中ADEM并GBS 4例,急性播散性脊髓炎(acute disseminated myelitis,ADM)并GBS 2例;脑累及4例、脊髓累及6例、周围神经累及6例(脑神经4例,脊神经6例)。(2)发病年龄40~67岁;急性起病2例,亚急性起病4例;前驱感染史4例,发热1例,无明确前驱史1例。首发症状分别为头晕(2例)、复视(1例)、双下肢无力(2例)及腹痛(1例)。后期主要表现为肢体无力和尿便障碍(6例)、四肢深反射减弱及消失(2例)、双下肢跟、膝腱反射减弱及消失(4例)及锥体束损害(6例)。(3)脑脊液:颅内压增高1例(230 mmH 2O),余5例正常;蛋白均不同程度增高(470~1310 mg/L);脑脊液有核细胞数增高5例〔(10~130)×106/L〕,红细胞增高4例〔(8~220)×106/L〕;髓鞘碱性蛋白(MBP)增高4例,24 h鞘内IgG合成率增高5例;脑脊液寡克隆区带、抗神经节苷脂(GM)抗体谱及脑脊液病毒筛查均阴性。(4)肌电图:双侧上肢运动、感觉神经传导速度减慢3例,波幅降低2例;双侧下肢运动、感觉神经传导速度减慢6例,波幅降低5例;F波检查5例(F波出现率降低4例,潜伏期延长5例);视觉诱发电位异常2例。(5)头MRI发现病灶4例(多发小病灶3例,单发小病灶1例),脊髓MRI均发现病灶(多发局灶性4例、节段性2例)。(6)治疗及预后:静脉注射免疫球蛋白(IVIg)治疗1例,糖皮质激素治疗1例,二者联合治疗4例,6例均预后良好。结论本组患者ADEM并GBS可累及脑、脊髓、神经根和周围神经,临床表型变异性明显;肢体无力及尿便障碍多见,深反射减低或消失及锥体束损害是主要的体征。脑脊液未见到蛋白-细胞分离现象。头和脊髓MRI检查发现白质散在异常信号;电生理检查及体征发现周围神经和神经根累及;免疫调节治疗效果好。 展开更多
关键词 ADEM GBS 临床特点 磁共振波谱学 电生理 预后
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文章速递超长促排卵方案中基础LH水平对排卵正常患者IVF/ICSI治疗结局的影响 认领
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作者 于春梅 王宇峰 +3 位作者 戴秀亮 夏西洋 高亭亭 陈莉 《南京医科大学学报:自然科学版》 CAS CSCD 北大核心 2021年第1期88-91,共4页
目的:探讨超长促排卵方案中基础黄体生成素(basic luteinizing hormone,BLH)水平对排卵正常患者体外受精/卵胞浆内单精子注射(in vitro fertilization or intracytoplasmic sperm injection,IVF/ICSI)治疗结局的影响。方法:回顾性分析... 目的:探讨超长促排卵方案中基础黄体生成素(basic luteinizing hormone,BLH)水平对排卵正常患者体外受精/卵胞浆内单精子注射(in vitro fertilization or intracytoplasmic sperm injection,IVF/ICSI)治疗结局的影响。方法:回顾性分析本中心2018—2019年就诊306例采用超长促排卵方案的排卵正常患者,按BLH水平不同分为低BLH组(BLH<5 U/L)158例和高BLH组(BLH≥5 U/L)148例。分别比较两组促性腺激素(gonadotrophic hormone,Gn)用量、平均Gn天数、扳机日血清激素水平、获卵数、优胚数、临床妊娠率等。结果:Gn用量、Gn天数、优势卵泡数、获卵数、成熟卵子数、正常受精数、优质胚胎数均无明显差异(P>0.05);获卵率、正常受精率、囊胚形成率两组也无统计学差异(P>0.05);但是高BLH组优质胚胎率明显高于低BLH组(P<0.001)。新鲜胚胎移植结果显示,低BLH组和高BLH组的临床妊娠率无统计学差异(65.3%vs. 64.8%,P>0.05);低BLH组的早期流产率(15.6%)明显高于高BLH组(4.4%),差异有统计学意义(P<0.05)。结论:超长促排卵方案中BLH水平对排卵正常患者IVF/ICSI治疗结局有一定影响,BLH水平偏高者更适合此方案。 展开更多
关键词 超长促排卵方案 BLH 排卵功能 IVF/ICSI 治疗结局
文章速递甲状旁腺癌32例临床特征及预后分析 认领
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作者 杨月 杨军平 王守俊 《河南医学研究》 CAS 2021年第8期1377-1381,共5页
目的探讨甲状旁腺癌(PC)的临床特征、诊治及预后,为临床提供诊疗思路,减少误诊及漏诊率。方法回顾性分析2013年6月至2020年1月郑州大学第一附属医院收治的32例甲状旁腺癌和90例甲状旁腺腺瘤(PA)患者的临床资料,如患者的病灶最大径、血... 目的探讨甲状旁腺癌(PC)的临床特征、诊治及预后,为临床提供诊疗思路,减少误诊及漏诊率。方法回顾性分析2013年6月至2020年1月郑州大学第一附属医院收治的32例甲状旁腺癌和90例甲状旁腺腺瘤(PA)患者的临床资料,如患者的病灶最大径、血清钙、血清碱性磷酸酶(ALP)、血清甲状旁腺素(PTH)水平及Ki-67指数等;比较PC与PA患者的临床生化特点。同时分析32例PC患者的无进展生存(progression-free survival,PFS)率和总体生存(overall survival,OS)率,采用Kaplan-Meier绘制PC患者的生存曲线,使用单因素COX回归模型分析影响PC患者预后的因素。结果PC组的病灶最大径、血清钙、血清ALP、血清PTH水平及Ki-67指数均高于PA组,差异有统计学意义(P<0.05)。在随访期间,32例PC患者中,有7例发生进展,4例死亡。PC患者的5 a PFS率为62.60%,5 a OS率为83.30%。PC患者若处于T4期,其疾病进展风险相对T1~T3期增高7.292倍(HR=7.292,95%CI:1.613~32.963,P=0.003),死亡风险增高12.596倍(HR=12.596,95%CI:1.302~122.832,P=0.005);PC患者若处于M 1期,其疾病进展风险相对M 0期增高4.921倍(HR=4.921,95%CI:1.060~22.846,P=0.026),死亡风险增高9.398倍(HR=9.398,95%CI:0.971~90.972,P=0.019)。结论当患者甲状旁腺区出现较大占位病变,血钙、血清ALP、血清PTH水平升高及Ki-67高表达时,需警惕PC可能。出现肿瘤局部严重侵犯或远处转移的PC患者预后更差。 展开更多
关键词 甲状旁腺癌 甲状旁腺腺瘤 临床特征 预后
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文章速递初发慢性髓性白血病慢性期不同年龄患者临床特征、治疗和结局 认领
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作者 彭楠 窦雪琳 +6 位作者 于露 秦亚溱 石红霞 赖悦云 侯悦 黄晓军 江倩 《中华血液学杂志》 CAS CSCD 北大核心 2021年第2期101-108,共8页
目的探讨初发慢性髓性白血病慢性期(CML-CP)不同年龄患者的临床特征、治疗和结局。方法回顾性分析2006年1月至2019年12月在北京大学人民医院确诊的≥14岁初诊酪氨酸激酶抑制剂(TKI)一线治疗的CML-CP连续病例。结果共收集957例患者,男性... 目的探讨初发慢性髓性白血病慢性期(CML-CP)不同年龄患者的临床特征、治疗和结局。方法回顾性分析2006年1月至2019年12月在北京大学人民医院确诊的≥14岁初诊酪氨酸激酶抑制剂(TKI)一线治疗的CML-CP连续病例。结果共收集957例患者,男性597例(62.4%),中位年龄40(14~83)岁。按年龄分为<40岁组(470例,49.1%)、40~59岁组(371例,38.8%)和≥60岁组(116例,12.1%)。随年龄增长,初诊时脾大(P<0.001)、WBC≥100×109/L(P<0.001)、贫血(P<0.001)、PLT<450×109/L(P=0.022)、外周血原始细胞比例高(P=0.010)和具有Ph染色体附加异常(P=0.006)的患者比例降低,有合并症(P<0.001)、Sokal积分中/高危(P<0.001)和初始选择伊马替尼(P<0.001)的患者比例增高。而性别、ELTS危险度分布在各年龄组间差异无统计学意义(P值均>0.05)。多因素分析显示,≥60岁仅是影响患者总生存(OS)的不利因素(OR=3.7,95%CI 1.5~9.2,P=0.005),年龄与治疗反应和其他结局无显著相关性。TKI治疗中,随年龄增长,非血液学不良反应发生率显著增加(P<0.001),而血液学不良反应发生率相似。随访末期,随年龄增长,仍服用伊马替尼(P=0.026)和服用减量TKI(P<0.001)的患者比例显著增加。结论初发CML-CP不同年龄组患者的临床特征、TKI用药选择和剂量、治疗反应、OS期和非血液学不良反应发生率存在差异。 展开更多
关键词 白血病 髓性 慢性 年龄 酪氨酸激酶抑制剂 临床特征 治疗结局
文章速递剖宫产术后再妊娠孕妇分娩方式与结局变化趋势及相关影响因素 认领
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作者 钱建美 杨洁茹 马袁英 《中国妇幼保健》 CAS 北大核心 2021年第7期1599-1602,共4页
目的探讨剖宫产术后再妊娠孕妇分娩方式与结局变化趋势及相关影响因素。方法回顾性选取2018年11月-2019年11月该院剖宫产术后再妊娠产妇100例,依据分娩方式分为阴道试产组和再次剖宫产组各50例,统计分析两组产妇的并发症发生情况、产后... 目的探讨剖宫产术后再妊娠孕妇分娩方式与结局变化趋势及相关影响因素。方法回顾性选取2018年11月-2019年11月该院剖宫产术后再妊娠产妇100例,依据分娩方式分为阴道试产组和再次剖宫产组各50例,统计分析两组产妇的并发症发生情况、产后出血量、住院时间及医疗费用,并分析剖宫产术后再妊娠孕妇分娩方式选择的态度相关影响因素。结果阴道试产组产妇的发热、恶露过长及子宫下段切口愈合不良发生率均显著低于再次剖宫产组(P<0.05),产后出血量显著少于再次剖宫产组(P<0.05),住院时间显著短于再次剖宫产组(P<0.05),医疗费用显著低于再次剖宫产组(P<0.05)。剖宫产术后再妊娠孕妇学历本科及以上、月收入3000元以上、产妇分娩意向剖宫产及医师分娩建议剖宫产选择态度评分分别显著高于学历大专及以下、月收入3000元及以下、产妇分娩意向阴道分娩及医师分娩建议阴道分娩(P<0.05)。Logistic回归分析显示,剖宫产术后再妊娠孕妇分娩方式选择态度相关影响因素包括学历、医师分娩建议(P<0.05)。结论剖宫产术后再妊娠孕妇阴道试产较再次剖宫产妊娠结局好,相关影响因素包括学历、医师分娩建议。 展开更多
关键词 剖宫产术后再妊娠 分娩方式 结局 变化趋势 相关影响因素
文章速递Comparison of outcomes for percutaneous coronary intervention in men and women with unprotected left main disease 认领
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作者 Sheng-Wen LIU Chang-Dong GUAN +7 位作者 Feng-Huan HU Jue CHEN Ke-Fei DOU Wei-Xian YANG Yong-Jian WU Yue-Jin YANG Bo XU Shu-Bin QIAO 《老年心脏病学杂志:英文版》 SCIE CAS CSCD 2021年第3期168-174,共7页
BACKGROUND Percutaneous coronary intervention(PCI)in patients with unprotected left main coronary artery disease(ULMCAD)is increasing strategy in coronary artery patients.However,there is a lack of knowledge on the im... BACKGROUND Percutaneous coronary intervention(PCI)in patients with unprotected left main coronary artery disease(ULMCAD)is increasing strategy in coronary artery patients.However,there is a lack of knowledge on the impact of sex on outcomes of patients undergoing ULMCAD PCI.METHODS From January 2004 to December 2015,there were 3,960 patients undergoing ULMCAD PCI at our institution,including 3,121(78.8%)men and 839(21.2%)women.The clinical outcome included the incidence of major adverse cardiac events(MACE)(the composite of all-cause death,myocardial infarction(MI),and revascularization),all-cause death,MI,revascularization at three years follow-up.RESULTS Compared with men,women had not significantly different MACE(14.7%vs.14.6%,P=0.89),all-cause death(3.5%vs.3.7%,P=0.76),MI(5.0%vs.4.3%,P=0.38),revascularization(9.1%vs.8.9%,P=0.86),respectively.After adjustment,rates of MACE(HR=1.49;95%CI:1.24−1.81;P<0.0001)and all-cause death(HR=1.65;95%CI:1.09−2.48;P=0.017)occurred more frequently in male patients,as well as revascularization(HR=1.46;95%CI:1.16−1.85;P=0.001).CONCLUSION In this analysis,compared to men,women undergoing ULMCAD PCI have better outcomes of MACE,allcause death,and revascularization. 展开更多
关键词 coronary outcome patients
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文章速递西藏地区不同血红蛋白水平与院内急性ST段抬高型心肌梗死患者转归分析 认领
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作者 蔡婷婷 达娃次仁 《中国现代医学杂志》 CAS CSCD 北大核心 2021年第7期74-79,共6页
目的探讨西藏高原地区不同血红蛋白(Hb)水平对急性ST段抬高型心肌梗死(STEMI)近期院内主要心脏不良事件(MACE)的影响。方法回顾性分析2013年10月—2018年10月西藏自治区人民医院高原病心血管内科收治的STEMI患者的临床资料,根据Hb水平... 目的探讨西藏高原地区不同血红蛋白(Hb)水平对急性ST段抬高型心肌梗死(STEMI)近期院内主要心脏不良事件(MACE)的影响。方法回顾性分析2013年10月—2018年10月西藏自治区人民医院高原病心血管内科收治的STEMI患者的临床资料,根据Hb水平分为正常组110例(男性:120 g/L≤Hb≤160 g/L,女性:110 g/L≤Hb≤150 g/L)、较高组69例(男性:160 g/L<Hb<180 g/L,女性:150 g/L<Hb<180 g/L)、极高组121例(Hb≥180 g/L)。对3组近期MACE的发生率进行分析。结果极高组患者较其他两组年龄偏小,吸烟及饮酒史情况发生率较高(P<0.05),白细胞、尿酸、白蛋白水平较高(P<0.05),低密度脂蛋白、D-二聚体较低(P<0.05)。正常组患者Killip分级中Ⅲ、Ⅳ级发生率较高(P<0.05)。3组患者住院时间及院内MACE发生率差异无统计学意义(P>0.05)。多因素Cox回归显示,中国心肌梗死注册登记研究-ST段抬高型心肌梗死(CAMI-STEMI)评分[HR=1.165(95%CI:1.007,1.347),P=0.040]、心肌梗死溶栓治疗临床试验(TIMI)评分[HR=0.861(95%CI:0.755,0.980),P=0.024]是患者院内MACE发生率的独立预测因子。结论高血红蛋白水平与近期院内心血管不良事件无关,其远期心血管风险是否具有相关性需要进一步探讨。CAMI-STEMI评分、TIMI评分是西藏高原地区STEMI患者院内MACE发生率的独立预测因子。 展开更多
关键词 急性ST段抬高型心肌梗死 高原 血红蛋白 评分 转归
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文章速递Radiotherapy combined with nimotuzumab for elderly esophageal cancer patients:A phaseⅡclinical trial 认领
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作者 Xu Yang Yirui Zhai +8 位作者 Nan Bi Tao Zhang Lei Deng Wenqing Wang Xin Wang Dongfu Chen Zongmei Zhou Luhua Wang Jun Liang 《中国癌症研究:英文版》 SCIE CAS CSCD 2021年第1期53-60,共8页
Objective:To investigate the safety and efficacy of nimotuzumab combined with radiotherapy for elderly patients with non-resectable esophageal carcinoma(EC).Methods:Eligible patients were aged 70 years or older and ha... Objective:To investigate the safety and efficacy of nimotuzumab combined with radiotherapy for elderly patients with non-resectable esophageal carcinoma(EC).Methods:Eligible patients were aged 70 years or older and had treatment-naive,histologically proven inoperable locally advanced EC.Enrolled patients received radiotherapy with a total dose of 50-60 Gy in 25-30 fractions,concurrent with weekly infusion of nimotuzumab.The primary end point was the rate of more than grade 3 toxicities.Results:From June 2011 to July 2016,46 patients with stageⅡ-IV EC with a median age of 76.5 years were enrolled.There were 10,28 and 8 patients with stageⅡ,III and IV disease,respectively.The common acute toxicities included esophagitis(grade 1-2,75.4%;grade 3,8.7%),pneumonitis(grade 1,4.3%;grade 2,6.5%;grade3,2.2%),leukopenia(grade 1-2,60.9%;grade 3-4,4.4%),gastrointestinal reaction(grade 1-2,17.3%;grade 3,2.2%),thrombocytopenia(grade 1-2,21.7%;grade 3,2.2%),and radiothermitis(grade 1-2,39.2%).The incidence of grade 3-4 adverse effects was 17.4%.No grade 5 toxicities were observed.Clinical complete response,partial response,stable disease,and progressive disease were observed in 1(2.2%),31(67.4%),12(26.1%),and 2(4.3%)patients,respectively.The median overall survival(OS)and progression-free survival(PFS)were 17 and 10 months,respectively.The 2-,3-,and 5-year OS and PFS rates were 30.4%,21.7%,19.6%,and 26.1%,19.6%,19.6%,respectively.Conclusions:Nimotuzumab combined with radiotherapy is a safe and effective therapy for elderly patients who are not surgical candidates.Further studies are warranted to confirm its therapeutic effects in elderly EC patients. 展开更多
关键词 Nimotuzumab esophageal neoplasm elderly radiotherapy treatment outcome
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不同体重指数新型冠状病毒肺炎患者的临床特点及转归 认领
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作者 王敏 杨芳 +5 位作者 朱新新 成传芳 李琪 赵涛 邹毅 晏益民 《中华内分泌代谢杂志》 CAS CSCD 北大核心 2021年第1期17-22,共6页
目的探讨不同体重指数(BMI)新型冠状病毒肺炎(COVID-19)患者的临床特点及转归,为病情评估及预后提供依据。方法收集2020年1月16日至2020年3月28日在武汉科技大学附属孝感医院确诊的541例COVID-19患者临床资料,根据BMI分为正常体重组、... 目的探讨不同体重指数(BMI)新型冠状病毒肺炎(COVID-19)患者的临床特点及转归,为病情评估及预后提供依据。方法收集2020年1月16日至2020年3月28日在武汉科技大学附属孝感医院确诊的541例COVID-19患者临床资料,根据BMI分为正常体重组、超重组和肥胖组,比较3组患者的临床特点及转归。采用有序logistic回归分析BMI和临床分型的关联性。结果正常体重组有288例(53.23%),超重组193例(35.67%),肥胖组60例(11.09%)。与正常体重组比较,超重组、肥胖组合并高血压比例更高,实验室检查结果中白细胞、中性粒细胞、C反应蛋白、丙氨酸氨基转移酶、天冬氨酸氨基转移酶、乳酸脱氢酶和三酰甘油更高,重症和危重症比例亦更高(P<0.05或P<0.01)。回归分析显示,校正年龄、性别和基础疾病后,BMI越高,临床分型越严重(OR=1.079,95%CI 1.010~1.154)。结论COVID-19患者中超重、肥胖患者更容易进展为重症和危重症,提示肥胖可能是影响COVID-19临床转归的重要危险因素。 展开更多
关键词 新型冠状病毒肺炎 体重指数 超重 肥胖 转归
基于循证的自我管理干预对老年高血压性脑梗死合并糖尿病患者心理弹性及生活质量的影响 认领
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作者 侯聪玲 刘小楠 段小凯 《中国实用神经疾病杂志》 2021年第5期436-441,共6页
目的探讨基于循证的自我管理干预对老年高血压性脑梗死合并糖尿病患者心理弹性和生活质量的影响。方法选取2018-06—2020-06郑州市中心医院确诊的老年高血压性脑梗死合并糖尿病患者116例,采用随机数表法分为2组,对照组58例患者研究期间... 目的探讨基于循证的自我管理干预对老年高血压性脑梗死合并糖尿病患者心理弹性和生活质量的影响。方法选取2018-06—2020-06郑州市中心医院确诊的老年高血压性脑梗死合并糖尿病患者116例,采用随机数表法分为2组,对照组58例患者研究期间接受常规药物治疗和健康教育,观察组60例患者在对照组的基础上行为期12周的基于循证的自我管理干预。采用Connor-Davidson心理弹性量表(CD-RISC)评估患者的心理弹性,一般自我效能感量表(GSES)评价患者的自我管理行为效能,同时采用症状自评量表(SCL-90)和改良Rankin量表(mRS)分别对患者的生活质量及转归进行评估。结果干预前2组CD-RISC、GSES评分比较差异均无统计学意义(P>0.05);干预后2组CD-RISC、GSES评分均有所提升,且观察组优于对照组(P<0.001)。干预前2组患者SCL-90得分比较差异无统计学意义(P>0.05),干预后观察组SCL-90得分低于对照组(P<0.01),且观察组转归良好情况优于对照组,差异有统计学意义(P<0.01)。结论基于循证的自我管理干预可有效改变老年高血压性脑梗死合并糖尿病患者的自我管理行为,提升其心理弹性,并明显改善患者生活质量及转归。 展开更多
关键词 脑梗死 高血压 糖尿病 循证 心理弹性 自我管理行为 自我效能 生活质量 转归
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新型冠状病毒肺炎患者病情严重程度及转归的影响因素研究 认领
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作者 马卫华 何翠萍 宋红涛 《中华诊断学电子杂志》 2021年第1期51-55,共5页
目的探讨新型冠状病毒肺炎(COVID-19)患者病情严重程度及转归的影响因素。方法选取2020年1月25日至3月7日在武汉红安县城COVID-19定点医院隔离病区收治的252例COVID-19患者作为研究对象,回顾性分析患者的临床资料及流行病史。采用Pearso... 目的探讨新型冠状病毒肺炎(COVID-19)患者病情严重程度及转归的影响因素。方法选取2020年1月25日至3月7日在武汉红安县城COVID-19定点医院隔离病区收治的252例COVID-19患者作为研究对象,回顾性分析患者的临床资料及流行病史。采用Pearson相关和Logistic逐步回归对病情严重程度及转归的影响因素进行分析,构建受试者工作特征(ROC)曲线分析影响因素对COVID-19患者病情严重程度和转归的预测。结果COVID-19患者的发病年龄与病情严重程度和转归明显相关(r=0.420,0.226;均P<0.01),住院天数、接触史和性别与病情严重程度(r=0.032,0.045,0.087)和转归(r=0.067,0.092,0.124)无显著相关性(均P>0.05)。年龄>70岁患者的病死率(4/18,22.22%)高于≤70岁患者(3/234,1.28%)(P<0.01),轻症组的平均年龄[(46.50±14.26)岁]明显小于重症组[(62.95±14.64)岁](t=4.70,P<0.01)。发病年龄是影响患者病情严重程度(OR=1.624)和转归(OR=2.179)的危险因素之一(均P<0.01),对患者的病情严重程度和转归均有一定的预测作用(AUC=0.785,0.896;均P<0.01)。结论发病年龄是COVID-19患者病情严重程度和转归的危险因素之一,对其病情严重程度和转归有一定的预测作用,在防控和治疗COVID-19的工作过程中应该重点保护高龄人群。 展开更多
关键词 新型冠状病毒肺炎 严重程度 转归 影响因素
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吸烟对肺结核发病、临床特征及转归的影响 认领
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作者 徐玥 王璞 《医学信息》 2021年第5期54-57,共4页
肺结核是威胁人类健康的全球公共卫生问题之一,了解肺结核的病因对控制肺结核的传播和改善患者预后至关重要,吸烟作为危险因素对结核分枝杆菌感染、肺结核发病、肺结核临床严重程度、肺结核的传播、肺结核的治疗及转归都有不利影响,关... 肺结核是威胁人类健康的全球公共卫生问题之一,了解肺结核的病因对控制肺结核的传播和改善患者预后至关重要,吸烟作为危险因素对结核分枝杆菌感染、肺结核发病、肺结核临床严重程度、肺结核的传播、肺结核的治疗及转归都有不利影响,关于吸烟对肺结核患者疾病全程的影响已有较多研究,本文主要从吸烟对肺结核发病、临床特征及转归的影响进行综述,旨在进一步了吸烟对肺结核的影响。 展开更多
关键词 吸烟 肺结核 结核分枝杆菌 转归
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Comparison of functional outcomes among subtypes of Fraser’s typeⅡfloating knee 认领
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作者 Deepak Chouhan Devendra K.Chouhan +1 位作者 Rajendra K.Kanojia Prateek Behera 《中华创伤杂志:英文版》 CAS CSCD 2021年第1期25-29,共5页
Purpose The poor prognosis in patients with floating knee injuries is mainly contributed to articular involvement(Fraser’s typeⅡ).This study aims to evaluate and compare the functional outcomes among different Frase... Purpose The poor prognosis in patients with floating knee injuries is mainly contributed to articular involvement(Fraser’s typeⅡ).This study aims to evaluate and compare the functional outcomes among different Fraser’s typeⅡfloating knee injuries after surgical management.Methods Twenty-seven patients with Fraser’s typeⅡfloating knee injuries(54 fractures)between September 2014 and December 2015 were enrolled prospectively in this study and were distributed according to Fraser’s floating knee classification into three different groups as typeⅡA(ipsilateral femoral shaft and tibial intra-articular involvement,n=11),typeⅡB(ipsilateral tibial shaft and femoral intra-articular involvement,n=9)and typeⅡC(both femoral and tibial intra-articular involvement,n=7).The differences among the groups were evaluated and compared.The functional outcomes of these injuries at one year were analyzed using Knee Injury and Osteoarthritis Outcome Score(KOOS)which covers 5 subscales of pain,other symptoms,activities of daily living,sports and recreation,and quality of life.The result was also compared with standardized age-sex matched healthy population using paired samples t-test.Results All the patients were male,and the injury mechanism was solely roadside accident.The mean age was 29.8 years and injury severity score 17.9(comparable in all the three groups).Most injuries were observed on the right side(20 cases,74.1%).Based on paired samples t-test,the KOOS score of patients with Fraser’s typeⅡA was found to be better than that of typeⅡB and typeⅡC.Compared with the reference age-sex matched control group,patients with Fraser’s typeⅡB andⅡC fractures had significantly lower mean score in all KOOS subscales(all p<0.01).However,Fraser’s typeⅡA only revealed significant difference regarding the subscales of activities of daily living(p<0.0001),sports and recreation(p<0.0001),and quality of life(p<0.0001).Conclusion The results of this study show that patients with Fraser’s typeⅡA fractures ha 展开更多
关键词 Floating knee Femur fractures Tibia fractures OUTCOME
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